SARS-CoV-2 infection causes dopaminergic neuron senescence

Authors: Yang, Liuliu, Kim, Tae Wan, Han, Yuling, Nair, Manoj S., Harschnitz, Oliver, Zhu, Jiajun, Wang, Pengfei, Koo, So Yeon, Lacko, Lauretta A., Chandar, Vasuretha, Bram, Yaron, Zhang, Tuo, Zhang, Wei, He, Feng, Pan, Chendong, Wu, Junjie, Huang, Yaoxing, Evans, Todd, van der Valk, Paul, Titulaer, Maarten J., Spoor, Jochem K.H., Furler O’Brien, Robert L., Bugiani, Marianna, D.J. Van de Berg, Wilma, Schwartz, Robert E., Ho, David D., Studer, Lorenz, Chen, Shuibing

Source: In Cell Stem Cell 1 February 2024 31(2):196-211

Evolving antibody evasion and receptor affinity of the Omicron BA.2.75 sublineage of SARS-CoV-2

Authors: Wang, Qian, Li, Zhiteng, Guo, Yicheng, Mellis, Ian A., Iketani, Sho, Liu, Michael, Yu, Jian, Valdez, Riccardo, Lauring, Adam S., Sheng, Zizhang, Gordon, Aubree, Liu, Lihong, Ho, David D.

Source: In iScience 17 November 2023 26(11)

Changes in serum-neutralizing antibody potency and breadth post-SARS-CoV-2 mRNA vaccine boost

Authors: Nair, Manoj S. ¹, Ribeiro, Ruy M. ², Wang, Maple ¹, Bowen, Anthony D. ^{1, 3}, Liu, Lihong ¹, Guo, Yicheng ¹, Chang, Jennifer Y. ³, Wang, Pengfei ^{1, 4}, Sheng, Zizhang ¹, Sobieszczyk, Magdalena E. ^{1, 3}, Perelson, Alan S. ^{2, ∗}, Huang, Yaoxing ^{1, ∗∗}, Ho, David D. ^{1, 3, 5, ∗∗∗}

Source: In iScience 21 April 2023 26(4)

A pseudovirus system enables deep mutational scanning of the full SARS-CoV-2 spike

Authors: Dadonaite, Bernadeta, Crawford, Katharine H.D., Radford, Caelan E., Farrell, Ariana G., Yu, Timothy C., Hannon, William W., Zhou, Panpan, Andrabi, Raiees, Burton, Dennis R., Liu, Lihong, Ho, David D., Chu, Helen Y., Neher, Richard A., Bloom, Jesse D.

Source: In Cell 16 March 2023 186(6):1263-1278

Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants

Authors: Wang, Qian, Iketani, Sho, Li, Zhiteng, Liu, Liyuan, Guo, Yicheng, Huang, Yiming, Bowen, Anthony D., Liu, Michael, Wang, Maple, Yu, Jian, Valdez, Riccardo, Lauring, Adam S., Sheng, Zizhang, Wang, Harris H., Gordon, Aubree, Liu, Lihong, Ho, David D.

Source: In Cell 19 January 2023 186(2):279-286

In vivo kinetics of SARS-CoV-2 infection and its relationship with a person’s infectiousness

Authors: Ke, Ruian, Zitzmann, Carolin, Ho, David D., Ribeiro, Ruy M., Perelson, Alan S.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Dec 01. 118(49), 1-9.

Access URL: https://www.jstor.org/stable/27094123

Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques

Authors: King, Hannah A. D., Joyce, M. Gordon, Lakhal-Naouar, Ines, Ahmed, Aslaa, Cincotta, Camila Macedo, Subra, Caroline, Peachman, Kristina K., Hack, Holly R., Chen, Rita E., Thomas, Paul V., Chen, Wei-Hung, Sankhala, Rajeshwer S., Hajduczki, Agnes, Martinez, Elizabeth J., Peterson, Caroline E., Chang, William C., Choe, Misook, Smith, Clayton, Headley, Jarrett A., Elyard, Hanne A., Cook, Anthony, Anderson, Alexander, Wuertz, Kathryn McGuckin, Dong, Ming, Swafford, Isabella, Case, James B., Currier, Jeffrey R., Lal, Kerri G., Amare, Mihret F., Dussupt, Vincent, Molnar, Sebastian, Daye, Sharon P., Zeng, Xiankun, Barkei, Erica K., Alfson, Kendra, Staples, Hilary M., Carrion, Ricardo, Krebs, Shelly J., Paquin-Proulx, Dominic, Karasavvas, Nicos, Polonis, Victoria R., Jagodzinski, Linda L., Vasan, Sandhya, Scott, Paul T., Huang, Yaoxing, Nair, Manoj S., Ho, David D., de Val, Natalia, Diamond, Michael S., Lewisi, Mark G., Rao, Mangala, Matyas, Gary R., Gromowski, Gregory D., Peel, Sheila A., Michael, Nelson L., Modjarrad, Kayvon, Bolton, Diane L.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Sep . 118(38), 1-11.

Access URL: https://www.jstor.org/stable/27075662

Prolonged severe acute respiratory syndrome coronavirus 2 persistence, attenuated immunologic response, and viral evolution in a solid organ transplant patient

Authors: Purpura, Lawrence J., Chang, Michelle, Annavajhala, Medini K., Mohri, Hiroshi, Liu, Lihong, Shah, Jayesh, Cantos, Anyelina, Medrano, Nicola, Laracy, Justin, Scully, Brian, Miko, Benjamin A., Habal, Marlena, Pereira, Marcus R., Tsuji, Moriya, Ho, David D., Uhlemann, Anne‐Catrin, Yin, Michael T.

Source: American journal of transplantation. 22(2):649-653

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100141565338.0x000001&indx=1&recIds=ETOCvdc_100141565338.0x000001

A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses

Authors: Wang, Pengfei, Casner, Ryan G., Nair, Manoj S., Yu, Jian, Guo, Yicheng, Wang, Maple, Chan, Jasper F.-W., Cerutti, Gabriele, Iketani, Sho, Liu, Lihong, Sheng, Zizhang, Chen, Zhiwei, Yuen, Kwok-Yung, Kwong, Peter D., Huang, Yaoxing, Shapiro, Lawrence, Ho, David D.

Source: Emerging microbes & infections. 11(1):147-157

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194659182.0x000001&indx=1&recIds=ETOCvdc_100194659182.0x000001

SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells

Authors: Han, Yuling, Zhu, Jiajun, Yang, Liuliu, Nilsson-Payant, Benjamin E., Hurtado, Romulo, Lacko, Lauretta A., Sun, Xiaolu, Gade, Aravind R., Higgins, Christina A., Sisso, Whitney J., Dong, Xue, Wang, Maple, Chen, Zhengming, Ho, David D., Pitt, Geoffrey S., Schwartz, Robert E., tenOever, Benjamin R., Evans, Todd, Chen, Shuibing

Source: Circulation research. 130(7):963-977

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100155224599.0x000001&indx=1&recIds=ETOCvdc_100155224599.0x000001

Development and performance of a point-of-care rapid antigen test for detection of SARS-COV-2 variants

Authors: Liu, Lihong, Meyers, Kathrine, Purpura, Lawrence J., Nguyen, Nadia, Mohri, Hiroshi, Chang, Jennifer Y., Annavajhala, Medini K., Lopez, Leo, III, Lee, Sang Won, Shah, Jayesh, Lane, Benjamin, Cantos, Anyelina, Tukuru, Sade A., Guo, Yicheng, Ford, Kenra, Chiu, Yueh-Ting, Sheng, Zizhang, Choesang, Tenzin, Castor, Delivette, Wang, Maple, Pili, Christina, Van Hoy, Michael N., Wallach, Andrew, Horton, Jamie, Chen, Zhiqiang, Rosenthal, Susan, McLaren, Son, Jiang, Baowei, Wang, Frank, Lu, Helen H., Uhlemann, Anne-Catrin, Ho, David D., Yin, Michael T.

Source: In Journal of Clinical Virology Plus August 2022 2(3)

Persistence of an Infectious Form of SARS-CoV-2 After Protease Inhibitor Treatment of Permissive Cells In Vitro.

Authors: Nair, Manoj S, Luck, Maria I, Huang, Yaoxing, Sabo, Yosef, Ho, David D

Source: Journal of Infectious Diseases; 1/15/2025, Vol. 231 Issue 1, pe68-e76, 9p

Subject Terms: SARS-CoV-2, COVID-19, PROTEASE inhibitors, VIRUS inhibitors, DRUG resistance

Functional properties of the spike glycoprotein of the emerging SARS-CoV-2 variant B.1.1.529

Authors: Wang, Qian, Anang, Saumya, Iketani, Sho, Guo, Yicheng, Liu, Lihong, Katsamba, Phinikoula S., Shapiro, Lawrence, Ho, David D., Sodroski, Joseph G.

Source: In Cell Reports 14 June 2022 39(11)

Quantifying the contribution of Fc-mediated effector functions to the antiviral activity of anti–HIV-1 IgG1 antibodies in vivo

Authors: Wang, Pengfei, Gajjar, Mili R., Yu, Jian, Padte, Neal N., Gettie, Agegnehu, Blanchard, James L., Russell-Lodrigue, Kasi, Liao, Laura E., Perelson, Alan S., Huang, Yaoxing, Ho, David D.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Jul . 117(30), 18002-18009.

Access URL: https://www.jstor.org/stable/26935529

Functional differences among the spike glycoproteins of multiple emerging severe acute respiratory syndrome coronavirus 2 variants of concern

Authors: Wang, Qian, Nair, Manoj S., Anang, Saumya, Zhang, Shijian, Nguyen, Hanh, Huang, Yaoxing, Liu, Lihong, Ho, David D., Sodroski, Joseph G.

Source: In iScience 19 November 2021 24(11)

An airway organoid-based screen identifies a role for the HIF1α-glycolysis axis in SARS-CoV-2 infection

Authors: Duan, Xiaohua, Tang, Xuming, Nair, Manoj S., Zhang, Tuo, Qiu, Yunping, Zhang, Wei, Wang, Pengfei, Huang, Yaoxing, Xiang, Jenny, Wang, Hui, Schwartz, Robert E., Ho, David D., Evans, Todd, Chen, Shuibing

Source: In Cell Reports 9 November 2021 37(6)

Cardiomyocytes recruit monocytes upon SARS-CoV-2 infection by secreting CCL2

Authors: Yang, Liuliu, Nilsson-Payant, Benjamin E., Han, Yuling, Jaffré, Fabrice, Zhu, Jiajun, Wang, Pengfei, Zhang, Tuo, Redmond, David, Houghton, Sean, Møller, Rasmus, Hoagland, Daisy, Carrau, Lucia, Horiuchi, Shu, Goff, Marisa, Lim, Jean K., Bram, Yaron, Richardson, Chanel, Chandar, Vasuretha, Borczuk, Alain, Huang, Yaoxing, Xiang, Jenny, Ho, David D., Schwartz, Robert E., tenOever, Benjamin R., Evans, Todd, Chen, Shuibing

Source: In Stem Cell Reports 14 September 2021 16(9):2274-2288

Structural basis for accommodation of emerging B.1.351 and B.1.1.7 variants by two potent SARS-CoV-2 neutralizing antibodies

Authors: Cerutti, Gabriele, Rapp, Micah, Guo, Yicheng, Bahna, Fabiana, Bimela, Jude, Reddem, Eswar R., Yu, Jian, Wang, Pengfei, Liu, Lihong, Huang, Yaoxing, Ho, David D., Kwong, Peter D., Sheng, Zizhang, Shapiro, Lawrence

Source: In Structure 1 July 2021 29(7):655-663

Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite

Authors: Cerutti, Gabriele, Guo, Yicheng, Zhou, Tongqing, Gorman, Jason, Lee, Myungjin, Rapp, Micah, Reddem, Eswar R., Yu, Jian, Bahna, Fabiana, Bimela, Jude, Huang, Yaoxing, Katsamba, Phinikoula S., Liu, Lihong, Nair, Manoj S., Rawi, Reda, Olia, Adam S., Wang, Pengfei, Zhang, Baoshan, Chuang, Gwo-Yu, Ho, David D., Sheng, Zizhang, Kwong, Peter D., Shapiro, Lawrence

Source: In Cell Host & Microbe 12 May 2021 29(5):819-833

Robust SARS-CoV-2 infection in nasal turbinates after treatment with systemic neutralizing antibodies

Authors: Zhou, Dongyan, Chan, Jasper Fuk-Woo, Zhou, Biao, Zhou, Runhong, Li, Shuang, Shan, Sisi, Liu, Li, Zhang, Anna Jinxia, Chen, Serena J., Chan, Chris Chung-Sing, Xu, Haoran, Poon, Vincent Kwok-Man, Yuan, Shuofeng, Li, Cun, Chik, Kenn Ka-Heng, Chan, Chris Chun-Yiu, Cao, Jianli, Chan, Chun-Yin, Kwan, Ka-Yi, Du, Zhenglong, Lau, Thomas Tsz-Kan, Zhang, Qi, Zhou, Jie, To, Kelvin Kai-Wang, Zhang, Linqi, Ho, David D., Yuen, Kwok-Yung, Chen, Zhiwei

Source: In Cell Host & Microbe 14 April 2021 29(4):551-563