In vivo analysis of Aicda gene regulation: a critical balance between upstream enhancers and intronic silencers governs appropriate expression.

Authors: Le Thi Huong, Maki Kobayashi, Mikiyo Nakata, Go Shioi, Hitoshi Miyachi, Tasuku Honjo, Hitoshi Nagaoka

Source: PLoS ONE, Vol 8, Iss 4, p e61433 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3628980?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/a1d20213fb734c9fa0e2c24d7855589c

Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age.

Authors: Hongyan Qin, Keiichiro Suzuki, Mikiyo Nakata, Shunsuke Chikuma, Nakako Izumi, Le Thi Huong, Mikako Maruya, Sidonia Fagarasan, Meinrad Busslinger, Tasuku Honjo, Hitoshi Nagaoka

Source: PLoS ONE, Vol 6, Iss 12, p e29141 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3247255?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/21bdde7dbf1646fe8566f589a732102e

AID mutant analyses indicate requirement for class-switch-specific cofactors.

Authors: Van-Thanh Ta¹, Hitoshi Nagaoka¹, Nadia Catalan², Anne Durandy², Alain Fischer², Kohsuke Imai^2,3, Shigeaki Nonoyama^3,4, Junko Tashiro¹, Masaya Ikegawa¹, Satomi Ito¹, Kazuo Kinoshita¹, Masamichi Muramatsu¹, Tasuku Honjo¹ honjo@mfour.med.kyoto-u.ac.jp

Source: Nature Immunology. Sep2003, Vol. 4 Issue 9, p843. 6p.

Subject Terms: *B cells, *GENETIC recombination, *GENETIC mutation, *PROTEINS

Molecular mechanism for generation of antibody memory.

Authors: Velizar Shivarov, Reiko Shinkura, Tomomitsu Doi, Nasim A. Begum, Hitoshi Nagaoka, Il-Mi Okazaki, Satomi Ito, Taichiro Nonaka, Kazuo Kinoshita, Tasuku Honjo

Source: Philosophical Transactions of the Royal Society B: Biological Sciences; Mar2009, Vol. 364 Issue 1517, p569-575, 7p

Subject Terms: DNA, AMINES, RNA, PROTEIN synthesis, SCISSION (Chemistry)

Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination.

Authors: Begum, Nasim A., Stanlie, Andre, Doi, Tomomitsu, Sasaki, Yoko, Hai Wei Jin, Yong Sung Kim, Hitoshi Nagaoka, Tasuku Honjo

Source: Proceedings of the National Academy of Sciences of the United States of America; 2/24/2009, Vol. 106 Issue 8, p2752-2757, 6p, 1 Chart, 1 Graph

Subject Terms: IMMUNOGLOBULIN genes, IR genes, DNA, DEOXYRIBOSE, NUCLEIC acids, ESTERIFICATION, B cells

Evolution of class switch recombination function in fish activation-induced cytidine deaminase, AID.

Authors: Koshou Wakae, Brad G. Magor, Holly Saunders, Hitoshi Nagaoka, Akemi Kawamura, Kazuo Kinoshita, Tasuku Honjo, Masamichi Muramatsu

Source: International Immunology; Jan2006, Vol. 18 Issue 1, p41-47, 7p

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Four-and-a-half LIM Domains 1 (FHL1) Protein Interacts with the Rho Guanine Nucleotide Exchange Factor PLEKHG2/FLJ00018 and Regulates Cell Morphogenesis.

Authors: Katsuya Sato^1,2, Masashi Kimura^3,4, Kazue Sugiyama¹, Masashi Nishikawa¹, Yukio Okano³, Hitoshi Nagaoka³, Takahiro Nagase⁵, Yukio Kitade^1,6, Hiroshi Ueda^1,6 hueda@gifu-u.ac.jp

Source: Journal of Biological Chemistry. 11/25/2016, Vol. 291 Issue 48, p25227-25238. 12p.

Subject Terms: *GUANINE nucleotide exchange factors, *MORPHOGENESIS, *CELLULAR control mechanisms, *GENETIC transcription, *CELL morphology