Retarding human adipose-derived MSCs senescence and promoting tendon repair using cell sheet engineering with a histone methyltransferase inhibitor

Authors: Junjuan Wang, Ke Jian, Qing Yang, Chunyi Gu, Jiajun Sheng, Yan Zhou, Hantian Yin, Zhihan Zhang, Kouzhen Hua, Can Zhang

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-15 (2025)

Subject Terms: Adipose-derived mesenchymal stem cells, Senescence, Histone methyltransferase, Cell sheet, Tendon repair, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/e10aed2307d448dbbc084fc4c76d7a63

The histone methyltransferase DOT1B is dispensable for stage differentiation and macrophage infection of Leishmania mexicana

Authors: Nicole Eisenhuth, Elisa Theres Rauh, Melina Mitnacht, Andrea Debus, Ulrike Schleicher, Falk Butter, Katerina Pruzinova, Petr Volf, Christian J. Janzen

Source: Frontiers in Cellular and Infection Microbiology, Vol 14 (2025)

Subject Terms: histone methyltransferase, DOT1, Leishmania mexicana, virulence, differentiation, sand fly, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcimb.2024.1502339/full; https://doaj.org/toc/2235-2988

Access URL: https://doaj.org/article/fc56401b15684082a3feeec78859b9f8

The Plasmodium falciparum histone methyltransferase PfSET10 is dispensable for the regulation of antigenic variation and gene expression in blood-stage parasites

Authors: Matthias Wyss, Abhishek Kanyal, Igor Niederwieser, Richard Bartfai, Till S. Voss

Source: mSphere, Vol 9, Iss 11 (2024)

Subject Terms: Plasmodium falciparum, malaria, antigenic variation, histone methyltransferase, PfSET10, RNA-seq, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2379-5042

Access URL: https://doaj.org/article/0caf02a1ac834e9799f7244f9e4df126

The Plasmodium falciparum histone methyltransferase SET10 participates in a chromatin modulation network crucial for intraerythrocytic development

Authors: Jean-Pierre Musabyimana, Sherihan Musa, Janice Manti, Ute Distler, Stefan Tenzer, Che Julius Ngwa, Gabriele Pradel

Source: mSphere, Vol 9, Iss 11 (2024)

Subject Terms: malaria, histone methyltransferase, transcription, DNA replication, epigenetic gene regulation, chromatin modulation, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2379-5042

Access URL: https://doaj.org/article/944351f611974aaf80930259b0204567

Histone-modifying enzymes and gastric cancer: Search for potential biomarkers and therapeutic targets based on Mendelian randomization

Authors: Wenbo Liu, Zhiyuan Wang, Zhiran Yang, Bingjie Huo, Yanru Song, Yong Li, Bibo Tan

Source: Heliyon, Vol 10, Iss 19, Pp e38582- (2024)

Subject Terms: Gastric cancer, Histone-modifying enzymes, Mendelian randomization analysis, Set1/Ash2 histone methyltransferase complex subunit ASH2, Histone-lysine N-Methyltransferase SETMAR, Histone acetyltransferase KAT6A, Science (General), Q1-390, Social sciences (General), H1-99

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844024146130; https://doaj.org/toc/2405-8440

Access URL: https://doaj.org/article/4e5cc26709144ffe9e1087965d444d6b

Identification and insights into the uncommon configuration of novel histone lysine acetyltransferase PCAF and methyltransferase GLP inhibitors from Wikstroemia chamaedaphne by molecular docking, and in vitro assessment

Authors: Hou, Xuefen ^{a, 1}, Yu, Tongtong ^{a, 1}, chol, Choe hyok ^b, An, Jingkai ^a, Zhang, Lin ^b, Sun, Meijia ^a, Mecinović, Jasmin ^c, Gao, Pinyi ^d, Li, Lingzhi ^{a, ⁎}

Source: In International Journal of Biological Macromolecules April 2025 304 Part 1

Role of histone methyltransferase KMT2D in BMSC osteogenesis via AKT signaling

Authors: Zhichun Zhang, Yanyan Guo, Xuejun Gao, Xiaoyan Wang, Chanyuan Jin

Source: Regenerative Therapy, Vol 26, Iss , Pp 775-782 (2024)

Subject Terms: Marrow mesenchymal stem cell, Osteogenesis, KMT2D, AKT signaling, Histone methyltransferase, Medicine (General), R5-920, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352320424001603; https://doaj.org/toc/2352-3204

Access URL: https://doaj.org/article/9eb636875c48482ead6ca11bec1aae6a

H3K4 methylation regulates development, DNA repair, and virulence in Mucorales

Authors: Macario Osorio-Concepción, Carlos Lax, Damaris Lorenzo-Gutiérrez, José Tomás Cánovas-Márquez, Ghizlane Tahiri, Eusebio Navarro, Ulrike Binder, Francisco Esteban Nicolás, Victoriano Garre

Source: IMA Fungus, Vol 15, Iss 1, Pp 1-15 (2024)

Subject Terms: Mucormycosis, Set1, Pathogenesis, Histone methyltransferase, Mucor, Botany, QK1-989

File Description: electronic resource

Relation: https://doaj.org/toc/2210-6359

Access URL: https://doaj.org/article/b9f413d3edd7414bab1b37a7c36dfcb4

Development and validation of a generic methyltransferase enzymatic assay based on an SAH riboswitch

Authors: Ha Pham, Meera Kumar, Anibal Ramos Martinez, Mahbbat Ali, Robert G. Lowery

Source: SLAS Discovery, Vol 29, Iss 4, Pp 100161- (2024)

Subject Terms: Epigenetics, Histone methyltransferase, DNA methyltransferase, Methyltransferase assay, Aptamer, Riboswitch, Medicine (General), R5-920, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2472555224000236; https://doaj.org/toc/2472-5552

Access URL: https://doaj.org/article/b24641d39fdd403a8bd985ead3a395eb

NSD family proteins: Rising stars as therapeutic targets

Authors: Lin He, Yiping Cao, Luyang Sun

Source: Cell Insight, Vol 3, Iss 2, Pp 100151- (2024)

Subject Terms: Epigenetic modification, Cell identity, Histone methyltransferase, Epigenetic inhibitor, Histone code, NSD, Biology (General), QH301-705.5, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2772892724000063; https://doaj.org/toc/2772-8927

Access URL: https://doaj.org/article/22d074ddc9164b66afb301575015ea3e

The pharmacoepigenetic paradigm in cancer treatment

Authors: Belén Ocaña-Paredes, Sebastián Rivera-Orellana, David Ramírez-Sánchez, Juliana Montalvo-Guerrero, María Paula Freire, Samantha Espinoza-Ferrao, Adriana Altamirano-Colina, Paulina Echeverría-Espinoza, María José Ramos-Medina, Gabriela Echeverría-Garcés, Danilo Granda-Moncayo, Andrea Jácome-Alvarado, María Gabriela Andrade, Andrés López-Cortés

Source: Frontiers in Pharmacology, Vol 15 (2024)

Subject Terms: epigenetic drugs, histone deacetylase inhibitors, histone acetyltransferase inhibitors, histone methyltransferase inhibitors, DNA methyltransferase inhibitors, clinical trials, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1381168/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/6aeb0f23da1d4129ad4c7d906668331a

The roles of histone methylation in the regulation of abiotic stress responses in plants

Authors: Lei Shi, Xiaoyun Cui, Yuan Shen

Source: Plant Stress, Vol 11, Iss , Pp 100303- (2024)

Subject Terms: Abiotic stress, Histone methylation, Histone methyltransferase, Histone demethylase, Epigenetic memory, Metabolic regulation, Plant ecology, QK900-989

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2667064X23001707; https://doaj.org/toc/2667-064X

Access URL: https://doaj.org/article/7292947df6e94893bf7de7868c95f8e7

A multi-layered computational structural genomics approach enhances domain-specific interpretation of Kleefstra syndrome variants in EHMT1

Authors: Young-In Chi, Salomão D. Jorge, Davin R. Jensen, Brian C. Smith, Brian F. Volkman, Angela J. Mathison, Gwen Lomberk, Michael T. Zimmermann, Raul Urrutia

Source: Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 5249-5258 (2023)

Subject Terms: EHMT1, GLP, Epigenetic regulator, Histone methyltransferase, Gene variation, Kleefstra syndrome, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2001037023003781; https://doaj.org/toc/2001-0370

Access URL: https://doaj.org/article/9c19c7d1321f48649e22f30b026ca4ac

Identification of a functional peptide of a probiotic bacterium-derived protein for the sustained effect on preventing colitis

Authors: Harpreet Kaur, Syed Azmal Ali, Sarah P. Short, Christopher S. Williams, Jeremy A. Goettel, M. Kay Washington, Richard M. Peek, Sari A. Acra, Fang Yan

Source: Gut Microbes, Vol 15, Iss 2 (2023)

Subject Terms: Histone methyltransferase, intestinal epithelial cell, p40, Setd1β, TGFβ, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/1949-0976; https://doaj.org/toc/1949-0984

Access URL: https://doaj.org/article/fbd498869d1e4dc9a38573f75067729d

Evidence of a synthetic lethality interaction between SETDB1 histone methyltransferase and CHD4 chromatin remodeling protein in a triple negative breast cancer cell line

Authors: M.S. Moraes-Almeida, M.C. Sogayar, M.A.A. Demasi

Source: Brazilian Journal of Medical and Biological Research, Vol 56 (2023)

Subject Terms: Breast cancer, Synthetic lethality, CRISPR-Cas9, CHD4 chromatin remodeling protein, SETDB1 histone methyltransferase, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2023000100688&lng=en&tlng=en; http://www.scielo.br/pdf/bjmbr/v56/1414-431X-bjmbr-56-e12854.pdf; https://doaj.org/toc/1414-431X

Access URL: https://doaj.org/article/333e1f700fdb4954b88732a18c01587a

The SET and ankyrin domains of the secreted Legionella pneumophila histone methyltransferase work together to modify host chromatin

Authors: Monica Rolando, Ivy Yeuk Wah Chung, Caishuang Xu, Laura Gomez-Valero, Patrick England, Miroslaw Cygler, Carmen Buchrieser

Source: mBio, Vol 14, Iss 5 (2023)

Subject Terms: Legionella pneumophila, host-pathogen interactions, histone methyltransferase, epigenetics, H3K14, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/26ec4e0656494b79ac181002d73bfbb5

Set2 family regulates mycotoxin metabolism and virulence via H3K36 methylation in pathogenic fungus Aspergillus flavus

Authors: Zhenhong Zhuang, Xiaohua Pan, Mengjuan Zhang, Yaju Liu, Chuanzhong Huang, Yu Li, Ling Hao, Shihua Wang

Source: Virulence, Vol 13, Iss 1, Pp 1358-1378 (2022)

Subject Terms: Aspergillus flavus, histone methyltransferase, Set2 family, virulence, mycotoxin, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/2150-5594; https://doaj.org/toc/2150-5608

Access URL: https://doaj.org/article/1892bf29c38147d09e66edc4477771f6

Comprehensive molecular evaluation of the histone methyltransferase gene family and their important roles in two-line hybrid wheat

Authors: Renwei Sun, Jie Gong, Yongjie Liu, Zhaobo Chen, Fengting Zhang, Jiangang Gao, Junmei Cao, Xianchao Chen, Shengquan Zhang, Changping Zhao, Shiqing Gao

Source: BMC Plant Biology, Vol 22, Iss 1, Pp 1-20 (2022)

Subject Terms: Hybrid wheat, Histone methyltransferase, Phylogenetic analysis, Gene expression, TaCCA1, Heterosis, Botany, QK1-989

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2229

Access URL: https://doaj.org/article/25faf2cb6fd441c99d500e2375e946fe

The role of histone methyltransferases in neurocognitive disorders associated with brain size abnormalities

Authors: Foster D. Ritchie, Sofia B. Lizarraga

Source: Frontiers in Neuroscience, Vol 17 (2023)

Subject Terms: autism, histone methyltransferase, brain size, neurodevelopment, chromatin, microcephaly, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnins.2023.989109/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/faa3df40cf4d4d8fb58cf56fd6fed2ed

Evidence of the Involvement of Spinal EZH2 in the Development of Bone Cancer Pain in Rats

Authors: Chen H, Yu J, Hang L, Li S, Lu W, Xu Z

Source: Journal of Pain Research, Vol Volume 14, Pp 3593-3600 (2021)

Subject Terms: enhancer of zeste homologue 2, bone cancer pain, histone methyltransferase, 3 deazaneplanocin a, intrathecal injection, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.dovepress.com/evidence-of-the-involvement-of-spinal-ezh2-in-the-development-of-bone--peer-reviewed-fulltext-article-JPR; https://doaj.org/toc/1178-7090

Access URL: https://doaj.org/article/b2ce7e59d32b4c08990066d4f2b04ad7