ER-mitochondria contacts mediate lipid radical transfer via RMDN3/PTPIP51 phosphorylation to reduce mitochondrial oxidative stress

Authors: Isshin Shiiba, Naoki Ito, Hijiri Oshio, Yuto Ishikawa, Takahiro Nagao, Hiroki Shimura, Kyu-Wan Oh, Eiki Takasaki, Fuya Yamaguchi, Ryoan Konagaya, Hisae Kadowaki, Hideki Nishitoh, Takehito Tanzawa, Shun Nagashima, Ayumu Sugiura, Yuuta Fujikawa, Keitaro Umezawa, Yasushi Tamura, Byung Il Lee, Yusuke Hirabayashi, Yasushi Okazaki, Tomohiro Sawa, Ryoko Inatome, Shigeru Yanagi

Source: Nature Communications, Vol 16, Iss 1, Pp 1-18 (2025)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/03c009a57b1144d7b7e9620a833a6e43

Chemical chaperones ameliorate neurodegenerative disorders in Derlin-1-deficient mice via improvement of cholesterol biosynthesis

Authors: Takashi Sugiyama, Naoya Murao, Hisae Kadowaki, Hideki Nishitoh

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/bb1f4c21843b40ea83c25b9c641f9649

ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function

Authors: Takashi Sugiyama, Naoya Murao, Hisae Kadowaki, Keizo Takao, Tsuyoshi Miyakawa, Yosuke Matsushita, Toyomasa Katagiri, Akira Futatsugi, Yohei Shinmyo, Hiroshi Kawasaki, Juro Sakai, Kazutaka Shiomi, Masamitsu Nakazato, Kohsuke Takeda, Katsuhiko Mikoshiba, Hidde L. Ploegh, Hidenori Ichijo, Hideki Nishitoh

Source: iScience, Vol 24, Iss 7, Pp 102758- (2021)

Subject Terms: Biological sciences, Neuroscience, Molecular neuroscience, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004221007264; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/b69667e8cdc0451bb9c8130fc2b00445

Molecular mechanism of ER stress-induced pre-emptive quality control involving association of the translocon, Derlin-1, and HRD1

Authors: Hisae Kadowaki, Pasjan Satrimafitrah, Yasunari Takami, Hideki Nishitoh

Source: Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/42deb39b64934e39b3a42ce238a7aa34

Pre-emptive Quality Control Protects the ER from Protein Overload via the Proximity of ERAD Components and SRP

Authors: Hisae Kadowaki, Atsushi Nagai, Takeshi Maruyama, Yasunari Takami, Pasjan Satrimafitrah, Hironori Kato, Arata Honda, Tomohisa Hatta, Tohru Natsume, Takashi Sato, Hirofumi Kai, Hidenori Ichijo, Hideki Nishitoh

Source: Cell Reports, Vol 13, Iss 5, Pp 944-956 (2015)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124715010724; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/0f566106dd3945e7a0dd4c3c62953602

A systematic immunoprecipitation approach reinforces the concept of common conformational alterations in amyotrophic lateral sclerosis-linked SOD1 mutants

Authors: Takao Fujisawa, Namiko Yamaguchi, Hisae Kadowaki, Yuka Tsukamoto, Naomi Tsuburaya, Atsushi Tsubota, Hiromitsu Takahashi, Isao Naguro, Yuji Takahashi, Jun Goto, Shoji Tsuji, Hideki Nishitoh, Kengo Homma, Hidenori Ichijo

Source: Neurobiology of Disease, Vol 82, Iss , Pp 478-486 (2015)

Subject Terms: Amyotrophic lateral sclerosis, Mutant SOD1, ER stress, Mutant SOD1-specific antibody, ELISA, Common conformational change, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996115300310; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/75c61bf9da0c485e922c8c413b437906

Signaling Pathways from the Endoplasmic Reticulum and Their Roles in Disease.

Authors: Hisae Kadowaki¹ kadowaki@med.miyazaki-u.ac.jp, Hideki Nishitoh¹ nishitoh@med.miyazaki-u.ac.jp

Source: Genes. Sep2013, Vol. 4 Issue 3, p306-333. 28p.

Subject Terms: *ENDOPLASMIC reticulum, *CELLULAR signal transduction, *MEMBRANE proteins, *GENETIC mutation, *GENES

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Role of Apoptosis Signal-regulating Kinase 1 (ASK1) as an Activator of the GAPDH-Siah1 Stress-Signaling Cascade.

Authors: Tristan, Carlos A.¹, Ramos, Adriana¹, Shahani, Neelam¹, Emiliani, Francesco E.¹, Hidemitsu Nakajima, Noeh, Christopher C.², Yoshinori Kato^2,3, Tadayoshi Takeuchi⁴, Takuya Noguchi⁵, Hisae Kadowaki⁵, Sedlak, Thomas W.¹, Koko Ishizuka¹, Hidenori Ichijo⁵, Akira Sawa^1,6 asawa1@jhmi.edu

Source: Journal of Biological Chemistry. 1/2/2015, Vol. 290 Issue 1, p56-64. 9p.

Subject Terms: *APOPTOSIS, *PROTEIN kinases, *GLYCOLYSIS, *PHOSPHORYLATION, *BIOCHEMICAL research