From Dyrk1A inhibitors to a novel class of antiviral agents: Targeting Enterovirus EV-A71 with 2-aryl-substituted thiophene scaffolds

Authors: Keddis, Parthiena M. ^{a, 1}, My Tu, Tuong-Khanh ^{b, 1}, Scherer, Hugo ^c, Kany, Andreas M. ^{c, d}, Hafez, Donia E. ^a, Darwish, Sarah S. ^e, Abadi, Ashraf H. ^a, Hirsch, Anna K.H. ^{c, d, f}, Engel, Matthias ^g, Hamed, Mostafa M. ^{c, d, ⁎}, Horng, Jim-Tong ^{b, h, i, j, k, ⁎⁎}, Abdel-Halim, Mohammad ^{a, ⁎⁎⁎}

Source: In European Journal of Medicinal Chemistry 5 April 2025 287

IspE kinase as an anti-infective target: Role of a hydrophobic pocket in inhibitor binding

Authors: Hamid, Rawia, Walsh, Danica J., Diamanti, Eleonora, Aguilar, Diana, Lacour, Antoine, Hamed, Mostafa M., Hirsch, Anna K.H.

Source: In Structure 5 December 2024 32(12):2390-2398

Discovery and optimization of thiazole-based quorum sensing inhibitors as potent blockers of Pseudomonas aeruginosa pathogenicity

Authors: Abdelsamie, Ahmed S., Hamed, Mostafa M., Schütz, Christian, Röhrig, Teresa, Kany, Andreas M., Schmelz, Stefan, Blankenfeldt, Wulf, Hirsch, Anna K.H., Hartmann, Rolf W., Empting, Martin

Source: In European Journal of Medicinal Chemistry 5 October 2024 276

Thermotropic liquid crystals in drug delivery: A versatile carrier for controlled release

Authors: Nesterkina, Mariia, Kravchenko, Iryna, Hirsch, Anna K.H., Lehr, Claus-Michael

Source: In European Journal of Pharmaceutics and Biopharmaceutics July 2024 200

Arg-biodynamers as antibiotic potentiators through interacting with Gram-negative outer membrane lipopolysaccharides

Authors: Kamal, Mohamed A.M., Bassil, Justine, Loretz, Brigitta, Hirsch, Anna K.H., Lee, Sangeun, Lehr, Claus-Michael

Source: In European Journal of Pharmaceutics and Biopharmaceutics July 2024 200

Two natural compounds as potential inhibitors against the Helicobacter pylori and Acinetobacter baumannii IspD enzymes

Authors: Chen, Xiaoyu, Zhao, Huilin, Wang, Chuandong, Hamed, Mostafa, Shang, Qinghong, Yang, Yating, Diao, Xiaotong, Sun, Xiangnan, Hu, Wei, Jiang, Xukai, Zhang, Youming, Hirsch, Anna K.H., Wu, Dalei, Zhuang, Jingjing

Source: In International Journal of Antimicrobial Agents May 2024 63(5)

Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity

Authors: Al-Saad, Omar M., Gabr, Moustafa, Darwish, Sarah S., Rullo, Mariagrazia, Pisani, Leonardo, Miniero, Daniela Valeria, Liuzzi, Grazia Maria, Kany, Andreas M., Hirsch, Anna K.H., Abadi, Ashraf H., Engel, Matthias, Catto, Marco, Abdel-Halim, Mohammad

Source: In European Journal of Medicinal Chemistry 5 April 2024 269

Genotoxic and mutational potential of monocyclic terpenoids (carvacrol, carvone and thymol) in Drosophila melanogaster

Authors: Nesterkina, Mariia, Bilokon, Svitlana, Alieksieieva, Tetiana, Kravchenko, Iryna, Hirsch, Anna K.H.

Source: Toxicology reports. 10:327-333

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193481303.0x000001&indx=1&recIds=ETOCvdc_100193481303.0x000001

Proteoid biodynamers for safe mRNA transfection via pH-responsive nanorods enabling endosomal escape

Authors: Lee, Sangeun, Nasr, Sarah, Rasheed, Sari, Liu, Yun, Hartwig, Olga, Kaya, Cansu, Boese, Annette, Koch, Marcus, Herrmann, Jennifer, Müller, Rolf, Loretz, Brigitta, Buhler, Eric, Hirsch, Anna K.H., Lehr, Claus-Michael

Source: Journal of controlled release. 353:915-929

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100180181529.0x000001&indx=1&recIds=ETOCvdc_100180181529.0x000001

Design of thiamine analogues for inhibition of thiamine diphosphate (ThDP)-dependent enzymes: Systematic investigation through Scaffold-Hopping and C2-Functionalisation

Authors: Chan, Alex H.Y., Ho, Terence C.S., Irfan, Rimsha, Hamid, Rawia A.A., Rudge, Emma S., Iqbal, Amjid, Turner, Alex, Hirsch, Anna K.H., Leeper, Finian J.

Source: In Bioorganic Chemistry September 2023 138

1-deoxy-D-xylulose-5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding

Authors: Hamid, Rawia, Adam, Sebastian, Lacour, Antoine, Monjas, Leticia, Köhnke, Jesko, Hirsch, Anna K.H.

Source: In Journal of Biological Chemistry September 2023 299(9)

Synthesis, biological evaluation, and molecular docking studies of aldotetronic acid-based LpxC inhibitors

Authors: Wimmer, Stefan, Hoff, Katharina, Martin, Benedikt, Grewer, Martin, Denni, Laura, Lascorz Massanet, Raquel, Raimondi, Maria Valeria, Bülbül, Emre F., Melesina, Jelena, Hotop, Sven-Kevin, Haupenthal, Jörg, Rohde, Holger, Heisig, Peter, Hirsch, Anna K.H., Brönstrup, Mark, Sippl, Wolfgang, Holl, Ralph

Source: In Bioorganic Chemistry February 2023 131

Baicalin lipid nanocapsules for treatment of glioma: characterization, mechanistic cytotoxicity, and pharmacokinetic evaluation

Authors: Ibrahim, Alaa, Abdel Gaber, Sara A., Fawzi Kabil, Mohamed, Ahmed-Farid, Omar A.H., Hirsch, Anna K.H., El-Sherbiny, Ibrahim M., Nasr, Maha

Source: Expert opinion on drug delivery. 19(11):1549-1560

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164114185.0x000001&indx=1&recIds=ETOCvdc_100164114185.0x000001

Metabolic Profiling of S-praziquantel: Structure Elucidation Using the Crystalline Sponge Method in Combination with Mass Spectrometry and Nuclear Magnetic Resonance

Authors: Rosenberger, Lara ^*, Jenniches, Judith, von Essen, Carolina, Khutia, Anupam, Kühn, Clemens, Marx, Andreas, Georgi, Katrin, Hirsch, Anna K.H., Hartmann, Rolf W., Badolo, Lassina

Source: In Drug Metabolism and Disposition April 2022 50(4):320-326

Redesigning of the cap conformation and symmetry of the diphenylethyne core to yield highly potent pan-genotypic NS5A inhibitors with high potency and high resistance barrier

Authors: Abdallah, Mennatallah, Hamed, Mostafa M., Frakolaki, Efseveia, Katsamakas, Sotirios, Vassilaki, Niki, Bartenschlager, Ralf, Zoidis, Grigoris, Hirsch, Anna K.H., Abdel-Halim, Mohammad, Abadi, Ashraf H.

Source: In European Journal of Medicinal Chemistry 5 February 2022 229

Crystalline sponge affinity screening: A fast tool for soaking condition optimization without the need of X-ray diffraction analysis

Authors: Rosenberger, Lara, von Essen, Carolina, Khutia, Anupam, Kühn, Clemens, Georgi, Katrin, Hirsch, Anna K.H., Hartmann, Rolf W., Badolo, Lassina

Source: In European Journal of Pharmaceutical Sciences 1 September 2021 164

“Clicking“ fragment leads to novel dual-binding cholinesterase inhibitors

Authors: Molęda, Zuzanna, Zawadzka, Anna, Czarnocki, Zbigniew, Monjas, Leticia, Hirsch, Anna K.H., Budzianowski, Armand, Maurin, Jan K.

Source: In Bioorganic & Medicinal Chemistry 15 July 2021 42

Mastering the Gram-negative bacterial barrier – Chemical approaches to increase bacterial bioavailability of antibiotics

Authors: Ropponen, Henni-Karoliina, Richter, Robert, Hirsch, Anna K.H., Lehr, Claus-Michael

Source: In Advanced Drug Delivery Reviews May 2021 172:339-360

Identification of a 1-deoxy-D-xylulose-5-phosphate synthase (DXS) mutant with improved crystallographic properties

Authors: Gierse, Robin M., Reddem, Eswar R., Alhayek, Alaa, Baitinger, Dominik, Hamid, Zhoor, Jakobi, Harald, Laber, Bernd, Lange, Gudrun, Hirsch, Anna K.H., Groves, Matthew R.

Source: Biochemical and biophysical research communications. 539:42-47

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A hydrogel-based in vitro assay for the fast prediction of antibiotic accumulation in Gram-negative bacteria

Authors: Richter, Robert, Kamal, Mohamed.A.M., García-Rivera, Mariel A., Kaspar, Jerome, Junk, Maximilian, Elgaher, Walid A.M., Srikakulam, Sanjay Kumar, Gress, Alexander, Beckmann, Anja, Grißmer, Alexander, Meier, Carola, Vielhaber, Michael, Kalinina, Olga, Hirsch, Anna K.H., Hartmann, Rolf W., Brönstrup, Mark, Schneider-Daum, Nicole, Lehr, Claus-Michael

Source: In Materials Today Bio September 2020 8