Comprehensive gene expression analysis in gallbladder mucosal epithelial cells of dogs with gallbladder mucocele

Authors: Itsuma Nagao, Tomoki Motegi, Yuko Goto‐Koshino, Masaya Tsuboi, Naohiro Takahashi, James K. Chambers, Kazuyuki Uchida, Kenji Baba, Hirotaka Tomiyasu, Masaru Okuda

Source: Journal of Veterinary Internal Medicine, Vol 38, Iss 6, Pp 3031-3037 (2024)

Subject Terms: ANO1, gallbladder epithelial cells, HTR4, RNA‐seq, Veterinary medicine, SF600-1100

File Description: electronic resource

Relation: https://doaj.org/toc/0891-6640; https://doaj.org/toc/1939-1676

Access URL: https://doaj.org/article/9efd5a763160421ab8757869f2a60c60

Comprehensive investigation of gene mutations in canine large cell gastrointestinal lymphoma

Authors: Naoki Matsumura, Takumi Tsuruta, Yuko Goto-Koshino, Keijiro Mizukami, Tomomi Aoi, Ryoko Yamada, Yuki Matsumoto, Itsuma Nagao, Megumi Sakamoto, Taisuke Nakagawa, Ray Fukuoka, Aki Ohmi, James K. Chambers, Kazuyuki Uchida, Yukihide Momozawa, Hirotaka Tomiyasu

Source: Frontiers in Veterinary Science, Vol 12 (2025)

Subject Terms: dog, targeted next-generation sequencing, T-cell lymphoma, whole exome sequencing, ZDBF2, Veterinary medicine, SF600-1100

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fvets.2025.1535446/full; https://doaj.org/toc/2297-1769

Access URL: https://doaj.org/article/843d9484ffb94c78b63fdd41554ee721

Characterization of faecal microbiota and serum inflammatory markers in dogs diagnosed with chronic enteropathy or small-cell lymphoma: a pilot study

Authors: Chiaki Kaga, Sayaka Kakiyama, Atsuko Hokkyo, Yuzuru Ogata, Junko Shibata, Takuro Nagahara, Maho Nakazawa, Taisuke Nakagawa, Hajime Tsujimoto, James K. Chambers, Kazuyuki Uchida, Satoshi Matsumoto, Toshihide Kobayashi, Hirotaka Tomiyasu, Naomi Mizusawa

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/57ece989e5474853a4cac0560579a2b4

Use of genome‐wide DNA methylation analysis to identify prognostic CpG site markers associated with longer survival time in dogs with multicentric high‐grade B‐cell lymphoma

Authors: Yong Bin Teoh, Teita Ishizaki, Yumiko Kagawa, Shoko Yokoyama, Jaroslav Jelinek, Yuki Matsumoto, Hirotaka Tomiyasu, Hajime Tsujimoto, Mitsuyoshi Takiguchi, Jumpei Yamazaki

Source: Journal of Veterinary Internal Medicine, Vol 38, Iss 1, Pp 316-325 (2024)

Subject Terms: biomarkers, canine DREAM, canine lymphoma, epigenetics, Veterinary medicine, SF600-1100

File Description: electronic resource

Relation: https://doaj.org/toc/0891-6640; https://doaj.org/toc/1939-1676

Access URL: https://doaj.org/article/590a5e0cc5ab4f7c9369768e3ed7d976

Increased plasma DR‐70 (fibrinogen‐fibrin degradation products) concentrations as a diagnostic biomarker in dogs with neoplasms

Authors: Chiao‐Hsu Ke, Ka‐Mei Sio, Chun‐Hung Wu, Yuan‐Yuan Xia, Jih‐Jong Lee, Chin‐Hao Hu, Cheng‐Chi Liu, Chueh‐Ling Lu, Chiao‐Lei Cheng, Keng‐Hsuan Lin, Hirotaka Tomiyasu, Yu‐Shan Wang, Chen‐Si Lin

Source: Journal of Veterinary Internal Medicine, Vol 37, Iss 6, Pp 2391-2401 (2023)

Subject Terms: biomarker, DR‐70, fibrinogen‐fibrin degradation products, tumor detection, Veterinary medicine, SF600-1100

File Description: electronic resource

Relation: https://doaj.org/toc/0891-6640; https://doaj.org/toc/1939-1676

Access URL: https://doaj.org/article/4c924bffaa224ef78728a76596a29a50

Canine diffuse large B-cell lymphoma downregulates the activity of CD8 + T-cells through tumor-derived extracellular vesicles

Authors: Hsin-Pei Weng, Chiao-Hsu Ke, Chun-Wei Tung, Akiyoshi Tani, Chia-Chi Wang, Wen-Yuan Yang, Yu-Shan Wang, Winston Han, Chi-Hsun Liao, Hirotaka Tomiyasu, Chen-Si Lin

Source: Cancer Cell International, Vol 23, Iss 1, Pp 1-22 (2023)

Subject Terms: Extracellular vesicles, Diffuse large B-cell lymphoma, Immune suppression, CD8 + T-cell, CTLA-4 blockade, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2867

Access URL: https://doaj.org/article/25558b396a7f4dce8cfe5d511c7a8803

Polyoxazoline-conjugated porcine serum albumin as an artificial plasma expander for dogs

Authors: Wataru Okamoto, Tomone Usui, Mai Hasegawa, Tatsuhiro Kobayashi, Junya Fujisawa, Kazuaki Taguchi, Kazuaki Matsumoto, Mitsutomo Kohno, Masayuki Iwazaki, Shotaro Shimano, Itsuma Nagao, Hiroto Toyoda, Naoki Matsumura, Hirotaka Tomiyasu, Ryota Tochinai, Teruyuki Komatsu

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/e265ef0d2d004cd0bc6c462a06f60241

Whole exome and transcriptome analysis revealed the activation of ERK and Akt signaling pathway in canine histiocytic sarcoma

Authors: Hajime Asada, Akiyoshi Tani, Hiroki Sakuma, Miyuki Hirabayashi, Yuki Matsumoto, Kei Watanabe, Masaya Tsuboi, Shino Yoshida, Kei Harada, Takao Uchikai, Yuko Goto-Koshino, James K. Chambers, Genki Ishihara, Tetsuya Kobayashi, Mitsuhiro Irie, Kazuyuki Uchida, Koichi Ohno, Makoto Bonkobara, Hajime Tsujimoto, Hirotaka Tomiyasu

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/af03d2782b0446e39e0c30681c9b4fd7

Clinical characteristics and outcomes of Mott cell lymphoma in nine miniature dachshunds

Authors: Aki Ohmi, Miho Tanaka, Jun Rinno, Masaya Tsuboi, James K. Chambers, Kazuyuki Uchida, Yuko Goto‐Koshino, Hirotaka Tomiyasu, Koichi Ohno, Hajime Tsujimoto

Source: Veterinary Medicine and Science, Vol 9, Iss 2, Pp 609-617 (2023)

Subject Terms: alimentary, breed, canine, dog, gastrointestinal, intestinal, Veterinary medicine, SF600-1100

File Description: electronic resource

Relation: https://doaj.org/toc/2053-1095

Access URL: https://doaj.org/article/a20ef652b7fa487f8a6769ff1910936c

Canine transmissible venereal tumour established in immunodeficient mice reprograms the gene expression profiles associated with a favourable tumour microenvironment to enable cancer malignancy

Authors: Chiao-Hsu Ke, Hirotaka Tomiyasu, Yu-Ling Lin, Wei-Hsiang Huang, Hsiao-Hsuan Huang, Hsin-Chien Chiang, Chen-Si Lin

Source: BMC Veterinary Research, Vol 18, Iss 1, Pp 1-14 (2022)

Subject Terms: Tumour biomarkers, Infectious cancer, Canine tumour model, Immunoediting, cDNA microarray, Veterinary medicine, SF600-1100

File Description: electronic resource

Relation: https://doaj.org/toc/1746-6148

Access URL: https://doaj.org/article/0c6a9ac50cff466682e7d63f8515c86d

Successful treatment of a lung abscess without surgical intervention in a cat

Authors: Reo Nishi, Aki Ohmi, Masaya Tsuboi, Kie Yamamoto, Hirotaka Tomiyasu

Source: Journal of Feline Medicine and Surgery Open Reports, Vol 8 (2022)

Subject Terms: Veterinary medicine, SF600-1100

File Description: electronic resource

Relation: https://doaj.org/toc/2055-1169

Access URL: https://doaj.org/article/c36e3f32c9e847a09c87da19796f6452

Genome-wide DNA methylation and RNA-seq analyses identify genes and pathways associated with doxorubicin resistance in a canine diffuse large B-cell lymphoma cell line.

Authors: Chia-Hsin Hsu, Hirotaka Tomiyasu, Chi-Hsun Liao, Chen-Si Lin

Source: PLoS ONE, Vol 16, Iss 5, p e0250013 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/e46d7dd0dcab4143aba8abd7b488c671

Comprehensive gene expression analysis of canine invasive urothelial bladder carcinoma by RNA-Seq

Authors: Shingo Maeda, Hirotaka Tomiyasu, Masaya Tsuboi, Akiko Inoue, Genki Ishihara, Takao Uchikai, James K. Chambers, Kazuyuki Uchida, Tomohiro Yonezawa, Naoaki Matsuki

Source: BMC Cancer, Vol 18, Iss 1, Pp 1-11 (2018)

Subject Terms: Dog, Transitional cell carcinoma, Animal model, RNA sequencing, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12885-018-4409-3; https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/3d0d330b400745a19306d1e6e6557864

Heterotypic mouse models of canine osteosarcoma recapitulate tumor heterogeneity and biological behavior

Authors: Milcah C. Scott, Hirotaka Tomiyasu, John R. Garbe, Ingrid Cornax, Clarissa Amaya, M. Gerard O'Sullivan, Subbaya Subramanian, Brad A. Bryan, Jaime F. Modiano

Source: Disease Models & Mechanisms, Vol 9, Iss 12, Pp 1435-1444 (2016)

Subject Terms: Osteosarcoma, Metastasis, Heterotypic models, Xenograft, Comparative studies, Tumor–stromal interactions, Medicine, Pathology, RB1-214

File Description: electronic resource

Relation: http://dmm.biologists.org/content/9/12/1435; https://doaj.org/toc/1754-8403; https://doaj.org/toc/1754-8411

Access URL: https://doaj.org/article/08fa8389824b4a929503584dbe596003

Comprehensive analysis of miRNA and protein profiles within exosomes derived from canine lymphoid tumour cell lines.

Authors: Hajime Asada, Hirotaka Tomiyasu, Takao Uchikai, Genki Ishihara, Yuko Goto-Koshino, Koichi Ohno, Hajime Tsujimoto

Source: PLoS ONE, Vol 14, Iss 4, p e0208567 (2019)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/92ebc4febf8245e08706c89eaeb8207c

Comparative Aspects of Molecular Mechanisms of Drug Resistance through ABC Transporters and Other Related Molecules in Canine Lymphoma

Authors: Hirotaka Tomiyasu, Hajime Tsujimoto

Source: Veterinary Sciences, Vol 2, Iss 3, Pp 185-205 (2015)

Subject Terms: ABC transporters, dog, epigenetics, LRP, MAPK pathways, Veterinary medicine, SF600-1100

File Description: electronic resource

Relation: http://www.mdpi.com/2306-7381/2/3/185; https://doaj.org/toc/2306-7381

Access URL: https://doaj.org/article/cf6589fa01a147ae9e2c835f39f1321e

Efficacy of vincristine as a rescue therapy for canine histiocytic sarcoma.

Authors: Hiroki SAKUMA, Akiyoshi TANI, Yuko GOTO-KOSHINO, Aki OHMI, Hajime TSUJIMOTO, Hirotaka TOMIYASU

Source: Journal of Veterinary Medical Science; 2024, Vol. 86 Issue 10, p1100-1104, 5p

Subject Terms: PROGRESSION-free survival, DENDRITIC cells, DOG diseases, DISEASE progression, VINCRISTINE, RETICULUM cell sarcoma

Investigation of the mutations in the genes involved in Janus kinase/signal transducer and activator of transcription pathway in canine large cell gastrointestinal lymphoma.

Authors: Takumi TSURUTA, Naoki MATSUMURA, Keijiro MIZUKAMI, Yuko GOTO-KOSHINO, Tomomi AOI, Ryoko YAMADA, Itsuma NAGAO, Megumi SAKAMOTO, Taisuke NAKAGAWA, Ray FUKUOKA, Aki OHMI, CHAMBERS, James K., Kazuyuki UCHIDA, Yukihide MOMOZAWA, Hirotaka TOMIYASU

Source: Journal of Veterinary Medical Science; 2024, Vol. 86 Issue 10, p1052-1055, 4p

Subject Terms: T-cell lymphoma, JAK-STAT pathway, GENETIC mutation, NUCLEOTIDE sequencing, GENETIC transcription

Transcriptomic analysis of bone marrow specimens collected from Miniature Dachshunds diagnosed with non-neoplastic bone marrow disorders.

Authors: Akiyoshi TANI, Kota NAKASE, Hirotaka TOMIYASU, Sakurako NEO, Aki OHMI, Yuko GOTO-KOSHINO, Koichi OHNO, Hajime TSUJIMOTO

Source: Journal of Veterinary Medical Science; 2024, Vol. 86 Issue 7, p737-743, 7p

Subject Terms: WNT signal transduction, BONE marrow, BLOOD cells, GENE expression profiling, CELLULAR signal transduction

Efficacy and adverse events of L-Asparaginase administration as a first-line treatment for feline large-cell gastrointestinal lymphoma.

Authors: Haruka INAZUMI, Hiroto TOYODA, Shotaro SHIMANO, Hiroki SAKUMA, Megumi SAKAMOTO, Taisuke NAKAGAWA, Ray FUKUOKA, Aki OHMI, CHAMBERS, James K., Kazuyuki UCHIDA, Yuko GOTO-KOSHINO, Hirotaka TOMIYASU

Source: Journal of Veterinary Medical Science; 2024, Vol. 86 Issue 7, p727-736, 10p

Subject Terms: OVERALL survival, PROGRESSION-free survival, MEDICAL records, DRUG utilization, CATS, CAT diseases