The Canadian Rare Diseases Models and Mechanisms (RDMM) Network: Connecting Understudied Genes to Model Organisms

Authors: Boycott, Kym M., Campeau, Philippe M., Howley, Heather E., Pavlidis, Paul, Rogic, Sanja, Oriel, Christine, Berman, Jason N., Hamilton, Robert M., Hicks, Geoffrey G., Lipshitz, Howard D., Masson, Jean-Yves, Shoubridge, Eric. A., Junker, Anne, Leroux, Michel R., McMaster, Christopher R., Michaud, Jaques L., Turvey, Stuart E., Dyment, David, Innes, A. Micheil, van Karnebeek, Clara D., Lehman, Anna, Cohn, Ronald D., MacDonald, Ian M., Rachubinski, Richard A., Frosk, Patrick, Vandersteen, Anthony, Wozniak, Richard W., Pena, Izabella A., Wen, Xiao-Yan, Lacaze-Masmonteil, Thierry, Rankin, Catharine, Hieter, Philip

Source: American journal of human genetics. 106(2):143-152

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100097780459.0x000001&indx=1&recIds=ETOCvdc_100097780459.0x000001

ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS

Authors: López-Erauskin, Jone, Tadokoro, Takahiro, Baughn, Michael W., Myers, Brian, McAlonis-Downes, Melissa, Chillon-Marinas, Carlos, Asiaban, Joshua N., Artates, Jonathan, Bui, Anh T., Vetto, Anne P., Lee, Sandra K., Le, Ai Vy, Sun, Ying, Jambeau, Mélanie, Boubaker, Jihane, Swing, Deborah, Qiu, Jinsong, Hicks, Geoffrey G., Ouyang, Zhengyu, Fu, Xiang-Dong, Tessarollo, Lino, Ling, Shuo-Chien, Parone, Philippe A., Shaw, Christopher E., Marsala, Martin, Lagier-Tourenne, Clotilde, Cleveland, Don W., Da Cruz, Sandrine

Source: In Neuron 21 November 2018 100(4):816-830

Risk and Resilience Variants in the Retinoic Acid Metabolic and Developmental Pathways Associated with Risk of FASD Outcomes.

Authors: McKay, Leo, Petrelli, Berardino, Pind, Molly, Reynolds, James N., Wintle, Richard F., Chudley, Albert E., Drögemöller, Britt, Fainsod, Abraham, Scherer, Stephen W., Hanlon-Dearman, Ana, Hicks, Geoffrey G.

Source: Biomolecules (2218-273X); May2024, Vol. 14 Issue 5, p569, 21p

Subject Terms: TRETINOIN, PRENATAL alcohol exposure, FETAL alcohol syndrome, DIGEORGE syndrome, DETOXIFICATION (Substance abuse treatment), GENETIC variation

Regulation of the cellular DNA double-strand break response.

Alternate Title: Review

Authors: Cann, Kendra L., Hicks, Geoffrey G.

Source: Biochemistry & Cell Biology; December 2007, Vol. 85 Issue 6, p663-674, 12p

Genome-Wide Transcriptome Landscape of Embryonic Brain-Derived Neural Stem Cells Exposed to Alcohol with Strain-Specific Cross-Examination in BL6 and CD1 Mice

Authors: Xu, Wayne, Liyanage, Vichithra R. B., MacAulay, Aaron, Levy, Romina D., Curtis, Kyle, Olson, Carl O., Zachariah, Robby M., Amiri, Shayan, Buist, Marjorie, Hicks, Geoffrey G., Davie, James R., Rastegar, Mojgan

Source: Scientific reports. 9(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131325700.0x000001&indx=1&recIds=ETOCvdc_100131325700.0x000001

Insights into retinoic acid deficiency and the induction of craniofacial malformations and microcephaly in fetal alcohol spectrum disorder

Authors: Petrelli, Berardino, Bendelac, Liat, Hicks, Geoffrey G., Fainsod, Abraham

Source: Genesis. 57(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100084025903.0x000001&indx=1&recIds=ETOCvdc_100084025903.0x000001

The emerging functions of the p53-miRNA network in stem cell biology

Authors: Lin, Chao-Po, Choi, Yong Jin, Hicks, Geoffrey G., He, Lin

Source: Cell cycle. 11(11):2063-2072

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100050710225.0x000001&indx=1&recIds=ETOCvdc_100050710225.0x000001

Copy number variation in fetal alcohol spectrum disorder.

Authors: Zarrei, Mehdi¹, Hicks, Geoffrey G.², Reynolds, James N.^3,4, Thiruvahindrapuram, Bhooma¹, Engchuan, Worrawat¹, Pind, Molly², Lamoureux, Sylvia¹, Wei, John¹, Wang, Zhouzhi¹, Marshall, Christian R.¹, Wintle, Richard F.¹, Chudley, Albert E.^5,6, Scherer, Stephen W.^1,7

Source: Biochemistry & Cell Biology. Apr2018, Vol. 96 Issue 2, p161-166. 6p.

Subject Terms: *ALCOHOL-induced disorders, *HUMAN abnormalities, *DEVELOPMENTAL genetics, *EPILEPSY, *AUTISM

Methods of constructing a gene mutation library and compounds and compositions thereof

ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS

Authors: López-Erauskin, Jone, Tadokoro, Takahiro, Baughn, Michael W., Myers, Brian, McAlonis-Downes, Melissa, Chillon-Marinas, Carlos, Asiaban, Joshua N., Artates, Jonathan, Bui, Anh T., Vetto, Anne P., Lee, Sandra K., Le, Ai Vy, Sun, Ying, Jambeau, Mélanie, Boubaker, Jihane, Swing, Deborah, Qiu, Jinsong, Hicks, Geoffrey G., Ouyang, Zhengyu, Fu, Xiang-Dong, Tessarollo, Lino, Ling, Shuo-Chien, Parone, Philippe A., Shaw, Christopher E., Marsala, Martin, Lagier-Tourenne, Clotilde, Cleveland, Don W., Da Cruz, Sandrine

Source: Neuron. 106(2):354-354

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100114299420.0x000001&indx=1&recIds=ETOCvdc_100114299420.0x000001

Effects of prenatal alcohol exposure (PAE): insights into FASD using mouse models of PAE.

Authors: Petrelli, Berardino¹, Weinberg, Joanne², Hicks, Geoffrey G.¹

Source: Biochemistry & Cell Biology; Apr2018, Vol. 96 Issue 2, p131-147, 17p

Translating to the Community (T2C): a protocol paper describing the development of Canada's first social epigenetic FASD biobank.

Authors: Elias, Brenda¹, Hanlon-Dearman, Ana², Head, Betty³, Hicks, Geoffrey G.⁴

Source: Biochemistry & Cell Biology; Apr2018, Vol. 96 Issue 2, p275-287, 13p

A novel, ataxic mouse model of ataxia telangiectasia caused by a clinically relevant nonsense mutation.

Authors: Perez, Harvey, Abdallah, May F., Chavira, Jose I., Norris, Angelina S., Egeland, Martin T., Vo, Karen L., Buechsenschuetz, Callan L., Sanghez, Valentina, Kim, Jeannie L., Pind, Molly, Nakamura, Kotoka, Hicks, Geoffrey G., Gatti, Richard A., Madrenas, Joaquin, Iacovino, Michelina, McKinnon, Peter J., Mathews, Paul J.

Source: eLife; 11/18/2021, p1-36, 36p

A generalizable pre-clinical research approach for orphan disease therapy

Authors: Beaulieu Chandree L, Samuels Mark E, Ekins Sean, McMaster Christopher R, Edwards Aled M, Krainer Adrian R, Hicks Geoffrey G, Frey Brendan J, Boycott Kym M, MacKenzie Alex E

Source: Orphanet Journal of Rare Diseases, Vol 7, Iss 1, p 39 (2012)

Subject Terms: Orphan disease therapy, Preclinical drug development, Generalizable screening methods, Translational toolbox, Medicine

File Description: electronic resource

Relation: http://www.ojrd.com/content/7/1/39; https://doaj.org/toc/1750-1172

Access URL: https://doaj.org/article/2528416a32214db7a73f1442198df527

H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection.

Authors: Martin, W. David, Hicks, Geoffrey G., Mendiratta, Sanjeev K.

Source: Cell; February 23 1996, Vol. 84, p543-550, 8p

Identification and characterization of Dlc1 isoforms in the mouse and study of the biological function of a single gene trapped isoform

Authors: Buse Cordula, Gu Yuan, Loewen Shauna, Wigle Nichola, Sabbir Mohammad G, Hicks Geoffrey G, Mowat Michael RA

Source: BMC Biology, Vol 8, Iss 1, p 17 (2010)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.biomedcentral.com/1741-7007/8/17; https://doaj.org/toc/1741-7007

Access URL: https://doaj.org/article/a6e6f950b2aa4bc59b6327a29f3d2138

Budget Impact Analysis of an Epigenetic Test Used for Diagnosing Fetal Alcohol Spectrum Disorder from the Perspective of a Laboratory Budget Holder in Manitoba, Canada

Authors: Berrigan, Patrick, Hicks, Geoffrey G., Ungar, Wendy J., Zwicker, Jennifer D.

Source: PharmacoEconomics - Open; March 2022, Vol. 6 Issue: 2 p253-263, 11p

Apoptosis in megaloblastic anemia occurs during DNA synthesis by a p53-independent, nucleoside-reversible mechanism

Authors: Koury, Mark J., Price, James O., Hicks, Geoffrey G.

Source: In Blood 1 November 2000 96(9):3249-3255

Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death.

Authors: Hicks, Geoffrey G., Singh, Nagendra, Nashabi, Abudi, Mai, Sabine, Bozek, Gracjan, Klewes, Ludger, Arapovic, Djula, White, Erica K., Koury, Mark J., Oltz, Eugene M., Van Kaer, Luc, Ruley, H. E.

Source: Nature Genetics. Feb2000, Vol. 24 Issue 2, p175. 5p.

Subject Terms: *TRANSCRIPTION factors, *MYELOID leukemia, *CHROMOSOMAL translocation

Endogenous p53 regulation and function in early stage Friend virus-induced tumor progression differs from that following DNA damage.

Authors: Kelley, Linda L, Hicks, Geoffrey G, Hsieh, Fen F, Prasher, Joanna M, Green, Wayne F, Miller, Matthew D, Eide, Erik J, Ruley, H Earl

Source: Oncogene. 9/3/98, Vol. 17 Issue 9, p1119. 12p.

Subject Terms: *FRIEND virus, *P53 antioncogene, *DNA damage