Alternative splicing landscape in mouse skeletal muscle and adipose tissue: Effects of intermittent fasting and exercise

Authors: Gaugel, Jasmin ^{a, b, c}, Jähnert, Markus ^{a, b}, Neumann, Alexander ^{d, e}, Heyd, Florian ^d, Schürmann, Annette ^{a, b, f}, Vogel, Heike ^{a, b, c, ⁎}

Source: In The Journal of Nutritional Biochemistry March 2025 137

Temperature-controlled molecular switches in mammalian cells

Authors: Absmeier, Eva, Heyd, Florian

Source: In Journal of Biological Chemistry November 2024 300(11)

One pipeline to predict them all? On the prediction of alternative splicing from RNA-Seq data

Authors: Olofsson, Didrik, Preußner, Marco, Kowar, Alexander, Heyd, Florian, Neumann, Alexander

Source: Biochemical and biophysical research communications. 653:31-37

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185623027.0x000001&indx=1&recIds=ETOCvdc_100185623027.0x000001

Structural and functional investigation of the human snRNP assembly factor AAR2 in complex with the RNase H‐like domain of PRPF8

Authors: Preussner, Marco, Santos, Karine F., Alles, Jonathan, Heroven, Christina, Heyd, Florian, Wahl, Markus C., Weber, Gert

Source: Acta crystallographica.Section D.Structural biology. 78(11):1373-1383

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100163911319.0x000001&indx=1&recIds=ETOCvdc_100163911319.0x000001

Alternative splicing of BUD13 determines the severity of a developmental disorder with lipodystrophy and progeroid features

Authors: Kornak, Uwe, Saha, Namrata, Keren, Boris, Neumann, Alexander, Taylor Tavares, Ana Lisa, Piard, Juliette, Kopp, Johannes, Rodrigues Alves, João Guilherme, Rodríguez de los Santos, Miguel, El Choubassi, Naji, Ehmke, Nadja, Jäger, Marten, Spielmann, Malte, Pantel, Jean Tori, Lejeune, Elodie, Fauler, Beatrix, Mielke, Thorsten, Hecht, Jochen, Meierhofer, David, Strom, Tim M., Laugel, Vincent, Brice, Alexis, Mundlos, Stefan, Bertoli-Avella, Aida, Bauer, Peter, Heyd, Florian, Boute, Odile, Dupont, Juliette, Depienne, Christel, Van Maldergem, Lionel, Fischer-Zirnsak, Björn

Source: In Genetics in Medicine September 2022 24(9):1927-1940

Immediate early splicing controls translation in activated T-cells and is mediated by hnRNPC2 phosphorylation.

Authors: Dróżdż, Mateusz, Zuvanov, Luíza, Sasikumar, Gopika, Bose, Debojit, Bruening, Franziska, Robles, Maria S, Preußner, Marco, Wahl, Markus, Heyd, Florian

Source: EMBO Journal; Mar2025, Vol. 44 Issue 6, p1692-1723, 32p

PTEN controls alternative splicing of autism spectrum disorder-associated transcripts in primary neurons.

Authors: Rademacher, Sebastian¹, Preußner, Marco², Rehm, Marie C¹, Fuchs, Joachim¹, Heyd, Florian², Eickholt, Britta J¹

Source: Brain: A Journal of Neurology; Jan2025, Vol. 148 Issue 1, p47-54, 8p

Temperature does matter—an additional dimension in kinase inhibitor development

Authors: Strauch, Miriam, Heyd, Florian

Source: FEBS journal. 288(10):3148-3153

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100121208250.0x000001&indx=1&recIds=ETOCvdc_100121208250.0x000001

The unfolded protein response regulates ER exit sites via SNRPB-dependent RNA splicing and contributes to bone development.

Authors: Zahoor, Muhammad, Dong, Yanchen, Preussner, Marco, Reiterer, Veronika, Shameen Alam, Sabrina, Haun, Margot, Horzum, Utku, Frey, Yannick, Hajdu, Renata, Geley, Stephan, Cormier-Daire, Valerie, Heyd, Florian, Jerome-Majewska, Loydie A, Farhan, Hesso

Source: EMBO Journal; Oct2024, Vol. 43 Issue 19, p4228-4247, 20p

Subject Terms: UNFOLDED protein response, BONE growth, CELL culture, PATHOLOGICAL physiology, GENETIC disorders, RNA splicing

Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation

Authors: Schwerbel, Kristin, Kamitz, Anne, Krahmer, Natalie, Hallahan, Nicole, Jähnert, Markus, Gottmann, Pascal, Lebek, Sandra, Schallschmidt, Tanja, Arends, Danny, Schumacher, Fabian, Kleuser, Burkhard, Haltenhof, Tom, Heyd, Florian, Gancheva, Sofiya, Broman, Karl W., Roden, Michael, Joost, Hans-Georg, Chadt, Alexandra, Al-Hasani, Hadi, Vogel, Heike, Jonas, Wenke, Schürmann, Annette

Source: In Journal of Hepatology October 2020 73(4):771-782

A Conserved Kinase-Based Body-Temperature Sensor Globally Controls Alternative Splicing and Gene Expression

Authors: Haltenhof, Tom, Kotte, Ana, De Bortoli, Francesca, Schiefer, Samira, Meinke, Stefan, Emmerichs, Ann-Kathrin, Petermann, Kristina Katrin, Timmermann, Bernd, Imhof, Petra, Franz, Andreas, Loll, Bernhard, Wahl, Markus C., Preußner, Marco, Heyd, Florian

Source: In Molecular Cell 2 April 2020 78(1):57-69

ASO targeting RBM3 temperature‐controlled poison exon splicing prevents neurodegeneration in vivo

Authors: Preußner, Marco, Smith, Heather L, Hughes, Daniel, Zhang, Min, Emmerichs, Ann‐Kathrin, Scalzitti, Silvia, Peretti, Diego, Swinden, Dean, Neumann, Alexander, Haltenhof, Tom, Mallucci, Giovanna R, Heyd, Florian

Source: EMBO molecular medicine. 15(5)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185476479.0x000001&indx=1&recIds=ETOCvdc_100185476479.0x000001

The zinc finger domains in U2AF26 and U2AF35 have diverse functionalities including a role in controlling translation

Authors: Herdt, Olga, Reich, Stefan, Medenbach, Jan, Timmermann, Bernd, Olofsson, Didrik, Preußner, Marco, Heyd, Florian

Source: RNA biology. 17(6):843-856

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100110861018.0x000001&indx=1&recIds=ETOCvdc_100110861018.0x000001

The nuclear GYF protein CD2BP2/U5-52K is required for T cell homeostasis.

Authors: Bertazzon, Miriam, Hurtado-Pico, Almudena, Plaza-Sirvent, Carlos, Schuster, Marc, Preußner, Marco, Kuropka, Benno, Fan Liu, Amandus Kirsten, Andor Zenon, Xiao Jakob Schmitt, Benjamin König, Álvaro-Benito, Miguel, Abualrous, Esam T., Albert, Gesa I., Kliche, Stefanie, Heyd, Florian, Schmitz, Ingo, Freund, Christian

Source: Frontiers in Immunology; 2024, p1-17, 17p

Subject Terms: T cells, IMMUNOLOGIC memory, CELL physiology, GENE expression profiling, NUCLEAR proteins

Thermoregulated transcriptomics: the molecular basis and biological significance of temperature-dependent alternative splicing.

Authors: Haltenhof, Tom, Preußner, Marco, Heyd, Florian

Source: Biochemical Journal; 8/1/2024, Vol. 481 Issue 15, p999-1013, 15p

Subject Terms: GENETIC regulation, ALTERNATIVE RNA splicing, BIOLOGICAL systems, PHYSIOLOGICAL adaptation, GENE expression, BODY temperature regulation

A homozygous genome‐edited Sept2‐EGFP fibroblast cell line

Authors: Banko, Monika, Mucha‐Kruczynska, Iwona, Weise, Christoph, Heyd, Florian, Ewers, Helge

Source: Cytoskeleton. 76(1):73-82

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100090540802.0x000001&indx=1&recIds=ETOCvdc_100090540802.0x000001

Body Temperature Cycles Control Rhythmic Alternative Splicing in Mammals

Authors: Preußner, Marco, Goldammer, Gesine, Neumann, Alexander, Haltenhof, Tom, Rautenstrauch, Pia, Müller-McNicoll, Michaela, Heyd, Florian

Source: In Molecular Cell 3 August 2017 67(3):433-446

Tageszeitabhängige Körpertemperaturrhythmen regulieren die Genexpression

Authors: Preussner, Marco, Heyd, Florian

Source: Biospektrum. 26(4):372-374

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100172222116.0x000001&indx=1&recIds=ETOCvdc_100172222116.0x000001

Characterization of cis-acting elements that control oscillating alternative splicing

Authors: Goldammer, Gesine, Neumann, Alexander, Strauch, Miriam, Müller-McNicoll, Michaela, Heyd, Florian, Preußner, Marco

Source: RNA biology. 15(8):1081-1092

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100071629743.0x000001&indx=1&recIds=ETOCvdc_100071629743.0x000001

The cancer-associated U2AF35 470A>G (Q157R) mutation creates an in-frame alternative 5′ splice site that impacts splicing regulation in Q157R patients

Authors: Herdt, Olga, Neumann, Alexander, Timmermann, Bernd, Heyd, Florian

Source: RNA. 23(12):1796-1806

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN613726080&indx=1&recIds=ETOCRN613726080