Evolving racial/ethnic disparities in AML survival in the novel therapy era

Authors: Wang, Xin ^{1, 2, ∗}, Gimotty, Phyllis A. ³, Matthews, Andrew H. ¹, Mamtani, Ronac ¹, Luger, Selina M. ¹, Hexner, Elizabeth O. ¹, Babushok, Daria V. ¹, McCurdy, Shannon R. ¹, Frey, Noelle V. ¹, Bruno, Ximena Jordan ¹, Gill, Saar ¹, Martin, Mary Ellen ¹, Paralkar, Vikram R. ¹, Maillard, Ivan ¹, Porter, David L. ¹, Loren, Alison W. ¹, Perl, Alexander E. ¹, Pratz, Keith W. ¹, Getz, Kelly D. ^{3, 4}, Lai, Catherine ¹

Source: In Blood Advances 11 February 2025 9(3):533-544

Novel MAGIC composite scores using both clinical symptoms and biomarkers best predict treatment outcomes of acute GVHD

Authors: Akahoshi, Yu, Spyrou, Nikolaos, Weber, Daniela, Aguayo-Hiraldo, Paibel, Ayuk, Francis, Chanswangphuwana, Chantiya, Choe, Hannah K., Eder, Matthias, Etra, Aaron M., Grupp, Stephan A., Hexner, Elizabeth O., Hogan, William J., Kitko, Carrie L., Kraus, Sabrina, Al Malki, Monzr M., Merli, Pietro, Qayed, Muna, Reshef, Ran, Schechter, Tal, Ullrich, Evelyn, Vasova, Ingrid, Wölfl, Matthias, Zeiser, Robert, Baez, Janna, Beheshti, Rahnuma, Eng, Gilbert, Gleich, Sigrun, Katsivelos, Nikolaos, Kowalyk, Steven, Morales, George, Young, Rachel, Chen, Yi-Bin, Nakamura, Ryotaro, Levine, John E., Ferrara, James L. M.

Source: In Blood 29 August 2024 144(9):1010-1021

The MAGIC algorithm probability predicts treatment response and long-term outcomes to second-line therapy for acute GVHD

Authors: DeFilipp, Zachariah, Kim, Haesook T., Spyrou, Nikolaos, Katsivelos, Nikolaos, Kowalyk, Steven, Eng, Gilbert, Kasikis, Stelios, Beheshti, Rahnuma, Baez, Janna, Akahoshi, Yu, Ayuk, Francis, Choe, Hannah, Etra, Aaron, Grupp, Stephan A., Hexner, Elizabeth O., Hogan, William J., Kitko, Carrie L., Qayed, Muna, Reshef, Ran, Vasova, Ingrid, Zeiser, Robert, Young, Rachel, Holler, Ernst, Ferrara, James L. M., Nakamura, Ryotaro, Levine, John E., Chen, Yi-Bin

Source: In Blood Advances 9 July 2024 8(13):3488-3496

Flares of acute graft-versus-host disease: a Mount Sinai Acute GVHD International Consortium analysis

Authors: Akahoshi, Yu, Spyrou, Nikolaos, Hoepting, Matthias, Aguayo-Hiraldo, Paibel, Ayuk, Francis, Chanswangphuwana, Chantiya, Choe, Hannah K., Eder, Matthias, Etra, Aaron M., Grupp, Stephan A., Hexner, Elizabeth O., Hogan, William J., Kitko, Carrie L., Kraus, Sabrina, Al Malki, Monzr M., Merli, Pietro, Qayed, Muna, Reshef, Ran, Schechter, Tal, Ullrich, Evelyn, Vasova, Ingrid, Wölfl, Matthias, Zeiser, Robert, Baez, Janna, Beheshti, Rahnuma, Eng, Gilbert, Gleich, Sigrun, Kasikis, Stelios, Katsivelos, Nikolaos, Kowalyk, Steven, Morales, George, Young, Rachel, DeFilipp, Zachariah, Ferrara, James L. M., Levine, John E., Nakamura, Ryotaro

Source: In Blood Advances 23 April 2024 8(8):2047-2057

Tissue-infiltrating alloreactive T cells require Id3 to deflect PD-1–mediated immune suppression during GVHD

Authors: Wang, Ying, He, Shan, Calendo, Gennaro, Bui, Tien, Tian, Yuanyuan, Lee, Che Young, Zhou, Yan, Zhao, Xin, Abraham, Ciril, Mo, Wenbin, Chen, Mimi, Sanders-Braggs, Ruqayyah, Madzo, Jozef, Issa, Jean-Pierre, Hexner, Elizabeth O., Wiest, David L., Reshef, Ran, Xue, Hai-Hui, Zhang, Yi

Source: In Blood 11 January 2024 143(2):166-177

Inconsistent Reporting and Definitions of Time-to-Event Endpoints in CAR T Clinical Trials: A Review

Authors: Grady, Connor B. ^{1, 2, 3}, Li, Yimei ^{1, 3, 4, 5, 6}, Maude, Shannon L. ^{3, 4, 5, 7}, Hexner, Elizabeth O. ^{3, 7, 8}, Frey, Noelle V. ^{3, 7, 8}, Porter, David L. ^{3, 7, 8}, Hwang, Wei-Ting ^{1, 3, 6, ⁎}

Source: In Transplantation and Cellular Therapy April 2025 31(4):271-271

Incidence, clinical presentation, risk factors, outcomes, and biomarkers in de novo late acute GVHD

Authors: Akahoshi, Yu, Spyrou, Nikolaos, Hogan, William J., Ayuk, Francis, DeFilipp, Zachariah, Weber, Daniela, Choe, Hannah K., Hexner, Elizabeth O., Rösler, Wolf, Etra, Aaron M., Sandhu, Karamjeet, Yanik, Gregory A., Chanswangphuwana, Chantiya, Kitko, Carrie L., Reshef, Ran, Kraus, Sabrina, Wölfl, Matthias, Eder, Matthias, Bertrand, Hannah, Qayed, Muna, Merli, Pietro, Grupp, Stephan A., Aguayo-Hiraldo, Paibel, Schechter, Tal, Ullrich, Evelyn, Baez, Janna, Beheshti, Rahnuma, Gleich, Sigrun, Kowalyk, Steven, Morales, George, Young, Rachel, Kwon, Deukwoo, Nakamura, Ryotaro, Levine, John E., Ferrara, James L. M., Chen, Yi-Bin

Source: In Blood Advances 22 August 2023 7(16):4479-4491

Differences in Acute Graft-Versus-Host Disease (GVHD) Severity and Its Outcomes Between Black and White Patients

Authors: Rios, Carlos A. Ortega ¹, Qayed, Muna ², Etra, Aaron M. ¹, Reshef, Ran ³, Newcomb, Richard ⁴, Yuhasz, Nicholas ⁵, Hexner, Elizabeth O. ⁶, Aguayo-Hiraldo, Paibel ⁷, Merli, Pietro ⁸, Hogan, William J. ⁹, Weber, Daniela ¹⁰, Kitko, Carrie L. ¹¹, Ayuk, Francis ¹², Eder, Matthias ¹³, Grupp, Stephan A. ¹⁴, Kraus, Sabrina ¹⁵, Sandhu, Karam ¹⁶, Ullrich, Evelyn ¹⁷, Vasova, Ingrid ¹⁸, Wölfl, Matthias ¹⁹, Baez, Janna ¹, Beheshti, Rahnuma ¹, Eng, Gilbert ¹, Gleich, Sigrun ¹⁷, Katsivelos, Nikolaos ¹, Kowalyk, Steven ¹, Louloudis, Ioannis Evangelos ¹, Morales, George ¹, Spyrou, Nikolaos ¹, Young, Rachel ¹, Nakamura, Ryotaro ¹⁶, Levine, John E. ^{1, †}, Ferrara, James L.M. ^{1, †}, Akahoshi, Yu ^{1, †, ⁎}

Source: In Transplantation and Cellular Therapy November 2024 30(11):1061-1061

Anti-CD19 CAR T cells in combination with ibrutinib for the treatment of chronic lymphocytic leukemia

Authors: Gill, Saar ^∗, Vides, Vanessa, Frey, Noelle V., Hexner, Elizabeth O., Metzger, Susan, O'Brien, Megan, Hwang, Wei-Ting, Brogdon, Jennifer L., Davis, Megan M., Fraietta, Joseph A., Gaymon, Avery L., Gladney, Whitney L., Lacey, Simon F., Lamontagne, Anne, Mato, Anthony R., Maus, Marcela V., Melenhorst, J. Joseph, Pequignot, Edward, Ruella, Marco, Shestov, Maksim, Byrd, John C., Schuster, Stephen J., Siegel, Donald L., Levine, Bruce L., June, Carl H., Porter, David L. ^∗∗

Source: In Blood Advances 8 November 2022 6(21):5774-5785

Low-Dose Total Body Irradiation Added to Fludarabine and Busulfan Reduced-Intensity Conditioning Reduces Graft Failure in Patients with Myelofibrosis

Authors: Freyer, Craig W., Babushok, Daria V., Frey, Noelle V., Gill, Saar I., Loren, Alison W., Luger, Selina M., Maity, Amit, Martin, Mary Ellen, Plastaras, John P., Porter, David L., Hexner, Elizabeth O.

Source: In Transplantation and Cellular Therapy September 2022 28(9):590-596

Real-world effectiveness of CPX-351 vs venetoclax and azacitidine in acute myeloid leukemia

Authors: Matthews, Andrew H., Perl, Alexander E., Luger, Selina M., Loren, Alison W., Gill, Saar I., Porter, David L., Babushok, Daria V., Maillard, Ivan P., Carroll, Martin P., Frey, Noelle V., Hexner, Elizabeth O., Martin, Mary Ellen, McCurdy, Shannon R., Stadtmauer, Edward A., Paralkar, Vikram R., Bruno, Ximena Jordan, Hwang, Wei-Ting, Margolis, David, Pratz, Keith W. ^*

Source: In Blood Advances 12 July 2022 6(13):3997-4005

Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies

Authors: Jadlowsky, Julie K., Hexner, Elizabeth O., Marshall, Amy, Grupp, Stephan A., Frey, Noelle V., Riley, James L., Veloso, Elizabeth, McConville, Holly, Rogal, Walter, Czuczman, Cory, Hwang, Wei-Ting, Li, Yimei, Leskowitz, Rachel M., Farrelly, Olivia, Karar, Jayashree, Christensen, Shannon, Barber-Rotenberg, Julie, Gaymon, Avery, Aronson, Naomi, Bernstein, Wendy, Melenhorst, Jan Joseph, Roche, Aoife M., Everett, John K., Zolnoski, Sonja A., McFarland, Alexander G., Reddy, Shantan, Petrichenko, Angelina, Cook, Emma J., Lee, Carole, Gonzalez, Vanessa E., Alexander, Kathleen, Kulikovskaya, Irina, Ramírez-Fernández, Ángel, Minehart, Janna C., Ruella, Marco, Gill, Saar I., Schuster, Stephen J., Cohen, Adam D., Garfall, Alfred L., Shah, Payal D., Porter, David L., Maude, Shannon L., Levine, Bruce L., Siegel, Donald L., Chew, Anne, McKenna, Stephen, Lledo, Lester, Davis, Megan M., Plesa, Gabriela, Herbst, Friederike, Stadtmauer, Edward A., Tebas, Pablo, DiNofia, Amanda, Haas, Andrew, Haas, Naomi B., Myers, Regina, O’Rourke, Donald M., Svoboda, Jakub, Tanyi, Janos L., Aplenc, Richard, Jacobson, Jeffrey M., Ko, Andrew H., Cohen, Roger B., June, Carl H., Bushman, Frederic D., Fraietta, Joseph A.

Source: Nature Medicine; April 2025, Vol. 31 Issue: 4 p1134-1144, 11p

Update in GVHD Prophylaxis: Novel Pharmacologic and Graft Manipulation Strategies.

Authors: Hexner, Elizabeth O., DeFilipp, Zachariah

Source: American Journal of Hematology; May2025 Supplement 1, Vol. 100, p30-39, 10p

Preconditioning Frailty Phenotype Influences Survival and Relapse for Older Allogeneic Transplantation Recipients

Authors: Sung, Anthony D., Koll, Thuy, Gier, Shannon H., Racioppi, Alessandro, White, Griffin, Lew, Meagan, Free, Marcia, Agarwal, Priyal, Bohannon, Lauren M., Johnson, Ernaya J., Selvan, Bharathi, Babushok, Daria V., Frey, Noelle V., Gill, Saar I., Hexner, Elizabeth O., Martin, MaryEllen, Perl, Alexander E., Pratz, Keith W., Luger, Selina M., Chao, Nelson J., Fisher, Alfred L., Stadtmauer, Edward A., Porter, David L., Loren, Alison W., Bhatt, Vijaya R., Gimotty, Phyllis A., McCurdy, Shannon R.

Source: In Transplantation and Cellular Therapy April 2024 30(4):415-415

Biomarker-guided preemption of steroid-refractory graft-versus-host disease with α-1-antitrypsin

Authors: Gergoudis, Stephanie C. ^*, DeFilipp, Zachariah ^*, Özbek, Umut, Sandhu, Karamjeet S., Etra, Aaron M., Choe, Hannah K., Kitko, Carrie L., Ayuk, Francis, Aziz, Mina, Baez, Janna, Ben-David, Kaitlyn, Bunworasate, Udomsak, Gandhi, Isha, Hexner, Elizabeth O., Hogan, William J., Holler, Ernst, Kasikis, Stelios, Kowalyk, Steven M., Lin, Jung-Yi, Merli, Pietro, Morales, George, Nakamura, Ryotaro, Reshef, Ran, Rösler, Wolf, Srinagesh, Hrishikesh, Young, Rachel, Chen, Yi-Bin, Ferrara, James L.M., Levine, John E.

Source: In Blood Advances 22 December 2020 4(24):6098-6105

Oral Vancomycin Prophylaxis Is Highly Effective in Preventing Clostridium difficile Infection in Allogeneic Hematopoietic Cell Transplant Recipients

Authors: Ganetsky, Alex, Han, Jennifer H., Hughes, Mitchell E., Babushok, Daria V., Frey, Noelle V., Gill, Saar I., Hexner, Elizabeth O., Loren, Alison W., Luger, Selina M., Mangan, James K., Martin, Mary Ellen, Smith, Jacqueline, Freyer, Craig W., Gilmar, Cheryl, Schuster, Mindy, Stadtmauer, Edward A., Porter, David L.

Source: Clinical Infectious Diseases, 2019 Jun . 68(12), 2003-2009.

Access URL: https://www.jstor.org/stable/26794970

The MAGIC algorithm probability is a validated response biomarker of treatment of acute graft-versus-host disease

Authors: Srinagesh, Hrishikesh K., Özbek, Umut, Kapoor, Urvi, Ayuk, Francis, Aziz, Mina, Ben-David, Kaitlyn, Choe, Hannah K., DeFilipp, Zachariah, Etra, Aaron, Grupp, Stephan A., Hartwell, Matthew J., Hexner, Elizabeth O., Hogan, William J., Karol, Alexander B., Kasikis, Stelios, Kitko, Carrie L., Kowalyk, Steven, Lin, Jung-Yi, Major-Monfried, Hannah, Mielke, Stephan, Merli, Pietro, Morales, George, Ordemann, Rainer, Pulsipher, Michael A., Qayed, Muna, Reddy, Pavan, Reshef, Ran, Rösler, Wolf, Sandhu, Karamjeet S., Schechter, Tal, Shah, Jay, Sigel, Keith, Weber, Daniela, Wölfl, Matthias, Wudhikarn, Kitsada, Young, Rachel, Levine, John E. ^*, Ferrara, James L.M.

Source: In Blood Advances 10 December 2019 3(23):4034-4042

Cytokine-mediated CAR T therapy resistance in AML

Authors: Bhagwat, Anand S., Torres, Leonel, Shestova, Olga, Shestov, Maksim, Mellors, Patrick W., Fisher, Han R., Farooki, Saamia N., Frost, Benjamin F., Loken, Michael R., Gaymon, Avery L., Frazee, Diane, Rogal, Walter, Frey, Noelle, Hexner, Elizabeth O., Luger, Selina M., Loren, Alison W., Martin, Mary Ellen, McCurdy, Shannon R., Perl, Alexander E., Stadtmauer, Edward A., Brogdon, Jennifer L., Fraietta, Joseph A., Hwang, Wei-Ting, Siegel, Don L., Plesa, Gabriela, Aplenc, Richard, Porter, David L., June, Carl H., Gill, Saar I.

Source: Nature Medicine; December 2024, Vol. 30 Issue: 12 p3697-3708, 12p

Extended CCR5 Blockade for Graft-versus-Host Disease Prophylaxis Improves Outcomes of Reduced-Intensity Unrelated Donor Hematopoietic Cell Transplantation: A Phase II Clinical Trial

Authors: Reshef, Ran, Ganetsky, Alex, Acosta, Edward P., Blauser, Robin, Crisalli, Lisa, McGraw, Jessica, Frey, Noelle V., Hexner, Elizabeth O., Hoxie, James A., Loren, Alison W., Luger, Selina M., Mangan, James, Stadtmauer, Edward A., Mick, Rosemarie, Vonderheide, Robert H., Porter, David L.

Source: In Biology of Blood and Marrow Transplantation March 2019 25(3):515-521

MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD

Authors: Major-Monfried, Hannah ^*, Renteria, Anne S. ^*, Pawarode, Attaphol, Reddy, Pavan, Ayuk, Francis, Holler, Ernst, Efebera, Yvonne A., Hogan, William J., Wölfl, Matthias, Qayed, Muna, Hexner, Elizabeth O., Wudhikarn, Kitsada, Ordemann, Rainer, Young, Rachel, Shah, Jay, Hartwell, Matthew J., Chaudhry, Mohammed S., Aziz, Mina, Etra, Aaron, Yanik, Gregory A., Kröger, Nicolaus, Weber, Daniela, Chen, Yi-Bin, Nakamura, Ryotaro, Rösler, Wolf, Kitko, Carrie L., Harris, Andrew C., Pulsipher, Michael, Reshef, Ran, Kowalyk, Steven, Morales, George, Torres, Ivan, Özbek, Umut, Ferrara, James L.M., Levine, John E.

Source: In Blood 21 June 2018 131(25):2846-2855