Biomarkers of aging for the identification and evaluation of longevity interventions

Authors: Moqri, Mahdi, Herzog, Chiara, Poganik, Jesse R., Justice, Jamie, Belsky, Daniel W., Higgins-Chen, Albert, Moskalev, Alexey, Fuellen, Georg, Cohen, Alan A., Bautmans, Ivan, Widschwendter, Martin, Ding, Jingzhong, Fleming, Alexander, Mannick, Joan, Han, Jing-Dong Jackie, Zhavoronkov, Alex, Barzilai, Nir, Kaeberlein, Matt, Cummings, Steven, Kennedy, Brian K., Ferrucci, Luigi, Horvath, Steve, Verdin, Eric, Maier, Andrea B., Snyder, Michael P., Sebastiano, Vittorio, Gladyshev, Vadim N.

Source: Cell. 186(18):3758-3775

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100196334864.0x000001&indx=1&recIds=ETOCvdc_100196334864.0x000001

HPV‐induced host epigenetic reprogramming is lost upon progression to high‐grade cervical intraepithelial neoplasia

Authors: Herzog, Chiara, Vavourakis, Charlotte D., Barrett, James E., Karbon, Gerlinde, Villunger, Andreas, Wang, Jiangrong, Sundström, Karin, Dillner, Joakim, Widschwendter, Martin

Source: International journal of cancer. 152(11):2321-2330

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184357680.0x000001&indx=1&recIds=ETOCvdc_100184357680.0x000001

The WID‐EC test for the detection and risk prediction of endometrial cancer

Authors: Barrett, James E., Jones, Allison, Evans, Iona, Herzog, Chiara, Reisel, Daniel, Olaitan, Adeola, Mould, Tim, MacDonald, Nicola, Doufekas, Konstantinos, Newton, Claire, Crosbie, Emma J., Bjørge, Line, Colombo, Nicoletta, Dostalek, Lukas, Costas, Laura, Peremiquel‐Trillas, Paula, Ponce, Jordi, Matias‐Guiu, Xavier, Zikan, Michal, Cibula, David, Wang, Jiangrong, Sundström, Karin, Dillner, Joakim, Widschwendter, Martin

Source: International journal of cancer. 152(9):1977-1988

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100177964407.0x000001&indx=1&recIds=ETOCvdc_100177964407.0x000001

The WID‐qEC test: Performance in a hospital‐based cohort and feasibility to detect endometrial and cervical cancers

Authors: Schreiberhuber, Lena, Herzog, Chiara, Vavourakis, Charlotte D., Redl, Elisa, Kastner, Christine, Jones, Allison, Evans, Iona, Zikan, Michal, Cibula, David, Widschwendter, Peter, Pfau, Karin, Math, Barbara, Seewald, Martin, Amory, Sylvain, Obrist, Peter, Widschwendter, Martin

Source: International journal of cancer. 152(6):1269-1274

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100171675492.0x000001&indx=1&recIds=ETOCvdc_100171675492.0x000001

A Simple Cervicovaginal Epigenetic Test for Screening and Rapid Triage of Women With Suspected Endometrial Cancer: Validation in Several Cohort and Case/Control Sets

Authors: Herzog, Chiara, Marín, Fátima, Jones, Allison, Evans, Iona, Reisel, Daniel, Redl, Elisa, Schreiberhuber, Lena, Paytubi, Sonia, Pelegrina, Beatriz, Carmona, Álvaro, Peremiquel-Trillas, Paula, Frias-Gomez, Jon, Pineda, Marta, Brunet, Joan, Ponce, Jordi, Matias-Guiu, Xavier, de Sanjosé, Silvia, Alemany, Laia, Olaitan, Adeola, Wong, Michael, Jurkovic, Davor, Crosbie, Emma J., Rosenthal, Adam N., Bjørge, Line, Zikan, Michal, Dostalek, Lukas, Cibula, David, Sundström, Karin, Dillner, Joakim, Costas, Laura, Widschwendter, Martin

Source: Journal of clinical oncology. 40(33):3828-3838

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100177475869.0x000001&indx=1&recIds=ETOCvdc_100177475869.0x000001

Validation of blood-based detection of breast cancer highlights importance for cross-population validation.

Authors: Theeuwes, Bente, Ambatipudi, Srikant, Herceg, Zdenko, Herzog, Chiara Maria, Widschwendter, Martin

Source: Nature Communications; 3/5/2025, Vol. 16 Issue 1, p1-6, 6p

Subject Terms: LOCUS (Genetics), MONONUCLEAR leukocytes, REGULATORY T cells, KILLER cells, BREAST, CORE needle biopsy, T cells

Performance of the WID‐qEC test to detect uterine cancers in black women with abnormal uterine bleeding: A prospective observational cohort study in Ghana.

Authors: Ken‐Amoah, Sebastian, Redl, Elisa, Domson, Bright K. S., Barrett, James E., Schreiberhuber, Lena, Herzog, Chiara, Arora, Rupali, Jones, Allison, Evans, Iona, Reisel, Dan, Lamptey‐Mills, Esther, Nachinab, Vincent B., Pepera, Theodora, Olaitan, Adeola, Obiri‐Yeboah, Dorcas, Akakpo, Patrick K., Widschwendter, Martin

Source: International Journal of Cancer; Mar2025, Vol. 156 Issue 5, p1055-1064, 10p

Subject Terms: UTERINE cancer, RECEIVER operating characteristic curves, EARLY detection of cancer, UTERINE hemorrhage, ENDOMETRIAL cancer

Technical and biological sources of unreliability of Infinium probes on Illumina methylation microarrays.

Authors: Nazarenko, Tatiana, Vavourakis, Charlotte Dafni, Jones, Allison, Evans, Iona, Schreiberhuber, Lena, Kastner, Christine, Ishaq-Parveen, Isma, Redl, Elisa, Watson, Anthony W., Brandt, Kirsten, Carter, Clive, Zaikin, Alexey, Herzog, Chiara Maria Stella, Widschwendter, Martin

Source: Clinical Epigenetics; 9/18/2024, Vol. 16 Issue 1, p1-14, 14p

Subject Terms: DNA methylation, METHYLATION, BLOOD sampling, EPIGENETICS, NOISE

High performance of the DNA methylation‐based WID‐qEC test for detecting uterine cancers independent of sampling modalities.

Authors: Illah, Ojone, Scott, Malcolm, Redl, Elisa, Barrett, James E., Schreiberhuber, Lena, Herzog, Chiara, Vavourakis, Charlotte D., Jones, Allison, Evans, Iona, Reisel, Dan, Chandrasekaran, Dhivya, Doufekas, Kostas, Graham, Radha, Kotsopoulos, Ioannis C., MacDonald, Nicola, Arora, Rupali, Olaitan, Adeola, Rosenthal, Adam, Widschwendter, Martin

Source: International Journal of Cancer; Sep2024, Vol. 155 Issue 5, p800-806, 7p

Subject Terms: UTERINE cancer, GYNECOLOGIC cancer, ENDOMETRIAL cancer, CLINICAL pathology, DNA methylation, ENDOMETRIAL surgery

A validated HPLC-MS/MS method for the quantification of systemic mifepristone after subcutaneous application in mice.

Authors: Tevini, Julia, Aminzadeh-Gohari, Sepideh, Weber, Daniela D., Catalano, Luca, Stefan, Victoria E., Redl, Elisa, Herzog, Chiara, Lang, Roland, Widschwendter, Martin, Felder, Thomas K., Kofler, Barbara

Source: Analytical Methods; 8/21/2024, Vol. 16 Issue 31, p5459-5466, 8p

Ketogenic Diet Enhances the Anti-Tumor Effect of Mifepristone in a Breast Cancer Mouse Model

Authors: Weber, Daniela D ¹, Tevini, Julia ¹, Barrett, James ², Aminzadeh-Gohari, Sepideh ³, Herzog, Chiara ², Catalano, Luca ¹, Stefan, Victoria ¹, Redl, Elisa ², Alkasalias, Twana ⁴, Lang, Roland ¹, Felder, Thomas K ¹, Widschwendter, Martin ⁵, Kofler, Barbara ¹

Source: In Current Developments in Nutrition July 2024 8 Supplement 2

Dietary restriction in senolysis and prevention and treatment of disease.

Authors: Aminzadeh-Gohari, Sepideh, Kofler, Barbara, Herzog, Chiara

Source: Critical Reviews in Food Science & Nutrition; 2024, Vol. 64 Issue 16, p5242-5268, 27p

Subject Terms: LOW-calorie diet, PREVENTIVE medicine, THERAPEUTICS, METABOLIC reprogramming, DISEASE risk factors, AGE factors in disease

Natural Killer Cell Dysfunction in Premenopausal BRCA1 Mutation Carriers: A Potential Mechanism for Ovarian Carcinogenesis.

Authors: Haran, Shaun, Chindera, Kantaraja, Sabry, May, Wilkinson, Nafisa, Arora, Rupali, Zubiak, Agnieszka, Bartlett, Thomas E., Evans, Iona, Jones, Allison, Reisel, Daniel, Herzog, Chiara, Alkasalias, Twana, Newman, Mark, Kim, Jaeyeon, Rådestad, Angelique Flöter, Gemzell-Danielsson, Kristina, Rosenthal, Adam N., Dubeau, Louis, Lowdell, Mark W., Widschwendter, Martin

Source: Cancers; Mar2024, Vol. 16 Issue 6, p1186, 13p

Subject Terms: FALLOPIAN tube surgery, PERIMENOPAUSE, PUBLIC health surveillance, RISK assessment, KILLER cells, BRCA genes, REPRODUCTIVE health, RESEARCH funding, OVARIAN tumors, IMMUNOTHERAPY, EARLY detection of cancer, DESCRIPTIVE statistics, GENETIC mutation, CARCINOGENESIS, COMPARATIVE studies, OVARIES

Plasma cell‐free DNA methylation analysis for ovarian cancer detection: Analysis of samples from a case‐control study and an ovarian cancer screening trial.

Authors: Herzog, Chiara, Jones, Allison, Evans, Iona, Reisel, Daniel, Olaitan, Adeola, Doufekas, Konstantinos, MacDonald, Nicola, Rådestad, Angelique Flöter, Gemzell‐Danielsson, Kristina, Zikan, Michal, Cibula, David, Dostálek, Lukáš, Paprotka, Tobias, Leimbach, Andreas, Schmitt, Markus, Ryan, Andy, Gentry‐Maharaj, Aleksandra, Apostolidou, Sophia, Rosenthal, Adam N, Menon, Usha

Source: International Journal of Cancer; Feb2024, Vol. 154 Issue 4, p679-691, 13p

Subject Terms: CELL-free DNA, OVARIAN cancer, DNA methylation, DNA analysis, EARLY detection of cancer, CIRCULATING tumor DNA, CASE-control method

Cervical cancer screening using DNA methylation triage in a real-world population

Authors: Schreiberhuber, Lena, Barrett, James E., Wang, Jiangrong, Redl, Elisa, Herzog, Chiara, Vavourakis, Charlotte D., Sundström, Karin, Dillner, Joakim, Widschwendter, Martin

Source: Nature Medicine; 20240101, Issue: Preprints p1-7, 7p

Validation of biomarkers of aging

Authors: Moqri, Mahdi, Herzog, Chiara, Poganik, Jesse R., Ying, Kejun, Justice, Jamie N., Belsky, Daniel W., Higgins-Chen, Albert T., Chen, Brian H., Cohen, Alan A., Fuellen, Georg, Hägg, Sara, Marioni, Riccardo E., Widschwendter, Martin, Fortney, Kristen, Fedichev, Peter O., Zhavoronkov, Alex, Barzilai, Nir, Lasky-Su, Jessica, Kiel, Douglas P., Kennedy, Brian K., Cummings, Steven, Slagboom, P. Eline, Verdin, Eric, Maier, Andrea B., Sebastiano, Vittorio, Snyder, Michael P., Gladyshev, Vadim N., Horvath, Steve, Ferrucci, Luigi

Source: Nature Medicine; 20240101, Issue: Preprints p1-13, 13p

DNA methylation at quantitative trait loci (mQTLs) varies with cell type and nonheritable factors and may improve breast cancer risk assessment.

Authors: Herzog, Chiara, Jones, Allison, Evans, Iona, Zikan, Michal, Cibula, David, Harbeck, Nadia, Colombo, Nicoletta, Rådestad, Angelique Flöter, Gemzell-Danielsson, Kristina, Pashayan, Nora, Widschwendter, Martin

Source: NPJ Precision Oncology; 9/27/2023, Vol. 7 Issue 1, p1-10, 10p

Subject Terms: LOCUS (Genetics), DNA methylation, EPIGENOMICS, DISEASE risk factors, BREAST cancer, RISK assessment

DNA methylation-based detection and prediction of cervical intraepithelial neoplasia grade 3 and invasive cervical cancer with the WID™-qCIN test.

Authors: Herzog, Chiara^1,2 (AUTHOR), Sundström, Karin^3,4 (AUTHOR), Jones, Allison⁵ (AUTHOR), Evans, Iona⁵ (AUTHOR), Barrett, James E.^1,2 (AUTHOR), Wang, Jiangrong³ (AUTHOR), Redl, Elisa^1,2 (AUTHOR), Schreiberhuber, Lena^1,2 (AUTHOR), Costas, Laura^6,7 (AUTHOR), Paytubi, Sonia⁶ (AUTHOR), Dostalek, Lukas⁸ (AUTHOR), Zikan, Michal⁹ (AUTHOR), Cibula, David⁸ (AUTHOR), Sroczynski, Gaby¹⁰ (AUTHOR), Siebert, Uwe^{10,11,12,13,14} (AUTHOR), Dillner, Joakim^3,4 (AUTHOR), Widschwendter, Martin^1,2,5,15 (AUTHOR) Martin.Widschwendter@uibk.ac.at

Source: Clinical Epigenetics. 11/21/2022, Vol. 14 Issue 1, p1-12. 12p.

Subject Terms: *CERVICAL intraepithelial neoplasia, *CANCER invasiveness, *CERVICAL cancer, *PAPILLOMAVIRUSES, *RANDOMIZED controlled trials, *METHYLATION

The WID-CIN test identifies women with, and at risk of, cervical intraepithelial neoplasia grade 3 and invasive cervical cancer.

Authors: Barrett, James E., Sundström, Karin, Jones, Allison, Evans, Iona, Wang, Jiangrong, Herzog, Chiara, Dillner, Joakim, Widschwendter, Martin

Source: Genome Medicine; 10/19/2022, Vol. 14 Issue 1, p1-11, 11p

Subject Terms: CERVICAL intraepithelial neoplasia, CERVICAL cancer, METHYLATION, CANCER invasiveness, RECEIVER operating characteristic curves, DNA methylation

Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women.

Authors: Bartlett, Thomas E., Evans, Iona, Jones, Allison, Barrett, James E., Haran, Shaun, Reisel, Daniel, Papaikonomou, Kiriaki, Jones, Louise, Herzog, Chiara, Pashayan, Nora, Simões, Bruno M., Clarke, Robert B., Evans, D. Gareth, Ghezelayagh, Talayeh S., Ponandai-Srinivasan, Sakthivignesh, Boggavarapu, Nageswara R., Lalitkumar, Parameswaran G., Howell, Sacha J., Risques, Rosa Ana, Rådestad, Angelique Flöter

Source: Genome Medicine; 7/20/2022, Vol. 14 Issue 1, p1-18, 18p

Subject Terms: BREAST, TRIPLE-negative breast cancer, LEVONORGESTREL intrauterine contraceptives, PROGESTERONE antagonists, YOUNG women, PROGESTERONE receptors