Wildfire-relevant woodsmoke and extracellular vesicles (EVs): Alterations in EV proteomic signatures involved in extracellular matrix degradation and tissue injury in airway organotypic models

Authors: Vitucci, Eva C.M., Carberry, Celeste K., Payton, Alexis, Herring, Laura E., Mordant, Angie L., Kim, Yong Ho, Gilmour, M Ian, McCullough, Shaun D., Rager, Julia E.

Source: In Environmental Research 1 January 2025 264 Part 2

Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton

Authors: Mouery, Ryan D. ^{1, 2}, Lukasik, Kimberly ³, Hsu, Carolyn ², Bonacci, Thomas ^{2, 4}, Bolhuis, Derek L. ⁶, Wang, Xianxi ^{2, 4}, Mills, C. Allie ⁵, Toomer, E. Drew ^{2, 4}, Canterbury, Owen G. ⁴, Robertson, Kevin C. ^{2, 4}, Branigan, Timothy B. ^{7, 8}, Brown, Nicholas G. ^{2, 4}, Herring, Laura E. ^{2, 4, 5}, Gupton, Stephanie L. ^{2, 3}, Emanuele, Michael J. ^{2, 4, 9, ∗}

Source: In Cell Reports 27 August 2024 43(8)

Auto-loaded TRAIL-exosomes derived from induced neural stem cells for brain cancer therapy

Authors: Zhang, Xiaopei, Taylor, Hannah, Valdivia, Alain, Dasari, Rajaneekar, Buckley, Andrew, Bonacquisti, Emily, Nguyen, Juliane, Kanchi, Krishna, Corcoran, David L., Herring, Laura E., Steindler, Dennis A., Baldwin, Albert, Hingtgen, Shawn, Satterlee, Andrew Benson

Source: In Journal of Controlled Release August 2024 372:433-445

SAFB associates with nascent RNAs and can promote gene expression in mouse embryonic stem cells

Authors: Cherney, Rachel E., Eberhard, Quinn E., Giri, Gilbert, Mills, Christine A., Porrello, Alessandro, Zhang, Zhiyue, White, David, Trotman, Jackson B., Herring, Laura E., Dominguez, Daniel

Source: RNA. 29(10):1535-1556

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN633573849&indx=1&recIds=ETOCRN633573849

PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components

Authors: Bashore, Frances M., Foley, Caroline A., Ong, Han Wee, Rectenwald, Justin M., Hanley, Ronan P., Norris-Drouin, Jacqueline L., Cholensky, Stephanie H., Mills, Christine A., Pearce, Kenneth H., Herring, Laura E.

Source: ACS chemical biology. 18(3):494-507

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631920339&indx=1&recIds=ETOCRN631920339

RBFOX2 regulated EYA3 isoforms partner with SIX4 or ZBTB1 to control transcription during myogenesis

Authors: Wiedner, Hannah J., Blue, R. Eric, Sadovsky, Matheus, Mills, C. Allie, Wehrens, Xander H.T., Herring, Laura E., Giudice, Jimena

Source: In iScience 17 November 2023 26(11)

Characterizing the extracellular vesicle proteomic landscape of the human airway using in vitro organotypic multi-cellular models

Authors: Vitucci, Eva C.M., Carberry, Celeste K., Payton, Alexis, Herring, Laura E., Mordant, Angie L., McCullough, Shaun D., Rager, Julia E.

Source: In iScience 17 November 2023 26(11)

PLIN5 interacts with FATP4 at membrane contact sites to promote lipid droplet-to-mitochondria fatty acid transport

Authors: Miner, Gregory E., So, Christina M., Edwards, Whitney, Ragusa, Joey V., Wine, Jonathan T., Wong Gutierrez, Daniel, Airola, Michael V., Herring, Laura E., Coleman, Rosalind A., Klett, Eric L., Cohen, Sarah

Source: In Developmental Cell 24 July 2023 58(14):1250-1265

Metatranscriptomics analysis reveals a novel transcriptional and translational landscape during Middle East respiratory syndrome coronavirus infection

Authors: Fritch, Ethan J. ¹, Sanders, Wes ^{1, 4}, Sims, Amy C. ², Herring, Laura E. ^{3, 5}, Barker, Natalie K. ^{3, 5}, Schepmoes, Athena A. ⁶, Weitz, Karl K. ⁶, Texier, Jordan R. ¹, Dittmer, Dirk P. ¹, Graves, Lee M. ^{3, 5}, Smith, Richard D. ⁶, Waters, Katrina M. ⁶, Moorman, Nathaniel J. ^{1, 4}, Baric, Ralph S. ^{1, 2, 4}, Graham, Rachel L. ^{2, 7, ∗}

Source: In iScience 16 June 2023 26(6)

Tandem detergent-extraction and immunoprecipitation of proteinopathy: Scalable enrichment of ALS-associated TDP-43 aggregates

Authors: Evangelista, Baggio A. ¹, Cahalan, Shannon R. ², Ragusa, Joey V. ¹, Mordant, Angie ³, Necarsulmer, Julie C. ¹, Perna, Robert J. ⁴, Ajit, Tejazaditya ⁴, White, Kristen ⁵, Barker, Natalie K. ³, Tian, Xu ⁴, Cohen, Sarah ¹, Meeker, Rick ⁴, Herring, Laura E. ³, Cohen, Todd J. ^{1, 4, 6, 7, 8, ∗}

Source: In iScience 19 May 2023 26(5)

Multi-omic profiling reveals the ataxia protein sacsin is required for integrin trafficking and synaptic organization

Authors: Romano, Lisa E.L., Aw, Wen Yih, Hixson, Kathryn M., Novoselova, Tatiana V., Havener, Tammy M., Howell, Stefanie, Taylor-Blake, Bonnie, Hall, Charlotte L., Xing, Lei, Beri, Josh, Nethisinghe, Suran, Perna, Laura, Hatimy, Abubakar, Altadonna, Ginevra Chioccioli, Graves, Lee M., Herring, Laura E., Hickey, Anthony J., Thalassinos, Konstantinos, Chapple, J. Paul, Wolter, Justin M.

Source: In Cell Reports 1 November 2022 41(5)

Green Chemistry Preservation and Extraction of Biospecimens for Multi-omic Analyses

Authors: Tikunov, Andrey P., Tipton, Jeremiah D., Garrett, Timothy J., Shinde, Sachi V., Kim, Hong Jin, Gerber, David A., Herring, Laura E., Graves, Lee M., Macdonald, Jeffrey M.

Source: Methods in molecular biology. 2394:267-298

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN628707545&indx=1&recIds=ETOCRN628707545

Potent and selective SETDB1 covalent negative allosteric modulator reduces methyltransferase activity in cells.

Authors: Uguen, Mélanie, Shell, Devan J., Silva, Madhushika, Deng, Yu, Li, Fengling, Szewczyk, Magdalena M., Yang, Ka, Zhao, Yani, Stashko, Michael A., Norris-Drouin, Jacqueline L., Waybright, Jarod M., Beldar, Serap, Rectenwald, Justin M., Mordant, Angie L., Webb, Thomas S., Herring, Laura E., Arrowsmith, Cheryl H., Ackloo, Suzanne, Gygi, Steven P., McGinty, Robert K.

Source: Nature Communications; 2/24/2025, Vol. 16 Issue 1, p1-16, 16p

Subject Terms: ALLOSTERIC regulation, LIFE sciences, DRUG target, NEURODEGENERATION, SMALL molecules

Respiratory extracellular vesicle isolation optimization through proteomic profiling of equine samples and identification of candidates for cell-of-origin studies.

Authors: Hickman, Elise, Carberry, Victoria, Carberry, Celeste, Cooper, Bethanie, Mordant, Angie L., Mills, Allie, Sokolsky, Marina, Herring, Laura E., Alexis, Neil E., Rebuli, Meghan E., Jaspers, Ilona, Sheats, Katie, Rager, Julia E.

Source: PLoS ONE; 1/24/2025, Vol. 20 Issue 1, p1-23, 23p

Subject Terms: GEL permeation chromatography, EXTRACELLULAR vesicles, COLUMN chromatography, PROTEOMICS, CELL size

Multi-monoubiquitylation controls VASP-mediated actin dynamics.

Authors: McCormick, Laura E., Suarez, Cristian, Herring, Laura E., Cannon, Kevin S., Kovar, David R., Brown, Nicholas G., Gupton, Stephanie L.

Source: Journal of Cell Science; Jan2025, Vol. 138 Issue 2, p1-17, 17p

Subject Terms: CAPPING proteins, CELL physiology, CYTOSKELETON, UBIQUITINATION, CELL morphology

Identification of a reciprocal negative feedback loop between tau-modifying proteins MARK2 kinase and CBP acetyltransferase

Authors: Tabassum, Zarin, Tseng, Jui-Heng, Isemann, Camryn, Tian, Xu, Chen, Youjun, Herring, Laura E., Cohen, Todd J.

Source: In Journal of Biological Chemistry June 2022 298(6)

The KRAS-regulated kinome identifies WEE1 and ERK coinhibition as a potential therapeutic strategy in KRAS-mutant pancreatic cancer

Authors: Diehl, J. Nathaniel, Klomp, Jennifer E., Snare, Kayla R., Hibshman, Priya S., Blake, Devon R., Kaiser, Zane D., Gilbert, Thomas S.K., Baldelli, Elisa, Pierobon, Mariaelena, Papke, Björn, Yang, Runying, Hodge, Richard G., Rashid, Naim U., Petricoin, Emanuel F., III, Herring, Laura E., Graves, Lee M., Cox, Adrienne D., Der, Channing J.

Source: In Journal of Biological Chemistry November 2021 297(5)

A multi-kinase inhibitor screen identifies inhibitors preserving stem-cell-like chimeric antigen receptor T cells

Authors: Song, Feifei, Tsahouridis, Ourania, Stucchi, Simone, Walhart, Tara, Mendell, Sophie, Hardy, P. Brian, Axtman, Matthew, Guduru, Shiva K. R., Gilbert, Thomas S. K., Graves, Lee M., Herring, Laura E., Savoldo, Barbara, Ma, Xingcong, Woodcock, Mark, Milner, Justin J., Ivanova, Anastasia, Pearce, Kenneth H., Xu, Yang, Dotti, Gianpietro

Source: Nature Immunology; 20250101, Issue: Preprints p1-15, 15p

Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition

Authors: Waters, Andrew M., Khatib, Tala O., Papke, Bjoern, Goodwin, Craig M., Hobbs, G. Aaron, Diehl, J. Nathaniel, Yang, Runying, Edwards, A. Cole, Walsh, Katherine H., Sulahian, Rita, McFarland, James M., Kapner, Kevin S., Gilbert, Thomas S.K., Stalnecker, Clint A., Javaid, Sehrish, Barkovskaya, Anna, Grover, Kajal R., Hibshman, Priya S., Blake, Devon R., Schaefer, Antje, Nowak, Katherine M., Klomp, Jennifer E., Hayes, Tikvah K., Kassner, Michelle, Tang, Nanyun, Tanaseichuk, Olga, Chen, Kaisheng, Zhou, Yingyao, Kalkat, Manpreet, Herring, Laura E., Graves, Lee M., Penn, Linda Z., Yin, Hongwei H., Aguirre, Andrew J., Hahn, William C., Cox, Adrienne D., Der, Channing J.

Source: In Cell Reports 29 June 2021 35(13)

Tau seeds are subject to aberrant modifications resulting in distinct signatures

Authors: Tseng, Jui-Heng, Ajit, Aditi, Tabassum, Zarin, Patel, Niyati, Tian, Xu, Chen, Youjun, Prevatte, Alex W., Ling, Karen, Rigo, Frank, Meeker, Rick B., Herring, Laura E., Cohen, Todd J.

Source: In Cell Reports 27 April 2021 35(4)