Integrated drug resistance and leukemic stemness gene-expression scores predict outcomes in large cohort of over 3500 AML patients from 10 trials

Authors: Abdelrahman H. Elsayed, Xueyuan Cao, Richard J. Marrero, Nam H. K. Nguyen, Huiyun Wu, Yonhui Ni, Raul C. Ribeiro, Herold Tobias, Peter J. Valk, François Béliveau, Guillaume Richard-Carpentier, Josée Hébert, C. Michel Zwaan, Alan Gamis, Edward Anders Kolb, Richard Aplenc, Todd A. Alonzo, Soheil Meshinchi, Jeffrey Rubnitz, Stanley Pounds, Jatinder K. Lamba

Source: npj Precision Oncology, Vol 8, Iss 1, Pp 1-12 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2397-768X

Access URL: https://doaj.org/article/8d2e5546c18f4cf3998b81a1211405a0

Pretransplant MRD does not seem to affect survival in NPM1-mutated AML undergoing allogeneic stem cell transplantation

Authors: Fraccaroli, Alessia ¹, Jurinovic, Vindi ^{1, 2}, Hirschbühl, Klaus ³, Stauffer, Elena ¹, Koch, Katrin ⁴, Breitkopf, Stephan ⁵, Haebe, Sarah ¹, Drolle, Heidrun ¹, Rothenberg-Thurley, Maja ⁶, Dufour, Annika ⁶, Metzeler, Klaus H. ^{6, 7}, Spiekermann, Karsten ^{1, 6}, Hentrich, Marcus ⁸, Hausmann, Andreas ⁵, Verbeek, Mareike ⁴, Schmid, Christoph ³, Herold, Tobias ^{1, 6}, Tischer, Johanna ^{1, ∗}

Source: In Blood Advances January 2025

Does combining numerous data types in multi-omics data improve or hinder performance in survival prediction? Insights from a large-scale benchmark study.

Authors: Li, Yingxia¹ (AUTHOR) liyingxia1991@hotmail.com, Herold, Tobias² (AUTHOR), Mansmann, Ulrich¹ (AUTHOR), Hornung, Roman^1,3 (AUTHOR)

Source: BMC Medical Informatics & Decision Making. 9/2/2024, Vol. 24 Issue 1, p1-14. 14p.

Subject Terms: *MULTIOMICS, *SURVIVAL rate, *PREDICTION models, *SURVIVAL analysis (Biometry), *DATABASES

Acute megakaryoblastic leukaemia shows high frequency of chromosome 1q aberrations and dismal outcome

Authors: Pastore, Friederike, Gittinger, Hanna, Raab, Susanne, Tschuri, Sebastian, Ksienzyk, Bianka, Konstandin, Nikola P., Schneider, Stephanie, Rothenberg‐Thurley, Maja, Horny, Hans‐Peter, Werner, Martin, Sauerland, Maria C., Amler, Susanne, Görlich, Dennis, Berdel, Wolfgang E., Wörmann, Bernhard, Braess, Jan, Hiddemann, Wolfgang, Tischer, Johanna, Herold, Tobias, Metzeler, Klaus H., Spiekermann, Karsten

Source: British journal of haematology. 202(6):1165-1177

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100192107343.0x000001&indx=1&recIds=ETOCvdc_100192107343.0x000001

Targeting FLT3 with a new-generation antibody-drug conjugate in combination with kinase inhibitors for treatment of AML

Authors: Roas, Maike, Vick, Binje, Kasper, Marc-André, Able, Marina, Polzer, Harald, Gerlach, Marcus, Kremmer, Elisabeth, Hecker, Judith S., Schmitt, Saskia, Stengl, Andreas, Waller, Verena, Hohmann, Natascha, Festini, Moreno, Ludwig, Alexander, Rohrbacher, Lisa, Herold, Tobias, Subklewe, Marion, Götze, Katharina S., Hackenberger, Christian P. R., Schumacher, Dominik, Helma-Smets, Jonas, Jeremias, Irmela ^∗, Leonhardt, Heinrich ^∗, Spiekermann, Karsten ^∗

Source: In Blood 2 March 2023 141(9):1023-1035

Specific effects of somatic GATA2 zinc finger mutations on erythroid differentiation

Authors: Redondo Monte, Enric, Leubolt, Georg, Windisch, Roland, Kerbs, Paul, Dutta, Sayantanee, Landspersky, Theresa, Istvánffy, Rouzanna, Oostendorp, Robert A.J., Chen-Wichmann, Linping, Herold, Tobias, Cusan, Monica, Schotta, Gunnar, Wichmann, Christian, Greif, Philipp A.

Source: Experimental hematology. 108:26-35

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100158502644.0x000001&indx=1&recIds=ETOCvdc_100158502644.0x000001

HERVs characterize normal and leukemia stem cells and represent a source of shared epitopes for cancer immunotherapy

Authors: Alcazer, Vincent, Bonaventura, Paola, Tonon, Laurie, Michel, Emilie, Mutez, Virginie, Fabres, Clémentine, Chuvin, Nicolas, Boulos, Rasha, Estornes, Yann, Maguer‐Satta, Véronique, Geistlich, Kevin, Viari, Alain, Metzeler, Klaus H., Hiddemann, Wolfgang, Batch, Aarif M. N., Herold, Tobias, Caux, Christophe, Depil, Stéphane

Source: American journal of hematology. 97(9):1200-1214

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100157722704.0x000001&indx=1&recIds=ETOCvdc_100157722704.0x000001

Differential impact of IDH1/2 mutational subclasses on outcome in adult AML: results from a large multicenter study

Authors: Middeke, Jan M. ^{*, **}, Metzeler, Klaus H. ^*, Röllig, Christoph, Krämer, Michael, Eckardt, Jan-Niklas, Stasik, Sebastian, Greif, Philipp A., Spiekermann, Karsten, Rothenberg-Thurley, Maja, Krug, Utz, Braess, Jan, Krämer, Alwin, Hochhaus, Andreas, Brümmendorf, Tim H., Naumann, Ralph, Steffen, Björn, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Görlich, Dennis, Sauerland, Cristina, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan W., Hänel, Mathias, Frickhofen, Norbert, Noppeney, Richard, Kaiser, Ulrich, Kaufmann, Martin, Kunadt, Desiree, Wörmann, Bernhard, Sockel, Katja, von Bonin, Malte, Herold, Tobias, Müller-Tidow, Carsten, Platzbecker, Uwe, Berdel, Wolfgang E., Serve, Hubert, Baldus, Claudia D., Ehninger, Gerhard, Schetelig, Johannes, Hiddemann, Wolfgang, Bornhäuser, Martin, Stölzel, Friedrich ^*, Thiede, Christian ^*

Source: In Blood Advances 8 March 2022 6(5):1394-1405

A clinically applicable gene expression–based score predicts resistance to induction treatment in acute myeloid leukemia

Authors: Moser, Christian, Jurinovic, Vindi, Sagebiel-Kohler, Sabine, Ksienzyk, Bianka, Batcha, Aarif M.N., Dufour, Annika, Schneider, Stephanie, Rothenberg-Thurley, Maja, Sauerland, Cristina M., Görlich, Dennis, Berdel, Wolfgang E., Krug, Utz, Mansmann, Ulrich, Hiddemann, Wolfgang, Braess, Jan, Spiekermann, Karsten, Greif, Philipp A., Vosberg, Sebastian, Metzeler, Klaus H., Kumbrink, Jörg, Herold, Tobias ^*

Source: In Blood Advances 23 November 2021 5(22):4752-4761

Low‐density lipoprotein receptor (LDLR) is an independent adverse prognostic factor in acute myeloid leukaemia

Authors: Floeth, Matthias, Elges, Sandra, Gerss, Joachim, Schwöppe, Christian, Kessler, Torsten, Herold, Tobias, Wardelmann, Eva, Berdel, Wolfgang E., Lenz, Georg, Mikesch, Jan‐Henrik, Hartmann, Wolfgang, Schliemann, Christoph, Angenendt, Linus

Source: British journal of haematology. 192(3):494-503

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100134818629.0x000001&indx=1&recIds=ETOCvdc_100134818629.0x000001

Elevated levels of IL-6 and CRP predict the need for mechanical ventilation in COVID-19

Authors: Herold, Tobias, Jurinovic, Vindi, Arnreich, Chiara, Lipworth, Brian J., Hellmuth, Johannes C., von Bergwelt-Baildon, Michael, Klein, Matthias, Weinberger, Tobias

Source: In The Journal of Allergy and Clinical Immunology July 2020 146(1):128-136

X‐linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL

Authors: Carlet, Michela, Schmelz, Karin, Vergalli, Jenny, Herold, Tobias, Senft, Daniela, Jurinovic, Vindi, Hoffmann, Thomas, Proba, Jutta, Weichert, Nina, Junghanß, Christian, Roth, Mareike, Eschenburg, Georg, Barz, Malwine, Henze, Günter, Eckert, Cornelia, Eggert, Angelika, Zuber, Johannes, Hundsdoerfer, Patrick, Jeremias, Irmela

Source: EMBO molecular medicine. 15(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100170734340.0x000001&indx=1&recIds=ETOCvdc_100170734340.0x000001

The ParaHox gene Cdx4 induces acute erythroid leukemia in mice

Authors: Thoene, Silvia ^*, Mandal, Tamoghna ^*, Vegi, Naidu M., Quintanilla-Martinez, Leticia, Rösler, Reinhild, Wiese, Sebastian, Metzeler, Klaus H., Herold, Tobias, Haferlach, Torsten, Döhner, Konstanze, Döhner, Hartmut, Schwarzmüller, Luisa, Klingmüller, Ursula, Buske, Christian, Rawat, Vijay P.S., Feuring-Buske, Michaela

Source: In Blood Advances 26 November 2019 3(22):3729-3739

Treosulfan-Versus Melphalan-Based Reduced Intensity Conditioning in HLA-Haploidentical Transplantation for Patients ≥ 50 Years with Advanced MDS/AML.

Authors: Fraccaroli, Alessia, Stauffer, Elena, Haebe, Sarah, Prevalsek, Dusan, Weiss, Lena, Dorman, Klara, Drolle, Heidrun, von Bergwelt-Baildon, Michael, Stemmler, Hans-Joachim, Herold, Tobias, Tischer, Johanna

Source: Cancers; Aug2024, Vol. 16 Issue 16, p2859, 13p

Subject Terms: THERAPEUTIC use of antineoplastic agents, MYELODYSPLASTIC syndromes, HEMATOPOIETIC stem cell transplantation, GRAFT versus host disease, STATISTICAL significance, SCIENTIFIC observation, KRUSKAL-Wallis Test, FISHER exact test, AGE distribution, TREATMENT effectiveness, RETROSPECTIVE studies, CHI-squared test, DESCRIPTIVE statistics, MELPHALAN, KAPLAN-Meier estimator, MEDICAL records, ACQUISITION of data, CANCER patient psychology, CONFIDENCE intervals, DATA analysis software, OVERALL survival

Geographic Terms: GERMANY

Identification of a gene expression signature associated with brain metastasis in colorectal cancer.

Authors: Michl, Marlies, Taverna, Francesco, Woischke, Christine, Li, Pan, Klauschen, Frederick, Kirchner, Thomas, Heinemann, Volker, von Bergwelt-Baildon, Michael, Stahler, Arndt, Herold, Tobias Marcus, Jurinovic, Vindi, Engel, Jutta, Kumbrink, Jörg, Neumann, Jens

Source: Clinical & Translational Oncology; Aug2024, Vol. 26 Issue 8, p1886-1895, 10p

Improving risk stratification for 2022 European LeukemiaNet favorable-risk patients with acute myeloid leukemia

Authors: Archer, Kellie J., Fu, Han, Mrózek, Krzysztof, Nicolet, Deedra, Mims, Alice S., Uy, Geoffrey L., Stock, Wendy, Byrd, John C., Hiddemann, Wolfgang, Metzeler, Klaus H., Rausch, Christian, Krug, Utz, Sauerland, Cristina, Görlich, Dennis, Berdel, Wolfgang E., Woermann, Bernhard J., Braess, Jan, Spiekermann, Karsten, Herold, Tobias, Eisfeld, Ann-Kathrin

Source: In The Innovation 4 November 2024 5(6)

Genetic heterogeneity of cytogenetically normal AML with mutations of CEBPA

Authors: Konstandin, Nikola P., Pastore, Friederike, Herold, Tobias, Dufour, Annika, Rothenberg-Thurley, Maja, Hinrichsen, Tanja, Ksienzyk, Bianka, Tschuri, Sebastian, Schneider, Stephanie, Hoster, Eva, Berdel, Wolfgang E., Woermann, Bernhard J., Sauerland, Maria C., Braess, Jan, Bohlander, Stefan K., Klein, Hanns-Georg, Hiddemann, Wolfgang, Metzeler, Klaus H., Spiekermann, Karsten

Source: In Blood Advances 23 October 2018 2(20):2724-2731

Update 2021: COVID-19 aus Sicht der Praxen und Notaufnahmen

Authors: Herold, Tobias, Wörnle, Markus, Schelling, Jörg

Source: Deutsche medizinische Wochenschrift. 146(13/14):924-926

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190741268.0x000001&indx=1&recIds=ETOCvdc_100190741268.0x000001

The neuropeptide receptor calcitonin receptor-like (CALCRL) is a potential therapeutic target in acute myeloid leukemia

Authors: Angenendt, Linus, Bormann, Eike, Pabst, Caroline, Alla, Vijay, Görlich, Dennis, Braun, Leonie, Dohlich, Kim, Schwöppe, Christian, Bohlander, Stefan, Arteaga, Maria, Wethmar, Klaus, Hartmann, Wolfgang, Angenendt, Adrian, Kessler, Torsten, Mesters, Rolf, Stelljes, Matthias, Rothenberg-Thurley, Maja, Spiekermann, Karsten, Hébert, Josée, Sauvageau, Guy, Valk, Peter, Löwenberg, Bob, Serve, Hubert, Müller-Tidow, Carsten, Lenz, Georg, Wörmann, Bernhard, Sauerland, M., Hiddemann, Wolfgang, Berdel, Wolfgang, Krug, Utz, Metzeler, Klaus, Mikesch, Jan-Henrik, Herold, Tobias, Schliemann, Christoph

Source: Leukemia. 33(12):2830-2841

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190908573.0x000001&indx=1&recIds=ETOCvdc_100190908573.0x000001

Allelic Imbalance of Recurrently Mutated Genes in Acute Myeloid Leukaemia

Authors: Batcha, Aarif, Bamopoulos, Stefanos, Kerbs, Paul, Kumar, Ashwini, Jurinovic, Vindi, Rothenberg-Thurley, Maja, Ksienzyk, Bianka, Philippou-Massier, Julia, Krebs, Stefan, Blum, Helmut, Schneider, Stephanie, Konstandin, Nikola, Bohlander, Stefan, Heckman, Caroline, Kontro, Mika, Hiddemann, Wolfgang, Spiekermann, Karsten, Braess, Jan, Metzeler, Klaus, Greif, Philipp, Mansmann, Ulrich, Herold, Tobias

Source: Scientific reports. 9(1):1-11

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189404336.0x000001&indx=1&recIds=ETOCvdc_100189404336.0x000001