Helicases DDX5 and DDX17 promote heterogeneity in HBV transcription termination in infected human hepatocytes

Authors: Chapus, Fleur, Giraud, Guillaume, Huchon, Pélagie, Rodà, Mélanie, Grand, Xavier, Charre, Caroline, Goldsmith, Chloé, Roca Suarez, Armando Andres, Martinez, Maria-Guadalupe, Fresquet, Judith, Diederichs, Audrey, Locatelli, Maëlle, Polvèche, Hélène, Scholtès, Caroline, Chemin, Isabelle, Hernandez Vargas, Hector, Rivoire, Michel, Bourgeois, Cyril F., Zoulim, Fabien, Testoni, Barbara

Source: In Journal of Hepatology October 2024 81(4):609-620

Transformed cells after senescence give rise to more severe tumor phenotypes than transformed non-senescent cells

Authors: Palazzo, Alberta, Hernandez-Vargas, Hector, Goehrig, Delphine, Médard, Jean-Jacques, Vindrieux, David, Flaman, Jean-Michel, Bernard, David

Source: In Cancer Letters 10 October 2022 546

Regulatory T cell differentiation is controlled by αKG-induced alterations in mitochondrial metabolism and lipid homeostasis

Authors: Matias, Maria I., Yong, Carmen S., Foroushani, Amir, Goldsmith, Chloe, Mongellaz, Cédric, Sezgin, Erdinc, Levental, Kandice R., Talebi, Ali, Perrault, Julie, Rivière, Anais, Dehairs, Jonas, Delos, Océane, Bertand-Michel, Justine, Portais, Jean-Charles, Wong, Madeline, Marie, Julien C., Kelekar, Ameeta, Kinet, Sandrina, Zimmermann, Valérie S., Levental, Ilya, Yvan-Charvet, Laurent, Swinnen, Johannes V., Muljo, Stefan A., Hernandez-Vargas, Hector, Tardito, Saverio, Taylor, Naomi, Dardalhon, Valérie

Source: In Cell Reports 2 November 2021 37(5)

PARP inhibitors and radiation potentiate liver cell death in vitro. Do hepatocellular carcinomas have an achilles’ heel?

Authors: Gerossier, Laetitia, Dubois, Anaëlle, Paturel, Alexia, Fares, Nadim, Cohen, Damien, Merle, Phillippe, Lachuer, Joel, Wierinckx, Anne, Saintigny, Pierre, Bancel, Brigitte, Selves, Janick, Schnitzler, Anne, Ouine, Bérengère, Cartier, Aurélie, de Koning, Leanne, Puard, Vincent, Bieche, Ivan, Hernandez-Vargas, Hector, Hall, Janet, Chemin, Isabelle

Source: In Clinics and Research in Hepatology and Gastroenterology September 2021 45(5)

Failed Apoptosis Enhances Melanoma Cancer Cell Aggressiveness

Authors: Berthenet, Kevin, Castillo Ferrer, Camila, Fanfone, Deborah, Popgeorgiev, Nikolay, Neves, David, Bertolino, Philippe, Gibert, Benjamin, Hernandez-Vargas, Hector, Ichim, Gabriel

Source: In Cell Reports 9 June 2020 31(10)

Oxidative stress and repetitive element methylation changes in artisanal gold miners occupationally exposed to mercury

Authors: Narváez, Diana M., Groot, Helena, Diaz, Sonia M., Palma, Ruth Marien, Muñoz, Nathalia, Cros, Marie-Pierre, Hernández-Vargas, Hector

Source: In Heliyon September 2017 3(9)

TET-Catalyzed 5-Hydroxymethylation Precedes HNF4A Promoter Choice during Differentiation of Bipotent Liver Progenitors

Authors: Ancey, Pierre-Benoit, Ecsedi, Szilvia, Lambert, Marie-Pierre, Talukdar, Fazlur Rahman, Cros, Marie-Pierre, Glaise, Denise, Narvaez, Diana Maria, Chauvet, Veronique, Herceg, Zdenko, Corlu, Anne, Hernandez-Vargas, Hector

Source: In Stem Cell Reports 11 July 2017 9(1):264-278

Capture of circulating metastatic cancer cell clusters from lung cancer patients can reveal unique genomic profiles and potential anti-metastatic molecular targets: A proof-of-concept study.

Authors: Kouhmareh, Kourosh, Martin, Erika, Finlay, Darren, Bhadada, Anukriti, Hernandez-Vargas, Hector, Downey, Francisco, Allen, Jeffrey K., Teriete, Peter

Source: PLoS ONE; 7/31/2024, Vol. 19 Issue 7, p1-22, 22p

Subject Terms: METASTASIS, LUNG cancer, GENOMICS, DRUG target, CANCER cells

DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility

Authors: Ambatipudi, Srikant, Horvath, Steve, Perrier, Flavie, Cuenin, Cyrille, Hernandez-Vargas, Hector, Le Calvez-Kelm, Florence, Durand, Geoffroy, Byrnes, Graham, Ferrari, Pietro, Bouaoun, Liacine, Sklias, Athena, Chajes, Véronique, Overvad, Kim, Severi, Gianluca, Baglietto, Laura, Clavel-Chapelon, Françoise, Kaaks, Rudolf, Barrdahl, Myrto, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Naska, Androniki, Masala, Giovanna, Agnoli, Claudia, Polidoro, Silvia, Tumino, Rosario, Panico, Salvatore, Dollé, Martijn, Peeters, Petra H.M., Onland-Moret, N. Charlotte, Sandanger, Torkjel M., Nøst, Therese H., Weiderpass, Elisabete, Quirós, J. Ramón, Agudo, Antonio, Rodriguez-Barranco, Miguel, Huerta Castaño, José María, Barricarte, Aurelio, Fernández, Ander Matheu, Travis, Ruth C., Vineis, Paolo, Muller, David C., Riboli, Elio, Gunter, Marc, Romieu, Isabelle, Herceg, Zdenko

Source: In European Journal of Cancer April 2017 75:299-307

DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis

Authors: Joubert, Bonnie R., Felix, Janine F., Yousefi, Paul, Bakulski, Kelly M., Just, Allan C., Breton, Carrie, Reese, Sarah E., Markunas, Christina A., Richmond, Rebecca C., Xu, Cheng-Jian, Küpers, Leanne K., Oh, Sam S., Hoyo, Cathrine, Gruzieva, Olena, Söderhäll, Cilla, Salas, Lucas A., Baïz, Nour, Zhang, Hongmei, Lepeule, Johanna, Ruiz, Carlos, Ligthart, Symen, Wang, Tianyuan, Taylor, Jack A., Duijts, Liesbeth, Sharp, Gemma C., Jankipersadsing, Soesma A., Nilsen, Roy M., Vaez, Ahmad, Fallin, M. Daniele, Hu, Donglei, Litonjua, Augusto A., Fuemmeler, Bernard F., Huen, Karen, Kere, Juha, Kull, Inger, Munthe-Kaas, Monica Cheng, Gehring, Ulrike, Bustamante, Mariona, Saurel-Coubizolles, Marie José, Quraishi, Bilal M., Ren, Jie, Tost, Jörg, Gonzalez, Juan R., Peters, Marjolein J., Håberg, Siri E., Xu, Zongli, van Meurs, Joyce B., Gaunt, Tom R., Kerkhof, Marjan, Corpeleijn, Eva, Feinberg, Andrew P., Eng, Celeste, Baccarelli, Andrea A., Benjamin Neelon, Sara E., Bradman, Asa, Merid, Simon Kebede, Bergström, Anna, Herceg, Zdenko, Hernandez-Vargas, Hector, Brunekreef, Bert, Pinart, Mariona, Heude, Barbara, Ewart, Susan, Yao, Jin, Lemonnier, Nathanaël, Franco, Oscar H., Wu, Michael C., Hofman, Albert, McArdle, Wendy, Van der Vlies, Pieter, Falahi, Fahimeh, Gillman, Matthew W., Barcellos, Lisa F., Kumar, Ashish, Wickman, Magnus, Guerra, Stefano, Charles, Marie-Aline, Holloway, John, Auffray, Charles, Tiemeier, Henning W., Smith, George Davey, Postma, Dirkje, Hivert, Marie-France, Eskenazi, Brenda, Vrijheid, Martine, Arshad, Hasan, Antó, Josep M., Dehghan, Abbas, Karmaus, Wilfried, Annesi-Maesano, Isabella, Sunyer, Jordi, Ghantous, Akram, Pershagen, Göran, Holland, Nina, Murphy, Susan K., DeMeo, Dawn L., Burchard, Esteban G., Ladd-Acosta, Christine, Snieder, Harold, Nystad, Wenche, Koppelman, Gerard H., Relton, Caroline L., Jaddoe, Vincent W.V., Wilcox, Allen, Melén, Erik, London, Stephanie J.

Source: In The American Journal of Human Genetics 7 April 2016 98(4):680-696

Modulation of DNA methylation states and infant immune system by dietary supplementation with ω-3 PUFA during pregnancy in an intervention study

Authors: Lee, Ho-Sun, Barraza-Villarreal, Albino, Hernandez-Vargas, Hector, Sly, Peter D, Biessy, Carine, Ramakrishnan, Usha, Romieu, Isabelle, Herceg, Zdenko

Source: In The American Journal of Clinical Nutrition August 2013 98(2):480-487

RSK3 switches cell fate: from stress-induced senescence to malignant progression.

Authors: Huna, Anda, Flaman, Jean-Michel, Lodillinsky, Catalina, Zhu, Kexin, Makulyte, Gabriela, Pakulska, Victoria, Coute, Yohann, Ruisseaux, Clémence, Saintigny, Pierre, Hernandez-Vargas, Hector, Defossez, Pierre-Antoine, Boissan, Mathieu, Martin, Nadine, Bernard, David

Source: Journal of Experimental & Clinical Cancer Research (17569966); 11/27/2023, Vol. 42 Issue 1, p1-16, 16p

Subject Terms: AGING, EPITHELIAL-mesenchymal transition, SERINE/THREONINE kinases, GENE expression, GENTIAN violet, MAMMARY glands

Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer.

Authors: Cassier, Philippe A., Navaridas, Raul, Bellina, Melanie, Rama, Nicolas, Ducarouge, Benjamin, Hernandez-Vargas, Hector, Delord, Jean-Pierre, Lengrand, Justine, Paradisi, Andrea, Fattet, Laurent, Garin, Gwenaële, Gheit, Hanane, Dalban, Cecile, Pastushenko, Ievgenia, Neves, David, Jelin, Remy, Gadot, Nicolas, Braissand, Nicolas, Léon, Sophie, Degletagne, Cyril

Source: Nature; Aug2023, Vol. 620 Issue 7973, p409-416, 8p

Pericyte stem cells induce Ly6G⁺ cell accumulation and immunotherapy resistance in pancreatic cancer.

Authors: Wu, Zhichong, Thierry, Kevin, Bachy, Sophie, Zhang, Xinyi, Gamradt, Pia, Hernandez‐Vargas, Hector, Mikaelian, Ivan, Tonon, Laurie, Pommier, Roxanne, Zhao, Yajie, Bertolino, Philippe, Hennino, Ana

Source: EMBO Reports; 4/5/2023, Vol. 24 Issue 4, p1-23, 23p

Human equilibrative nucleoside transporter-1 (hENT1) is required for the transcriptomic response of the nucleoside-derived drug 5′-DFUR in breast cancer MCF7 cells

Authors: Molina-Arcas, Míriam, Moreno-Bueno, Gema, Cano-Soldado, Pedro, Hernández-Vargas, Héctor, Casado, F. Javier, Palacios, José, Pastor-Anglada, Marçal

Source: In Biochemical Pharmacology 2006 72(12):1646-1656

Gene signature of circulating platelet‐bound neutrophils is associated with poor prognosis in cancer patients.

Authors: Lecot, Pacôme, Ardin, Maude, Dussurgey, Sébastien, Alcazer, Vincent, Moudombi, Lyvia, Pereira Abrantes, Manuela, Hubert, Margaux, Swalduz, Aurélie, Hernandez‐Vargas, Hector, Viari, Alain, Caux, Christophe, Michallet, Marie‐Cécile

Source: International Journal of Cancer; Jul2022, Vol. 151 Issue 1, p138-152, 15p

Subject Terms: CANCER prognosis, NEUTROPHILS, IMMUNE response, BLOOD platelet disorders, BLOOD platelets, LEUKOCYTES

NF‐κB‐dependent secretome of senescent cells can trigger neuroendocrine transdifferentiation of breast cancer cells.

Authors: Raynard, Clotilde, Ma, Xingjie, Huna, Anda, Tessier, Nolwenn, Massemin, Amélie, Zhu, Kexin, Flaman, Jean‐Michel, Moulin, Florentin, Goehrig, Delphine, Medard, Jean‐Jacques, Vindrieux, David, Treilleux, Isabelle, Hernandez‐Vargas, Hector, Ducreux, Sylvie, Martin, Nadine, Bernard, David

Source: Aging Cell; Jul2022, Vol. 21 Issue 7, p1-13, 13p

Subject Terms: CANCER cells, BREAST cancer, CELLULAR aging, P53 protein, EXTRACELLULAR matrix, OLDER patients, GROWTH factors

SMAD4 TGF-β-independent function preconditions naive CD8+ T cells to prevent severe chronic intestinal inflammation.

Authors: Igalouzene, Ramdane¹, Hernandez-Vargas, Hector¹, Benech, Nicolas¹, Guyennon, Alexandre¹, Bauché, David¹, Barrachina, Célia², Dubois, Emeric², Marie, Julien C.¹ julien.marie@inserm.fr, Soudja, Saïdi M'Homa¹ soudja@inserm.fr

Source: Journal of Clinical Investigation. 4/15/2022, Vol. 132 Issue 8, p1-19. 19p.

Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness.

Authors: Fanfone, Deborah, Zhichong Wu, Mammi, Jade, Berthenet, Kevin, Neves, David, Weber, Kathrin, Halaburkova, Andrea, Virard, François, Bunel, Félix, Jamard, Catherine, Hernandez-Vargas, Hector, Tait, Stephen W. G., Hennino, Ana, Ichim, Gabriel

Source: eLife; 3/8/2022, p1-27, 27p

Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation.

Authors: Lainé, Alexandra, Labiad, Ossama, Hernandez-Vargas, Hector, This, Sébastien, Sanlaville, Amélien, Léon, Sophie, Dalle, Stéphane, Sheppard, Dean, Travis, Mark A., Paidassi, Helena, Marie, Julien C.

Source: Nature Communications; 10/28/2021, Vol. 12 Issue 1, p1-14, 14p

Subject Terms: REGULATORY T cells, CYTOTOXIC T cells, CANCER cells, INTEGRINS, IMMUNE response