Exploring the genetics of airflow limitation in lung function across the lifespan – a polygenic risk score study

Authors: Hernandez-Pacheco, Natalia, Kilanowski, Anna, Kumar, Ashish, Curtin, John A., Olvera, Núria, Kress, Sara, Bertels, Xander, Lahousse, Lies, Bhatta, Laxmi, Granell, Raquel, Marí, Sergi, Bilbao, Jose Ramon, Sun, Yidan, Tingskov Pedersen, Casper-Emil, Karramass, Tarik, Thiering, Elisabeth, Dardani, Christina, Kebede Merid, Simon, Wang, Gang, Hallberg, Jenny, Koch, Sarah, Garcia-Aymerich, Judith, Esplugues, Ana, Torrent, Maties, Ibarluzea, Jesus, Lowe, Lesley, Simpson, Angela, Gehring, Ulrike, Vermeulen, Roel C.H., Roberts, Graham, Bergström, Anna, Vonk, Judith M., Felix, Janine F., Duijts, Liesbeth, Bønnelykke, Klaus, Timpson, Nic, Brusselle, Guy, Brumpton, Ben M., Langhammer, Arnulf, Turner, Stephen, Holloway, John W., Arshad, Syed Hasan, Ullah, Anhar, Custovic, Adnan, Cullinan, Paul, Murray, Clare S., van den Berge, Maarten, Kull, Inger, Schikowski, Tamara, Wedzicha, Jadwiga A., Koppelman, Gerard, Faner, Rosa, Agustí, Àlvar, Standl, Marie, Melén, Erik

Source: In eClinicalMedicine September 2024 75

Lung-function trajectories: relevance and implementation in clinical practice

Authors: Abellan, Alicia, Adcock, Ian, Afzal, Shoaib, Alter, Peter, Backman, Helena, Bertels, Xander, Bloom, Chloe, Bønnelykke, Klaus, Breyer, Marie-Kathrin, Casas, Sandra, Chung, Fan (Kian), Colak, Yunus, Cosio, Borja G., Duijts, Liesbeth, Fabbri, Leonardo, Fontanella, Sara, Fuertes, Elaine, Gonzalez, Juan Ramón, Granell, Raquel, Hartl, Sylvia, Hernandez-Pacheco, Natalia, Holloway, John, Jarvis, Deborah, Koefoed, Hans Jacob, Kole, Tessa, Kumar, Ashish, Langhammer, Arnulf, Lindberg, Anne, Llopis, Maria, Maitland van der Zee, Anke-Hilse, Meteran, Howraman, Minelli, Cosetta, Nwaru, Bright, Olvera, Nuria, Peralta, Gabriela, Ritchie, Andrew, Rönmark, Eva, Ross Chapman, James, Sangüesa Boix, Júlia, Schikowski, Tamara, Schlünssen, Vivi, Shaheen, Seif, Sigsgaard, Torben, Standl, Marie, Talaei, Mohammad, Ullah, Anhar, Ullman, Anders, Valencia-Hernandez, Carlos, van den Berge, Maarten, van Dijk, Yoni, Vestbo, Jørgen, Vijverberg, Susanne, Vikjord, Sigrid Anna, Volgelmeier, Claus, Vonk, Judith, Zounemat Kermani, Nazanin, Melén, Erik ^{*, *}, Faner, Rosa ^*, Allinson, James P, Bui, Dinh, Bush, Andrew, Custovic, Adnan, Garcia-Aymerich, Judith, Guerra, Stefano, Breyer-Kohansal, Robab, Hallberg, Jenny, Lahousse, Lies, Martinez, Fernando D, Merid, Simon Kebede, Powell, Pippa, Pinnock, Hilary, Stanojevic, Sanja, Vanfleteren, Lowie E G W, Wang, Gang, Dharmage, Shyamali C, Wedzicha, Jadwiga, Agusti, Alvar

Source: In The Lancet 13-19 April 2024 403(10435):1494-1503

Exploring proteomic plasma biomarkers in eosinophilic and neutrophilic asthma

Authors: Kere, Maura, Klevebro, Susanna, Hernandez‐Pacheco, Natalia, Ödling, Maria, Ekström, Sandra, Mogensen, Ida, Janson, Christer, Palmberg, Lena, Hage, Marianne, Georgelis, Antonios, Bergström, Anna, Kull, Inger, Melén, Erik, Björkander, Sophia

Source: Clinical & experimental allergy. 53(2):186-197

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100175797234.0x000001&indx=1&recIds=ETOCvdc_100175797234.0x000001

Multiomics analysis identifies BIRC3 as a novel glucocorticoid response–associated gene

Authors: Kan, Mengyuan, Diwadkar, Avantika R., Shuai, Haoyue, Joo, Jaehyun, Wang, Alberta L., Ong, Mei-Sing, Sordillo, Joanne E., Iribarren, Carlos, Lu, Meng X., Hernandez-Pacheco, Natalia, Perez-Garcia, Javier, Gorenjak, Mario, Potočnik, Uroš, Burchard, Esteban G., Pino-Yanes, Maria, Wu, Ann Chen, Himes, Blanca E.

Source: Journal of allergy and clinical immunology. 149(6):1981-1991

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164767739.0x000001&indx=1&recIds=ETOCvdc_100164767739.0x000001

Combined analysis of transcriptomic and genetic data for the identification of loci involved in glucocorticosteroid response in asthma

Authors: Hernandez‐Pacheco, Natalia, Gorenjak, Mario, Jurgec, Staša, Corrales, Almudena, Jorgensen, Andrea, Karimi, Leila, Vijverberg, Susanne J., Berce, Vojko, Schieck, Maximilian, Acosta‐Herrera, Marialbert, Kerick, Martin, Samedy‐Bates, Lesly‐Anne, Tavendale, Roger, Villar, Jesús, Mukhopadhyay, Somnath, Pirmohamed, Munir, Verhamme, Katia M. C., Kabesch, Michael, Hawcutt, Daniel B., Turner, Steve, Palmer, Colin N., Burchard, Esteban G., Maitland‐van der Zee, Anke H., Flores, Carlos, Potočnik, Uroš, Pino‐Yanes, Maria

Source: Allergy. 76(4):1238-1243

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131888105.0x000001&indx=1&recIds=ETOCvdc_100131888105.0x000001

Genome‐wide association studies of exacerbations in children using long‐acting beta2‐agonists

Authors: Slob, Elise M. A., Richards, Levi B., Vijverberg, Susanne J. H., Longo, Cristina, Koppelman, Gerard H., Pijnenburg, Mariëlle W. H., Bel, Elisabeth H. D., Neerincx, Anne H., Herrera Luis, Esther, Perez‐Garcia, Javier, Tim Chew, Fook, Yie Sio, Yang, Andiappan, Anand K., Turner, Steve W., Mukhopadhyay, Somnath, Palmer, Colin N. A., Hawcutt, Daniel, Jorgensen, Andrea L., Burchard, Esteban G., Hernandez‐Pacheco, Natalia, Pino‐Yanes, Maria, Maitland‐van der Zee, Anke H., Kalaycı, Ömer

Source: Pediatric allergy and immunology. 32(6):1197-1207

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131521539.0x000001&indx=1&recIds=ETOCvdc_100131521539.0x000001

BMI trajectories from birth to young adulthood associate with distinct cardiometabolic profiles.

Authors: Wang, Gang, Wei, Dang, Kebede Merid, Simon, Ekström, Sandra, Klevebro, Susanna, Hernandez-Pacheco, Natalia, Björkander, Sophia, Ljungman, Petter, Kull, Inger, Schwenk, Jochen M., Bergström, Anna, Melén, Erik

Source: BMC Medicine; 11/5/2024, Vol. 22 Issue 1, p1-19, 19p

Subject Terms: YOUNG adults, BODY mass index, HIGH density lipoproteins, LEUKOCYTE count, COHORT analysis

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Obese asthma phenotypes display distinct plasma biomarker profiles

Authors: Björkander, Sophia, Klevebro, Susanna, Hernandez‐Pacheco, Natalia, Kere, Maura, Ekström, Sandra, Sparreman Mikus, Maria, Hage, Marianne, James, Anna, Kull, Inger, Bergström, Anna, Mjösberg, Jenny, Tibbitt, Christopher Andrew, Melén, Erik

Source: Clinical and translational allergy. 13(3)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181669250.0x000001&indx=1&recIds=ETOCvdc_100181669250.0x000001

Integrative approach identifies corticosteroid response variant in diverse populations with asthma

Authors: Levin, Albert M. ^∗, Gui, Hongsheng ^∗, Hernandez-Pacheco, Natalia, Yang, Mao, Xiao, Shujie, Yang, James J., Hochstadt, Samantha, Barczak, Andrea J., Eckalbar, Walter L., Rynkowski, Dean, Samedy, Lesly-Anne, Kwok, Pui-Yan, Pino-Yanes, Maria, Erle, David J., Lanfear, David E., Burchard, Esteban G., Williams, L. Keoki

Source: In The Journal of Allergy and Clinical Immunology May 2019 143(5):1791-1802

IL1RL1 gene variations are associated with asthma exacerbations in children and adolescents using inhaled corticosteroids

Authors: Dijk, F. Nicole, Vijverberg, Susanne J., Hernandez‐Pacheco, Natalia, Repnik, Katja, Karimi, Leila, Mitratza, Marianna, Farzan, Niloufar, Nawijn, Martijn C., Burchard, Esteban G., Engelkes, Marjolein, Verhamme, Katia M., Potočnik, Uroš, Pino‐Yanes, Maria, Postma, Dirkje S., Maitland‐van der Zee, Anke‐Hilse, Koppelman, Gerard H.

Source: Allergy. 75(4):984-989

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100106635492.0x000001&indx=1&recIds=ETOCvdc_100106635492.0x000001

Genome‐wide association study of inhaled corticosteroid response in admixed children with asthma

Authors: Hernandez‐Pacheco, Natalia, Farzan, Niloufar, Francis, Ben, Karimi, Leila, Repnik, Katja, Vijverberg, Susanne J., Soares, Patricia, Schieck, Maximilian, Gorenjak, Mario, Forno, Erick, Eng, Celeste, Oh, Sam S., Pérez‐Méndez, Lina, Berce, Vojko, Tavendale, Roger, Samedy, Lesly‐Anne, Hunstman, Scott, Hu, Donglei, Meade, Kelley, Farber, Harold J., Avila, Pedro C., Serebrisky, Denise, Thyne, Shannon M., Brigino‐Buenaventura, Emerita, Rodriguez‐Cintron, William, Sen, Saunak, Kumar, Rajesh, Lenoir, Michael, Rodriguez‐Santana, Jose R., Celedón, Juan C., Mukhopadhyay, Somnath, Potočnik, Uroš, Pirmohamed, Munir, Verhamme, Katia M., Kabesch, Michael, Palmer, Colin N. A., Hawcutt, Daniel B., Flores, Carlos, Maitland‐van der Zee, Anke H., Burchard, Esteban G., Pino‐Yanes, Maria

Source: Clinical & experimental allergy. 49(6):789-798

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100084010254.0x000001&indx=1&recIds=ETOCvdc_100084010254.0x000001

Bacterial salivary microbiome associates with asthma among african american children and young adults

Authors: Espuela‐Ortiz, Antonio, Lorenzo‐Diaz, Fabian, Baez‐Ortega, Adrian, Eng, Celeste, Hernandez‐Pacheco, Natalia, Oh, Sam S., Lenoir, Michael, Burchard, Esteban G., Flores, Carlos, Pino‐Yanes, Maria

Source: Pediatric pulmonology. 54(12):1948-1956

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100092837258.0x000001&indx=1&recIds=ETOCvdc_100092837258.0x000001

Multi‐ancestry genome‐wide association study of asthma exacerbations

Authors: Herrera‐Luis, Esther, Ortega, Victor E., Ampleford, Elizabeth J., Sio, Yang Yie, Granell, Raquel, Roos, Emmely, Terzikhan, Natalie, Vergara, Ernesto Elorduy, Hernandez‐Pacheco, Natalia, Perez‐Garcia, Javier, Martin‐Gonzalez, Elena, Lorenzo‐Diaz, Fabian, Hashimoto, Simone, Brinkman, Paul, Jorgensen, Andrea L., Yan, Qi, Forno, Erick, Vijverberg, Susanne J., Lethem, Ryan, Espuela‐Ortiz, Antonio, Gorenjak, Mario, Eng, Celeste, González‐Pérez, Ruperto, Hernández‐Pérez, José M., Poza‐Guedes, Paloma, Sardón, Olaia, Corcuera, Paula, Hawkins, Greg A., Marsico, Annalisa, Bahmer, Thomas, Rabe, Klaus F., Hansen, Gesine, Kopp, Matthias Volkmar, Rios, Raimon, Cruz, Maria Jesus, González‐Barcala, Francisco‐Javier, Olaguibel, José María, Plaza, Vicente, Quirce, Santiago, Canino, Glorisa, Cloutier, Michelle, Pozo, Victoria, Rodriguez‐Santana, Jose R., Korta‐Murua, Javier, Villar, Jesús, Potočnik, Uroš, Figueiredo, Camila, Kabesch, Michael, Mukhopadhyay, Somnath, Pirmohamed, Munir, Hawcutt, Daniel B., Melén, Erik, Palmer, Colin N., Turner, Steve, Maitland‐van der Zee, Anke H., Mutius, Erika, Celedón, Juan C., Brusselle, Guy, Chew, Fook Tim, Bleecker, Eugene, Meyers, Deborah, Burchard, Esteban G., Pino‐Yanes, Maria

Source: Pediatric allergy and immunology. 33(6)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185261534.0x000001&indx=1&recIds=ETOCvdc_100185261534.0x000001

Gene‐environment interactions in childhood asthma revisited; expanding the interaction concept

Authors: Hernandez‐Pacheco, Natalia, Kere, Maura, Melén, Erik

Source: Pediatric allergy and immunology. 33(5)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100153964539.0x000001&indx=1&recIds=ETOCvdc_100153964539.0x000001

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

Authors: Waage, Johannes, Standl, Marie, Curtin, John, Jessen, Leon, Thorsen, Jonathan, Tian, Chao, Schoettler, Nathan, Flores, Carlos, Abdellaoui, Abdel, Ahluwalia, Tarunveer, Alves, Alexessander, Amaral, Andre, Antó, Josep, Arnold, Andreas, Barreto-Luis, Amalia, Baurecht, Hansjörg, Beijsterveldt, Catharina, Bleecker, Eugene, Bonàs-Guarch, Sílvia, Boomsma, Dorret, Brix, Susanne, Bunyavanich, Supinda, Burchard, Esteban, Chen, Zhanghua, Curjuric, Ivan, Custovic, Adnan, Dekker, Herman, Dharmage, Shyamali, Dmitrieva, Julia, Duijts, Liesbeth, Ege, Markus, Gauderman, W., Georges, Michel, Gieger, Christian, Gilliland, Frank, Granell, Raquel, Gui, Hongsheng, Hansen, Torben, Heinrich, Joachim, Henderson, John, Hernandez-Pacheco, Natalia, Holt, Patrick, Imboden, Medea, Jaddoe, Vincent, Jarvelin, Marjo-Riitta, Jarvis, Deborah, Jensen, Kamilla, Jónsdóttir, Ingileif, Kabesch, Michael, Kaprio, Jaakko, Kumar, Ashish, Lee, Young-Ae, Levin, Albert, Li, Xingnan, Lorenzo-Diaz, Fabian, Melén, Erik, Mercader, Josep, Meyers, Deborah, Myers, Rachel, Nicolae, Dan, Nohr, Ellen, Palviainen, Teemu, Paternoster, Lavinia, Pennell, Craig, Pershagen, Göran, Pino-Yanes, Maria, Probst-Hensch, Nicole, Rüschendorf, Franz, Simpson, Angela, Stefansson, Kari, Sunyer, Jordi, Sveinbjornsson, Gardar, Thiering, Elisabeth, Thompson, Philip, Torrent, Maties, Torrents, David, Tung, Joyce, Wang, Carol, Weidinger, Stephan, Weiss, Scott, Willemsen, Gonneke, Williams, L., Ober, Carole, Hinds, David, Ferreira, Manuel, Bisgaard, Hans, Strachan, David, Bønnelykke, Klaus

Source: Nature genetics. 50(8):1072-1080

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100175117262.0x000001&indx=1&recIds=ETOCvdc_100175117262.0x000001

Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium

Authors: Farzan, Niloufar, Vijverberg, Susanne J, Andiappan, Anand K, Arianto, Lambang, Berce, Vojko, Blanca-López, Natalia, Bisgaard, Hans, Bønnelykke, Klaus, Burchard, Esteban G, Campo, Paloma, Canino, Glorisa, Carleton, Bruce, Celedón, Juan C, Chew, Fook Tim, Chiang, Wen Chin, Cloutier, Michelle M, Daley, Denis, Den Dekker, Herman T, Dijk, F Nicole, Duijts, Liesbeth, Flores, Carlos, Forno, Erick, Hawcutt, Daniel B, Hernandez-Pacheco, Natalia, de Jongste, Johan C, Kabesch, Michael, Koppelman, Gerard H, Manolopoulos, Vangelis G, Melén, Erik, Mukhopadhyay, Somnath, Nilsson, Sara, Palmer, Colin N, Pino-Yanes, Maria, Pirmohamed, Munir, Potočnki, Uros, Raaijmakers, Jan A, Repnik, Katja, Schieck, Maximilian, Sio, Yang Yie, Smyth, Rosalind L, Szalai, Csaba, Tantisira, Kelan G, Turner, Steve, van der Schee, Marc P, Verhamme, Katia M, Maitland-van der Zee, Anke H

Source: Pharmacogenomics. 18(10):931-943

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100150061496.0x000001&indx=1&recIds=ETOCvdc_100150061496.0x000001

Unraveling the Complexity of Asthma: Insights from Omics Approaches.

Authors: Herrera-Luis, Esther, Hernandez-Pacheco, Natalia

Source: Biomedicines; May2024, Vol. 12 Issue 5, p1062, 3p

Subject Terms: ASTHMA, WHEEZE, GENETIC risk score

LTA4H rs2660845 association with montelukast response in early and late-onset asthma.

Authors: Maroteau, Cyrielle, Espuela-Ortiz, Antonio, Herrera-Luis, Esther, Srinivasan, Sundararajan, Carr, Fiona, Tavendale, Roger, Wilson, Karen, Hernandez-Pacheco, Natalia, Chalmers, James D., Turner, Steve, Mukhopadhyay, Somnath, Maitland-van der Zee, Anke-Hilse, Burchard, Esteban G., Pino-Yanes, Maria, Young, Simon, Lassi, Glenda, Platt, Adam, Palmer, Colin N. A.

Source: PLoS ONE; 9/22/2021, Vol. 16 Issue 9, p1-17, 17p

Subject Terms: ASTHMA, MONTELUKAST, GENETIC variation, ADULTS, ODDS ratio, ASTHMATICS

ADRB2 haplotypes and asthma exacerbations in children and young adults: An individual participant data meta‐analysis.

Authors: Karimi, Leila, Vijverberg, Susanne J., Engelkes, Marjolein, Hernandez‐Pacheco, Natalia, Farzan, Niloufar, Soares, Patricia, Pino‐Yanes, Maria, Jorgensen, Andrea L., Eng, Celeste, Mukhopadhyay, Somnath, Schieck, Maximilian, Kabesch, Michael, Burchard, Esteban G., Chew, Fook Tim, Sio, Yang Yie, Potočnik, Uroš, Gorenjak, Mario, Hawcutt, Daniel B., Palmer, Colin N., Turner, Steve

Source: Clinical & Experimental Allergy; Sep2021, Vol. 51 Issue 9, p1157-1171, 15p, 1 Diagram, 3 Charts, 3 Graphs

Subject Terms: ASTHMA in children, YOUNG adults, HAPLOTYPES, TREATMENT effectiveness, ASTHMA