Quantitative proteomic analysis unveils a critical role of VARS1 in hepatocellular carcinoma aggressiveness through the modulation of MAGI1 expression.

Authors: Hermán-Sánchez, Natalia^1,2 (AUTHOR), del Rio-Moreno, Mercedes^1,2 (AUTHOR), Ciria, Rubén^2,3 (AUTHOR), Sánchez-Frias, Marina E.^2,4 (AUTHOR), Fernández-Barrena, Maite G.^5,6 (AUTHOR), Uriarte, Iker⁵ (AUTHOR), Chicano-Galvez, Eduardo⁷ (AUTHOR), Ortea, Ignacio⁸ (AUTHOR), Peralbo-Molina, Ángela⁷ (AUTHOR), Briceño, Javier^2,3 (AUTHOR), Avila, Matías A.^5,6 (AUTHOR), Rodríguez-Perálvarez, Manuel^2,9 (AUTHOR), Luque, Raúl M.^1,2 (AUTHOR), López-Cánovas, Juan L.^1,2 (AUTHOR), Gahete, Manuel D.^1,2 (AUTHOR) bc2gaorm@uco.es

Source: Molecular Cancer. 1/14/2025, Vol. 24 Issue 1, p1-16. 16p.

Subject Terms: *AMINOACYL-tRNA synthetases, *MEDICAL sciences, *CYTOLOGY, *LIFE sciences, *HEPATOCELLULAR carcinoma

SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer

Authors: Lachiondo-Ortega, Sofia ^{1, 30}, Rejano-Gordillo, Claudia M. ^{1, 2, 3, 30}, Simon, Jorge ^{1, 4}, Lopitz-Otsoa, Fernando ¹, C. Delgado, Teresa ¹, Mazan-Mamczarz, Krystyna ⁵, Goikoetxea-Usandizaga, Naroa ¹, Zapata-Pavas, L. Estefanía ¹, García-del Río, Ana ⁶, Guerra, Pietro ⁷, Peña-Sanfélix, Patricia ¹, Hermán-Sánchez, Natalia ⁸, Al-Abdulla, Ruba ^{9, 10}, Fernandez-Rodríguez, Carmen ¹, Azkargorta, Mikel ^{4, 11}, Velázquez-Cruz, Alejandro ¹², Guyon, Joris ^{13, 14}, Martín, César ³, Zalamea, Juan Diego ¹⁵, Egia-Mendikute, Leire ⁶, Sanz-Parra, Arantza ¹, Serrano-Maciá, Marina ¹, González-Recio, Irene ¹, Gonzalez-Lopez, Monika ¹⁶, Martínez-Cruz, Luis Alfonso ¹, Pontisso, Patrizia ⁷, Aransay, Ana M. ¹⁶, Barrio, Rosa ¹⁷, Sutherland, James D. ¹⁷, Abrescia, Nicola G.A. ^{15, 18}, Elortza, Félix ^{4, 11}, Lujambio, Amaia ^{19, 20, 21, 22}, Banales, Jesus M. ^{4, 18, 23, 24}, Luque, Raúl M. ⁸, Gahete, Manuel D. ⁸, Palazón, Asís ^{6, 18}, Avila, Matias A. ^{4, 25, 26}, G. Marin, Jose J. ^{4, 27}, De, Supriyo ⁵, Daubon, Thomas ²⁸, Díaz-Quintana, Antonio ¹², Díaz-Moreno, Irene ¹², Gorospe, Myriam ⁵, Rodríguez, Manuel S. ²⁹, Martínez-Chantar, María Luz ^{1, 4, 31, ∗}

Source: In Cell Reports 26 March 2024 43(3)

The splicing machinery is dysregulated and represents a therapeutic vulnerability in breast cancer.

Authors: Hermán-Sánchez, Natalia^1,2,3,4 (AUTHOR), G-García, Miguel E.^1,2,3,4 (AUTHOR), Jiménez-Vacas, Juan M.^1,2,3,4 (AUTHOR), Yubero-Serrano, Elena M.^1,3,4,5 (AUTHOR), López-Sánchez, Laura M.^1,2,3,4 (AUTHOR), Romero-Martín, Sara^1,3,6 (AUTHOR), Raya-Povedano, Jose L.^1,3,6 (AUTHOR), Álvarez-Benito, Marina^1,3,6 (AUTHOR), Castaño, Justo P.^1,2,3,4 (AUTHOR) justo@uco.es, Luque, Raúl M.^1,2,3,4 (AUTHOR) bc2luhur@uco.es, Gahete, Manuel D.^1,2,3,4 (AUTHOR) bc2gaorm@uco.es

Source: Cellular & Molecular Life Sciences. 12/27/2024, Vol. 82 Issue 1, p1-16. 16p.

Subject Terms: *MEDICAL sciences, *HORMONE receptors, *OVERALL survival, *BREAST cancer, *CELL lines, *RNA splicing, *BREAST

MAP17 promotes an epithelial-mesenchymal-amoeboid transition in hepatocellular carcinoma by switching one-carbon metabolism

Authors: Gil-Pitarch, Claudia, Uriarte, Iker, Bertran, Esther, Hermán-Sánchez, Natalia, García-Heredia, José Manuel, Agudo, Rubén Rodríguez, Goikoetxea, Naroa, Lachiondo-Ortega, Sofia, Mercado-Gómez, Maria, González-Recio, Irene, Delgado, Teresa Cardoso, Vivanco, Maria, Martinez-Cruz, Luis Alfonso, Martín, Cesar Augusto, Artuch, Rafael, Fernández, Mario, Ortiz, Manuel Gahete, Fabregat, Isabel, Avila, Matías A, Carnero, Amancio, Martínez-Chantar, María Luz

Source: Journal of hepatology. 78(S1):S529-S530

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195505096.0x000001&indx=1&recIds=ETOCvdc_100195505096.0x000001

Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation of FGFR4 splicing

Authors: López‐Cánovas, Juan L., Hermán‐Sánchez, Natalia, Moreno‐Montilla, Maria Trinidad, del Rio‐Moreno, Mercedes, Alors‐Perez, Emilia, Sánchez‐Frias, Marina E., Amado, Víctor, Ciria, Rubén, Briceño, Javier, Mata, Manuel, Castaño, Justo P., Rodriguez‐Perálvarez, Manuel, Luque, Raúl M., Gahete, Manuel D.

Source: Clinical and translational medicine. 12(11)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187362870.0x000001&indx=1&recIds=ETOCvdc_100187362870.0x000001

MAP17 promotes metastasis in hepatocellular carcinoma by modulating the epithelial-mesenchymal-amoeboid transition

Authors: Gil-Pitarch, Claudia, Bertran, Esther, Uriarte, Iker, Hermán-Sánchez, Natalia, García-Heredia, José Manuel, Goikoetxea, Naroa, Serrano-Macia, Marina, Agudo, Rubén Rodríguez, Lachiondo-Ortega, Sofia, Mercado-Gómez, Maria, Rábano, Miriam, Delgado, Teresa Cardoso, Espinosa, Jorge Simón, Martinez-Cruz, Luis Alfonso, Martín, Cesar Augusto, Vivanco, Maria, Avila, Matías A., Ortiz, Manuel Gahete, Fabregat, Isabel, Carnero, Amancio, Martínez-Chantar, María Luz

Source: Journal of hepatology. 77(S1):S48-S48

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167076633.0x000001&indx=1&recIds=ETOCvdc_100167076633.0x000001

FRI-462-YI Aminoacyl-tRNA synthetases characterization and clinical potential in aggressive hepatocellular carcinoma

Authors: Hermán-Sánchez, Natalia, Zamora-Olaya, Javier M., Rodríguez-Perálvarez, Manuel, Luque, Raul M, López-Cánovas, Juan L., Gahete, Manuel D.

Source: In Journal of Hepatology June 2024 80 Supplement 1:S415-S415

PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating FAK/AKT pathway via fibronectin 1 splicing.

Authors: López-Cánovas, Juan L., Hermán-Sánchez, Natalia, del Rio-Moreno, Mercedes, Fuentes-Fayos, Antonio C., Lara-López, Araceli, Sánchez-Frias, Marina E., Amado, Víctor, Ciria, Rubén, Briceño, Javier, de la Mata, Manuel, Castaño, Justo P., Rodriguez-Perálvarez, Manuel, Luque, Raúl M., Gahete, Manuel D.

Source: Experimental & Molecular Medicine EMM; Jan2023, Vol. 55 Issue 1, p132-142, 11p

Multidisciplinary Prehabilitation and Postoperative Rehabilitation for Avoiding Complications in Patients Undergoing Resection of Colon Cancer: Rationale, Design, and Methodology of the ONCOFIT Study.

Authors: Amaro-Gahete, Francisco J., Jurado, Javier, Cisneros, Andrea, Corres, Pablo, Marmol-Perez, Andres, Osuna-Prieto, Francisco J., Fernández-Escabias, Manuel, Salcedo, Estela, Hermán-Sánchez, Natalia, Gahete, Manuel D., Aparicio, Virginia A., González-Callejas, Cristina, Mirón Pozo, Benito, R. Ruiz, Jonatan, Nestares, Teresa, Carneiro-Barrera, Almudena

Source: Nutrients; Nov2022, Vol. 14 Issue 21, p4647, 25p

SAT-216 - MAP17 promotes an epithelial-mesenchymal-amoeboid transition in hepatocellular carcinoma by switching one-carbon metabolism

Authors: Gil-Pitarch, Claudia, Uriarte, Iker, Bertran, Esther, Hermán-Sánchez, Natalia, García-Heredia, José Manuel, Agudo, Rubén Rodríguez, Goikoetxea, Naroa, Lachiondo-Ortega, Sofia, Mercado-Gómez, Maria, González-Recio, Irene, Delgado, Teresa Cardoso, Vivanco, Maria, Martinez-Cruz, Luis Alfonso, Martín, Cesar Augusto, Artuch, Rafael, Fernández, Mario, Ortiz, Manuel Gahete, Fabregat, Isabel, Avila, Matías A, Carnero, Amancio, Martínez-Chantar, María Luz

Source: In Journal of Hepatology June 2023 78 Supplement 1:S529-S530

OS060 - MAP17 promotes metastasis in hepatocellular carcinoma by modulating the epithelial-mesenchymal-amoeboid transition

Authors: Gil-Pitarch, Claudia, Bertran, Esther, Uriarte, Iker, Hermán-Sánchez, Natalia, García-Heredia, José Manuel, Goikoetxea, Naroa, Serrano-Macia, Marina, Agudo, Rubén Rodríguez, Lachiondo-Ortega, Sofia, Mercado-Gómez, Maria, Rábano, Miriam, Delgado, Teresa Cardoso, Espinosa, Jorge Simón, Martinez-Cruz, Luis Alfonso, Martín, Cesar Augusto, Vivanco, Maria, Avila, Matías A., Ortiz, Manuel Gahete, Fabregat, Isabel, Carnero, Amancio, Martínez-Chantar, María Luz

Source: In Journal of Hepatology July 2022 77 Supplement 1:S48-S48

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