Combined deletion of cytosolic 5′-nucleotidases IA and II lowers glycemia by improving skeletal muscle insulin action and lowering hepatic glucose production

Authors: Jacobs, Roxane ¹, Herinckx, Gaëtan ¹, Galland, Noémie ², Balty, Clémence ¹, Vertommen, Didier ¹, Rider, Mark H. ¹, Johanns, Manuel ^{1, ∗}

Source: In Journal of Biological Chemistry March 2025 301(3)

Decellularized extracellular matrix from bovine ovarian tissue maintains the protein composition of the native matrisome

Authors: León-Félix, Cecibel M., Ouni, Emna, Herinckx, Gaëtan, Vertommen, Didier, Amorim, Christiani A., Lucci, Carolina M.

Source: In Journal of Proteomics 16 January 2025 311

Identification of RSK substrates using an analog-sensitive kinase approach

Authors: Lizcano-Perret, Belén, Vertommen, Didier, Herinckx, Gaëtan, Calabrese, Viviane, Gatto, Laurent, Roux, Philippe P., Michiels, Thomas

Source: In Journal of Biological Chemistry March 2024 300(3)

Peroxiredoxin-1 is an H2O2 safe-guard antioxidant and signalling enzyme in M1 macrophages

Authors: Ezeriņa, Daria, Nghia Vo, Trung, Luo, Ting, Elkrim, Yvon, Suarez, Anna Escoda, Herinckx, Gaëtan, Vertommen, Didier, Laoui, Damya, Van Ginderachter, Jo A., Messens, Joris

Source: In Advances in Redox Research December 2023 9

Proteome-wide and matrisome-specific atlas of the human ovary computes fertility biomarker candidates and open the way for precision oncofertility

Authors: Ouni, Emna, Nedbal, Valerie, Da Pian, Marta, Cao, Hangbao, Haas, Kalina T., Peaucelle, Alexis, Van Kerk, Olivier, Herinckx, Gaetan, Marbaix, Etienne, Dolmans, Marie-Madeleine, Tuuri, Timo, Otala, Marjut, Amorim, Christiani A., Vertommen, Didier

Source: In Matrix Biology May 2022 109:91-120

Stress granules are not present in Kras mutant cancers and do not control tumor growth.

Authors: Libert, Maxime, Quiquempoix, Sophie, Fain, Jean S, Pyr dit Ruys, Sébastien, Haidar, Malak, Wulleman, Margaux, Herinckx, Gaëtan, Vertommen, Didier, Bouchart, Christelle, Arsenijevic, Tatjana, Van Laethem, Jean-Luc, Jacquemin, Patrick

Source: EMBO Reports; Nov2024, Vol. 25 Issue 11, p4693-4707, 15p

Saturated fatty acids induce NLRP3 activation in human macrophages through K+ efflux resulting from phospholipid saturation and Na, K-ATPase disruption

Authors: Gianfrancesco, Marco A., Dehairs, Jonas, L'homme, Laurent, Herinckx, Gaëtan, Esser, Nathalie, Jansen, Olivia, Habraken, Yvette, Lassence, Cédric, Swinnen, Johan V., Rider, Mark H., Piette, Jacques, Paquot, Nicolas, Legrand-Poels, Sylvie

Source: In BBA - Molecular and Cell Biology of Lipids July 2019 1864(7):1017-1030

Genetic deletion of soluble 5′-nucleotidase II reduces body weight gain and insulin resistance induced by a high-fat diet

Authors: Johanns, Manuel, Kviklyte, Samanta, Chuang, Sheng-Ju, Corbeels, Katrien, Jacobs, Roxane, Herinckx, Gaëtan, Vertommen, Didier, Schakman, Olivier, Duparc, Thibaut, Cani, Patrice D., Bouzin, Caroline, Andersén, Harriet, Bohlooly-Y, Mohammad, Van der Schueren, Bart, Oscarsson, Jan, Rider, Mark H.

Source: In Molecular Genetics and Metabolism April 2019 126(4):377-387

HBP1 phosphorylation by AKT regulates its transcriptional activity and glioblastoma cell proliferation

Authors: Bollaert, Emeline, Johanns, Manuel, Herinckx, Gaëtan, de Rocca Serra, Audrey, Vandewalle, Virginie A., Havelange, Violaine, Rider, Mark H., Vertommen, Didier, Demoulin, Jean-Baptiste

Source: In Cellular Signalling April 2018 44:158-170

Cardiovirus leader proteins retarget RSK kinases toward alternative substrates to perturb nucleocytoplasmic traffic.

Authors: Lizcano-Perret, Belén¹, Lardinois, Cécile¹, Wavreil, Fanny¹, Hauchamps, Philippe², Herinckx, Gaëtan³, Sorgeloos, Frédéric¹, Vertommen, Didier³, Gatto, Laurent², Michiels, Thomas¹, thomas.michiels@uclouvain.be

Source: PLoS Pathogens; 12/12/2022, Vol. 18 Issue 12, p1-27, 27p

Ascorbate peroxidase 2 of Chlamydomonas reinhardtii is involved in the regulation of the plastocyanin levels

Authors: Caccamo, Anna, Vega de Luna, Felix, Amelii, Antonello, Herinckx, Gaëtan, Pyr dit Ruys, Sébastien, Vertommen, Didier, Cardol, Pierre, Messens, Joris, Remacle, Claire

Source: In Free Radical Biology and Medicine 20 August 2022 189 Supplement 1

Specific post-translational modifications of soluble tau protein distinguishes Alzheimer's disease and primary tauopathies.

Authors: Kyalu Ngoie Zola, Nathalie, Balty, Clémence, Pyr dit Ruys, Sébastien, Vanparys, Axelle A. T., Huyghe, Nicolas D. G., Herinckx, Gaëtan, Johanns, Manuel, Boyer, Emilien, Kienlen-Campard, Pascal, Rider, Mark H., Vertommen, Didier, Hanseeuw, Bernard J.

Source: Nature Communications; 6/22/2023, Vol. 14 Issue 1, p1-17, 17p

Subject Terms: TAU proteins, TAUOPATHIES, ALZHEIMER'S disease, NEUROFIBRILLARY tangles, POST-translational modification, ALZHEIMER'S patients, NEURODEGENERATION

In-Depth Analysis of the Pancreatic Extracellular Matrix during Development for Next-Generation Tissue Engineering.

Authors: Glorieux, Laura, Vandooren, Laura, Derclaye, Sylvie, Pyr dit Ruys, Sébastien, Oncina-Gil, Paloma, Salowka, Anna, Herinckx, Gaëtan, Aajja, Elias, Lemoine, Pascale, Spourquet, Catherine, Lefort, Hélène, Henriet, Patrick, Tyteca, Donatienne, Spagnoli, Francesca M., Alsteens, David, Vertommen, Didier, Pierreux, Christophe E.

Source: International Journal of Molecular Sciences; Jun2023, Vol. 24 Issue 12, p10268, 22p

Subject Terms: EXTRACELLULAR matrix, TISSUE engineering, ATOMIC force microscopy, HOMEOSTASIS, MASS spectrometry

Inhibition of basal and glucagon-induced hepatic glucose production by 991 and other pharmacological AMPK activators.

Authors: Johanns, Manuel, Corbet, Cyril, Jacobs, Roxane, Drappier, Melissa, Bommer, Guido T., Herinckx, Gaëtan, Vertommen, Didier, Tajeddine, Nicolas, Young, David, Messens, Joris, Feron, Olivier, Steinberg, Gregory R., Hue, Louis, Rider, Mark H.

Source: Biochemical Journal; 6/15/2022, Vol. 479 Issue 12, p1317-1336, 20p

Subject Terms: AMP-activated protein kinases, GLUCOSE, TYPE 2 diabetes, INSULIN, PYRUVATES

Absolute quantification of tau isoforms in human brain by mass spectrometry: Developing topics.

Authors: Zola, Nathalie Kyalu Ngoie, Herinckx, Gaëtan, dit Ruys, Sébastien Pyr, Vertommen, Didier, Rider, Mark H, Hanseeuw, Bernard J

Source: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2020 Supplement S11, Vol. 16 Issue 11, p1-4, 4p

Two isoprenylated flavonoids from Dorstenia psilurus activate AMPK, stimulate glucose uptake, inhibit glucose production and lower glycemia.

Authors: Choumessi, Aphrodite T., Johanns, Manuel, Beaufay, Claire, Herent, Marie-France, Stroobant, Vincent, Vertommen, Didier, Corbet, Cyril, Jacobs, Roxane, Herinckx, Gaëtan, Steinberg, Gregory R., Feron, Olivier, Quetin-Leclercq, Joëlle, Rider, Mark H.

Source: Biochemical Journal; Dec2019, Vol. 476 Issue 24, p3687-3704, 18p

Subject Terms: ELECTROSPRAY ionization mass spectrometry, CANCER cell culture, HUMAN cell culture, LIVER mitochondria, GLUCOSE, ISOMERS, FLAVONOID glycosides

Geographic Terms: CAMEROON

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Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase.

Authors: PYR DIT RUYS, Sébastien, WANG, Xuemin, SMITH, Ewan M., HERINCKX, Gaëtan, HUSSAIN, Nusrat, RIDER, Mark H., VERTOMMEN, Didier, PROUD, Christopher G.

Source: Biochemical Journal; 3/15/2012, Vol. 442 Issue 3, p681-693, 13p

Subject Terms: AUTOPHOSPHORYLATION, PROTEIN kinases, CALMODULIN, PHOSPHORYLATION, IMMUNOBLOTTING, ENZYMES

Divide-and-Conquer Matrisome Protein (DC-MaP) Strategy: An MS-Friendly Approach to Proteomic Matrisome Characterization.

Authors: Ouni, Emna, Ruys, Sébastien Pyr dit, Dolmans, Marie-Madeleine, Herinckx, Gaëtan, Vertommen, Didier, Amorim, Christiani A.

Source: International Journal of Molecular Sciences; Dec2020, Vol. 21 Issue 23, p9141, 1p

Subject Terms: PROTEOMICS, PROTEINS, TISSUE engineering, EXTRACELLULAR matrix, MACROMOLECULES