Regular Exercise Training Induces More Changes on Intestinal Glucose Uptake from Blood and Microbiota Composition in Leaner Compared to Heavier Individuals in Monozygotic Twins Discordant for BMI.

Authors: Lietzén, Martin S., Guzzardi, Maria Angela, Ojala, Ronja, Hentilä, Jaakko, Heiskanen, Marja A., Honkala, Sanna M., Lautamäki, Riikka, Löyttyniemi, Eliisa, Kirjavainen, Anna K., Rajander, Johan, Malm, Tarja, Lahti, Leo, Rinne, Juha O., Pietiläinen, Kirsi H., Iozzo, Patricia, Hannukainen, Jarna C.

Source: Nutrients; Oct2024, Vol. 16 Issue 20, p3554, 19p

Sprint and Strength Training Modulates Autophagy and Proteostasis in Aging Sprinters

Authors: HENTILÄ, JAAKKO, HULMI, JUHA J., LAAKKONEN, EIJA K., AHTIAINEN, JUHA P., SUOMINEN, HARRI, KORHONEN, MARKO T.

Source: Medicine and science in sports and exercise. 52(9):1948-1959

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100175855005.0x000001&indx=1&recIds=ETOCvdc_100175855005.0x000001

Effects of Obesity and Exercise on Hepatic and Pancreatic Lipid Content and Glucose Metabolism: PET Studies in Twins Discordant for BMI.

Authors: Lietzén, Martin S., Mari, Andrea, Ojala, Ronja, Hentilä, Jaakko, Koskensalo, Kalle, Lautamäki, Riikka, Löyttyniemi, Eliisa, Parkkola, Riitta, Saunavaara, Virva, Kirjavainen, Anna K., Rajander, Johan, Malm, Tarja, Lahti, Leo, Rinne, Juha O., Pietiläinen, Kirsi H., Iozzo, Patricia, Hannukainen, Jarna C.

Source: Biomolecules (2218-273X); Sep2024, Vol. 14 Issue 9, p1070, 19p

Subject Terms: EXERCISE physiology, MONOZYGOTIC twins, NUCLEAR magnetic resonance spectroscopy, INSULIN sensitivity, EXERCISE therapy

Evaluation of bone marrow glucose uptake and adiposity in male rats after diet and exercise interventions.

Authors: Ojala, Ronja, Widjaja, Nicko, Hentilä, Jaakko, Jalo, Anna, Helin, Jatta S., Nissinen, Tuuli A., Jalava, Niki, Eskola, Olli, Rajander, Johan, Löyttyniemi, Eliisa, Ivaska, Kaisa K., Hannukainen, Jarna C.

Source: Frontiers in Endocrinology; 2024, p1-12, 12p

Subject Terms: EXERCISE therapy, BONE marrow, DIET, HIGH-fat diet, OBESITY, RATS

Mechanisms Leading to Increased Insulin-Stimulated Cerebral Glucose Uptake in Obesity and Insulin Resistance: A High-Fat Diet and Exercise Training Intervention PET Study with Rats (CROSRAT).

Authors: Jalo, Anna, Helin, Jatta S., Hentilä, Jaakko, Nissinen, Tuuli A., Honkala, Sanna M., Heiskanen, Marja A., Löyttyniemi, Eliisa, Malm, Tarja, Hannukainen, Jarna C.

Source: Journal of Functional Morphology & Kinesiology; Jun2024, Vol. 9 Issue 2, p58, 11p

Subject Terms: HIGH-fat diet, INSULIN resistance, EXERCISE physiology, EXERCISE therapy, INSULIN sensitivity, SPRAGUE Dawley rats, FECAL contamination

Effects of muscular dystrophy, exercise and blocking activin receptor IIB ligands on the unfolded protein response and oxidative stress

Authors: Hulmi, Juha J., Hentilä, Jaakko, DeRuisseau, Keith C., Oliveira, Bernardo M., Papaioannou, Konstantinos G., Autio, Reija, Kujala, Urho M., Ritvos, Olli, Kainulainen, Heikki, Korkmaz, Ayhan, Atalay, Mustafa

Source: In Free Radical Biology and Medicine October 2016 99:308-322

Bone marrow metabolism is affected by body weight and response to exercise training varies according to anatomical location.

Authors: Ojala, Ronja¹ (AUTHOR) rahoja@utu.fi, Hentilä, Jaakko¹ (AUTHOR), Lietzén, Martin S.¹ (AUTHOR), Arponen, Milja² (AUTHOR), Heiskanen, Marja A.^1,3,4 (AUTHOR), Honkala, Sanna M.¹ (AUTHOR), Virtanen, Heidi¹ (AUTHOR), Koskensalo, Kalle⁵ (AUTHOR), Lautamäki, Riikka⁶ (AUTHOR), Löyttyniemi, Eliisa⁷ (AUTHOR), Parkkola, Riitta^8,9 (AUTHOR), Heinonen, Olli J.¹⁰ (AUTHOR), Malm, Tarja¹¹ (AUTHOR), Lahti, Leo¹² (AUTHOR), Rinne, Juha^1,13 (AUTHOR), Eskola, Olli¹⁴ (AUTHOR), Rajander, Johan¹⁵ (AUTHOR), Pietiläinen, Kirsi H.^16,17 (AUTHOR), Kaprio, Jaakko¹⁸ (AUTHOR), Ivaska, Kaisa K.² (AUTHOR)

Source: Diabetes, Obesity & Metabolism. Jan2024, Vol. 26 Issue 1, p251-261. 11p.

Subject Terms: *BONE metabolism, *EXERCISE therapy, *BODY weight, *WEIGHT loss, *BONE marrow, *RESISTANCE training

Muscle follistatin gene delivery increases muscle protein synthesis independent of periodical physical inactivity and fasting

Authors: Nissinen, Tuuli A., Hentilä, Jaakko, Fachada, Vasco, Lautaoja, Juulia H., Pasternack, Arja, Ritvos, Olli, Kivelä, Riikka, Hulmi, Juha J.

Source: FASEB journal. 35(3)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100132968628.0x000001&indx=1&recIds=ETOCvdc_100132968628.0x000001

Segmentation of Dynamic Total-Body [¹⁸F]-FDG PET Images Using Unsupervised Clustering.

Authors: Jaakkola, Maria K., Rantala, Maria, Jalo, Anna, Saari, Teemu, Hentilä, Jaakko, Helin, Jatta S., Nissinen, Tuuli A., Eskola, Olli, Rajander, Johan, Virtanen, Kirsi A., Hannukainen, Jarna C., López-Picón, Francisco, Klén, Riku

Source: International Journal of Biomedical Imaging; 12/5/2023, p1-13, 13p

Subject Terms: ANIMAL experimentation, ORGANS (Anatomy), DIAGNOSTIC imaging, RATS, RADIOPHARMACEUTICALS, POSITRON emission tomography, RESEARCH funding, FACTOR analysis, DEOXY sugars, CLUSTER analysis (Statistics)

Systemic cross-talk between brain, gut, and peripheral tissues in glucose homeostasis: effects of exercise training (CROSSYS). Exercise training intervention in monozygotic twins discordant for body weight.

Authors: Heiskanen, Marja A., Honkala, Sanna M., Hentilä, Jaakko, Ojala, Ronja, Lautamäki, Riikka, Koskensalo, Kalle, Lietzén, Martin S., Saunavaara, Virva, Saunavaara, Jani, Helmiö, Mika, Löyttyniemi, Eliisa, Nummenmaa, Lauri, Collado, Maria C., Malm, Tarja, Lahti, Leo, Pietiläinen, Kirsi H., Kaprio, Jaakko, Rinne, Juha O., Hannukainen, Jarna C.

Source: BMC Sports Science, Medicine & Rehabilitation; 2/24/2021, Vol. 13 Issue 1, p1-19, 19p

Subject Terms: TWINS, AEROBIC capacity, MAGNETIC resonance imaging, BODY weight, NUCLEAR magnetic resonance spectroscopy, TYPE 2 diabetes, INSULIN, OBESITY

Geographic Terms: TURKU (Finland)

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Muscle and serum metabolomes are dysregulated in colon-26 tumor-bearing mice despite amelioration of cachexia with activin receptor type 2B ligand blockade.

Authors: Lautaoja, Juulia H., Lalowski, Maciej, Nissinen, Tuuli A., Hentilä, Jaakko, Yi Shi, Ritvos, Olli, Sulin Cheng, Hulmi, Juha J.

Source: American Journal of Physiology: Endocrinology & Metabolism; May2019, Vol. 316 Issue 5, pE852-E865, 14p

Subject Terms: ACTIVIN receptors, ACTIVIN, METABOLOMICS, NUCLEOTIDE synthesis, MUSCLES, RIBOSOMAL RNA

Company/Entity: PUBLIC Broadcasting Service (U.S.)

Activin Receptor Ligand Blocking and Cancer Have Distinct Effects on Protein and Redox Homeostasis in Skeletal Muscle and Liver.

Authors: Hentilä, Jaakko, Nissinen, Tuuli A., Korkmaz, Ayhan, Lensu, Sanna, Silvennoinen, Mika, Pasternack, Arja, Ritvos, Olli, Atalay, Mustafa, Hulmi, Juha J.

Source: Frontiers in Physiology; 1/18/2019, pN.PAG-N.PAG, 16p

Subject Terms: ACTIVIN receptors, SKELETAL muscle, PROTEIN metabolism, HOMEOSTASIS, CARBONYL compounds

Blocking Activin Receptor Ligands Is Not Sufficient to Rescue Cancer-Associated Gut Microbiota—A Role for Gut Microbial Flagellin in Colorectal Cancer and Cachexia?

Authors: Pekkala, Satu, Keskitalo, Anniina, Kettunen, Emilia, Lensu, Sanna, Nykänen, Noora, Kuopio, Teijo, Ritvos, Olli, Hentilä, Jaakko, Nissinen, Tuuli A., Hulmi, Juha J.

Source: Cancers; Nov2019, Vol. 11 Issue 11, p1799-1799, 1p

Subject Terms: CELL receptors, BACTERIAL protein metabolism, REACTIVE oxygen species, ANIMALS, BIOLOGICAL models, CACHEXIA, COLON tumors, INFLAMMATORY mediators, INTERLEUKINS, LIGANDS (Biochemistry), MICE, RECTUM tumors, RESEARCH funding, GUT microbiome, MYOSTATIN, IN vitro studies, DISEASE complications, CELL physiology