R-Roscovitine Improves Motoneuron Function in Mouse Models for Spinal Muscular Atrophy

Authors: Tejero, Rocio, Balk, Stefanie, Franco-Espin, Julio, Ojeda, Jorge, Hennlein, Luisa, Drexl, Hans, Dombert, Benjamin, Clausen, Jan-Dierk, Torres-Benito, Laura, Saal-Bauernschubert, Lena, Blum, Robert, Briese, Michael, Appenzeller, Silke, Tabares, Lucia, Jablonka, Sibylle

Source: In iScience 21 February 2020 23(2)

Plastin 3 rescues cell surface translocation and activation of TrkB in spinal muscular atrophy

Authors: Hennlein, Luisa, Ghanawi, Hanaa, Gerstner, Florian, García, Eduardo Palominos, Yildirim, Ezgi, Saal-Bauernschubert, Lena, Moradi, Mehri, Deng, Chunchu, Klein, Teresa, Appenzeller, Silke

Source: Journal of cell biology. 222(3):e202204113-e202204113

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631579539&indx=1&recIds=ETOCRN631579539

Nifedipine Ameliorates Cellular Differentiation Defects of Smn-Deficient Motor Neurons and Enhances Neuromuscular Transmission in SMA Mice.

Authors: Tejero, Rocio, Alsakkal, Mohammad, Hennlein, Luisa, Lopez-Cabello, Ana M., Jablonka, Sibylle, Tabares, Lucia

Source: International Journal of Molecular Sciences; Apr2023, Vol. 24 Issue 8, p7648, 17p

Subject Terms: MOTOR neurons, NEUROMUSCULAR transmission, SPINAL muscular atrophy, NIFEDIPINE, NERVE endings, MOTOR neuron diseases, NEURAL transmission

Impaired dynamic interaction of axonal endoplasmic reticulum and ribosomes contributes to defective stimulus–response in spinal muscular atrophy.

Authors: Deng, Chunchu, Reinhard, Sebastian, Hennlein, Luisa, Eilts, Janna, Sachs, Stefan, Doose, Sören, Jablonka, Sibylle, Sauer, Markus, Moradi, Mehri, Sendtner, Michael

Source: Translational Neurodegeneration; 6/2/2022, Vol. 11 Issue 1, p1-22, 22p

Subject Terms: SPINAL muscular atrophy, ENDOPLASMIC reticulum, RIBOSOMES, BRAIN-derived neurotrophic factor, PATHOLOGICAL physiology

Therapy development for spinal muscular atrophy: perspectives for muscular dystrophies and neurodegenerative disorders.

Authors: Jablonka, Sibylle, Hennlein, Luisa, Sendtner, Michael

Source: Neurological Research & Practice; 1/4/2022, Vol. 4 Issue 1, p1-32, 32p

Subject Terms: SPINAL muscular atrophy, MUSCULAR dystrophy, NEURODEGENERATION, ANTISENSE nucleic acids, RNA splicing

Loss of full-length hnRNP R isoform impairs DNA damage response in motoneurons by inhibiting Yb1 recruitment to chromatin.

Authors: Ghanawi, Hanaa, Hennlein, Luisa, Zare, Abdolhossein, Bader, Jakob, Salehi, Saeede, Hornburg, Daniel, Ji, Changhe, Sivadasan, Rajeeve, Drepper, Carsten, Meissner, Felix, Mann, Matthias, Jablonka, Sibylle, Briese, Michael, Sendtner, Michael

Source: Nucleic Acids Research; 12/2/2021, Vol. 49 Issue 21, p12284-12305, 22p

Dynamic remodeling of ribosomes and endoplasmic reticulum in axon terminals of motoneurons.

Authors: Chunchu Deng, Moradi, Mehri, Reinhard, Sebastian, Changhe Ji, Jablonka, Sibylle, Hennlein, Luisa, Lüningschrör, Patrick, Doose, Sören, Sauer, Markus, Sendtner, Michael

Source: Journal of Cell Science; Nov2021, Vol. 134 Issue 22, p1-16, 16p

Subject Terms: RIBOSOMES, ENDOPLASMIC reticulum, BRAIN-derived neurotrophic factor, MOLECULAR motor proteins, MOTOR neurons, AXONS, HOMEOSTASIS

Interaction of 7SK with the Smn complex modulates snRNP production.

Authors: Ji, Changhe, Bader, Jakob, Ramanathan, Pradhipa, Hennlein, Luisa, Meissner, Felix, Jablonka, Sibylle, Mann, Matthias, Fischer, Utz, Sendtner, Michael, Briese, Michael

Source: Nature Communications; 2/24/2021, Vol. 12 Issue 1, p1-15, 15p

Subject Terms: SPLICEOSOMES, NON-coding RNA, RNA splicing, GENE expression