Comparison of immune responses to SARS-CoV-2 spike following Omicron infection or Omicron BA.4/5 vaccination in kidney transplant recipients

Authors: Inga Tometten, Tobias Brandt, Maike Schlotz, Ricarda Stumpf, Sinje Landmann, Marta Kantauskaite, Joshua Lamberti, Jonas Hillebrandt, Lisa Müller, Margarethe Kittel, Katrin Ivens, Henning Gruell, Anja Voges, Heiner Schaal, Nadine Lübke, Eva Königshausen, Lars Christian Rump, Florian Klein, Johannes Stegbauer, Jörg Timm

Source: Frontiers in Immunology, Vol 15 (2025)

Subject Terms: SARS-CoV-2, Omicron BA.4/5, Omicron XBB.1.5, bivalent vaccination, kidney transplant recipients, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1476294/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/30df7d91f4654874b484a8879f2d26df

Therapeutic interfering particles against HIV: molecular parasites reducing viremia

Authors: Henning Gruell, Stanley Odidika, Philipp Schommers

Source: Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-3 (2024)

Subject Terms: Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2059-3635

Access URL: https://doaj.org/article/b3a5cd4041aa48b484bf7dfa59a11ee7

Probabilities of developing HIV-1 bNAb sequence features in uninfected and chronically infected individuals

Authors: Christoph Kreer, Cosimo Lupo, Meryem S. Ercanoglu, Lutz Gieselmann, Natanael Spisak, Jan Grossbach, Maike Schlotz, Philipp Schommers, Henning Gruell, Leona Dold, Andreas Beyer, Armita Nourmohammad, Thierry Mora, Aleksandra M. Walczak, Florian Klein

Source: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/e900725c8c9741e5a635d16c5aac862f

Impaired humoral immunity to BQ.1.1 in convalescent and vaccinated patients

Authors: Felix Dewald, Martin Pirkl, Martha Paluschinski, Joachim Kühn, Carina Elsner, Bianca Schulte, Jacqueline Knüfer, Elvin Ahmadov, Maike Schlotz, Göksu Oral, Michael Bernhard, Mark Michael, Maura Luxenburger, Marcel Andrée, Marc Tim Hennies, Wali Hafezi, Marlin Maybrit Müller, Philipp Kümpers, Joachim Risse, Clemens Kill, Randi Katrin Manegold, Ute von Frantzki, Enrico Richter, Dorian Emmert, Werner O. Monzon-Posadas, Ingo Gräff, Monika Kogej, Antonia Büning, Maximilian Baum, Finn Teipel, Babak Mochtarzadeh, Martin Wolff, Henning Gruell, Veronica Di Cristanziano, Volker Burst, Hendrik Streeck, Ulf Dittmer, Stephan Ludwig, Jörg Timm, Florian Klein

Source: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/7e717247ee2347da9986fd97ed699afb

Early intervention with azelastine nasal spray may reduce viral load in SARS-CoV-2 infected patients

Authors: Jens Peter Klussmann, Maria Grosheva, Peter Meiser, Clara Lehmann, Eszter Nagy, Valéria Szijártó, Gábor Nagy, Robert Konrat, Michael Flegel, Frank Holzer, Dorothea Groß, Charlotte Steinmetz, Barbara Scherer, Henning Gruell, Maike Schlotz, Florian Klein, Paula Aguiar de Aragão, Henning Morr, Helal Al Saleh, Andreas Bilstein, Belisa Russo, Susanne Müller-Scholtz, Cengizhan Acikel, Hacer Sahin, Nina Werkhäuser, Silke Allekotte, Ralph Mösges

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/6a4de9c597c74fe1adf2c213f26a7b9e

15-month post-COVID syndrome in outpatients: Attributes, risk factors, outcomes, and vaccination status - longitudinal, observational, case-control study

Authors: Max Augustin, Melanie Stecher, Hauke Wüstenberg, Veronica Di Cristanziano, Ute Sandaradura de Silva, Lea Katharina Picard, Elisabeth Pracht, Dominic Rauschning, Henning Gruell, Florian Klein, Christoph Wenisch, Michael Hallek, Philipp Schommers, Clara Lehmann

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: post-COVID syndrome, PCS, long COVID, therapeutic vaccination, symptom clusters, outcome, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1226622/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/cd68ffa85084495d8def15fe468e058c

Immunological fingerprint in coronavirus disease-19 convalescents with and without post-COVID syndrome

Authors: Max Augustin, Ferdinand Heyn, Stella Ullrich, Ute Sandaradura de Silva, Marie-Christine Albert, Viktoria Linne, Maike Schlotz, Philipp Schommers, Elisabeth Pracht, Carola Horn, Isabelle Suarez, Alexander Simonis, Lea Katharina Picard, Alexander Zoufaly, Christoph Wenisch, Gerd Fätkenheuer, Henning Gruell, Florian Klein, Michael Hallek, Henning Walczak, Jan Rybniker, Sebastian J. Theobald, Clara Lehmann

Source: Frontiers in Medicine, Vol 10 (2023)

Subject Terms: post-COVID syndrome, long COVID, immunosuppression, immune activation, immunological fingerprint, PCS, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2023.1129288/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/8cfddbe633b846a390c185607e2ac33d

Cross-Variant Neutralizing Serum Activity after SARS-CoV-2 Breakthrough Infections

Authors: Pinkus Tober-Lau, Henning Gruell, Kanika Vanshylla, Willi M. Koch, David Hillus, Philipp Schommers, Isabelle Suárez, Norbert Suttorp, Leif Erik Sander, Florian Klein, Florian Kurth

Source: Emerging Infectious Diseases, Vol 28, Iss 5, Pp 1050-1052 (2022)

Subject Terms: COVID-19, 2019 novel coronavirus disease, coronavirus disease, severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, viruses, Medicine, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://wwwnc.cdc.gov/eid/article/28/5/22-0271_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059

Access URL: https://doaj.org/article/4cc3d635c8a94f9985a3a25698bb2443

Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19

Authors: Sebastian J Theobald, Alexander Simonis, Theodoros Georgomanolis, Christoph Kreer, Matthias Zehner, Hannah S Eisfeld, Marie‐Christine Albert, Jason Chhen, Susanne Motameny, Florian Erger, Julia Fischer, Jakob J Malin, Jessica Gräb, Sandra Winter, Andromachi Pouikli, Friederike David, Boris Böll, Philipp Koehler, Kanika Vanshylla, Henning Gruell, Isabelle Suárez, Michael Hallek, Gerd Fätkenheuer, Norma Jung, Oliver A Cornely, Clara Lehmann, Peter Tessarz, Janine Altmüller, Peter Nürnberg, Hamid Kashkar, Florian Klein, Manuel Koch, Jan Rybniker

Source: EMBO Molecular Medicine, Vol 13, Iss 8, Pp 1-20 (2021)

Subject Terms: inflammasome, innate immunity, macrophage, NLRP3, SARS‐CoV‐2, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/2445731f5efd43e7bf9dcd749ffcad99

Design of an optimal combination therapy with broadly neutralizing antibodies to suppress HIV-1

Authors: Colin LaMont, Jakub Otwinowski, Kanika Vanshylla, Henning Gruell, Florian Klein, Armita Nourmohammad

Source: eLife, Vol 11 (2022)

Subject Terms: broadly neutralizing antibody, HIV combination therapy, population genetics, evolutionary control, optimization, stochastic processes, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/76004; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/86a8df6aeacc4e3fb7de5ecd0db0f68b

SARS-CoV-2-specific cellular response following third COVID-19 vaccination in patients with chronic lymphocytic leukemia

Authors: Sibylle C. Mellinghoff, Leonie Mayer, Sandra Robrecht, Leonie M. Weskamm, Christine Dahlke, Henning Gruell, Maike Schlotz, Kanika Vanshylla, Hans A. Schloser, Martin Thelen, Anna-Maria Fink, Kirsten Fischer, Florian Klein, Marylyn M. Addo, Barbara Eichhorst, Michael Hallek, Petra Langerbeins

Source: Haematologica, Vol 107, Iss 10 (2022)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/10687; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/05ba2f11c8a84d01b9218e99cc55c62f

No substantial preexisting B cell immunity against SARS-CoV-2 in healthy adults

Authors: Meryem Seda Ercanoglu, Lutz Gieselmann, Sabrina Dähling, Nareshkumar Poopalasingam, Susanne Detmer, Manuel Koch, Michael Korenkov, Sandro Halwe, Michael Klüver, Veronica Di Cristanziano, Hanna Janicki, Maike Schlotz, Johanna Worczinski, Birgit Gathof, Henning Gruell, Matthias Zehner, Stephan Becker, Kanika Vanshylla, Christoph Kreer, Florian Klein

Source: iScience, Vol 25, Iss 3, Pp 103951- (2022)

Subject Terms: Immunity, Immune response, Virology, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004222002218; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/2404de6fd5954a088328929e1de3cfe8

Effect of 3BNC117 and romidepsin on the HIV-1 reservoir in people taking suppressive antiretroviral therapy (ROADMAP): a randomised, open-label, phase 2A trial

Authors: Henning Gruell, MD, Jesper D Gunst, MD, Yehuda Z Cohen, MD, Marie H Pahus, Jakob J Malin, MD, Martin Platten, MD, Katrina G Millard, RN, Martin Tolstrup, PhD, R Brad Jones, PhD, Winnifer D Conce Alberto, Julio C C Lorenzi, PhD, Thiago Y Oliveira, PhD, Tim Kümmerle, MD, Isabelle Suárez, MD, Cecilia Unson-O'Brien, PhD, Lilian Nogueira, PhD, Rikke Olesen, PhD, Lars Østergaard, ProfMD, Henrik Nielsen, ProfMD, Clara Lehmann, MD, Michel C Nussenzweig, ProfMD, Gerd Fätkenheuer, ProfMD, Florian Klein, ProfMD, Marina Caskey, ProfMD, Ole S Søgaard, ProfMD

Source: The Lancet Microbe, Vol 3, Iss 3, Pp e203-e214 (2022)

Subject Terms: Medicine (General), R5-920, Microbiology, QR1-502

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666524721002391; https://doaj.org/toc/2666-5247

Access URL: https://doaj.org/article/b572a4bc81f74c27b4e7e697acac132e

Case Report: Clinical Management of a Patient With Metastatic Non-Small Cell Lung Cancer Newly Receiving Immune Checkpoint Inhibition During Symptomatic COVID-19

Authors: Sibylle C. Mellinghoff, Kanika Vanshylla, Christine Dahlke, Marylyn M. Addo, Oliver A. Cornely, Florian Klein, Thorsten Persigehl, Jan Rybniker, Henning Gruell, Paul J. Bröckelmann

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: SARS-CoV-2, COVID-19, NSCLC, anti-PD1, immune checkpoint, immunotherapy, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.798276/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/4bd0eb2be9c743dcaa115e41d3eae795

Post-COVID syndrome in non-hospitalised patients with COVID-19: a longitudinal prospective cohort study

Authors: Max Augustin, MD, Philipp Schommers, M.D. PhD., Melanie Stecher, Ph.D., Felix Dewald, M.D., Lutz Gieselmann, M.D., Henning Gruell, M.D., Carola Horn, M.D., Kanika Vanshylla, Ph.D., Veronica Di Cristanziano, M.D., Luise Osebold, Maria Roventa, Toqeer Riaz, Nikolai Tschernoster, M.Sc, Janine Altmueller, M.D., Leonard Rose, M.D., Susanne Salomon, Ph.D., Vanessa Priesner, M.D., Jan Christoffer Luers, Prof., Christian Albus, Prof., Stephan Rosenkranz, Prof., Birgit Gathof, Prof., Gerd Fätkenheuer, Prof., Michael Hallek, Prof., Florian Klein, Prof., Isabelle Suárez, M.D., Clara Lehmann, Prof.

Source: The Lancet Regional Health. Europe, Vol 6, Iss , Pp 100122- (2021)

Subject Terms: COVID-19, Post-COVID syndrome, PCS, Long COVID, SARS-CoV-2, Long-term health consequences, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666776221000995; https://doaj.org/toc/2666-7762

Access URL: https://doaj.org/article/e5d644b7a4e54dd5a3dde9608aaa3500

Contact-dependent inhibition of HIV-1 replication in ex vivo human tonsil cultures by polymorphonuclear neutrophils

Authors: Tatjana Reif, Gerhard Dyckhoff, Ralph Hohenberger, Carl-Christian Kolbe, Henning Gruell, Florian Klein, Eicke Latz, Bettina Stolp, Oliver T. Fackler

Source: Cell Reports Medicine, Vol 2, Iss 6, Pp 100317- (2021)

Subject Terms: HIV-1 replication, polymorphonuclear neutrophils, antiviral activity, human tonsil explant culture, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666379121001609; https://doaj.org/toc/2666-3791

Access URL: https://doaj.org/article/2411acf8c3fd4a5ab6301faf1c2701f9

Antibody-mediated prevention and treatment of HIV-1 infection

Authors: Henning Gruell, Florian Klein

Source: Retrovirology, Vol 15, Iss 1, Pp 1-11 (2018)

Subject Terms: HIV-1 broadly neutralizing antibodies, Immunotherapy, Passive immunization, (S)HIV animal models, Clinical trials, Neutralization, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12977-018-0455-9; https://doaj.org/toc/1742-4690

Access URL: https://doaj.org/article/55f4c20c7db1480c949e3592a01fb67d

The Alpha Variant (B.1.1.7) of SARS-CoV-2 in Children: First Experience from 3544 Nucleic Acid Amplification Tests in a Cohort of Children in Germany

Authors: Meike Meyer, Anna Holfter, Esra Ruebsteck, Henning Gruell, Felix Dewald, Robert Walter Koerner, Florian Klein, Clara Lehmann, Christoph Huenseler, Lutz Thorsten Weber

Source: Viruses, Vol 13, Iss 8, p 1600 (2021)

Subject Terms: Germany, COVID-19, Alpha, children, Ct-value, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/13/8/1600; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/7889fdd25f984f90b56c1d29648e91cb

Intranasal Administration of a Monoclonal Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection

Authors: Sandro Halwe, Alexandra Kupke, Kanika Vanshylla, Falk Liberta, Henning Gruell, Matthias Zehner, Cornelius Rohde, Verena Krähling, Michelle Gellhorn Serra, Christoph Kreer, Michael Klüver, Lucie Sauerhering, Jörg Schmidt, Zheng Cai, Fei Han, David Young, Guangwei Yang, Marek Widera, Manuel Koch, Anke Werner, Lennart Kämper, Nico Becker, Michael S. Marlow, Markus Eickmann, Sandra Ciesek, Felix Schiele, Florian Klein, Stephan Becker

Source: Viruses, Vol 13, Iss 8, p 1498 (2021)

Subject Terms: SARS-CoV-2, monoclonal antibody, neutralizing antibody, virus, animal experiments, mice, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/13/8/1498; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/a952a8244dfc4b74bafbb2519784edf5

Evaluation of a New Spike (S)-Protein-Based Commercial Immunoassay for the Detection of Anti-SARS-CoV-2 IgG

Authors: Kirsten Alexandra Eberhardt, Felix Dewald, Eva Heger, Lutz Gieselmann, Kanika Vanshylla, Maike Wirtz, Franziska Kleipass, Wibke Johannis, Philipp Schommers, Henning Gruell, Karl August Brensing, Roman-Ulrich Müller, Max Augustin, Clara Lehmann, Manuel Koch, Florian Klein, Veronica Di Cristanziano

Source: Microorganisms, Vol 9, Iss 4, p 733 (2021)

Subject Terms: pandemic, humoral response, neutralization, titer, protection, non-responder, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2076-2607/9/4/733; https://doaj.org/toc/2076-2607

Access URL: https://doaj.org/article/6c630c7a08bd4ce88b38dcb9bbf93f92