Ribonuclease 1 Induces T‐Cell Dysfunction and Impairs CD8+ T‐Cell Cytotoxicity to Benefit Tumor Growth through Hijacking STAT1

Authors: Wen‐Hao Yang, Bao‐Yue Huang, Hsing‐Yu Rao, Peng Ye, Bi Chen, Hao‐Ching Wang, Chih‐Hung Chung, Heng‐Hsiung Wu, Hung‐Rong Yen, Shao‐Chun Wang, Jong‐Ho Cha, Xiuwen Yan, Muh‐Hwa Yang, Mien‐Chie Hung

Source: Advanced Science, Vol 12, Iss 13, Pp n/a-n/a (2025)

Subject Terms: effector cytokine, immune checkpoint protein, ribonuclease 1, STAT1, T‐cell dysfunction, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/ddd5bf58f02b4ec08151fc82c5453170

Interplay between lncRNA RP11-367G18.1 variant 2 and YY1 plays a vital role in hypoxia-mediated gene expression and tumorigenesis

Authors: Pei-Hua Peng, Ji-Lin Chen, Heng-Hsiung Wu, Wen-Hao Yang, Li-Jie Lin, Joseph Chieh-Yu Lai, Jeng-Shou Chang, Jia-Ling Syu, Han-Tsang Wu, Fei-Ting Hsu, Wei-Chung Cheng, Kai-Wen Hsu

Source: Cancer Cell International, Vol 23, Iss 1, Pp 1-13 (2023)

Subject Terms: Hypoxia, lncRNA RP11-367G18.1 variant 2, YY1, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2867

Access URL: https://doaj.org/article/8dd4697709b048498ccf690dad5a8067

RP11‐367G18.1 V2 enhances clear cell renal cell carcinoma progression via induction of epithelial–mesenchymal transition

Authors: I‐Hung Shao, Pei‐Hua Peng, Heng‐Hsiung Wu, Ji‐Lin Chen, Joseph Chieh‐Yu Lai, Jeng‐Shou Chang, Han‐Tsang Wu, Kou‐Juey Wu, See‐Tong Pang, Kai‐Wen Hsu

Source: Cancer Medicine, Vol 12, Iss 8, Pp 9788-9801 (2023)

Subject Terms: clear cell renal cell carcinoma, epithelial–mesenchymal transition, H4K16Ac, hypoxia, lncRNA RP11‐367G18.1, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2045-7634

Access URL: https://doaj.org/article/0a9475d585f249369bc43712fd3e745c

Using bioinformatics approaches to identify survival-related oncomiRs as potential targets of miRNA-based treatments for lung adenocarcinoma

Authors: Chia-Hsin Liu, Shu-Hsuan Liu, Yo-Liang Lai, Yi-Chun Cho, Fang-Hsin Chen, Li-Jie Lin, Pei-Hua Peng, Chia-Yang Li, Shu-Chi Wang, Ji-Lin Chen, Heng-Hsiung Wu, Min-Zu Wu, Yuh-Pyng Sher, Wei-Chung Cheng, Kai-Wen Hsu

Source: Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 4626-4635 (2022)

Subject Terms: oncomiR, antagomiR, Lung adenocarcinoma, miRNA treatment, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2001037022003762; https://doaj.org/toc/2001-0370

Access URL: https://doaj.org/article/0142da904d0e48d8bb1bb3790a3773d0

Systematic identification of clinically relevant miRNAs for potential miRNA-based therapy in lung adenocarcinoma

Authors: Shu-Hsuan Liu, Kai-Wen Hsu, Yo-Liang Lai, Yu-Feng Lin, Fang-Hsin Chen, Pei-Hwa Peng, Li-Jie Lin, Heng-Hsiung Wu, Chia-Yang Li, Shu-Chi Wang, Min-Zu Wu, Yuh-Pyng Sher, Wei-Chung Cheng

Source: Molecular Therapy: Nucleic Acids, Vol 25, Iss , Pp 1-10 (2021)

Subject Terms: lung adenocarcinoma, miRNA, therapy, nucleotide drug, miRNA mimics, additive effect, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253121001141; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/cd747dbc44cd48deb46fab9b2c4a9054

Identification and validation of a miRNA-based prognostic signature for cervical cancer through an integrated bioinformatics approach

Authors: Yumei Qi, Yo-Liang Lai, Pei-Chun Shen, Fang-Hsin Chen, Li-Jie Lin, Heng-Hsiung Wu, Pei-Hua Peng, Kai-Wen Hsu, Wei-Chung Cheng

Source: Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/12a635dbd4f94295b89f26b127f24e09

Curcumin Analogue L48H37 Suppresses Human Osteosarcoma U2OS and MG-63 Cells’ Migration and Invasion in Culture by Inhibition of uPA via the JAK/STAT Signaling Pathway

Authors: Ko-Hsiu Lu, Heng-Hsiung Wu, Renn-Chia Lin, Ya-Chiu Lin, Peace Wun-Ang Lu, Shun-Fa Yang, Jia-Sin Yang

Source: Molecules, Vol 26, Iss 1, p 30 (2020)

Subject Terms: L48H37, migration, osteosarcoma, JAK/STAT, uPA, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/26/1/30; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/39e2ae17a0e44a51976bc79269d15c4d

CLEFMA Activates the Extrinsic and Intrinsic Apoptotic Processes through JNK1/2 and p38 Pathways in Human Osteosarcoma Cells

Authors: Jia-Sin Yang, Renn-Chia Lin, Yi-Hsien Hsieh, Heng-Hsiung Wu, Geng-Chung Li, Ya-Chiu Lin, Shun-Fa Yang, Ko-Hsiu Lu

Source: Molecules, Vol 24, Iss 18, p 3280 (2019)

Subject Terms: apoptosis, CLEFMA, JNK, osteosarcoma, p38, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/24/18/3280; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/62efce36989f4198bc485f568311ec23

Prescription of glucagon-like peptide 1 agonists and risk of subsequent open-angle glaucoma in individuals with type 2 diabetes mellitus.

Authors: Chih-Chun Chuang, Kai Wang, Chao-Kai Chang, Chia-Yi Lee, Jing-Yang Huang, Heng-Hsiung Wu, Po-Jen Yang, Shun-Fa Yang

Source: International Journal of Medical Sciences; 2024, Vol. 21 Issue 3, p540-546, 7p

Involvement of prohibitin 1 and prohibitin 2 upregulation in cBSA-induced podocyte cytotoxicity.

Authors: Heng-Hsiung Wu¹, Chao-Jung Chen², Pei-Yu Lin², Yu-Huei Liu^2,3 yuhueiliu@mail.cmu.edu.tw

Source: Journal of Food & Drug Analysis. Oct2019, Vol. 27 Issue 4, p1-12. 12p.

Subject Terms: *PROTEIN metabolism, *TREATMENT of glomerulonephritis, *ANIMAL experimentation, *BIOMARKERS, *CELL physiology, *GENE expression, *GLOMERULONEPHRITIS, *IMMUNOHISTOCHEMISTRY, *MICE, *MITOCHONDRIA, *PROTEINURIA, *PROTEOLYTIC enzymes, *SERUM albumin, *PROTEOMICS, *MICROARRAY technology