Structural mechanism underlying variations in DNA binding by the androgen receptor

Authors: Lee, Xiao Yin, Van Eynde, Wout, Helsen, Christine, Willems, Hanne, Peperstraete, Kaat, De Block, Sofie, Voet, Arnout, Claessens, Frank

Source: In Journal of Steroid Biochemistry and Molecular Biology July 2024 241

Discovery of a novel androgen receptor antagonist, MEL-6, with stereoselective activity and optimization of its metabolic stability

Authors: Helsen, Christine, Karypidou, Konstantina, Thomas, Joice, De Leger, Wout, Nguyen, Tien, Joniau, Steven, Voet, Arnout, Dehaen, Wim, Claessens, Frank

Source: In Journal of Steroid Biochemistry and Molecular Biology May 2024 239

Androgens differentially modulate glucocorticoid effects on adipose tissue and lean mass.

Authors: Sommers, Vera, David, Karel, Helsen, Christine, Moermans, Karen, Stockmans, Ingrid, Ferrari, Gabriele, Dmitriev, Ruslan I., Stegen, Steve, Meijer, Onno C., Kroon, Jan, Claessens, Frank, Dubois, Vanessa

Source: Journal of Endocrinology; Mar2025, Vol. 264 Issue 3, p1-18, 18p

Subject Terms: BROWN adipose tissue, WHITE adipose tissue, LEAN body mass, ANDROGEN receptors, ADIPOSE tissues

Small-molecule profiling for steroid receptor activity using a universal steroid receptor reporter assay

Authors: Eerlings, Roy, Barbakadze, Nana, Nguyen, Tien, Nadaraia, Nanuli, Smeets, Elien, Moris, Lisa, Handle, Florian, El Kharraz, Sarah, Devlies, Wout, Voet, Arnout, Dehaen, Wim, Claessens, Frank, Helsen, Christine ^*

Source: In Journal of Steroid Biochemistry and Molecular Biology March 2022 217

A disease‐associated missense mutation in CYP4F3 affects the metabolism of leukotriene B4 via disruption of electron transfer

Authors: Smeets, Elien, Huang, Shengyun, Lee, Xiao Yin, Van Nieuwenhove, Erika, Helsen, Christine, Handle, Florian, Moris, Lisa, El Kharraz, Sarah, Eerlings, Roy, Devlies, Wout, Willemsen, Mathijs, Bücken, Leoni, Prezzemolo, Teresa, Humblet‐Baron, Stephanie, Voet, Arnout, Rochtus, Anne, Van Schepdael, Ann, Zegher, Francis, Claessens, Frank

Source: Journal of cachexia, sarcopenia and muscle. 13(4):2242-2253

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100158663513.0x000001&indx=1&recIds=ETOCvdc_100158663513.0x000001

A Mechanistic High-Content Analysis Assay Using a Chimeric Androgen Receptor That Rapidly Characterizes Androgenic Chemicals

Authors: Szafran, Adam T., Bolt, Michael J., Obkirchner, Caroline E., Mancini, Maureen G., Helsen, Christine, Claessens, Frank, Stossi, Fabio, Mancini, Michael A. ^*

Source: In SLAS Discovery August 2020 25(7):695-708

Study of novel androgen receptor V770 variant in androgen insensitivity syndrome patients reveals the transitional state of the androgen receptor ligand binding domain homodimer

Authors: Helsen, Christine, Rocca, Maria Santa, Nguyen, Tien T., Eerlings, Roy, Lee, Xiao Yin, De Block, Sofie, Vinanzi, Cinzia, Di Millo, Francesco, Giagulli, Vito, Voet, Arnout, Ferlin, Alberto, Claessens, Frank

Source: Protein science. 32(4)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184906491.0x000001&indx=1&recIds=ETOCvdc_100184906491.0x000001

Validation of the Decipher Test for Predicting Distant Metastatic Recurrence in Men with High-risk Nonmetastatic Prostate Cancer 10 Years After Surgery

Authors: Van den Broeck, Thomas, Moris, Lisa, Gevaert, Thomas, Tosco, Lorenzo, Smeets, Elien, Fishbane, Nick, Liu, Yang, Helsen, Christine, Margrave, Jennifer, Buerki, Christine, Davicioni, Elai, Van Poppel, Hendrik, Everaerts, Wouter, Weinmann, Sheila, Den, Robert, Davis, John, Schaeffer, Edward, Karnes, R. Jeffrey, Claessens, Frank, Joniau, Steven

Source: In European Urology Oncology September 2019 2(5):589-596

N/C Interactions Are Dispensable for Normal In Vivo Functioning of the Androgen Receptor in Male Mice

Authors: El Kharraz, Sarah, Dubois, Vanessa, Launonen, Kaisa-Mari, Helminen, Laura, Palvimo, Jorma J, Libert, Claude, Smeets, Elien, Moris, Lisa, Eerlings, Roy, Vanderschueren, Dirk, Helsen, Christine, Claessens, Frank

Source: Endocrinology. 163(9)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100165482790.0x000001&indx=1&recIds=ETOCvdc_100165482790.0x000001

Synthesis, biological evaluation and molecular modeling of a novel series of fused 1, 2, 3-triazoles as potential anti-coronavirus agents

Authors: Karypidou, Konstantina, Ribone, Sergio R., Quevedo, Mario A., Persoons, Leentje, Pannecouque, Christophe, Helsen, Christine, Claessens, Frank, Dehaen, Wim

Source: Bioorganic & medicinal chemistry letters. 28(21):3472-3476

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100068288287.0x000001&indx=1&recIds=ETOCvdc_100068288287.0x000001

Effects of sex hormone-binding globulin (SHBG) on androgen bioactivity in vitro

Authors: Laurent, Michaël R., Helsen, Christine, Antonio, Leen, Schollaert, Dieter, Joniau, Steven, Vos, Michel J., Decallonne, Brigitte, Hammond, Geoffrey L., Vanderschueren, Dirk, Claessens, Frank

Source: In Molecular and Cellular Endocrinology 5 December 2016 437:280-291

Rational evolution for altering the ligand preference of estrogen receptor alpha.

Authors: Eerlings, Roy, Gupta, Purvi, Lee, Xiao Yin, Nguyen, Tien, El Kharraz, Sarah, Handle, Florian, Smeets, Elien, Moris, Lisa, Devlies, Wout, Vandewinkel, Bram, Thiry, Irina, Ta, Duy Tien, Gorkovskiy, Anton, Voordeckers, Karin, Henckaerts, Els, Pinheiro, Vitor B., Claessens, Frank, Verstrepen, Kevin J., Voet, Arnout, Helsen, Christine

Source: Protein Science: A Publication of the Protein Society; Apr2024, Vol. 33 Issue 4, p1-19, 19p

The androgen receptor depends on ligand‐binding domain dimerization for transcriptional activation

Authors: El Kharraz, Sarah, Dubois, Vanessa, Royen, Martin E, Houtsmuller, Adriaan B, Pavlova, Ekatarina, Atanassova, Nina, Nguyen, Tien, Voet, Arnout, Eerlings, Roy, Handle, Florian, Prekovic, Stefan, Smeets, Elien, Moris, Lisa, Devlies, Wout, Ohlsson, Claes, Poutanen, Matti, Verstrepen, Kevin J, Carmeliet, Geert, Launonen, Kaisa‐Mari, Helminen, Laura, Palvimo, Jorma J, Libert, Claude, Vanderschueren, Dirk, Helsen, Christine, Claessens, Frank

Source: EMBO reports. 22(12)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100136014924.0x000001&indx=1&recIds=ETOCvdc_100136014924.0x000001

Looking at nuclear receptors from a new angle

Authors: Helsen, Christine, Claessens, Frank

Source: In Molecular and Cellular Endocrinology 25 January 2014 382(1):97-106

Structural basis for nuclear hormone receptor DNA binding

Authors: Helsen, Christine, Kerkhofs, Stefanie, Clinckemalie, Liesbeth, Spans, Lien, Laurent, Michaël, Boonen, Steven, Vanderschueren, Dirk, Claessens, Frank

Source: In Molecular and Cellular Endocrinology 30 January 2012 348(2):411-417

Drivers of AR indifferent anti-androgen resistance in prostate cancer cells

Authors: Handle, Florian, Prekovic, Stefan, Helsen, Christine, Van den Broeck, Thomas, Smeets, Elien, Moris, Lisa, Eerlings, Roy, Kharraz, Sarah El, Urbanucci, Alfonso, Mills, Ian G., Joniau, Steven, Attard, Gerhardt, Claessens, Frank

Source: Scientific reports. 9(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131430544.0x000001&indx=1&recIds=ETOCvdc_100131430544.0x000001

A kindred with mutant IKAROS and autoimmunity

Authors: Van Nieuwenhove, Erika, Garcia-Perez, Josselyn E., Helsen, Christine, Rodriguez, Princess D., van Schouwenburg, Pauline A., Dooley, James, Schlenner, Susan, van der Burg, Mirjam, Verhoeyen, Els, Gijsbers, Rik, Frietze, Seth, Schjerven, Hilde, Meyts, Isabelle, Claessens, Frank, Humblet-Baron, Stephanie, Wouters, Carine, Liston, Adrian

Source: Journal of allergy and clinical immunology. 142(2):699-702.e12

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100065952014.0x000001&indx=1&recIds=ETOCvdc_100065952014.0x000001

N/C Interactions Are Dispensable for Normal In Vivo Functioning of the Androgen Receptor in Male Mice.

Authors: Kharraz, Sarah El, Dubois, Vanessa, Launonen, Kaisa-Mari, Helminen, Laura, Palvimo, Jorma J, Libert, Claude, Smeets, Elien, Moris, Lisa, Eerlings, Roy, Vanderschueren, Dirk, Helsen, Christine, Claessens, Frank

Source: Endocrinology; Sep2022, Vol. 163 Issue 9, p1-16, 16p

Subject Terms: ANDROGEN receptors, PHENOTYPES

Synthesis, biological evaluation and molecular modeling of a novel series of fused 1,2,3-triazoles as potential anti-coronavirus agents

Authors: Karypidou, Konstantina, Ribone, Sergio R., Quevedo, Mario A., Persoons, Leentje, Pannecouque, Christophe, Helsen, Christine, Claessens, Frank, Dehaen, Wim

Source: In Bioorganic & Medicinal Chemistry Letters 15 November 2018 28(21):3472-3476

Structure and stability of the designer protein WRAP-T and its permutants.

Authors: Mylemans, Bram, Lee, Xiao Yin, Laier, Ina, Helsen, Christine, Voet, Arnout R. D.

Source: Scientific Reports; 9/22/2021, Vol. 11 Issue 1, p1-11, 11p

Subject Terms: STRUCTURAL stability, SYNTHETIC proteins, PROTEIN stability, PROTEIN analysis, MONOMERS