Vulnerabilities of Mutant SWI/SNF Complexes in Cancer

Authors: Helming, Katherine C., Wang, Xiaofeng, Roberts, Charles W.M.

Source: In Cancer Cell 8 September 2014 26(3):309-317

Swi/Snf chromatin remodeling/tumor suppressor complex establishes nucleosome occupancy at target promoters

Authors: Tolstorukov, Michael Y., Sansam, Courtney G., Lu, Ping, Koellhoffer, Edward C., Helming, Katherine C., Alver, Burak H., Tillman, Erik J., Evans, Julia A., Wilson, Boris G., Park, Peter J., Roberts, Charles W. M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2013 Jun . 110(25), 10165-10170.

Access URL: https://www.jstor.org/stable/42706161

ARID1B is a specific vulnerability in ARID1A-mutant cancers.

Authors: Helming, Katherine C¹, Wang, Xiaofeng², Wilson, Boris G³, Vazquez, Francisca⁴, Haswell, Jeffrey R³, Manchester, Haley E³, Kim, Youngha³, Kryukov, Gregory V⁵, Ghandi, Mahmoud⁵, Aguirre, Andrew J⁶, Jagani, Zainab⁷, Wang, Zhong⁸, Garraway, Levi A⁶, Hahn, William C⁶, Roberts, Charles W M⁹

Source: Nature Medicine. Mar2014, Vol. 20 Issue 3, p251-254. 4p.

Subject Terms: *CANCER risk factors, *GENETIC mutation, *TUMOR suppressor proteins, *HOMOLOGY (Biology), *CANCER cells, *THERAPEUTIC use of proteins

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