Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism

Authors: Killion, Elizabeth A., Chen, Michelle, Falsey, James R., Sivits, Glenn, Hager, Todd, Atangan, Larissa, Helmering, Joan, Lee, Jae, Li, Hongyan, Wu, Bin, Cheng, Yuan, Véniant, Murielle M., Lloyd, David J.

Source: Nature communications. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174489413.0x000001&indx=1&recIds=ETOCvdc_100174489413.0x000001

Identification of three loci affecting HDL-cholesterol levels in a screen for chemically induced recessive mutations in mice

Authors: Juan, Todd, Véniant, Murielle M. ^*, Helmering, Joan ^*, Babij, Philip ^*, Baker, Daniel M., Damore, Michael A., Bass, Michael B. ^**, Gyuris, Tibor, Chhoa, Mark, Li, Chi-Ming, Ebeling, Chris, Amato, Julie, Carlson, George A., Lloyd, David J. ^*

Source: In Journal of Lipid Research March 2009 50(3):534-545

An optimized fast-performance liquid chromatography method for analyzing lipoprotein profiles using microliter volumes of serum

Authors: Kim, Ki Won, McCormick, Jocelyn, Helmering, Joan, Véniant, Murielle M., Wang, Minghan

Source: In Analytical Biochemistry 2008 376(2):268-274

Generation and characterization of two novel mouse models exhibiting the phenotypes of the metabolic syndrome: Apob48-/-Lepob/ob mice devoid of ApoE or Ldlr.

Authors: Lloyd, David J., McCormick, Jocelyn, Helmering, Joan

Source: American Journal of Physiology; March 2008 pt1, Vol. 294 Issue 3, pE496-E505, 10p

A mutation in Ampd2 is associated with nephrotic syndrome and hypercholesterolemia in mice.

Authors: Helmering, Joan¹, Juan, Todd², Chi Ming Li², Chhoa, Mark², Baron, Will², Gyuris, Tibor², Richards, William G.¹, Turk, James R.³, Lawrence, Jeff³, Cosgrove, Patrick A.³, Busby, Jim¹, Ki Won Kim¹, Kaufman, Stephen A.³, Cummings, Connie⁴, Carlson, George⁵, Véniant, Murielle M.¹, Lloyd, David J.¹ lloyd@amgen.com

Source: Lipids in Health & Disease. 2014, Vol. 13, p1-11. 11p. 3 Diagrams, 4 Graphs.

Subject Terms: *GENETIC mutation, *AMP deaminase, *NEPHROTIC syndrome, *HYPERCHOLESTEREMIA, *LOW density lipoproteins

A Volumetric Method for Quantifying Atherosclerosis in Mice by Using MicroCT: Comparison to En Face.

Authors: Lloyd, David J.¹ dlloyd@amgen.com, Helmering, Joan¹, Kaufman, Stephen A.², Turk, James², Silva, Matt³, Vasquez, Sergio⁴, Weinstein, David⁴, Johnston, Brad⁴, Hale, Clarence¹, Véniant, Murielle M.¹

Source: PLoS ONE. 2011, Vol. 6 Issue 4, p1-9. 9p.

Subject Terms: *ATHEROSCLEROSIS, *LABORATORY mice, *ATHEROSCLEROTIC plaque, *MICE, *VETERINARY tomography, *TOMOGRAPHY, *DIAGNOSIS

Pharmacologic Effects of FGF21 Are Independent of the “Browning” of White Adipose Tissue

Authors: Véniant, Murielle M., Sivits, Glenn, Helmering, Joan, Komorowski, Renee, Lee, Jae, Fan, Wei, Moyer, Carolyn, Lloyd, David J.

Source: In Cell Metabolism 5 May 2015 21(5):731-738

This result is not displayed to guests.
Login for full access.

Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors.

Authors: Lloyd, David J., St Jean, David J., Kurzeja, Robert J. M., Wahl, Robert C., Michelsen, Klaus, Cupples, Rod, Chen, Michelle, Wu, John, Sivits, Glenn, Helmering, Joan, Komorowski, Renée, Ashton, Kate S., Pennington, Lewis D., Fotsch, Christopher, Vazir, Mukta, Chen, Kui, Chmait, Samer, Zhang, Jiandong, Liu, Longbin, Norman, Mark H.

Source: Nature. 12/19/2013, Vol. 504 Issue 7480, p437-440. 4p.

Subjects: HYPOGLYCEMIC agents, REGULATION of glucokinase, MOLECULES, HOMEOSTASIS, TYPE 2 diabetes, PHOSPHORYLATION

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N → S (nN → s*S-X) Interaction for Conformational...

Authors: Pennington, Lewis D., Bartberger, Michael D., Croghan, Michael D., Andrews, Kristin L., Ashton, Kate S., Bourbeau, Matthew P., Jie Chen, Chmait, Samer, Cupples, Rod, Fotsch, Christopher, Helmering, Joan, Fang-Tsao Hong, Hungate, Randall W., Jordan, Steven R., Ke Kong, Longbin Liu, Michelsen, Klaus, Moyer, Carolyn, Nobuko Nishimura, Norman, Mark H.

Source: Journal of Medicinal Chemistry; Dec2015, Vol. 58 Issue 24, p9663-9679, 17p

This result is not displayed to guests.
Login for full access.

Small Molecule Disruptorsof the Glucokinase–GlucokinaseRegulatory Protein Interaction: 3. Structure–Activity Relationshipswithin the Aryl Carbinol Region of the N-Arylsulfonamido-N′-arylpiperazine Series.

Authors: Nishimura, Nobuko, Norman, Mark H., Liu, Longbin, Yang, Kevin C., Ashton, Kate S., Bartberger, Michael D., Chmait, Samer, Chen, Jie, Cupples, Rod, Fotsch, Christopher, Helmering, Joan, Jordan, Steven R., Kunz, Roxanne K., Pennington, Lewis D., Poon, Steve F., Siegmund, Aaron, Sivits, Glenn, Lloyd, David J., Hale, Clarence, St. Jean, David J.

Source: Journal of Medicinal Chemistry; Apr2014, Vol. 57 Issue 7, p3094-3116, 23p

Small Molecule Disruptorsof the Glucokinase–GlucokinaseRegulatory Protein Interaction: 2. Leveraging Structure-Based DrugDesign to Identify Analogues with Improved Pharmacokinetic Profiles.

Authors: St. Jean, David J., Ashton, Kate S., Bartberger, Michael D., Chen, Jie, Chmait, Samer, Cupples, Rod, Galbreath, Elizabeth, Helmering, Joan, Hong, Fang-Tsao, Jordan, Steven R., Liu, Longbin, Kunz, Roxanne K., Michelsen, Klaus, Nishimura, Nobuko, Pennington, Lewis D., Poon, Steve F., Reid, Darren, Sivits, Glenn, Stec, Markian M., Tadesse, Seifu

Source: Journal of Medicinal Chemistry; Jan2014, Vol. 57 Issue 2, p325-338, 14p

Small Molecule Disruptorsof the Glucokinase–GlucokinaseRegulatory Protein Interaction: 1. Discovery of a Novel Tool Compoundfor in Vivo Proof-of-Concept.

Authors: Ashton, Kate S., Andrews, Kristin L., Bryan, Marion C., Chen, Jie, Chen, Kui, Chen, Michelle, Chmait, Samer, Croghan, Michael, Cupples, Rod, Fotsch, Christopher, Helmering, Joan, Jordan, Steve R., Kurzeja, Robert J. M., Michelsen, Klaus, Pennington, Lewis D., Poon, Steve F., Sivits, Glenn, Van, Gwyneth, Vonderfecht, Steve L., Wahl, Robert C.

Source: Journal of Medicinal Chemistry; Jan2014, Vol. 57 Issue 2, p309-324, 16p

Generation and characterization of two novel mouse models exhibiting the phenotypes of the metabolic syndrome: Apob48^-/-Lepob/ob mice devoid of ApoE or Ldlr.

Authors: Lloyd, David J., McCormick, Jocelyn, Helmering, Joan, Ki Won Kim, Minghan Wang, Fordstrom, Preston, Kaufman, Stephen A., Lindberg, Richard A., Véniant, Murielle M.

Source: American Journal of Physiology: Endocrinology & Metabolism; Mar2008, Vol. 294, pE496-E505, 10p, 1 Chart, 5 Graphs

Subject Terms: METABOLIC syndrome, PHENOTYPES, APOLIPOPROTEIN E, ATHEROSCLEROSIS, OBESITY, DIABETES

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.