Intratumoral immune triads are required for immunotherapy-mediated elimination of solid tumors

Authors: Espinosa-Carrasco, Gabriel ^{1, ∗}, Chiu, Edison ¹, Scrivo, Aurora ², Zumbo, Paul ^{3, 4}, Dave, Asim ¹, Betel, Doron ^{4, 5, 6}, Kang, Sung Wook ⁷, Jang, Hee-Jin ⁷, Hellmann, Matthew D. ^{8, 9}, Burt, Bryan M. ^{7, 10}, Lee, Hyun-Sung ⁷, Schietinger, Andrea ^{1, 11, 12, ∗∗}

Source: In Cancer Cell 8 July 2024 42(7):1202-1216

Clinical and molecular features of acquired resistance to immunotherapy in non-small cell lung cancer

Authors: Memon, Danish, Schoenfeld, Adam J., Ye, Darwin, Fromm, George, Rizvi, Hira, Zhang, Xiang, Keddar, Mohamed Reda, Mathew, Divij, Yoo, Kyung Jin, Qiu, Jingya, Lihm, Jayon, Miriyala, Jayalaksmi, Sauter, Jennifer L., Luo, Jia, Chow, Andrew, Bhanot, Umesh K., McCarthy, Caroline, Vanderbilt, Chad M., Liu, Cailian, Abu-Akeel, Mohsen, Plodkowski, Andrew J., McGranahan, Nicholas, Łuksza, Marta, Greenbaum, Benjamin D., Merghoub, Taha, Achour, Ikbel, Barrett, J. Carl, Stewart, Ross, Beltrao, Pedro, Schreiber, Taylor H., Minn, Andy J., Miller, Martin L., Hellmann, Matthew D.

Source: In Cancer Cell 12 February 2024 42(2):209-224

Clinical Benefit From Immunotherapy in Patients With SCLC Is Associated With Tumor Capacity for Antigen Presentation

Authors: Rudin, Charles M., Balli, David, Lai, W. Victoria, Richards, Allison L., Nguyen, Evelyn, Egger, Jacklynn V., Choudhury, Noura J., Sen, Triparna, Chow, Andrew, Poirier, John T., Geese, William J., Hellmann, Matthew D., Forslund, Ann

Source: In Journal of Thoracic Oncology September 2023 18(9):1222-1232

Baseline Radiomic Signature to Estimate Overall Survival in Patients With NSCLC

Authors: Dercle, Laurent, Fronheiser, Matthew, Rizvi, Naiyer A., Hellmann, Matthew D., Maier, Sabine, Hayes, Wendy, Yang, Hao, Guo, Pingzhen, Fojo, Tito, Schwartz, Lawrence H., Zhao, Binsheng, Leung, David K.

Source: In Journal of Thoracic Oncology May 2023 18(5):587-598

Lineage tracing reveals clonal progenitors and long-term persistence of tumor-specific T cells during immune checkpoint blockade

Authors: Pai, Joy A., Hellmann, Matthew D., Sauter, Jennifer L., Mattar, Marissa, Rizvi, Hira, Woo, Hyung Jun, Shah, Nisargbhai, Nguyen, Evelyn M., Uddin, Fathema Z., Quintanal-Villalonga, Alvaro, Chan, Joseph M., Manoj, Parvathy, Allaj, Viola, Baine, Marina K., Bhanot, Umesh K., Jain, Mala, Linkov, Irina, Meng, Fanli, Brown, David, Chaft, Jamie E., Plodkowski, Andrew J., Gigoux, Mathieu, Won, Helen H., Sen, Triparna, Wells, Daniel K., Donoghue, Mark T.A., de Stanchina, Elisa, Wolchok, Jedd D., Loomis, Brian, Merghoub, Taha, Rudin, Charles M., Chow, Andrew, Satpathy, Ansuman T.

Source: In Cancer Cell 10 April 2023 41(4):776-790

The ectonucleotidase CD39 identifies tumor-reactive CD8+ T cells predictive of immune checkpoint blockade efficacy in human lung cancer

Authors: Chow, Andrew, Uddin, Fathema Z., Liu, Michael, Dobrin, Anton, Nabet, Barzin Y., Mangarin, Levi, Lavin, Yonit, Rizvi, Hira, Tischfield, Sam E., Quintanal-Villalonga, Alvaro, Chan, Joseph M., Shah, Nisargbhai, Allaj, Viola, Manoj, Parvathy, Mattar, Marissa, Meneses, Maximiliano, Landau, Rebecca, Ward, Mariana, Kulick, Amanda, Kwong, Charlene, Wierzbicki, Matthew, Yavner, Jessica, Egger, Jacklynn, Chavan, Shweta S., Farillas, Abigail, Holland, Aliya, Sridhar, Harsha, Ciampricotti, Metamia, Hirschhorn, Daniel, Guan, Xiangnan, Richards, Allison L., Heller, Glenn, Mansilla-Soto, Jorge, Sadelain, Michel, Klebanoff, Christopher A., Hellmann, Matthew D., Sen, Triparna, de Stanchina, Elisa, Wolchok, Jedd D., Merghoub, Taha, Rudin, Charles M.

Source: In Immunity 10 January 2023 56(1):93-106

A Definitive Prognostication System for Patients With Thoracic Malignancies Diagnosed With Coronavirus Disease 2019: An Update From the TERAVOLT Registry

Authors: Whisenant, Jennifer G., Baena, Javier, Cortellini, Alessio, Huang, Li-Ching, Lo Russo, Giuseppe, Porcu, Luca, Wong, Selina K., Bestvina, Christine M., Hellmann, Matthew D., Roca, Elisa, Rizvi, Hira, Monnet, Isabelle, Boudjemaa, Amel, Rogado, Jacobo, Pasello, Giulia, Leighl, Natasha B., Arrieta, Oscar, Aujayeb, Avinash, Batra, Ullas, Azzam, Ahmed Y., Unk, Mojca, Azab, Mohammed A., Zhumagaliyeva, Ardak N., Gomez-Martin, Carlos, Blaquier, Juan B., Geraedts, Erica, Mountzios, Giannis, Serrano-Montero, Gloria, Reinmuth, Niels, Coate, Linda, Marmarelis, Melina, Presley, Carolyn J., Hirsch, Fred R., Garrido, Pilar, Khan, Hina, Baggi, Alice, Mascaux, Celine, Halmos, Balazs, Ceresoli, Giovanni L., Fidler, Mary J., Scotti, Vieri, Métivier, Anne-Cécile, Falchero, Lionel, Felip, Enriqueta, Genova, Carlo, Mazieres, Julien, Tapan, Umit, Brahmer, Julie, Bria, Emilio, Puri, Sonam, Popat, Sanjay, Reckamp, Karen L., Morgillo, Floriana, Nadal, Ernest, Mazzoni, Francesca, Agustoni, Francesco, Bar, Jair, Grosso, Federica, Avrillon, Virginie, Patel, Jyoti D., Gomes, Fabio, Ibrahim, Ehab, Trama, Annalisa, Bettini, Anna C., Barlesi, Fabrice, Dingemans, Anne-Marie, Wakelee, Heather, Peters, Solange, Horn, Leora, Garassino, Marina Chiara, Torri, Valter

Source: In Journal of Thoracic Oncology May 2022 17(5):661-674

Diminished Efficacy of Programmed Death-(Ligand)1 Inhibition in STK11- and KEAP1-Mutant Lung Adenocarcinoma Is Affected by KRAS Mutation Status

Authors: Ricciuti, Biagio, Arbour, Kathryn C., Lin, Jessica J., Vajdi, Amir, Vokes, Natalie, Hong, Lingzhi, Zhang, Jianjun, Tolstorukov, Michael Y., Li, Yvonne Y., Spurr, Liam F., Cherniack, Andrew D., Recondo, Gonzalo, Lamberti, Giuseppe, Wang, Xinan, Venkatraman, Deepti, Alessi, Joao V., Vaz, Victor R., Rizvi, Hira, Egger, Jacklynn, Plodkowski, Andrew J., Khosrowjerdi, Sara, Digumarthy, Subba, Park, Hyesun, Vaz, Nuno, Nishino, Mizuki, Sholl, Lynette M., Barbie, David, Altan, Mehmet, Heymach, John V., Skoulidis, Ferdinandos, Gainor, Justin F., Hellmann, Matthew D., Awad, Mark M.

Source: In Journal of Thoracic Oncology March 2022 17(3):399-410

First-Line Nivolumab Plus Ipilimumab in Advanced NSCLC: 4-Year Outcomes From the Randomized, Open-Label, Phase 3 CheckMate 227 Part 1 Trial

Authors: Paz-Ares, Luis G., Ramalingam, Suresh S., Ciuleanu, Tudor-Eliade, Lee, Jong-Seok, Urban, Laszlo, Caro, Reyes Bernabe, Park, Keunchil, Sakai, Hiroshi, Ohe, Yuichiro, Nishio, Makoto, Audigier-Valette, Clarisse, Burgers, Jacobus A., Pluzanski, Adam, Sangha, Randeep, Gallardo, Carlos, Takeda, Masayuki, Linardou, Helena, Lupinacci, Lorena, Lee, Ki Hyeong, Caserta, Claudia, Provencio, Mariano, Carcereny, Enric, Otterson, Gregory A., Schenker, Michael, Zurawski, Bogdan, Alexandru, Aurelia, Vergnenegre, Alain, Raimbourg, Judith, Feeney, Kynan, Kim, Sang-We, Borghaei, Hossein, O'Byrne, Kenneth John, Hellmann, Matthew D., Memaj, Arteid, Nathan, Faith Ellen, Bushong, Judith, Tran, Phuong, Brahmer, Julie R., Reck, Martin

Source: In Journal of Thoracic Oncology February 2022 17(2):289-308

Pre-treatment immune status predicts disease control in NSCLCs treated with chemoradiation and durvalumab

Authors: Thor, Maria, Shepherd, Annemarie F., Preeshagul, Isabel, Offin, Michael, Gelblum, Daphna Y., Wu, Abraham J., Apte, Aditya, Simone, Charles B., II, Hellmann, Matthew D., Rimner, Andreas, Chaft, Jamie E., Gomez, Daniel R., Deasy, Joseph O., Shaverdian, Narek

Source: In Radiotherapy and Oncology February 2022 167:158-164

Intra- and inter-reader agreement of iRECIST and RECIST 1.1 criteria for the assessment of tumor response in patients receiving checkpoint inhibitor immunotherapy for lung cancer

Authors: Huicochea Castellanos, Sandra, Pagano, Andrew, Plodkowski, Andrew J., Girshman, Jeffrey, Hellmann, Matthew D., Rizvi, Hira, Flynn, Jessica, Zheng, Junting, Capanu, Marinela, Halpenny, Darragh F, Ginsberg, Michelle S

Source: In Lung Cancer November 2021 161:60-67

The Impact of Durvalumab on Local-Regional Control in Stage III NSCLCs Treated With Chemoradiation and on KEAP1-NFE2L2-Mutant Tumors

Authors: Shaverdian, Narek, Offin, Michael, Shepherd, Annemarie F., Simone, Charles B., II, Gelblum, Daphna Y., Wu, Abraham J., Hellmann, Matthew D., Rimner, Andreas, Paik, Paul K., Chaft, Jamie E., Gomez, Daniel R.

Source: In Journal of Thoracic Oncology August 2021 16(8):1392-1402

Tim-4+ cavity-resident macrophages impair anti-tumor CD8+ T cell immunity

Authors: Chow, Andrew, Schad, Sara, Green, Michael D., Hellmann, Matthew D., Allaj, Viola, Ceglia, Nicholas, Zago, Giulia, Shah, Nisargbhai S., Sharma, Sai Kiran, Mattar, Marissa, Chan, Joseph, Rizvi, Hira, Zhong, Hong, Liu, Cailian, Bykov, Yonina, Zamarin, Dmitriy, Shi, Hongyu, Budhu, Sadna, Wohlhieter, Corrin, Uddin, Fathema, Gupta, Aditi, Khodos, Inna, Waninger, Jessica J., Qin, Angel, Markowitz, Geoffrey J., Mittal, Vivek, Balachandran, Vinod, Durham, Jennifer N., Le, Dung T., Zou, Weiping, Shah, Sohrab P., McPherson, Andrew, Panageas, Katherine, Lewis, Jason S., Perry, Justin S.A., de Stanchina, Elisa, Sen, Triparna, Poirier, John T., Wolchok, Jedd D., Rudin, Charles M., Merghoub, Taha

Source: In Cancer Cell 12 July 2021 39(7):973-988

Predicting immunotherapy outcomes under therapy in patients with advanced NSCLC using dNLR and its early dynamics

Authors: Mezquita, Laura, Preeshagul, Isabel, Auclin, Edouard, Saravia, Diana, Hendriks, Lizza, Rizvi, Hira, Park, Wungki, Nadal, Ernest, Martin-Romano, Patricia, Ruffinelli, Jose C., Ponce, Santiago, Audigier-Valette, Clarisse, Carnio, Simona, Blanc-Durand, Felix, Bironzo, Paolo, Tabbò, Fabrizio, Reale, Maria Lucia, Novello, Silvia, Hellmann, Matthew D., Sawan, Peter, Girshman, Jeffrey, Plodkowski, Andrew J., Zalcman, Gerard, Majem, Margarita, Charrier, Melinda, Naigeon, Marie, Rossoni, Caroline, Mariniello, AnnaPaola, Paz-Ares, Luis, Dingemans, Anne Marie, Planchard, David, Cozic, Nathalie, Cassard, Lydie, Lopes, Gilberto, Chaput, Nathalie, Arbour, Kathryn, Besse, Benjamin

Source: In European Journal of Cancer July 2021 151:211-220

Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition

Authors: Litchfield, Kevin, Reading, James L., Puttick, Clare, Thakkar, Krupa, Abbosh, Chris, Bentham, Robert, Watkins, Thomas B.K., Rosenthal, Rachel, Biswas, Dhruva, Rowan, Andrew, Lim, Emilia, Al Bakir, Maise, Turati, Virginia, Guerra-Assunção, José Afonso, Conde, Lucia, Furness, Andrew J.S., Saini, Sunil Kumar, Hadrup, Sine R., Herrero, Javier, Lee, Se-Hoon, Van Loo, Peter, Enver, Tariq, Larkin, James, Hellmann, Matthew D., Turajlic, Samra, Quezada, Sergio A., McGranahan, Nicholas, Swanton, Charles

Source: In Cell 4 February 2021 184(3):596-614

Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction

Authors: Khan, Aly A., Lugade, Amit, Lazic, Ana M. Mijalkovic, Frentzen, Angela A. Elizabeth, Tadmor, Arbel D., Sasson, Ariella S., Rao, Arjun A., Pei, Baikang, Schrörs, Barbara, Berent-Maoz, Beata, Carreno, Beatriz M., Song, Bin, Peters, Bjoern, Li, Bo, Higgs, Brandon W., Stevenson, Brian J., Iseli, Christian, Miller, Christopher A., Morehouse, Christopher A., Melief, Cornelis J.M., Puig-Saus, Cristina, van Beek, Daphne, Balli, David, Gfeller, David, Haussler, David, Jäger, Dirk, Cortes, Eduardo, Esaulova, Ekaterina, Sherafat, Elham, Arcila, Francisco, Bartha, Gabor, Liu, Geng, Coukos, George, Richard, Guilhem, Chang, Han, Si, Han, Zörnig, Inka, Xenarios, Ioannis, Mandoiu, Ion, Kooi, Irsan, Conway, James P., Kessler, Jan H., Greenbaum, Jason A., Perera, Jason F., Harris, Jason, Hundal, Jasreet, Shelton, Jennifer M., Wang, Jianmin, Wang, Jiaqian, Greshock, Joel, Blake, Jonathon, Szustakowski, Joseph, Kodysh, Julia, Forman, Juliet, Wei, Lei, Lee, Leo J., Fanchi, Lorenzo F., Slagter, Maarten, Lang, Maren, Mueller, Markus, Lower, Martin, Vormehr, Mathias, Artyomov, Maxim N., Kuziora, Michael, Princiotta, Michael, Bassani-Sternberg, Michal, Macabali, Mignonette, Kojicic, Milica R., Yang, Naibo, Raicevic, Nevena M. Ilic, Guex, Nicolas, Robine, Nicolas, Halama, Niels, Skundric, Nikola M., Milicevic, Ognjen S., Gellert, Pascal, Jongeneel, Patrick, Charoentong, Pornpimol, Srivastava, Pramod K., Tanden, Prateek, Shah, Priyanka, Hu, Qiang, Gupta, Ravi, Chen, Richard, Petit, Robert, Ziman, Robert, Hilker, Rolf, Shukla, Sachet A., Al Seesi, Sahar, Boyle, Sean M., Qiu, Si, Sarkizova, Siranush, Salama, Sofie, Liu, Song, Wu, Song, Sridhar, Sriram, Ketelaars, Steven L.C., Jhunjhunwala, Suchit, Shcheglova, Tatiana, Schuepbach, Thierry, Creasy, Todd H., Josipovic, Veliborka, Kovacevic, Vladimir B., Fu, Weixuan, Krebber, Willem-Jan, Hsu, Yi-Hsiang, Sebastian, Yinong, Yalcin, Zeynep Kosaloglu, Huang, Zhiqin, Wells, Daniel K., van Buuren, Marit M., Dang, Kristen K., Hubbard-Lucey, Vanessa M., Sheehan, Kathleen C.F., Campbell, Katie M., Lamb, Andrew, Ward, Jeffrey P., Sidney, John, Blazquez, Ana B., Rech, Andrew J., Zaretsky, Jesse M., Comin-Anduix, Begonya, Ng, Alphonsus H.C., Chour, William, Yu, Thomas V., Rizvi, Hira, Chen, Jia M., Manning, Patrice, Steiner, Gabriela M., Doan, Xengie C., Merghoub, Taha, Guinney, Justin, Kolom, Adam, Selinsky, Cheryl, Ribas, Antoni, Hellmann, Matthew D., Hacohen, Nir, Sette, Alessandro, Heath, James R., Bhardwaj, Nina, Ramsdell, Fred, Schreiber, Robert D., Schumacher, Ton N., Kvistborg, Pia, Defranoux, Nadine A.

Source: In Cell 29 October 2020 183(3):818-834

A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer

Authors: Ott, Patrick A., Hu-Lieskovan, Siwen, Chmielowski, Bartosz, Govindan, Ramaswamy, Naing, Aung, Bhardwaj, Nina, Margolin, Kim, Awad, Mark M., Hellmann, Matthew D., Lin, Jessica J., Friedlander, Terence, Bushway, Meghan E., Balogh, Kristen N., Sciuto, Tracey E., Kohler, Victoria, Turnbull, Samantha J., Besada, Rana, Curran, Riley R., Trapp, Benjamin, Scherer, Julian, Poran, Asaf, Harjanto, Dewi, Barthelme, Dominik, Ting, Ying Sonia, Dong, Jesse Z., Ware, Yvonne, Huang, Yuting, Huang, Zhengping, Wanamaker, Amy, Cleary, Lisa D., Moles, Melissa A., Manson, Kelledy, Greshock, Joel, Khondker, Zakaria S., Fritsch, Ed, Rooney, Michael S., DeMario, Mark, Gaynor, Richard B., Srinivasan, Lakshmi

Source: In Cell 15 October 2020 183(2):347-362

Noninvasive Early Identification of Therapeutic Benefit from Immune Checkpoint Inhibition

Authors: Nabet, Barzin Y., Esfahani, Mohammad S., Moding, Everett J., Hamilton, Emily G., Chabon, Jacob J., Rizvi, Hira, Steen, Chloe B., Chaudhuri, Aadel A., Liu, Chih Long, Hui, Angela B., Almanza, Diego, Stehr, Henning, Gojenola, Linda, Bonilla, Rene F., Jin, Michael C., Jeon, Young-Jun, Tseng, Diane, Liu, Cailian, Merghoub, Taha, Neal, Joel W., Wakelee, Heather A., Padda, Sukhmani K., Ramchandran, Kavitha J., Das, Millie, Plodkowski, Andrew J., Yoo, Christopher, Chen, Emily L., Ko, Ryan B., Newman, Aaron M., Hellmann, Matthew D., Alizadeh, Ash A., Diehn, Maximilian

Source: In Cell 15 October 2020 183(2):363-376

Clinical outcomes, local–regional control and the role for metastasis-directed therapies in stage III non-small cell lung cancers treated with chemoradiation and durvalumab

Authors: Offin, Michael, Shaverdian, Narek, Rimner, Andreas, Lobaugh, Stephanie, Shepherd, Annemarie F., Simone, Charles B., II, Gelblum, Daphna Y., Wu, Abraham J., Lee, Nancy, Kris, Mark G., Rudin, Charles M., Zhang, Zhigang, Hellmann, Matthew D., Chaft, Jamie E., Gomez, Daniel R.

Source: In Radiotherapy and Oncology August 2020 149:205-211

Acquired Resistance to Immune Checkpoint Inhibitors

Authors: Schoenfeld, Adam J., Hellmann, Matthew D.

Source: In Cancer Cell 13 April 2020 37(4):443-455