Host genetic diversity contributes to disease outcome in Crimean-Congo hemorrhagic fever virus infection

Authors: Deepashri Rao, Matthew Lewis, Kimberly Meade-White, Carl Shaia, Atsushi Okumura, Martin T. Ferris, Alexandra Schäfer, Ralph Baric, Heinz Feldmann, David W. Hawman

Source: npj Viruses, Vol 3, Iss 1, Pp 1-9 (2025)

Subject Terms: Infectious and parasitic diseases, RC109-216, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2948-1767

Access URL: https://doaj.org/article/98bf288ab94a42609fd5998d5fe2cabd

Clade 2.3.4.4b but not historical clade 1 HA replicating RNA vaccine protects against bovine H5N1 challenge in mice

Authors: David W. Hawman, Thomas Tipih, Eddie Hodge, E. Taylor Stone, Nikole Warner, Natalie McCarthy, Brian Granger, Kimberly Meade-White, Shanna Leventhal, Kiara Hatzakis, Stephanie Park, Karen Gaffney, Kyle Rosenke, Jesse H. Erasmus, Heinz Feldmann

Source: Nature Communications, Vol 16, Iss 1, Pp 1-8 (2025)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f35c443c8c6e42bcbf155e3aa546d96b

Replicating RNA vaccine confers durable immunity against Crimean Congo hemorrhagic fever virus challenge in mice

Authors: Shanna S. Leventhal, Carl Shaia, Deepashri Rao, Matthew Lewis, Kimberly Meade-White, Jesse H. Erasmus, Heinz Feldmann, David W. Hawman

Source: npj Vaccines, Vol 9, Iss 1, Pp 1-9 (2024)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2059-0105

Access URL: https://doaj.org/article/ef557fd2bab64e7589a41fc32cb11dfc

The DNA-based Lassa vaccine INO-4500 confers durable protective efficacy in cynomolgus macaques against lethal Lassa fever

Authors: Viviane M. Andrade, Kathleen Cashman, Kyle Rosenke, Eric Wilkinson, Nicole Josleyn, Ginger Lynn, Jesse Steffens, Sean Vantongeren, Jay Wells, Connie Schmaljohn, Paul Facemire, Jingjing Jiang, Jean Boyer, Aditya Patel, Friederike Feldmann, Patrick Hanley, Jamie Lovaglio, Kimberly White, Heinz Feldmann, Stephanie Ramos, Kate E. Broderick, Laurent M. Humeau, Trevor R. F. Smith

Source: Communications Medicine, Vol 4, Iss 1, Pp 1-14 (2024)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2730-664X

Access URL: https://doaj.org/article/db3fb6d49d26402a8130cf02b1e9ffb8

Filovirus vaccines as a response paradigm for emerging infectious diseases

Authors: Andrea Marzi, Heinz Feldmann

Source: npj Vaccines, Vol 9, Iss 1, Pp 1-7 (2024)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2059-0105

Access URL: https://doaj.org/article/e6da47e51d8c46dd8d2cd1de276954f1

Antibodies targeting the Crimean-Congo Hemorrhagic Fever Virus nucleoprotein protect via TRIM21

Authors: Shanna S. Leventhal, Thomas Bisom, Dean Clift, Deepashri Rao, Kimberly Meade-White, Carl Shaia, Justin Murray, Evan A. Mihalakakos, Troy Hinkley, Steven J. Reynolds, Sonja M. Best, Jesse H. Erasmus, Leo C. James, Heinz Feldmann, David W. Hawman

Source: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/a6d956186c9942bda98b2bc1f3d16cfd

In vivo delivery of engineered synthetic DNA-encoded SARS-CoV-2 monoclonal antibodies for pre-exposure prophylaxis in non-human primates

Authors: Ami Patel, Kyle Rosenke, Elizabeth M. Parzych, Friederike Feldmann, Suman Bharti, Amanda J. Griffin, Blake Schouest, Matt Lewis, Jihae Choi, Neethu Chokkalingam, Viviane Machado, Brian J. Smith, Drew Frase, Ali R. Ali, Jamie Lovaglio, Brian Nguyen, Patrick W. Hanley, Susanne N. Walker, Ebony N. Gary, Abhijeet Kulkarni, Allison Generotti, Joseph R. Francica, Kim Rosenthal, Daniel W. Kulp, Mark T. Esser, Trevor R. F. Smith, Carl Shaia, David B. Weiner, Heinz Feldmann

Source: Emerging Microbes and Infections, Vol 13, Iss 1 (2024)

Subject Terms: SARS-CoV-2, monoclonal antibody, DNA, DNA-encoded monoclonal antibody, prevention, gene-encoded antibody, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/b981edf4969f4fdb9843528b197ac517

A replicating RNA vaccine confers protection in a rhesus macaque model of Crimean-Congo hemorrhagic fever

Authors: David W. Hawman, Shanna S. Leventhal, Kimberly Meade-White, Amit Khandhar, Justin Murray, Jamie Lovaglio, Carl Shaia, Greg Saturday, Troy Hinkley, Jesse Erasmus, Heinz Feldmann

Source: npj Vaccines, Vol 9, Iss 1, Pp 1-9 (2024)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2059-0105

Access URL: https://doaj.org/article/ab14f955c4a64e3d9272d9bbe34d7b75

Identification of CCZ1 as an essential lysosomal trafficking regulator in Marburg and Ebola virus infections

Authors: Vanessa Monteil, Hyesoo Kwon, Lijo John, Cristiano Salata, Gustav Jonsson, Sabine U. Vorrink, Sofia Appelberg, Sonia Youhanna, Matheus Dyczynski, Alexandra Leopoldi, Nicole Leeb, Jennifer Volz, Astrid Hagelkruys, Max J. Kellner, Stéphanie Devignot, Georg Michlits, Michelle Foong-Sobis, Friedemann Weber, Volker M. Lauschke, Moritz Horn, Heinz Feldmann, Ulrich Elling, Josef M. Penninger, Ali Mirazimi

Source: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/138c2c1cad6c485e9bafa12b9c5adf5c

CD8+ T-cells target the Crimean-Congo haemorrhagic fever virus Gc protein to control the infection in wild-type miceResearch in context

Authors: Deepashri Rao, Kimberly Meade-White, Shanna Leventhal, Evan Mihalakakos, Aaron Carmody, Heinz Feldmann, David W. Hawman

Source: EBioMedicine, Vol 97, Iss , Pp 104839- (2023)

Subject Terms: Crimean-Congo haemorrhagic fever, CCHFV, T-cells, Mouse model, Adaptive immunity, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S235239642300405X; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/8376ad720a87492293567c01503f90f0

Bivalent VSV Vectors Mediate Rapid and Potent Protection from Andes Virus Challenge in Hamsters

Authors: Joshua Marceau, David Safronetz, Cynthia Martellaro, Andrea Marzi, Kyle Rosenke, Heinz Feldmann

Source: Viruses, Vol 16, Iss 2, p 279 (2024)

Subject Terms: Orthohantavirus, Andes virus, VSV, vaccine, Syrian hamster, emergency vaccination, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/16/2/279; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/51d114e90f5e4a1abcf81c7b40f785c0

Species-specific MARCO-alphavirus interactions dictate chikungunya virus viremia

Authors: Frances S. Li, Kathryn S. Carpentier, David W. Hawman, Cormac J. Lucas, Stephanie E. Ander, Heinz Feldmann, Thomas E. Morrison

Source: Cell Reports, Vol 42, Iss 5, Pp 112418- (2023)

Subject Terms: CP: Microbiology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124723004291; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/2d0c7a1f21d4487fb3d8295abcdea33a

A replicon RNA vaccine can induce durable protective immunity from SARS-CoV-2 in nonhuman primates after neutralizing antibodies have waned.

Authors: Megan A O'Connor, David W Hawman, Kimberly Meade-White, Shanna Leventhal, Wenjun Song, Samantha Randall, Jacob Archer, Thomas B Lewis, Brieann Brown, Megan N Fredericks, Kaitlin R Sprouse, Hillary C Tunggal, Mara Maughan, Naoto Iwayama, Chul Ahrens, William Garrison, Solomon Wangari, Kathryn A Guerriero, Patrick Hanley, Jamie Lovaglio, Greg Saturday, David Veesler, Paul T Edlefsen, Amit P Khandhar, Heinz Feldmann, Deborah Heydenburg Fuller, Jesse H Erasmus

Source: PLoS Pathogens, Vol 19, Iss 4, p e1011298 (2023)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/d4af23eb43be40bcaa467db922cd5121

Combined molnupiravir-nirmatrelvir treatment improves the inhibitory effect on SARS-CoV-2 in macaques

Authors: Kyle Rosenke, Matt C. Lewis, Friederike Feldmann, Eric Bohrnsen, Benjamin Schwarz, Atsushi Okumura, W. Forrest Bohler, Julie Callison, Carl Shaia, Catharine M. Bosio, Jamie Lovaglio, Greg Saturday, Michael A. Jarvis, Heinz Feldmann

Source: JCI Insight, Vol 8, Iss 4 (2023)

Subject Terms: COVID-19, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/8c4c6d11714643ca966ef175993be046

Distinct VSV-based Nipah virus vaccines expressing either glycoprotein G or fusion protein F provide homologous and heterologous protection in a nonhuman primate modelResearch in context

Authors: Emmie de Wit, Friederike Feldmann, Jacqueline Cronin, Kerry Goldin, Reinaldo Mercado-Hernandez, Brandi N. Williamson, Kimberly Meade-White, Atsushi Okumura, Julie Callison, Sarah Weatherman, Rebecca Rosenke, Victoria A. Avanzato, Jamie Lovaglio, Dana P. Scott, Andrea Marzi, Heinz Feldmann

Source: EBioMedicine, Vol 87, Iss , Pp 104405- (2023)

Subject Terms: Nipah virus, VSV-based vaccines, African green monkey, Vaccine efficacy, Heterologous protection, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396422005874; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/dfff7aaf39d542d6855906a23c3664cd

A live-attenuated viral vector vaccine protects mice against lethal challenge with Kyasanur Forest disease virus

Authors: Bharti Bhatia, Kimberly Meade-White, Elaine Haddock, Friederike Feldmann, Andrea Marzi, Heinz Feldmann

Source: npj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2059-0105

Access URL: https://doaj.org/article/48b8a551263b4477bb31c747b6f7a083

Therapeutic Efficacy of Human Monoclonal Antibodies against Andes Virus Infection in Syrian Hamsters

Authors: Brandi N. Williamson, Joseph Prescott, Jose L. Garrido, Raymond A. Alvarez, Heinz Feldmann, Maria I. Barría

Source: Emerging Infectious Diseases, Vol 27, Iss 10, Pp 2707-2710 (2021)

Subject Terms: recombinant human monoclonal antibodies, Andes orthohantavirus, Syrian hamster, viruses, zoonoses, Medicine, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://wwwnc.cdc.gov/eid/article/27/10/21-0735_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059

Access URL: https://doaj.org/article/1f5f799122d1481f90e267d97e87fac0

Histopathologic Characterization of Experimental Peracute SARS-CoV-2 Infection in the Syrian Hamster

Authors: Chad S. Clancy, Kimberly Meade-White, Carl Shaia, Greg Saturday, Heinz Feldmann, Kyle Rosenke

Source: Veterinary Sciences, Vol 10, Iss 9, p 536 (2023)

Subject Terms: histopathology, immunohistochemistry, disease modeling, SARS-CoV-2, hamster, Veterinary medicine, SF600-1100

File Description: electronic resource

Relation: https://www.mdpi.com/2306-7381/10/9/536; https://doaj.org/toc/2306-7381

Access URL: https://doaj.org/article/3af8442529d84d9b9fd3237d94369e9d

Ebola Virus IgG Seroprevalence in Southern Mali

Authors: Sidy Bane, Kyle Rosenke, Ousmane Maiga, Friederike Feldmann, Kimberly Meade-White, Julie Callison, David Safronetz, Nafomon Sogoba, Heinz Feldmann

Source: Emerging Infectious Diseases, Vol 27, Iss 6, Pp 1681-1684 (2021)

Subject Terms: Ebola virus, ebolaviruses, filoviruses, serology, viruses, zoonoses, Medicine, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://wwwnc.cdc.gov/eid/article/27/6/20-3510_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059

Access URL: https://doaj.org/article/4698ea7eb2e341e3ae9540af0e8c052b

Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model

Authors: Kyle Rosenke, Frederick Hansen, Benjamin Schwarz, Friederike Feldmann, Elaine Haddock, Rebecca Rosenke, Kent Barbian, Kimberly Meade-White, Atsushi Okumura, Shanna Leventhal, David W. Hawman, Emily Ricotta, Catharine M. Bosio, Craig Martens, Greg Saturday, Heinz Feldmann, Michael A. Jarvis

Source: Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/9a78a63a312847aa863ae1016f4d581a