Current state-of-the-art and gaps in platform trials: 10 things you should know, insights from EU-PEARL

Authors: Sánchez-Montalva, Adrian, Estevez, Ana Belén, Sánchez, Àlex, Sanjuan, Anna, Sena, Elena, Granados, Emma, Arévalo de Andrés, Esther, Nuñez, Fátima, Arteaga, Gara, Fuentes Ruiz, Gabriela Perez, Fernández, Guillermo, Rivera-Esteban, Jesus, Comella, Joan, Ramos-Quiroga, Josep Antoni, Genescà, Joan, Espinosa, Juan, Pericàs, Juan Manuel, Murcia, Lada, Cash-Gibson, Lucinda, de Valles Silvosa, Maria, Barroso de Sousa, María Fernanda, Sánchez-Maroto Carrizo, Olga, Ibañez-Jiménez, Pol, Augustin, Salvador, Perez-Hoyos, Santiago, Rodríguez-Navarro, Sarai, Muñoz-Martínez, Sergio, Serres, Silvia, Kalko, Susana, Michon, Amelie, Ussi, Anton, Lydall, Ben, van de Ketterij, Edwin, Quiles, Ignacio, Carapina, Tamara, Kumaus, Constantin, Ramazanova, Dariga, Meyer, Elias Laurin, Koenig, Franz, Roig, Marta Bofill, Brunner, Martin, Posch, Martin, Krotka, Pavla, Zehetmayer, Sonja, Carton, Charlotte, Legius, Eric, Begum, Amina, Pariante, Carmine, Worrell, Courtney, Lombardo, Giulia, Sforzini, Luca, Brown, Mollie, Gullet, Nancy, Amasi-Hartoonian, Nare, Ferner, Rosalie, Kose, Melisa, Spitaleri, Andrea, Ghodousi, Arash, Di Serio, Clelia, Cirillo, Daniela, Cugnata, Federica, Saluzzo, Francesca, Benedetti, Francesco, Scarale, Maria Giovanna, Zini, Michela, Rancoita, Paola Maria, Alagna, Riccardo, Poletti, Sara, Dhaenens, Britt, Van Der Lei, Johan, de Steenwinkel, Jurriaan, Moinat, Maxim, Oostenbrink, Rianne, Hoogendijk, Witte, Hölscher, Michael, Heinrich, Norbert, Otte, Christian, Potratz, Cornelia, Zocholl, Dario, Kulakova, Eugenia, Tacke, Frank, Brasanac, Jelena, Leubner, Jonas, Krajewska, Maja, Freitag, Michaela Maria, Gold, Stefan, Zoller, Thomas, Chae, Woo Ri, Daniel, Christel, Kara, Leila, Vaterkowski, Morgan, Griffon, Nicolas, Wolkenstein, Pierre, Pais, Raluca, Ratziu, Vlad, Voets, David, Maes, Christophe, Kalra, Dipak, Thienpoint, Geert, Deckerck, Jens, Lea, Nathan, Singleton, Peter, Viele, Kert, Jacko, Peter, Berry, Scott, Parke, Tom, Aydin, Burç, Kubiak, Christine, Demotes, Jacques, Ueda, Keiko, Matei, Mihaela, Contrino, Sergio, Röhl, Claas, Cordero, Estefania, Greenhalgh, Fiona, Jarke, Hannes, Angelova, Juliana, Boudes, Mathieu, Dressler, Stephan, Strammiello, Valentina, Anstee, Quentin, Gutierrez-Ibarluzea, Iñaki, Otte, Maximilian, Heimbach, Natalie, Hofner, Benjamin, Burgwinkel, Cora, Kaestel, Hue, Hees, Katharina, Nguyen, Quynh, Prieto-Alhambra, Daniel, Tan, Eng Hooi (Cheryl), Raviglione, Mario, de Colombani, Pierpaolo, Villa, Simone, Maron, Eduard, Evans, Gareth, Savitz, Adam J., Van Dessel, Ann, Duca, Anna, Kaminski, Anne, Wouters, Bie, Porter, Brandon, Charron, Catherine, Spiertz, Cecile, Zizzamia, Christopher, Millar, Daniel, Hasselbaink, Danny, Orr, David, Kesters, Divya, Hubin, Ellen, Davies, Emma, Didden, Eva-Maria, Guz, Gabriela, Verstraete, Evelyn, Mao, Gary, Capuano, George, Martynowicz, Heddie, De Smedt, Heidi, Larsson, Ingela, Bruegelmans, Ines, Coste, Isabelle, Gonzalez Moreno, Jesus Maria, Niewczas, Julia, Xu, Jiajun, Rombouts, Karin, Woo, Katherine, Wuyts, Kathleen, Hersh, Kathryn, Oldenburg, Khrista, Zhang, Lingjiao, Schmidt, Mark, Szuch, Mark, Todorovic, Marija, Mangelaars, Maartje, Grewal, Melissa, Sandor, Molli, Di Prospero, Nick, Van Houten, Pamela, Minnick, Pansy, Bastos, Polyana, Patrizi, Robert, Morello, Salvatore, De Wilde, Severijn, Sun, Tao, Kline, Timothy, de Marez, Tine, Mielke, Tobias, Reijns, Tom, Popova, Vanina, Flossbach, Yanina, Tymofyeyev, Yevgen, De Groote, Zeger, Sverdlov, Alex, Bobirca, Alexandra, Krause, Annekatrin, Bobrica, Catalin, Heintz, Daniela, Magirr, Dominic, Glimm, Ekkehard, Baffert, Fabienne, Castiglione, Federica, Caruso, Franca, Patalano, Francesco, Bretz, Frank, Heimann, Guenter, Carbarns, Ian, Rodríguez, Ignacio, Ratescu, Ioana, Hampson, Lisa, Pedrosa, Marcos, Hark, Mareile, Mesenbrink, Peter, Penna, Sabina Hernandez, Bergues-Lang, Sarah, Baltes-Engler, Susanne, Arsiwala, Tasneem, Mondragon, Valeria Jordan, Guo, Hua, Da Costa, Jose Leite, Burman, Carl-Fredrik, Kirk, George, Aaes-Jørgensen, Anders, Dirach, Jorgen, Kjær, Mette Skalshøi, Martin, Alexandra, Hristov, Diyan, Rousseaux, Florent, Hittel, Norbert, Dornheim, Robert, Evans, Daniel, Sykes, Nick, Couvert, Camille, Leuven, Catherine, Notelet, Loïc, Gidh-Jain, Madhavi, Jouannin, Mathieu, Ammour, Nadir, Pierre, Suzanne, Haufe, Volker, Dong, Yingwen, Dubanchet, Catherine, de Préville, Nathalie, Baltauss, Tania, Jian, Zhu, Shnider, Sara, Bar-El, Tal, Bakker, Annette, Nievo, Marco, Iloeje, Uche, Conradie, Almari, Auffarrth, Ece, Lombard, Leandra, Benhayoun, Majda, Olugbosi, Morounfolu, Seidel, Stephanie S., Gumí, Berta, Guzmán, Claudia García, Molero, Eva, Pairó, Gisela, Machin, Núria, Cardelús, Raimon, Ramasastry, Saira, Pelzer, Saskia, Kremer, Andreas, Lindfors, Erno, Lynch, Chris, Spiertz, Cécile, Machín, Núria, Pericàs, Juan M.

Source: In eClinicalMedicine January 2024 67

Efficacy and tolerability of combination therapy with valsartan plus hydrochlorothiazide compared with amlodipine monotherapy in hypertensive patients with other cardiovascular risk factors: The VAST study

Authors: Ruilope, Luis M., Malacco, Ettore, Khder, Yasser, Kandra, Albert, Bönner, Gerd, Heintz, Daniela

Source: In Clinical Therapeutics May 2005 27(5):578-588

Mobility of the N-terminal segment of rabbit skeletal muscle F-actin detected by 1H and 19F nuclear magnetic resonance spectroscopy.

Authors: Heintz, Daniela, Kany, Harry, Kalbitzer, Hans Robert

Source: Biochemistry; October 1 1996, Vol. 35, p12686-12693, 8p

Cross-link between cys 374 and cys 10 of actin abolishes polymerizability and allows study of the properties of the “F-actin monomer”.

Authors: Heintz, Daniela, Faulstich, Heinz

Source: Biochemistry; January 9 1996, Vol. 35, p258-265, 8p

The sulfoxide of thymosin β4 almost lacks the polymerization-inhibiting capacity for actin.

Authors: Heintz, Daniela¹, Reichert, Andreas¹, Mihelic-Rapp, Mirna¹, Stoeva, Stanka¹, Voelter, Wolfgang¹, Faulstich, Heinz¹

Source: European Journal of Biochemistry. 7/15/94, Vol. 223 Issue 2, p345-350. 6p.

Subject Terms: *THYMOSIN, *THYMIC hormones, *ACTIN, *AMINO acids, *TISSUES, *LUNGS

Probing the phalloidin binding site of actin

Authors: Faulstich, Heinz, Zobeley, Susanne, Heintz, Daniela, Drewes, Gerard

Source: FEBS Letters; March 1993, Vol. 318 Issue: 3 p218-222, 5p

Polymerization of actin from the thymosin β4 complex initiated by the addition of actin nuclei, nuclei stabilizing agents or myosin S1

Authors: Reichert, Andreas, Heintz, Daniela, Voelter, Wolfgang, Mihelic, Mirna, Faulstich, Heinz

Source: FEBS Letters; June 1994, Vol. 347 Issue: 2-3 p247-250, 4p

Mobile segments in rabbit skeletal muscle F-actin detected by 1H nuclear magnetic resonance spectroscopy

Authors: Ślósarek, Genowefa, Heintz, Daniela, Kalbitzer, Hans Robert

Source: FEBS Letters; January 1994, Vol. 351 Issue: 3 p405-410, 6p

Complete¹H Nuclear Magnetic Resonance Assignments and Structural Characterization of a Fusion Protein of the α-Amylase Inhibitor Tendamistat with the Activation Domain of the Human Immunodeficiency Virus Type 1 Tat Protein

Authors: Freund, Jens, Vértesy, László, Koller, Klaus-Peter, Wolber, Vera, Heintz, Daniela, Kalbitzer, Hans Robert

Source: JMB Online (Journal of Molecular Biology); July 28,1995, Vol. 250 Issue: 5 p672-688, 17p

Interchain and intrachain crosslinking of actin thiols by a bifunctional thiol reagent

Authors: Faulstich, Heinz, Heintz, Daniela, Drewes, Gerard

Source: FEBS Letters; January 1992, Vol. 302 Issue: 3 p201-205, 5p

Identification of Contact Sites in the Actin-Thymosin β4 Complex by Distance-dependent Thiol Cross-linking (∗)

Authors: Reichert, Andreas, Heintz, Daniela, Echner, Hartmut, Voelter, Wolfgang, Faulstich, Heinz

Source: Journal of Biological Chemistry; January 1996, Vol. 271 Issue: 3 p1301-1308, 8p

The ternary complex of DNase I, actin and thymosin β4

Authors: Reichert, Andreas, Heintz, Daniela, Echner, Hartmut, Voelter, Wolfgang, Faulstich, Heinz

Source: FEBS Letters; June 1996, Vol. 387 Issue: 2-3 p132-136, 5p

Use of bimanyl actin derivative (TMB‐actin) for studying complexation of β‐thymosins

Authors: Heintz, Daniela, Reichert, Andreas, Mihelic, Mirna, Voelter, Wolfgang, Faulstich, Heinz

Source: FEBS Letters; August 1993, Vol. 329 Issue: 1-2 p9-12, 4p

24-hour ambulatory blood-pressure effects of valsartan + hydrochlorothiazide combinations compared with amlodipine in hypertensive patients at increased cardiovascular risk

Authors: Ruilope, Luis M., Heintz, Daniela, Brandao, Andrea A., Stolt, Pelle, Kandra, Albert, Santonastaso, Massimo, Khder, Yasser

Source: In American Journal of Hypertension 2005 18(5) Supplement:A73-A73

Fixed-dose valsartan + hydrochlorothiazide combination therapy compared with amlodipine monotherapy in hypertensive patients with additional cardiovascular risk factors: The vast study

Authors: Ruilope, Luis M., Malacco, Ettore, Khder, Yasser, Bönner, Gert, Heintz, Daniela

Source: In American Journal of Hypertension 2005 18(5) Supplement:A72-A73

Complete 1H Nuclear Magnetic Resonance Assignments and Structural Characterization of a Fusion Protein of the α-Amylase Inhibitor Tendamistat with the Activation Domain of the Human Immunodeficiency Virus Type 1 Tat Protein

Authors: Freund, Jens, Vértesy, László, Koller, Klaus-Peter, Wolber, Vera, Heintz, Daniela, Kalbitzer, Hans Robert ^{* f1 Corresponding author}

Source: In Journal of Molecular Biology 1995 250(5):672-688

[34] Reversible introduction of thiol compounds into proteins by use of activated mixed disulfides

Authors: Faulstich, Heinz, Heintz, Daniela

Source: In Methods in Enzymology 1995 251:357-366