Intermediate monocytes are associated with the first major adverse cardiovascular event in patients with stable coronary artery disease

Authors: Dregoesc, Mihaela I., Țigu, Adrian B., Bekkering, Siroon, van der Heijden, Charlotte D.C.C., Rodwell, Laura, Bolboacă, Sorana D., Joosten, Leo A.B., Netea, Mihai G., Riksen, Niels P., Iancu, Adrian C.

Source: In International Journal of Cardiology 1 April 2024 400

Peripheral blood mononuclear cell hyperresponsiveness in patients with premature myocardial infarction without traditional risk factors

Authors: Mol, Jan-Quinten, van Tuijl, Julia, Bekkering, Siroon, van der Heijden, Charlotte D.C.C., Damen, Sander A.J., Cossins, Benjamin C., van Emst, Liesbeth, Nielen, Tim M., Rodwell, Laura, Li, Yang, Pop, Gheorghe A.M., Netea, Mihai G., van Royen, Niels, Riksen, Niels P., El Messaoudi, Saloua

Source: In iScience 21 July 2023 26(7)

The role of the mineralocorticoid receptor in immune cells in cardiovascular disease

Authors: Heijden, Charlotte D. C. C., Bode, Marlies, Riksen, Niels P., Wenzel, Ulrich O.

Source: British journal of pharmacology. 179(13):3135-3151

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168235650.0x000001&indx=1&recIds=ETOCvdc_100168235650.0x000001

Effects of dalteparin on anti‐Xa activities cannot be predicted in critically ill COVID‐19 patients

Authors: Heijden, Charlotte D. C. C., Heine, Rob, Kooistra, Emma J., Brüggemann, Roger J., Walburgh Schmidt, Jesper W. J., Grouw, Elke P. L. M., Frenzel, Tim, Pickkers, Peter, Leentjens, Jenneke

Source: British journal of clinical pharmacology. 88(6):2982-2987

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100153620676.0x000001&indx=1&recIds=ETOCvdc_100153620676.0x000001

An integrative genomics approach identifies KDM4 as a modulator of trained immunity

Authors: Moorlag, Simone J.C.F.M., Matzaraki, Vasiliki, Puffelen, Jelmer H., Heijden, Charlotte, Keating, Sam, Groh, Laszlo, Röring, Rutger Jan, Bakker, Olivier B., Mourits, Vera P., Koeken, Valerie A.C.M., Bree, L. Charlotte J., Smeekens, Sanne P., Oosting, Marije, Gamboa, Raúl Aguirre, Riksen, Niels P., Xavier, Ramnik J., Wijmenga, Cisca, Kumar, Vinod, Crevel, Reinout, Novakovic, Boris, Joosten, Leo A.B., Li, Yang, Netea, Mihai G.

Source: European journal of immunology. 52(3):431-446

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100144657483.0x000001&indx=1&recIds=ETOCvdc_100144657483.0x000001

Immune modulatory effects of progesterone on oxLDL‐induced trained immunity in monocytes

Authors: Groh, Laszlo A., Verel, Dagmar E., Heijden, Charlotte D.C.C, Matzaraki, Vasiliki, Moorlag, Simone J.C.F.M., Bree, L. Charlotte, Koeken, Valerie A.C.M., Mourits, Vera P., Keating, Samuel T., Puffelen, Jelmer H., Joosten, Leo A. B., Netea, Mihai G., Riksen, Niels P.

Source: Journal of leukocyte biology. 112(2):279-288

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100156365872.0x000001&indx=1&recIds=ETOCvdc_100156365872.0x000001

The role of sirtuin 1 on the induction of trained immunity

Authors: Mourits, Vera P., Helder, Leonie S., Matzaraki, Vasiliki, Koeken, Valerie A.C.M., Groh, Laszlo, de Bree, L. Charlotte J., Moorlag, Simone J.C.F.M., van der Heijden, Charlotte D.C.C., Keating, Samuel T., van Puffelen, Jelmer H., Jaeger, Martin, Joosten, Leo A.B., Netea, Mihai G.

Source: In Cellular Immunology August 2021 366

Growth differentiation factor 15 levels are similar in primary aldosteronism and essential hypertension and do not predict arterial inflammation

Authors: van der Heijden, Charlotte D.C.C., Smeets, Esther M.M., Aarntzen, Erik H.J.G., Wesseling, Marian, de Jager, Saskia C.A., Riksen, Niels P.

Source: Journal of hypertension.Supplement. 39(3):593-596

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115979625.0x000001&indx=1&recIds=ETOCvdc_100115979625.0x000001

The Set7 Lysine Methyltransferase Regulates Plasticity in Oxidative Phosphorylation Necessary for Trained Immunity Induced by β-Glucan

Authors: Keating, Samuel T., Groh, Laszlo, van der Heijden, Charlotte D.C.C., Rodriguez, Hanah, dos Santos, Jéssica C., Fanucchi, Stephanie, Okabe, Jun, Kaipananickal, Harikrishnan, van Puffelen, Jelmer H., Helder, Leonie, Noz, Marlies P., Matzaraki, Vasiliki, Li, Yang, de Bree, L. Charlotte J., Koeken, Valerie A.C.M., Moorlag, Simone J.C.F.M., Mourits, Vera P., Domínguez-Andrés, Jorge, Oosting, Marije, Bulthuis, Elianne P., Koopman, Werner J.H., Mhlanga, Musa, El-Osta, Assam, Joosten, Leo A.B., Netea, Mihai G., Riksen, Niels P.

Source: In Cell Reports 21 April 2020 31(3)

The role of Toll‐like receptor 10 in modulation of trained immunity

Authors: Mourits, Vera P., Arts, Rob J.W., Novakovic, Boris, Matzaraki, Vasiliki, Bree, L. Charlotte J., Koeken, Valerie A.C.M., Moorlag, Simone J.C.F.M., Puffelen, Jelmer H., Groh, Laszlo, Heijden, Charlotte D.C.C., Keating, Sam T., Netea, Mihai G., Oosting, Marije, Joosten, Leo A.B.

Source: Immunology. 159(3):289-297

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100102924951.0x000001&indx=1&recIds=ETOCvdc_100102924951.0x000001

Catecholamines Induce Trained Immunity in Monocytes In Vitro and In Vivo

Authors: van der Heijden, Charlotte D.C.C., Groh, Laszlo, Keating, Samuel T., Kaffa, Charlotte, Noz, Marlies P., Kersten, Simone, van Herwaarden, Antonius E., Hoischen, Alexander, Joosten, Leo A.B., Timmers, Henri J.L.M., Netea, Mihai G., Riksen, Niels P.

Source: Circulation research. 127(2):269-283

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190134785.0x000001&indx=1&recIds=ETOCvdc_100190134785.0x000001

Metabolic Induction of Trained Immunity through the Mevalonate Pathway

Authors: Bekkering, Siroon, Arts, Rob J.W., Novakovic, Boris, Kourtzelis, Ioannis, van der Heijden, Charlotte D.C.C., Li, Yang, Popa, Calin D., ter Horst, Rob, van Tuijl, Julia, Netea-Maier, Romana T., van de Veerdonk, Frank L., Chavakis, Triantafyllos, Joosten, Leo A.B., van der Meer, Jos W.M., Stunnenberg, Henk, Riksen, Niels P., Netea, Mihai G.

Source: In Cell 11 January 2018 172(1-2):135-146

The role of the mineralocorticoid receptor in immune cells in cardiovascular disease.

Authors: van der Heijden, Charlotte D. C. C.¹ (AUTHOR), Bode, Marlies² (AUTHOR), Riksen, Niels P.^1,3 (AUTHOR) niels.riksen@radboudumc.nl, Wenzel, Ulrich O.² (AUTHOR) wenzel@uke.de

Source: British Journal of Pharmacology. Jul2022, Vol. 179 Issue 13, p3135-3151. 17p. 2 Diagrams, 1 Chart.

Arterial Wall Inflammation and Increased Hematopoietic Activity in Patients With Primary Aldosteronism

Authors: van der Heijden, Charlotte D C C, Smeets, Esther M M, Aarntzen, Erik H J G, Noz, Marlies P, Monajemi, Houshang, Kersten, Simone, Kaffa, Charlotte, Hoischen, Alexander, Deinum, Jaap, Joosten, Leo A B, Netea, Mihai G, Riksen, Niels P

Source: Journal of clinical endocrinology & metabolism. 105(5):e1967-e1980

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100114471345.0x000001&indx=1&recIds=ETOCvdc_100114471345.0x000001

Intravenous flucloxacillin treatment is associated with a high incidence of hypokalaemia

Authors: Heijden, Charlotte D.C.C., Duizer, Marleen L., Fleuren, Hanneke W.H.A., Veldman, Bart A., Sprong, Tom, Dofferhoff, Anton T.S.M., Kramers, Cornelis

Source: British journal of clinical pharmacology. 85(12):2886-2890

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100097856668.0x000001&indx=1&recIds=ETOCvdc_100097856668.0x000001

Aldosterone induces trained immunity: the role of fatty acid synthesis

Authors: van der Heijden, Charlotte D C C, Keating, Samuel T, Groh, Laszlo, Joosten, Leo A B, Netea, Mihai G, Riksen, Niels P

Source: Cardiovascular research. 116(2):317-328

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100099931727.0x000001&indx=1&recIds=ETOCvdc_100099931727.0x000001

Effects of dalteparin on anti‐Xa activities cannot be predicted in critically ill COVID‐19 patients.

Authors: van der Heijden, Charlotte D. C. C.¹ (AUTHOR), ter Heine, Rob² (AUTHOR), Kooistra, Emma J.³ (AUTHOR), Brüggemann, Roger J.³ (AUTHOR), Walburgh Schmidt, Jesper W. J.² (AUTHOR), de Grouw, Elke P. L. M.⁴ (AUTHOR), Frenzel, Tim² (AUTHOR), Pickkers, Peter² (AUTHOR), Leentjens, Jenneke¹ (AUTHOR) jenneke.leentjens@radboudumc.nl

Source: British Journal of Clinical Pharmacology. Jun2022, Vol. 88 Issue 6, p2982-2987. 6p.

Subject Terms: *COVID-19, *CRITICALLY ill, *LOW-molecular-weight heparin, *MONTE Carlo method, *NONLINEAR analysis

Metamizole (Dipyrone) as an Alternative Agent in Postoperative Analgesia in Patients with Contraindications for Nonsteroidal Anti-Inflammatory Drugs.

Authors: Konijnenbelt ‐ Peters, Jorieke¹, Heijden, Charlotte¹, Ekhart, Corine², Bos, Jacqueline³, Bruhn, Jörgen⁴, Kramers, Cornelis^3,5,6 kees.kramers@radboudumc.nl

Source: Pain Practice. Mar2017, Vol. 17 Issue 3, p402-408. 7p. 1 Chart.

Subject Terms: *KIDNEY disease risk factors, *PARASYMPATHOLYTIC agents, *ACETAMINOPHEN, *AGRANULOCYTOSIS, *ANALGESIA, *ANALGESICS, *ANESTHESIOLOGY, *COMBINED modality therapy, *CONFIDENCE intervals, *DATABASES, *DUODENAL ulcers, *HEMORRHAGE, *KIDNEYS, *MEDLINE, *NARCOTICS, *NONSTEROIDAL anti-inflammatory agents, *ONLINE information services, *PHARMACOLOGY, *POSTOPERATIVE care, *POSTOPERATIVE pain, *KIDNEY failure, *STOMACH, *PAIN management, *PROTON pump inhibitors, *DATA analysis software, *THERAPEUTICS

Vasculometabolic and Inflammatory Effects of Aldosterone in Obesity.

Authors: van der Heijden, Charlotte D. C. C., ter Horst, Rob, van den Munckhof, Inge C. L., Schraa, Kiki, de Graaf, Jacqueline, Joosten, Leo A. B., Danser, A. H. Jan, Netea, Mihai G., Deinum, Jaap, Rutten, Joost, Riksen, Niels P.

Source: Journal of Clinical Endocrinology & Metabolism; Aug2020, Vol. 105 Issue 8, p1-13, 13p

Rewiring of glucose metabolism defines trained immunity induced by oxidized low-density lipoprotein.

Authors: Keating, Samuel T., Groh, Laszlo, Thiem, Kathrin, Bekkering, Siroon, Li, Yang, Matzaraki, Vasiliki, van der Heijden, Charlotte D. C. C., van Puffelen, Jelmer H., Lachmandas, Ekta, Jansen, Trees, Oosting, Marije, de Bree, L. Charlotte J., Koeken, Valerie A. C. M., Moorlag, Simone J. C. F. M., Mourits, Vera P., van Diepen, Janna, Strienstra, Rinke, Novakovic, Boris, Stunnenberg, Hendrik G., van Crevel, Reinout

Source: Journal of Molecular Medicine; Jun2020, Vol. 98 Issue 6, p819-831, 13p

Subject Terms: MONOCYTES, GLUCOSE metabolism, IMMUNITY, MICROBIAL products, OXYGEN consumption, GLYCOLYSIS