KRASG12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T cells

Authors: Mahadevan, Krishnan K., McAndrews, Kathleen M., LeBleu, Valerie S., Yang, Sujuan, Lyu, Hengyu, Li, Bingrui, Sockwell, Amari M., Kirtley, Michelle L., Morse, Sami J., Moreno Diaz, Barbara A., Kim, Michael P., Feng, Ningping, Lopez, Anastasia M., Guerrero, Paola A., Paradiso, Francesca, Sugimoto, Hikaru, Arian, Kent A., Ying, Haoqiang, Barekatain, Yasaman, Sthanam, Lakshmi Kavitha, Kelly, Patience J., Maitra, Anirban, Heffernan, Timothy P., Kalluri, Raghu

Source: In Cancer Cell 11 September 2023 41(9):1606-1620

Sequential Administration of XPO1 and ATR Inhibitors Enhances Therapeutic Response in TP53-mutated Colorectal Cancer

Authors: Inoue, Akira, Robinson, Frederick S., Minelli, Rosalba, Tomihara, Hideo, Rizi, Bahar Salimian, Rose, Johnathon L., Kodama, Takahiro, Srinivasan, Sanjana, Harris, Angela L., Zuniga, Andy M., Mullinax, Robert A., Ma, Xiaoyan, Seth, Sahil, Daniele, Joseph R., Peoples, Michael D., Loponte, Sara, Akdemir, Kadir C., Khor, Tin Oo, Feng, Ningping, Roszik, Jason, Sobieski, Mary M., Brunell, David, Stephan, Clifford, Giuliani, Virginia, Deem, Angela K., Shingu, Takashi, Deribe, Yonathan Lissanu, Menter, David G., Heffernan, Timothy P., Viale, Andrea, Bristow, Christopher A., Kopetz, Scott, Draetta, Giulio F., Genovese, Giannicola, Carugo, Alessandro

Source: In Gastroenterology July 2021 161(1):196-210

Evolutionary fingerprints of epithelial-to-mesenchymal transition

Authors: Perelli, Luigi, Zhang, Li, Mangiameli, Sarah, Giannese, Francesca, Mahadevan, Krishnan K., Peng, Fuduan, Citron, Francesca, Khan, Hania, Le, Courtney, Gurreri, Enrico, Carbone, Federica, Russell, Andrew J. C., Soeung, Melinda, Lam, Truong Nguyen Anh, Lundgren, Sebastian, Marisetty, Sujay, Zhu, Cihui, Catania, Desiree, Mohamed, Alaa M. T., Feng, Ningping, Augustine, Jithesh Jose, Sgambato, Alessandro, Tortora, Giampaolo, Draetta, Giulio F., Tonon, Giovanni, Futreal, Andrew, Giuliani, Virginia, Carugo, Alessandro, Viale, Andrea, Kim, Michael P., Heffernan, Timothy P., Wang, Linghua, Kalluri, Raghu, Cittaro, Davide, Chen, Fei, Genovese, Giannicola

Source: Nature; 20250101, Issue: Preprints p1-10, 10p

Targeting DNA damage response in head and neck cancers through abrogation of cell cycle checkpoints

Authors: Molkentine, Jessica M., Molkentine, David P., Bridges, Kathleen A., Xie, Tongxin, Yang, Liangpeng, Sheth, Aakash, Heffernan, Timothy P., Clump, David A., Faust, Alma Z., Ferris, Robert L., Myers, Jeffrey N., Frederick, Mitchell J., Mason, Kathryn A., Meyn, Raymond E., Pickering, Curtis R., Skinner, Heath D.

Source: International journal of radiation biology. 97(8):1121-1128

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Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma

Authors: Msaouel, Pavlos, Malouf, Gabriel G., Su, Xiaoping, Yao, Hui, Tripathi, Durga N., Soeung, Melinda, Gao, Jianjun, Rao, Priya, Coarfa, Cristian, Creighton, Chad J., Bertocchio, Jean-Philippe, Kunnimalaiyaan, Selvi, Multani, Asha S., Blando, Jorge, He, Rong, Shapiro, Daniel D., Perelli, Luigi, Srinivasan, Sanjana, Carbone, Federica, Pilié, Patrick G., Karki, Menuka, Seervai, Riyad N.H., Vokshi, Bujamin H., Lopez-Terrada, Dolores, Cheng, Emily H., Tang, Ximing, Lu, Wei, Wistuba, Ignacio I., Thompson, Timothy C., Davidson, Irwin, Giuliani, Virginia, Schlacher, Katharina, Carugo, Alessandro, Heffernan, Timothy P., Sharma, Padmanee, Karam, Jose A., Wood, Christopher G., Walker, Cheryl L., Genovese, Giannicola, Tannir, Nizar M.

Source: In Cancer Cell 11 May 2020 37(5):720-734

Neddylation inhibition sensitises renal medullary carcinoma tumours to platinum chemotherapy

Authors: Shapiro, Daniel D., Zacharias, Niki Millward, Tripathi, Durga N., Karki, Menuka, Bertocchio, Jean‐Philippe, Soeung, Melinda, He, Rong, Westerman, Mary E., Gao, Jianjun, Rao, Priya, Lam, Truong N. A., Jonasch, Eric, Perelli, Luigi, Cheng, Emily H., Carugo, Alessandro, Heffernan, Timothy P., Walker, Cheryl L., Genovese, Giannicola, Tannir, Nizar M., Karam, Jose A., Msaouel, Pavlos

Source: Clinical and translational medicine. 13(5)

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Discovery of ART0380, a Potent and Selective ATR Kinase Inhibitor Undergoing Phase 2 Clinical Studies for the Treatment of Advanced or Metastatic Solid Cancers

Authors: Carroll, Christopher L., Johnson, Michael G., Ding, Yanbing, Kang, Zhijun, Vijayan, R. S. K., Bardenhagen, Jennifer P., Fang, Cheng, Lapointe, David, Li, Meng, Liu, Chiu-Yi, Lv, Xiaobing, Ma, XiaoYan, Pang, Jihai, Shepard, Hannah E., Suarez, Catalina, Yau, Anne Ju, Williams, Christopher C., Wu, Qi, Heald, Robert A., Robinson, Helen M. R., Smith, Graeme C. M., Cross, Jason B., Do, Mary K. Geck, Jiang, Yongying, Lively, Sarah, Yap, Timothy A., Giuliani, Virginia, Heffernan, Timothy, Jones, Philip, Di Francesco, M. Emilia

Source: Journal of Medicinal Chemistry; December 2024, Vol. 67 Issue: 24 p21890-21904, 15p

Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation

Authors: Sun, Yuting, Bandi, Madhavi, Lofton, Timothy, Smith, Melinda, Bristow, Christopher A., Carugo, Alessandro, Rogers, Norma, Leonard, Paul, Chang, Qing, Mullinax, Robert, Han, Jing, Shi, Xi, Seth, Sahil, Meyers, Brooke A., Miller, Meredith, Miao, Lili, Ma, Xiaoyan, Feng, Ningping, Giuliani, Virginia, Geck Do, Mary, Czako, Barbara, Palmer, Wylie S., Mseeh, Faika, Asara, John M., Jiang, Yongying, Morlacchi, Pietro, Zhao, Shuping, Peoples, Michael, Tieu, Trang N., Warmoes, Marc O., Lorenzi, Philip L., Muller, Florian L., DePinho, Ronald A., Draetta, Giulio F., Toniatti, Carlo, Jones, Philip, Heffernan, Timothy P., Marszalek, Joseph R.

Source: In Cell Reports 8 January 2019 26(2):469-482

PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy

Authors: Hsu, Joanne I., Dayaram, Tajhal, Tovy, Ayala, De Braekeleer, Etienne, Jeong, Mira, Wang, Feng, Zhang, Jianhua, Heffernan, Timothy P., Gera, Sonal, Kovacs, Jeffrey J., Marszalek, Joseph R., Bristow, Christopher, Yan, Yuanqing, Garcia-Manero, Guillermo, Kantarjian, Hagop, Vassiliou, George, Futreal, P. Andrew, Donehower, Lawrence A., Takahashi, Koichi, Goodell, Margaret A.

Source: In Cell Stem Cell 1 November 2018 23(5):700-713

Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy

Authors: Cascone, Tina, McKenzie, Jodi A., Mbofung, Rina M., Punt, Simone, Wang, Zhe, Xu, Chunyu, Williams, Leila J., Wang, Zhiqiang, Bristow, Christopher A., Carugo, Alessandro, Peoples, Michael D., Li, Lerong, Karpinets, Tatiana, Huang, Lu, Malu, Shruti, Creasy, Caitlin, Leahey, Sara E., Chen, Jiong, Chen, Yuan, Pelicano, Helen, Bernatchez, Chantale, Gopal, Y.N. Vashisht, Heffernan, Timothy P., Hu, Jianhua, Wang, Jing, Amaria, Rodabe N., Garraway, Levi A., Huang, Peng, Yang, Peiying, Wistuba, Ignacio I., Woodman, Scott E., Roszik, Jason, Davis, R. Eric, Davies, Michael A., Heymach, John V., Hwu, Patrick, Peng, Weiyi

Source: In Cell Metabolism 1 May 2018 27(5):977-987

Telomere Dysfunction Drives Aberrant Hematopoietic Differentiation and Myelodysplastic Syndrome

Authors: Colla, Simona, Ong, Derrick Sek Tong, Ogoti, Yamini, Marchesini, Matteo, Mistry, Nipun A., Clise-Dwyer, Karen, Ang, Sonny A., Storti, Paola, Viale, Andrea, Giuliani, Nicola, Ruisaard, Kathryn, Ganan Gomez, Irene, Bristow, Christopher A., Estecio, Marcos, Weksberg, David C., Ho, Yan Wing, Hu, Baoli, Genovese, Giannicola, Pettazzoni, Piergiorgio, Multani, Asha S., Jiang, Shan, Hua, Sujun, Ryan, Michael C., Carugo, Alessandro, Nezi, Luigi, Wei, Yue, Yang, Hui, D’Anca, Marianna, Zhang, Li, Gaddis, Sarah, Gong, Ting, Horner, James W., Heffernan, Timothy P., Jones, Philip, Cooper, Laurence J.N., Liang, Han, Kantarjian, Hagop, Wang, Y. Alan, Chin, Lynda, Bueso-Ramos, Carlos, Garcia-Manero, Guillermo, DePinho, Ronald A.

Source: In Cancer Cell 11 May 2015 27(5):644-657

Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase

Authors: Kawasumi, Masaoki, Lemos, Bianca, Bradner, James E., Thibodeau, Renee, Kim, Yong-son, Schmidt, Miranda, Higgins, Erin, Koo, Sang-wahn, Angle-Zahn, Aimee, Chen, Adam, Levine, Douglas, Nguyen, Lynh, Heffernan, Timothy P., Longo, Isabel, Mandinova, Anna, Lu, Yao-Ping, Conney, Allan H., Nghiem, Paul

Source: Proceedings of the National Academy of Sciences of the United States of America, 2011 Aug . 108(33), 13716-13721.

Access URL: https://www.jstor.org/stable/27979264

Preclinical development of 1B7/CD3, a novel anti-TSLPR bispecific antibody that targets CRLF2-rearranged Ph-like B-ALL

Authors: Tian, Ze, Shi, Chunhua, Yang, Guojun, Allen, Jason K., Shi, Qing, AI-Shami, Amin, Olson, Jill Wardell, Smith, Melinda G., Chang, Qing, Kaur, Jasbir, You, Junping, Lofton, Timothy E., Gonzalez, Michelle A., Zhang, Qi, Zha, DongXing, Tasian, Sarah K., Jain, Nitin, Konopleva, Marina Y., Heffernan, Timothy, Molldrem, Jeffrey J.

Source: Leukemia; October 2023, Vol. 37 Issue: 10 p2006-2016, 11p

Proinvasion Metastasis Drivers in Early-Stage Melanoma Are Oncogenes

Authors: Scott, Kenneth L., Nogueira, Cristina, Heffernan, Timothy P., van Doorn, Remco, Dhakal, Sabin, Hanna, Jason A., Min, Chengyin, Jaskelioff, Mariela, Xiao, Yonghong, Wu, Chang-Jiun, Cameron, Lisa A., Perry, Samuel R., Zeid, Rhamy, Feinberg, Tamar, Kim, Minjung, Vande Woude, George, Granter, Scott R., Bosenberg, Marcus, Chu, Gerald C., DePinho, Ronald A., Rimm, David L., Chin, Lynda

Source: In Cancer Cell 2011 20(1):92-103

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

Authors: Delmore, Jake E., Issa, Ghayas C., Lemieux, Madeleine E., Rahl, Peter B., Shi, Junwei, Jacobs, Hannah M., Kastritis, Efstathios, Gilpatrick, Timothy, Paranal, Ronald M., Qi, Jun, Chesi, Marta, Schinzel, Anna C., McKeown, Michael R., Heffernan, Timothy P., Vakoc, Christopher R., Bergsagel, P. Leif, Ghobrial, Irene M., Richardson, Paul G., Young, Richard A., Hahn, William C., Anderson, Kenneth C., Kung, Andrew L., Bradner, James E., Mitsiades, Constantine S.

Source: In Cell 2011 146(6):904-917

P53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors

Authors: Carugo, Alessandro, Minelli, Rosalba, Sapio, Luigi, Soeung, Melinda, Carbone, Federica, Robinson, Frederick S., Tepper, James, Chen, Ziheng, Lovisa, Sara, Svelto, Maria, Amin, Samirkumar, Srinivasan, Sanjana, Del Poggetto, Edoardo, Loponte, Sara, Puca, Francesca, Dey, Prasenjit, Malouf, Gabriel G., Su, Xiaoping, Li, Liren, Lopez-Terrada, Dolores, Rakheja, Dinesh, Lazar, Alexander J., Netto, George J., Rao, Priya, Sgambato, Alessandro, Maitra, Anirban, Tripathi, Durga N., Walker, Cheryl L., Karam, Jose A., Heffernan, Timothy P., Viale, Andrea, Roberts, Charles W.M., Msaouel, Pavlos, Tannir, Nizar M., Draetta, Giulio F., Genovese, Giannicola

Source: Cancer cell. 35(2):204-220.e9

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ATR–Chk1 Pathway Inhibition Promotes Apoptosis after UV Treatment in Primary Human Keratinocytes: Potential Basis for the UV Protective Effects of Caffeine

Authors: Heffernan, Timothy P., Kawasumi, Masaoki, Blasina, Alessandra, Anderes, Kenna, Conney, Allan H., Nghiem, Paul ^*

Source: In Journal of Investigative Dermatology July 2009 129(7):1805-1815

A functional genomic screen in vivo identifies CEACAM5 as a clinically relevant driver of breast cancer metastasis

Authors: Powell, Emily, Shao, Jiansu, Picon, Hector M., Bristow, Christopher, Ge, Zhongqi, Peoples, Michael, Robinson, Frederick, Jeter-Jones, Sabrina L., Schlosberg, Christopher, Grzeskowiak, Caitlin L., Yang, Fei, Wu, Yun, Wistuba, Ignacio, Moulder, Stacy L., Symmans, William F., Scott, Kenneth L., Edwards, John R., Liang, Han, Heffernan, Timothy P., Piwnica-Worms, Helen

Source: NPJ breast cancer. 4(1)

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High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer

Authors: Echeverria, Gloria V., Powell, Emily, Seth, Sahil, Ge, Zhongqi, Carugo, Alessandro, Bristow, Christopher, Peoples, Michael, Robinson, Frederick, Qiu, Huan, Shao, Jiansu, Jeter-Jones, Sabrina L., Zhang, Xiaomei, Ramamoorthy, Vandhana, Cai, Shirong, Wu, Wenhui, Draetta, Giulio, Moulder, Stacy L., Symmans, William F., Chang, Jeffrey T., Heffernan, Timothy P., Piwnica-Worms, Helen

Source: Nature communications. 9(1)

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Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development

Authors: Wiedemeyer, Ruprecht, Brennan, Cameron, Heffernan, Timothy P., Xiao, Yonghong, Mahoney, John, Protopopov, Alexei, Zheng, Hongwu, Bignell, Graham, Furnari, Frank, Cavenee, Webster K., Hahn, William C., Ichimura, Koichi, Collins, V. Peter, Chu, Gerald C., Stratton, Michael R., Ligon, Keith L., Futreal, P. Andrew, Chin, Lynda

Source: In Cancer Cell 8 April 2008 13(4):355-364