Efficacy and safety of SGLT2 inhibitors with and without glucagon-like peptide 1 receptor agonists: a SMART-C collaborative meta-analysis of randomised controlled trials

Authors: Apperloo, Ellen M ^{a, *}, Neuen, Brendon L ^{b, c, *}, Fletcher, Robert A ^b, Jongs, Niels ^a, Anker, Stefan D ^d, Bhatt, Deepak L ^e, Butler, Javed ^{f, g}, Cherney, David Z I ^h, Herrington, William G ⁱ, Inzucchi, Silvio E ^j, Jardine, Meg J ^{b, k, l}, Liu, Chih-Chin ^m, Mahaffey, Kenneth W ⁿ, McGuire, Darren K ^o, McMurray, John J V ^p, Neal, Bruce ^{b, q}, Packer, Milton ^{r, s}, Perkovic, Vlado ^b, Sabatine, Marc S ^{t, u}, Solomon, Scott D ^u, Staplin, Natalie ⁱ, Szarek, Michael ^{v, w, x}, Vaduganathan, Muthiah ^u, Wanner, Christoph ^y, Wheeler, David C ^z, Wiviott, Stephen D ^{t, u}, Zannad, Faiez ^aa, Heerspink, Hiddo J L ^{a, b, *}

Source: In The Lancet Diabetes & Endocrinology August 2024 12(8):545-557

Efficacy and safety of aldosterone synthase inhibition with and without empagliflozin for chronic kidney disease: a randomised, controlled, phase 2 trial

Authors: Tuttle, Katherine R, Hauske, Sibylle J, Canziani, Maria Eugenia, Caramori, Maria Luiza, Cherney, David, Cronin, Lisa, Heerspink, Hiddo J L, Hugo, Christian, Nangaku, Masaomi, Rotter, Ricardo Correa, Silva, Arnold, Shah, Shimoli V, Sun, Zhichao, Urbach, Dorothea, de Zeeuw, Dick, Rossing, Peter, SZETO, Cheuk Chun, Echeverri, Diego, Martin, Edouard, Yee, Ming Li, Wah, William, Wang, Ray, Chacko, Bobby, Swaminathan, Shriram, MacIsaac, Richard, Hashimura, Hikaru, Ward, Glenn, De Vusser, Katrien, Claes, Kathleen, Kuypers, Dirk, Meijers, Björn, Van Craenenbroeck, Amaryllis, Hilbrands, Robert, Debroye, Corinne, Wissing, Karl Martin, Jadoul, Michel, Demoulin, Nathalie, Treille De Grandsaigne, Serge, Beklevic, Ishak, Marcoux, Diane, Liénart, Fabienne, Daper, Claude, De Brouckere, Véronique, Heureux, Mercédès, Felicio, Joao, Felicio, Karem Mileo, Leite, Daniella, Melo, Franciane, Queiroz, Natercia, Souza, Ana Carolina, Vieira, Jocyelle, Franco, Roberto, Mendes, Adriana, Picolli, Giovana, Canani, Luis Henrique, Sartori, Carla, Valenti, Adriana, Eliaschewitz, Freddy, Bona, Renata, Franco, Denise, Ludovico Costa de Castro, Denise, Magalhaes, Vanessa, Oliveira, Marcelo, Sampaio, Célia Regina, Visconti, Guilherme, Halpern, Bruno, Nihei, Camila, Pessoa, Bruna, Seraphim, Carlos, Santos, Daniel, Brito, Claudia, Douverny, Joao, Colella, Marina, Gazeta, Cristina, Vercia, Monique, Watanabe, Renato, Temelkova, Theodora, Kjurkchiev, Dimo, Statkova, Silviya, Popov, Iliya, Radeva, Radosveta, Arabadzhiev, Lachezar, Binova, Mariya, Bosilkov, Aleksandar, Koleva-Stoicheva, Neli, Ivanov, Ivaylo, Ivanova, Zornitsa, Kotseva, Viktoria, Spasov, Petar, Tsvetkov, Ivaylo, Jolly, Shivinder, Bailey, Gordon, Ye, Zhiming, Niu, Jianying, Li, Hongmei, Wu, Qing, Liao, Bing, Hao, Chuanming, Lai, Lingyun, Xu, Yunyu, Zhang, Min, Li, Yiwen, Liu, Bo, Shao, Lina, Chen, Wei, Wu, Haishan, Pirchala, Marian, Skarpova, Iva, Hraskova, Marketa, Soukupova, Simoneta, Veberova, Lucie, Drasnar, Tomas, Falc, Matej, Racz, Blazej, Votocek, Stepan, Weissova, Danica, Syc-Krivanova, Lenka, Slezak, Dagmar, Kantola, Ilkka, Nieminen, Sakari, Anttonen, Milla, Taurio, Jyrki, Lahtela, Jorma, Tsimihodimos, Vasileios, Balafa, Olga, Dounousi, Evangelia, Sakkou, Sissy, Tentolouris, Nikolaos, Siafarikas, Christos, Siami, Evangelia, Doupis, Ioannis, Angelopoulos, Theodoros, Georgoulias, Christodoulos, Pall, Denes, Esze, Regina, Kobling, Tamas, Varadi, Zita, Zsiros, Noemi, Vass, Viktor, Balo, Timea, Csanyi, Erika, Ory, Ivan, Pall, Istvan, Patai, Valentina, Zeak, Zsuzsanna, Takacs, Istvan, Petho, Akos, Szili, Balazs, Koranyi, Laszlo, Bezzegh, Katalin, Pauer, Jozsef, Peterfai, Eva, Konyves, Laszlo, Szoke, Brigitta, Hajdu, Csaba, Kalman, Krisztina, Yadav, Raj, Saxena, Navneet, Bhattacharya, Meenakshi, Sharma, Bal, Thomas, Nihal, K, Felix Jebasingh, Kapoor, Nitin, Kurian, Mathews E., Paul, Jinson, Ramesh, Priyadharshini, Varghese, Sheeba, Shibusawa, Nobuyuki, Nishi, Hiroshi, Noritake, Nobuyasu, Oda, Takashi, Okamoto, Hideki, Kasuga, Hirotake, Hori, Hiroshi, Ito, Yukiko, Mizukoshi, Toshihiro, Ishii, Hideto, Han, Seung Hyeok, Kim, Hyung Woo, Oh, Kook-Hwan, Han, Seung Seok, Han, Sang Youb, Cha, Dae Ryong, Cha, Jin Joo, Kwon, Soon-Kil, Cho, Hyunjeong, Kim, Hye-Young, Kim, Sun Moon, Lee, Jung Pyo, Lee, Jeonghwan, Lee, Li Yuan, Chang, Meng Lee, Laang, Shian Tuck, Tan, Zhao Zhi, Ahmad Rosdi, Hajar, Mohammad Ismail, Siti Hafizah, Simatherai, Devamalar, Tay, Ju Fan, Wong, Eddie, Fook Sem, Yakob, Suryati, Abdul Sukur, Noorhafini, Anuar, Amalina, Md. Rasid, Syaliza, Mushaddik, Irma Liyana, Mustafar, Ruslinda, Abu Shamsi, Muhammad Yusuf, Fong, Voon Ken, Kamaruzaman, Lydia, Mohd, Rozita, Wan Daud, Wan Rohaslizan, Wan Hassan, Wan Hasnul Halimi, Ab Hamid, Suhaidarwani, Abdullah, Muhammad Nabil, Yusoff, Mohd Yusran, Ramanathan, G R Letchuman, Lee, Kim Yen, Wan Ismail, Wan Fadhilah, Morales Villegas, Enrique, Ramirez Baez, Rubria, Vital Lopez, Jorge, Arias Delgadillo, Cristhian, Herrera Marmolejo, Marisol, Parra Perez, Rosa, Alpizar Salazar, Melchor, Flores Montealegre, Ana, Galvan Magaña, Jose, Gutierrez Tlapale, Minerva, Reyes Munguia, Daniela, Witczak, Bartlomiej, Gøransson, Lasse, Strand Thorsen, Inga, Caringal, Clodoaido, Villardo, Mario, Toledo, Ronaldo, Dijamco, Emerlinda Fausto, De Asis, Norman Cornelio, Kuizon, Angelica, Catindig, Elizabeth Ann, Perez, Ronald, Aquitania, Grace, Pableo, Jimrie David, Sanchez, Jay Karlou, Czernecka, Ewa, Cegiel, Aleksandra, Knychas, Dorota, Ochnio, Malgorzata, Kuligowska-Jakubowska, Monika, Cesarz, Marek, Kowalewska-Celejewska, Milena, Masajtis-Zagajewska, Anna, Jankowski, Lukasz, Ojrzanowski, Marcin, Olszewska-Jander, Magdalena, Skokowska, Ewa, Giermakowska-Samek, Malgorzata, Luchowska, Elzbieta, Patkowska, Renata, Sekulska, Marzenna, Marczuk-Krynicka, Dorota, Marciniak, Andrzej, Barwijuk, Michal, Myslicki, Marcin, Siek, Michal, Wronska, Danuta, Tomsia-Goncerz, Jadwiga, Wronski, Krzysztof, Junik, Roman, Dzialak, Szymon, Kurlapska, Ewelina, Malecha, Wieslaw, Suwala, Szymon, Branco, Patrícia, Birne, Rita, Raposo, João, Ferreira, Marta, Alexandrino, Henrique, Alves, Helena, Correia, Sara, Oliveira, Maria João, Ramalho, Diogo, Tavares, Patricia, Coetzee, Kathleen, Blignaut, Sue, Viljoen, Winifred, Potgieter, Elsje, Malherbe, Elmien, Ortiz Arduán, Alberto, Goma Garcés, Elena, Pérez, María, Santamaría, Rafael, López López, Isabel, Pendón de Mier, Victoria, Rodelo Haad, Cristian, Marques, María, Domènech, Esther, Portoles, Josep Maria, Soler, María José, Agraz, Irene, Azancot, María Antonieta, Bermejo, Sheila, Bolufer, Mónica, López, Marina, Ramos, Natalia, Toapanta, Néstor, Cigarrán Guldris, Secundino, Primo, Juan Carlos, Pérez, Luis Enrique, Rebollido Fernández, María, Holmer, Helene, Bruchfeld, Annette, Rofors, Justus, Tengmark, Bengt-Olov, Wuerzner, Gregoire, Leanizbarrutia, Garazi, Ozturk, Savas, Guler, Nurana, Safak, Seda, Lee, Keung, Campbell, Stephen, Siddiqui, Imran, Abbasi, Nadia, Tahir, Faiza, Azizad, Masoud, Jackson, Timothy, Everhart, Brian, Oliver, Michael, Rust, William, Sniezek, Matthew, Arif, Ahmed, Syed, Mohammed, Bhasin, Nitin, Bien, Michael, Gallego, Claudio, Jamal, Aamir, Moghadam, Mojtaba, Rizvi, Abid, Rizvi, Amna, Rizvi, Syed, Wong, Christopher, Lucas, Kathryn, Buery, Andrea, Chang, Ku-Lang, Presswood, Claire, Smith, Justin, Doshi, Ankur, Parikh, Manish, Wallace, Jeannine, Krishna, Arvind, Daugherty, Heidi, Fearday, Aaron, Keller, Christopher, Meng, Jerry, Nielsen, Alexandra, Rovner, Sergio, Almeida, Javier, Marranzini, Benito, Selby, Lisa, Yablon, Zachary, Jean-Louis, Daphne, Kotzker, Wayne, Perez, Chabely, Richards, Marc, Rosario, Reinaldo, Marcus, Roy, Okechukwu, Chike, Ross, Dennis, Gromala, Rachel, Reed, Matthew, Weber, Lisa, Nazeer, Imran, Kumar, Prashant, Mir, Muhammad, Shea, Heidi, Hart, Amanda, Wiebel, Jaime, Kooienga, Laura, Newsome, Britt, Suyumova, Irina, Alvarez, German, Bireddy, Venkata, Lansang, Maria, Mandry, Jose, Freire, Maria, Herrera Albornoz, Oscarina, Desai, Anant, Gandhi, Dayan, Rajan, Sibu, Raymond, Louis, Posada, Jorge, Garcia-Mayol, Luis, Gutierrez-Alsina, Rodolfo, Fernandez, Juan, Bruce, Kendaling, Cuellar, Juan, Ranz y Alvarez, Maria, Bartolacci, Ines, Pautasso, Mauro, Stoppa, Daniela, Riella, Miguel, Barbosa, Maria, Harcsa, Eleonora, Gulati, Yuvraj, Savalia, Denish, Khetan, Prakash, Sinha, Dhananjay, R, Niranjan, K, Srinivas, Pazos, Fabiola, Gacutan-Liwag, Aretha, Duszynska, Malgorzata, Antkowiak-Piatyszek, Karolina, Konieczny, Grzegorz, Sidorowicz-Bialynicka, Anna, Ciesiolkiewicz-Wojcik, Agnieszka, Dwojak, Marek, Szymkowiak, Katarzyna, Gorczyca-Siudak, Daria, Janik-Palazzolo, Marzena, Siudak, Lukasz, Opiela, Jaroslaw, Iwanow, Dariusz, Solkiewicz, Monika, Sipinska-Surzynska, Malgorzata, Olszanecka - Glinianowicz, Magdalena, Rozmilowska, Izabela, Trokis, Julian, Prozesky, Hans, Burgess, Lesley, Cyster, Henry, Jordaan, Jurie, Mohamed, Hawa, Naude, Christina, Sitsila, Thembie, Mehta, Arvind, Mocherla, Bharat, Lee, Sungchun, Boren, Kenneth, Rudolph, Lance, Benjamin, Sabrina, Sugimoto, Danny, Hammoud, Jamal, Bakleh, Muhammad, Hashish, Yaseen, Da Costa, Jonathan, Gold, Marina, Majul, Claudio, Buscema, Juan, Gatto, Maria, Lombardi, Facundo, Paez, Olga, Puleio, Pablo, Alvarisqueta, Andrés, Pajon, Vanessa, Suarez, Gabriel, Hernandez Gauna, Adrian, Pereyra, Alejandro, Reig, Moira, Gelersztein, Elizabeth, Campestri, Gina, Gonzalez Santos, Maria, Sambresqui, Julieta, Catalano, Gustavo, Igarzabal, Cecilia, Vallejos, Augusto, Escobari, Claudio, Marchetto, Rocio, Chahin, Mariano, Aguilera, Andrea, Comes, Ana, Rodriguez Segade, Silvia, Baccaro, Claudia, Larrieu Lacoste, María Verónica, Saurral, Ruben, Cristino, Alberto, Dran, Dario, Koretzky, Martin, Ponti, Juan, Porto, Alejandro, Tenaglia, Yasmin, Maldonado, Natacha, Bertollo, Natalia, Van Perdeck, Verónica, Lopau, Kai, Wanner, Christoph, Berfelo, Florieke, Contzen, Christel, Arbi, Abdulwahab, Lee-Barkey, Young Hee, Maciejewska, Aleksandra, Arelin, Katrin, Haller, Hermann, Kaufeld, Jessica, Schmidt-Ott, Kai, Heinrichs, Sven, Krüger, Thilo, Gebauer, Chris, Paliege, Alexander, Henkel, Elena, Axthelm, Christoph, Derwahl, Karl-Michael, Trevisan, Roberto, Bellante, Rosalia, Borrella, Nicolò, Corsi, Anna, Gesualdo, Loreto, Ardillo, Teodora, Ficarella, Maria, Fikry, Sameh, Mazza, Giuseppe, Poirier, Lysane, Bajaj, Harpreet, Hatziagelaki, Erifili, Katopodis, Sokratis, Katsoudas, Spiros, Yamaura, Shuichi, Shikano, Tsutomu, Tosaki, Takahiro, Miho, Otoya, Tachibana, Naoki, Yumita, Wataru, Kado, Hiroshi, Villarreal Martinez, Jesus, Soto Miranda, Ernesto, Gonzalez Rodriguez, David, Panelo, Araceli, Santos, Telma, Martins, Ana, Mateus, Catarina, Teixeira e Costa, Fernando, Barreto, Sara, Silva Costa, Joana, Ferrer, Francisco, Silva, Joana, Awad, Ahmed, Khaleel, Shatha, Lustig, Ryan, Maharjan, Gajendra, Moya, Jaynier, Johnsingh, Amit, Acosta, Idalia, Newman, George, Buckle, Anita, Hendon, Kendra

Source: In The Lancet 27 January-2 February 2024 403(10424):379-390

Overall and inter‐individual effect of four different drug classes on soluble urokinase plasminogen activator receptor in type 1 and type 2 diabetes

Authors: Rotbain Curovic, Viktor, Houlind, Morten B., Kroonen, Marjolein Y. A. M., Jongs, Niels, Zobel, Emilie H., Hansen, Tine W., Tavenier, Juliette, Eugen‐Olsen, Jesper, Laverman, Gozewijn D., Kooy, Adriaan, Persson, Frederik, Rossing, Peter, Heerspink, Hiddo J. L.

Source: Diabetes, obesity & metabolism. 25(11):3152-3160

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194581552.0x000001&indx=1&recIds=ETOCvdc_100194581552.0x000001

Estimated lifetime benefit of novel pharmacological therapies in patients with type 2 diabetes and chronic kidney disease: A joint analysis of randomized controlled clinical trials

Authors: Heerspink, Hiddo J. L., Vart, Priya, Jongs, Niels, Neuen, Brendon L., Bakris, George, Claggett, Brian, Vaduganathan, Muthiah, McCausland, Finnian, Docherty, Kieran F., Jhund, Pardeep S., Solomon, Scott D., Perkovic, Vlado, McMurray, John J. V.

Source: Diabetes, obesity & metabolism. 25(11):3327-3336

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194581823.0x000001&indx=1&recIds=ETOCvdc_100194581823.0x000001

Sparsentan in patients with IgA nephropathy: a prespecified interim analysis from a randomised, double-blind, active-controlled clinical trial

Authors: Heerspink, Hiddo J L, Radhakrishnan, Jai, Alpers, Charles E, Barratt, Jonathan, Bieler, Stewart, Diva, Ulysses, Inrig, Jula, Komers, Radko, Mercer, Alex, Noronha, Irene L, Rheault, Michelle N, Rote, William, Rovin, Brad, Trachtman, Howard, Trimarchi, Hernán, Wong, Muh Geot, Perkovic, Vlado

Source: Lancet. 401(10388):1584-1594

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191564344.0x000001&indx=1&recIds=ETOCvdc_100191564344.0x000001

Effects of baricitinib, empagliflozin, linagliptin and telmisartan on cardiovascular autonomic neuropathy in type 1 diabetes: An exploratory, randomized, open‐label, crossover trial

Authors: Laursen, Jens Christian, Rotbain Curovic, Viktor, Kroonen, Marjolein Y. A. M., Jongs, Niels, Zobel, Emilie H., Hansen, Tine W., Frimodt‐Møller, Marie, Laverman, Gozewijn D., Kooy, Adriaan, Persson, Frederik, Heerspink, Hiddo J. L., Hansen, Christian Stevns, Rossing, Peter

Source: Diabetes, obesity & metabolism. 25(10):3064-3067

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191650563.0x000001&indx=1&recIds=ETOCvdc_100191650563.0x000001

Effects of albuminuria‐lowering treatments on inflammation markers: A post hoc analysis from the ROTATE trials

Authors: Sen, Taha, Curovic, Viktor Rotbain, Jongs, Niels, Laverman, Gozewijn D., Kooy, Adriaan, Persson, Frederik, Rossing, Peter, Heerspink, Hiddo J. L.

Source: Diabetes, obesity & metabolism. 25(8):2413-2418

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186344789.0x000001&indx=1&recIds=ETOCvdc_100186344789.0x000001

Diuretic medication and change in fluid retention biomarkers during treatment with the endothelin receptor antagonist atrasentan

Authors: Smeijer, J. David, Kohan, Donald E., Zeeuw, Dick, Heerspink, Hiddo J. L.

Source: Diabetes, obesity & metabolism. 25(8):2419-2422

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186344791.0x000001&indx=1&recIds=ETOCvdc_100186344791.0x000001

Change in Albuminuria and GFR Slope as Joint Surrogate End Points for Kidney Failure: Implications for Phase 2 Clinical Trials in CKD

Authors: Heerspink, Hiddo J. L., Inker, Lesley A., Tighiouart, Hocine, Collier, Willem H., Haaland, Benjamin, Luo, Jiyu, Appel, Gerald B., Chan, Tak Mao, Estacio, Raymond O., Fervenza, Fernando

Source: Journal of the American Society of Nephrology. 34(6):955-968

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN632479589&indx=1&recIds=ETOCRN632479589

Safety, tolerability, pharmacodynamics and pharmacokinetics of the soluble guanylyl cyclase activator BI 685509 in patients with diabetic kidney disease: A randomized trial

Authors: Cherney, David Z. I., Zeeuw, Dick, Heerspink, Hiddo J. L., Cardona, Jose, Desch, Marc, Wenz, Arne, Schulze, Friedrich, Nangaku, Masaomi

Source: Diabetes, obesity & metabolism. 25(8):2218-2226

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186344764.0x000001&indx=1&recIds=ETOCvdc_100186344764.0x000001

The sodium‐glucose cotransporter‐2 inhibitor canagliflozin does not increase risk of non‐genital skin and soft tissue infections in people with type 2 diabetes mellitus: A pooled post hoc analysis from the CANVAS Program and CREDENCE randomized double‐blind trials

Authors: Kang, Amy, Smyth, Brendan, Neuen, Brendon L., Heerspink, Hiddo J. L., Di Tanna, Gian Luca, Zhang, Hong, Arnott, Clare, Hockham, Carinna, Agarwal, Rajiv, Bakris, George, Charytan, David M., Zeeuw, Dick, Greene, Tom, Levin, Adeera, Pollock, Carol, Wheeler, David C., Mahaffey, Kenneth W., Perkovic, Vlado, Jardine, Meg J.

Source: Diabetes, obesity & metabolism. 25(8):2151-2162

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186344754.0x000001&indx=1&recIds=ETOCvdc_100186344754.0x000001

Feasibility Study to Assess Canagliflozin Distribution and Sodium‐Glucose Co‐Transporter 2 Occupancy Using [18F]Canagliflozin in Patients with Type 2 Diabetes

Authors: Hoek, Sjoukje, Willemsen, Antoon T. M., Visser, Ton, Heeres, Andre, Mulder, Douwe J., Bokkers, Reinoud P. H., Slart, Riemer H. J. A., Elsinga, Philip H., Heerspink, Hiddo J. L., Stevens, Jasper

Source: Clinical pharmacology & therapeutics. 113(6):1295-1303

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185318192.0x000001&indx=1&recIds=ETOCvdc_100185318192.0x000001

Albuminuria‐lowering effect of dapagliflozin, exenatide, and their combination in patients with type 2 diabetes: A randomized cross‐over clinical study

Authors: Aart‐van der Beek, Annemarie B., Apperloo, Ellen, Jongs, Niels, Rouw, Dennis B., Sjöström, C. David, Friedli, Iris, Johansson, Lars, Raalte, Daniël H., Hoogenberg, Klaas, Heerspink, Hiddo J. L.

Source: Diabetes, obesity & metabolism. 25(6):1758-1768

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181082521.0x000001&indx=1&recIds=ETOCvdc_100181082521.0x000001

The importance of targeting multiple risk markers in patients with type 2 diabetes: A post‐hoc study from the CANVAS programme

Authors: Tye, SokCin, Oshima, Megumi, Arnott, Clare, Neuen, Brendon L., Fletcher, Robert A., Neal, Bruce, Heerspink, Hiddo J. L.

Source: Diabetes, obesity & metabolism. 25(6):1638-1645

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181082351.0x000001&indx=1&recIds=ETOCvdc_100181082351.0x000001

Effects of canagliflozin on liver steatosis and fibrosis markers in patients with type 2 diabetes and chronic kidney disease: A post hoc analysis of the CREDENCE trial

Authors: Koshino, Akihiko, Oshima, Megumi, Arnott, Clare, Fletcher, Robert A., Bakris, George L., Jardine, Meg, Mahaffey, Kenneth W., Perkovic, Vlado, Pollock, Carol, Heerspink, Hiddo J. L., Neuen, Brendon L.

Source: Diabetes, obesity & metabolism. 25(5):1413-1418

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178753074.0x000001&indx=1&recIds=ETOCvdc_100178753074.0x000001

Endothelin receptor antagonists in kidney protection for diabetic kidney disease and beyond?

Authors: Chung, Edmund Y. M., Badve, Sunil V., Heerspink, Hiddo J. L., Wong, Muh Geot

Source: Nephrology. 28(2):97-108

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100177405457.0x000001&indx=1&recIds=ETOCvdc_100177405457.0x000001

Mechanisms underlying the blood pressure‐lowering effects of empagliflozin, losartan and their combination in people with type 2 diabetes: A secondary analysis of a randomized crossover trial

Authors: Scholtes, Rosalie A., Mosterd, Charlotte M., Hesp, Anne C., Smits, Mark M., Heerspink, Hiddo J. L., Raalte, Daniël H.

Source: Diabetes, obesity & metabolism. 25(1):198-207

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100172967144.0x000001&indx=1&recIds=ETOCvdc_100172967144.0x000001

Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial

Authors: Abbasciano, Isabella, Abrantes, Catarina, Accarino, Simone, Adler, Sharon, Adoberg, Annika, Afsari, Rouzbeh, Ahmad, Syeda, Ahmed, Jafar, Ahn, Wooin, Ajayi, Bamidele, Aksamit, Dariusz, Al Chalabi, Saif, Alamartine, Eric, Alchi, Bassam, Ali, Mohammad, Aliotta, Roberta, Almaani, Salem, Almeida, Catarina, Almeida, Edgar, Alvarez, Francisco de la Prada, Alves, Patricia, Annese, Francesca, Appel, Gerald, Arduan, Alberto Ortiz, Arena, Maria, Arevalo, Marta Calvo, Arfaania, Dariush, Arias, Carlos, Aristoy, Emma Calatayud, Asakiene, Egle, Ashley, Sarah, Assefi, Ali, Atenza, Alba, Auerbach, Asta, Augustyniak-Bartosik, Hanna, Avella, Monroy, Ayling-Smith, Jonathan, Ayoub, Isabelle, Ayvazyan, Christine, Baccaro, Rocco, Bailey, Asha, Baker, Bruce, Balamuthusamy, Saravanan, Ballarin, Jose, Barata, Rui, Barbic, Jerko, Barisic, Dunja, Barratt, Jonathan, Barreto, Jose Carlos de Jesus, Barrios, Clara, Belingheri, Mirco, Benesova, Anna, Bernabeu, Ana Avila, Bernhardt, Wanja, Bhadra, Shamik, Biancone, Luigi, Blanchard, Anne, Boaglio, Elena, Bolignano, Davide, Bomback, Andrew, Bonilla, Gustavo Andres Useche, Bordoli, Monica, Bose, Bhadran, Boudville, Neil, Brandon, Donald, Brown, Karen, Broyet, Christian, Bucknall, Thomas, Buffet, Alexandre, Bumblyte', Inga Arune, Burdese, Manuel, Burgos, Natalia Allende, Burguet, Laure, Burtey, Stephane, Busch, Martin, Cakiroglu, Figen, Campbell, Victoria, Canetta, Pietro, Capaccio, Flavia, Carbonell, Juan, Cardoso, Filipa, Carro, Clara Garcia, Carroll, Robert, Carron, Pierre-Louis, Carullo, Nazareno, Cassia, Matthias, Caster, Dawn, Castillo, Belen Vizcaino, Catucci, Davide, Cavalli, Andrea, Chae, Dong-Wan, Chakera, Aron, Chan, Doris, Chan, Gary Chi Wang, Chan, Anthony Ting Pong, Chan, Lai Wan, Chang, Jae Hyun, Chang, Ming-Shan, Chapman, Fiona, Charytan, Chaim, Chaudhry, Asghar, Cheetham, Melissa, Chen, Cheng-Hsu, Chen, Hsin-Yu, Chen, Chien-Liang, Chen, Hung-Yuan, Chen, Hung-Chun, Chenine, Leila, Cheung, Siu Fai, Cheung, Chee Kay, Chiche-Jourde, Noemie, Chiu, Hsien-Fu, Chiu, Yen-Ling, Chiu, Yi-Wen, Chiu, Ian, Choi, Hoon Young, Chou, Kang-Ju, Chowdhury, Paramit, Chowdhury, Pradip, Chrysochou, Constantina, Chukwu, Chukwuma, Chun, Ka Yeong, Chung, Wookyung, Cieniawski, Dominik, Claisse, Guillaume, Clayton, Philip, Cleary, Catalina Martín, Clement, Nisha, Coates, Toby, Cogno, Chiara, Colla, Loredana, Collins, Michael, Colucci, Marco, Combe, Christian, Comi, Nicolino, Comunale, Roderick, Contreras, Gabriel, Cooper, Bruce, Coppock, Gaia, Costa, Ana Cortesão, Costanzi, Stefano, Cozzolino, Mario, Crail, Susan, Cunha, Liliana, Curry, Elizabeth, Dai, Tiane, Daina, Erica, Daneshvari, Sam, Dasgupta, Indranil, DaSilva, Louise, Davidson, Robert, De Bhailis, Aine Maire, de Précigout, Valérie, Decupere, Marc, Delmas, Yahsou, Deodato, Francesca, Dhaun, Neeraj, Dhaygude, Ajay, Dhelaria, Ranjit, Di Maio, Federica, Diezhandino, Maria Angeles Goicoechea, Dika, Zivka, Dinic, Miriana, Dittmer, Ian, Dobre, Mirela, Doctor, Gabriel, Donati, Gabriele, Doubel, Peter, Douthit, Nicole, Draganova, Diliana, Drexler, Yelena, Drinkovic, Martin, Drinovska, Klara, Dudreuilh, Caroline, Dumond, Clement, Durlen, Ivan, Dussol, Bertrand, Encarnacion, Montserrat Diaz, Endre, Zoltan, Enrique, Jorge, Eqbal, Yusuf, Erlich, Jonathan, Esposito, Vittoria, Esposito, Ciro, Fakih, Faisal, Fang, Hua-Chang, Farinha, Ana, Fearday, Aaron, Felgueiras, Joana de Sousa Soares, Felicjanczuk, Elzbieta, Fernandes, João Carlos, Fernandes, Sara, Fernandes, Adriana, Fernandez, Jose Luño, Fernandez, Victor, Fernando, Mangalee, Figueiredo, Ana Carolina, Firre, Eric, Floege, Jürgen, Flossmann, Oliver, Floyd, Lauren, Fonseca, Nuno, Fonseca, Jose Nuno de Almeida Agapito, Foote, Celine, Forbes, Suzanne, Forcen, Angel, Fornoni, Alessia, Fouassier, David, Fraser, Ian, Fung, Ka Shun Samuel, Furlano, Monica, Furtado, Teresa, Gadh, Rajdeep, Gaisset, Roxane, Gallagher, Martin, Gameiro, Joana, Gangadharan, Muralikrishna, Garcia, Fabiola Alonso, Garcia, Olga Gracia, Garg, Gunjan, Garrouste, Cyril, Gautam, Archana, Geara, Abdallah, Geddes, Colin, Gellineo, Lana, Germain, Michael, Gesualdo, Loreto, Ghalli, Farid, Giaroni, Francesco, Giles, Harold, Gillies, Alastair, Gimeno, Ana Vilar, Girardet, Annette, Glaze, Jeffrey, Goh, Tze, Gois, Mario, Goldsmith, Christopher, Goma, Elena, Gomes, Ana Marta, Goncalves, Luis Pedro Falcao, Goncalves, Sara, Gontarek-Kacprzak, Julita, Gonzalez, Carlos, Gopu, Arun, Gowda, Nayan, Gray, Nicholas, Greco, Barbara, Green, Heather, Greze, Clarisse, Griffin, Sian, Guldris, Secundino Cigarran, Guzman, Ursula Verdalles, Ha, Jeffrey Tsun Kit, Hall, Amanda, Hamilton, Patrick, Han, Seung Hyeok, Haws, Robert, Hayat, Ashik, Heath, Lauren, Heinrichs, Sven, Henderson, Andrew, Henderson, Amy, Hendren, Elizabeth, Heng, Anne-Elisabeth, Heres, Salia Virxinia Pol, Herfurth, Johann Konstantin, Herrero, Evangelina Merida, Ho, Tzung-Yo, Hogan, Jonathan, Hohenstein, Bernd, Hollett, Peter, Horvatic, Ivica, Hsu, Bang-Gee, Hsu, Chia-Tien, Hsu, Chih-Yang, Hsu, Shih-Ping, Huang, Chien-Wei, Hudson, Amy, Hung, Chi-Chih, Hwang, Shang-Jyh, Hwang, Daw-Yang, Hyun, Young Youl, Ilmoja, Madis, Irish, Georgina, Jacob, Radu, Jahan, Sadia, Jain, Arunima, Jamar, Sofie, Jander, Anna, Jang, Hye Ryoun, Janko, Catherine, Jardine, Meg, Jaskowski, Piotr, Jeantet, Guillaume, Jelakovic, Bojan, Jeon, Junseok, Jeong, Jong Cheol, Jesudason, Shilpanjali, Jittirat, Arksarapuk, Jo, Sang-Kyung, Jones, Rachel, Joo, Narae, Jorge, Sofia, Julian, Bruce, Jung, JiYong, Jyothinagaram, Praveena, Kadakia, Jigar, Kamal, Fahameedah, Kanigicherla, Durga, Karanovic, Sandra, Karras, Alexandre, Kasimatis, Theodoros, Kassem, Mohamad, Kattamanchi, Siddhartha, Keller, Christopher, Kentric, Dubravka Trajbar, Kettner, Christiane, Khalil, Kassem, Kim, Dana, Kim, Se Joong, Kim, Yeong Hoon, Kim, Yunmi, Kim, Hyung Wook, Kim, Sunggyun, Kim, Jwa-Kyung, Kim, Aejin, Kim, Myung-Gyu, Kimber, Cassandra, Klamm, Kathryn, Koch, Annegret, Koester, Eric, Kolvald, Kulli, Kon, Sui, Kooienga, Laura Ann, Kotwal, Sradha, Krajewska, Magdalena, Kratka, Karolina, Krishnan, Anoushka, Krishnasamy, Rathika, Krueger, Thilo, Kruljac, Ivan, Kulka, Simone, Kunzendorf, Ulrich, Kuo, Mei-Chuan, Kuo, Hung-Tien, Kuo, Sheng, Kwan, Lorraine Pui Yuen, Kwella, Norbert, Kwella, Bogna, Kyaw, Kay, Labat, Aurore, Lafayette, Richard, Lagatta, Mark, Lam, Chi Kwan Darwin, Lambie, Mark, Lanaret, Camille, Latif, Farah, Laute, Margo, Law, Wai Ping, Lawman, Sarah, Lazo, Mercedes Salgueira, Lee, Hajeong, Lee, Moon Hyoung, Lee, Kyu-Beck, Lee, Hyung-seok, Lee, JungEun, Lee, Hyun Hee, Lee, Po-Tsang, Leis, Liisi, Lemahieu, Wim, Leung, Janson, Li, Yan, Lie, Davina Ngoi Wah, Lifland, Howard, Lilienthal, Kadri, Lim, Wai, Limardo, Monica, Livrozet, Marine, Longhi, Selena, Lopes, Daniela, Lopes, Jose Antonio, Lorde, Nathan, Luxton, Grant, Ma, Mingyao, Madhrira, Machaiah, Madonia, Phillip, Maes, Bart, Mahadevan, Kumaradevan, Mahdi, Amar, Mahdi, Eamon, Maillard, Nicolas, Maixnerova, Dita, Majstorovic Barac, Karolina, Malecki, Robert, Malfait, Thomas, Malvica, Silvia, Mandayam, Sreedhar, Manley, Paul, Mansfield, Nick, Marcantoni, Carmelita, Mariat, Christophe, Marin, Tamara Malek, Marin, Lida Maria Rodas, Mark, Patrick, Marques, Joana, Martinez, Eduardo Gutierrez, Martinez, Stacy, Masset, Catherine, Masson, Ingrid, Mather, Amanda, Maung Myint, Thida Maung, Mayet, Valentin, McCafferty, Kieran, McCarthy, Ellen, McDonald, Stephen, McGreal, Kerri, McMahon, Kellyn, McNally, Andrew, McQuarrie, Emily, Medina, Allyson, Meeus, Gert, Mehta, Kshama, Mendoza, Elder, Menezes, Maria, Meng, Jerry, Messa, Piergiorgio, Messias, Ana, Miarka, Przemyslaw, Miglinas, Marius, Mikacic, Ivana, Mikhail, Ashraf, Milicevic, Martina, Minasian, Raffi, Moeller, Marcus, Mohey, Hesham, Mojarrab, Javad, Mok, Maggie Ming Yee, Moncasi, Eduardo Parra, Moonen, Martial, Morales, Wenceslao Adrian Aguilera, Moreno, Eduardo Verde, Moreno, Antolina, Morris, Adam, Moutzouris, Dimitrios, Moya, Mercedes Gonzalez, Mucha, Simon, Musolino, Michela, Napodano, Pietro, Natario, Ana, Negrea, Lavinia, Nelson, Bradley, Neuen, Brendon, Newsome, Britt, Ng, Kit Chung Jack, Nguyen, Thu, Nguyen, Viet, Nicolo, Clementine, Nitschke, Martin, Noble, Euan, Nolasco, Fernando, O'Lone, Emma, Ochoa, Adriana Sierra, Oh, Kook-Hwan, Oh, SeWon, Okoh, Pedro, Ombelet, Sara, O'Shaughnessy, Michelle, Ou, Shih-Hsiang, Packham, David, Padiyar, Aparna, Pai, Mei-Fen, Pamplona, Irene Agraz, Pan, Szu-Yu, Pandya, Bhavna, Papadia, Federica, Pardinhas, Clara, Parikh, Nishita, Parikh, Samir, Park, Hyeong Cheon, Park, Jung Tak, Parreira, Lucia, Passerini, Patrizia, Patak, Ramachandra, Patecki, Margret, Patel, Rajan, Patel, Jusmin, Patel Suthar, Meera, Patella, Gemma, Patrikyan, Artashes, Pavlovic, Drasko, Paxton, William, Peh, Chen, Peleg, Yonatan, Pelicano, Josep Miquel Blasco, Peng, Yu-Sen, Pereira de Vicente, Manuel, Perez, Jonay Pantoja, Perez, Erika, Perez de Jose, Ana, Pérez Gómez, María Vanessa, Perez Lluna, Leticia, Peri, Usha, Perico, Norberto, Philipponnet, Carole, Phua, Elaine, Piel, Julia, Pillai, Unnikrishnan, Pilmore, Helen, Plavljanic, Djuro, Plaza, Mercedes Velo, Pollock, Carol, Ponnusamy, Arvind, Ponti, Serena, Powell, Thomas, Pradhan, Nishigandha, Prado, Raul Fernandez, Prkacin, Ingrid, Pruthi, Rishi, Pugh, Dan, Quinn, Sarah, Quintana, Luis F, Raakesh, Lathika, Rabindranath, Kannaiyan, Radermacher, Luc, Radhakrishnan, Jai, Ragy, Omar Sherin Ibrahim, Raichoudhury, Ritesh, Raimundo, Mario, Randone, Paolo, Razavian, Mona, Reichel, Helmut, Reis, Marina, Remuzzi, Giuseppe, Reynolds, Annie, Ricchiuto, Anna, Rico, Ivon Maritza Bobadilla, Rigothier, Claire, Ritchie, Angus, Rivero, Maria Antonieta Azancot, Rizk, Dana, Ro, Han, Rodriguez, Alfred, Rodriguez Garcia, Eva, Roger, Simon, Rony, Mohammad, Rosenberg, Mai, Roueff, Stephane, Rovin, Brad, Roxburgh, Sarah, Ruiz, Mario, Rusinol, Helena Marco, Rychlik, Ivan, Sá, Helena, Salehi, Tania, Sánchez de la Nieta, Maria Dolores, Sanden, Silja, Santockiene, Lina, Santos, Patricia Valerio, Santos, Iara Da Silva, Sargsyan, Mari, Sarnow, Franziska, Sat, Sebahat, Satora, Ewa, Savuk, Ana, Sayer, Matthew, Schlieper, Georg, Schlosser, Mandy, Schmidt-Guertler, Hans, Schockaert, Olivier, Schulte, Kevin, Schulz, Lisa, Selvaskandan, Haresh, Semple, David, Sen, Shaundeep, Seppet, Elviira, Serrano, Antonio Galan, Serre, Jean-Emmanuel, Sevillano, Angel, Shah, Sapna, Shen, Yvonne, Sheridan, Brittany, Shu, Kai-Hsiang, Sightler, Ford, Silva, Sónia, Silva, Arnold, Sinha, Smeeta, Siriwardana, Amanda, Sitas, Zvonimir, Sivo, Carmen, Sizeland, Peter, Sly, Cathylee, Smith, Priscilla, Snow, Brian, Soares, Elsa Sofia Quadrado, Solazzo, Andrea, Solis, Elena Gutierrez, Solomon, Laurence, Song, Young Rim, Sousa, Helena, Spinowitz, Bruce, Stallworthy, Elizabeth, Stamellou, Eleni, Stanczyk, Malgorzata, Stangenberg, Stefanie, Stankovic, Marija, Stankuviene, Asta, Stea, Emma Diletta, Stompor, Tomasz, Storrar, Joshua, Sullivan, James, Sulowicz, Wladyslaw, Suyumova, Irina, Szeto, Cheuk Chun, Tamarit, Esther, Tan, Eddie, Tan, May, Tang, Sydney Chi Wai, Tang, Hon, Teixeira, Catarina, Telling, Kadri, Terrades, Natalia Ramos, Tesar, Vladimir, Tez, Didem, Thervet, Eric, Thibaudin, Damien, Thomas, Mark, Thyagarajan, Nikhil, Tkaczyk, Marcin, Torreggiani, Massimo, Trillini, Matias, Tsai, Shang-Feng, Tsai, Wan-Chuan, Tsai, Jer-Chia, Tseng, Po-Yu, Tumlin, James, Tung, Kuei-Ting, Turnbull, Angus, Udani, Suneel, Uhlinova, Jana, Unt, Kristin, Urciuolo, Federica, Vanacker, An, Vandewiele, Bert, Vaz, Alvaro, Veermae, Kristi, Viaene, Liesbeth, Vickiene, Alvita, Vigano, Sara, Vila, Maria Antonia Munar, Vilayur, Eswari, Villanueva, Caridad Martinez, Villarroya, Cristina Medrano, Villen, Alejandro Soria, Viramontes, Veronica, Vita, Caterina, Vujcic, Dunja, Wahba, Mona, Wan, Susan, Wang, Chih-Hsien, Warling, Xavier, Waters, Gerald, Waugh, Jane, Weiland, Lea, Weiner, Stefan, Weinreich, Thomas, Werth, Stephan Christian, Wickens, Olivia, Wijeratne, Vidu, Wilder, Karen, Willcocks, Lisa, Williams, Allister, Winiarska, Agata, Wirtz, Nikolaus, Wolf, Lothar, Wolf, Gunter, Wong, Muh Geot, Wong, Yick Hei, Wong, Sze Ho Sunny, Workeneh, Biruh, Wu, Ming-Ju, Wu, Hon-Yen, Wyndham, Roger, Yang, Jihyun, Yang, Ju-Yeh, Yeap, Chii, Yim, Ka Fai, Yong, Kenneth, Yoo, Tae-Hyun, Yoon, Songuk, Yu, Tung-Min, Yue, Tak Tai Andrew, Zakari, Michel, Zakauskiene, Urte, Zaoui, Philippe, Zbrzezniak, Justyna, Zielinska, Dorota, Zizzi, Carlotta Federica, Rovin, Brad H ^{*, *}, Heerspink, Hiddo J L, Alpers, Charles E, Bieler, Stewart, Diva, Ulysses A, Inrig, Jula K, Kohan, Donald E, Komers, Radko, Małecki, Robert, Mercer, Alex, Noronha, Irene L, Oh, Se Won, Peh, Chen Au, Praga, Manuel, Preciado, Priscila, Rheault, Michelle N, Rote, William E, Tang, Sydney C W, Trachtman, Howard, Trimarchi, Hernán, Tumlin, James A, Perkovic, Vlado

Source: In The Lancet 2-8 December 2023 402(10417):2077-2090

Zibotentan in combination with dapagliflozin compared with dapagliflozin in patients with chronic kidney disease (ZENITH-CKD): a multicentre, randomised, active-controlled, phase 2b, clinical trial

Authors: Heerspink, Hiddo J L ^*, Kiyosue, Arihiro, Wheeler, David C, Lin, Min, Wijkmark, Emma, Carlson, Glenn, Mercier, Anne-Kristina, Åstrand, Magnus, Ueckert, Sebastian, Greasley, Peter J, Ambery, Phil

Source: In The Lancet 25 November-1 December 2023 402(10416):2004-2017

Participation rate and yield of two home-based screening methods to detect increased albuminuria in the general population in the Netherlands (THOMAS): a prospective, randomised, open-label implementation study

Authors: van Mil, Dominique, Kieneker, Lyanne M, Evers-Roeten, Birgitte, Thelen, Marc H M, de Vries, Hanne, Hemmelder, Marc H, Dorgelo, Annemiek, van Etten, Ronald W, Heerspink, Hiddo J L, Gansevoort, Ron T ^*

Source: In The Lancet 23-29 September 2023 402(10407):1052-1064