Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with Wnt pathway dysregulation

Authors: Mohammad Alhashmi, Abdulrahman M. E. Gremida, Santosh K. Maharana, Marco Antonaci, Amy Kerr, Shijian Fu, Sharna Lunn, David A. Turner, Noor A. Al-Maslamani, Ke Liu, Maria M. Meschis, Hazel Sutherland, Peter Wilson, Peter Clegg, Grant N. Wheeler, Robert J. van ‘t Hof, George Bou-Gharios, Kazuhiro Yamamoto

Source: Bone Research, Vol 13, Iss 1, Pp 1-17 (2025)

Subject Terms: Biology (General), QH301-705.5, Physiology, QP1-981

File Description: electronic resource

Relation: https://doaj.org/toc/2095-6231

Access URL: https://doaj.org/article/2259694d1ffe43dfad518550b97013a1

Metabolomic studies in the inborn error of metabolism alkaptonuria reveal new biotransformations in tyrosine metabolism

Authors: Brendan P. Norman, Andrew S. Davison, Juliette H. Hughes, Hazel Sutherland, Peter JM. Wilson, Neil G. Berry, Andrew T. Hughes, Anna M. Milan, Jonathan C. Jarvis, Norman B. Roberts, Lakshminarayan R. Ranganath, George Bou-Gharios, James A. Gallagher

Source: Genes and Diseases, Vol 9, Iss 4, Pp 1129-1142 (2022)

Subject Terms: Alkaptonuria, Biotransformation, Metabolism, Metabolomics, Mice, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352304221000271; https://doaj.org/toc/2352-3042

Access URL: https://doaj.org/article/957bdcfaa6bb4d9d97d9bf338e2f3358

Comprehensive Biotransformation Analysis of Phenylalanine-Tyrosine Metabolism Reveals Alternative Routes of Metabolite Clearance in Nitisinone-Treated Alkaptonuria

Authors: Brendan P. Norman, Andrew S. Davison, Bryony Hickton, Gordon A. Ross, Anna M. Milan, Andrew T. Hughes, Peter J. M. Wilson, Hazel Sutherland, Juliette H. Hughes, Norman B. Roberts, George Bou-Gharios, James A. Gallagher, Lakshminarayan R. Ranganath

Source: Metabolites, Vol 12, Iss 10, p 927 (2022)

Subject Terms: alkaptonuria, hypertyrosinaemia, biotransformations, detoxification, metabolomics, Microbiology, QR1-502

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Relation: https://www.mdpi.com/2218-1989/12/10/927; https://doaj.org/toc/2218-1989

Access URL: https://doaj.org/article/e39b7f67a9a743138b22b940540aaf21

Impact of Nitisinone on the Cerebrospinal Fluid Metabolome of a Murine Model of Alkaptonuria

Authors: Andrew S. Davison, Brendan P. Norman, Hazel Sutherland, Anna M. Milan, James A. Gallagher, Jonathan C. Jarvis, Lakshminarayan R. Ranganath

Source: Metabolites, Vol 12, Iss 6, p 477 (2022)

Subject Terms: Alkaptonuria, hypertyrosinaemia, neurotransmitters, cognitive function, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-1989/12/6/477; https://doaj.org/toc/2218-1989

Access URL: https://doaj.org/article/c33bb1c7d4f54f3a80a4b8bfe25f1bed

SpillOver stimulation: A novel hypertrophy model using co-contraction of the plantar-flexors to load the tibial anterior muscle in rats.

Authors: Martin Schmoll, Ewald Unger, Hazel Sutherland, Michael Haller, Manfred Bijak, Hermann Lanmüller, Jonathan Charles Jarvis

Source: PLoS ONE, Vol 13, Iss 11, p e0207886 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC6245836?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/f66499ff8fda4ebc83c47abc0fe1d68c

Fractional Synthesis Rates of Individual Proteins in Rat Soleus and Plantaris Muscles

Authors: Connor A. Stead, Stuart J. Hesketh, Samuel Bennett, Hazel Sutherland, Jonathan C. Jarvis, Paulo J. Lisboa, Jatin G. Burniston

Source: Proteomes, Vol 8, Iss 2, p 10 (2020)

Subject Terms: deuterium oxide, fractional synthesis rate, stable isotope labelling, skeletal muscle, protein synthesis, protein turnover, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2227-7382/8/2/10; https://doaj.org/toc/2227-7382

Access URL: https://doaj.org/article/ed55ab1f0762467bb0a290f36d0bbf6d

On the Rate of Synthesis of Individual Proteins within and between Different Striated Muscles of the Rat

Authors: Stuart Hesketh, Kanchana Srisawat, Hazel Sutherland, Jonathan Jarvis, Jatin Burniston

Source: Proteomes, Vol 4, Iss 1, p 12 (2016)

Subject Terms: deuterium oxide, stable isotope labelling, mass isotopomer distribution analysis, matrix-assisted laser desorption ionisation mass spectrometry, 2D gel electrophoresis, skeletal muscle, cardiac muscle, protein synthesis, Microbiology, QR1-502

File Description: electronic resource

Relation: http://www.mdpi.com/2227-7382/4/1/12; https://doaj.org/toc/2227-7382

Access URL: https://doaj.org/article/f0a848788a3f43049d542ddf87b841fa

Effects of chronic electrical stimulation on long-term denervated muscles of the rabbit hind limb.

Authors: Zoe Ashley, Stanley Salmons, Simona Boncompagni, Feliciano Protasi, Hermann Lanmuller, Winfried Mayr, Hazel Sutherland, Jonathan Jarvis

Source: Journal of Muscle Research & Cell Motility; Apr2007, Vol. 28 Issue 4/5, p203-217, 15p