Risk factors for head and neck cancer in more and less developed countries: Analysis from the INHANCE consortium

Authors: Goyal, Neerav, Hennessy, Max, Lehman, Erik, Lin, Wenxue, Agudo, Antonio, Ahrens, Wolfgang, Boccia, Stefania, Brennan, Paul, Brenner, Hermann, Cadoni, Gabriella, Canova, Cristina, Chen, Chu, Conway, David, Curado, Maria Paula, Dal Maso, Luigino, Daudt, Alexander W., Edefonti, Valeria, Fabianova, Eleonora, Fernandez, Leticia, Franceschi, Silvia, Garavello, Werner, Gillison, Maura, Hayes, Richard B., Healy, Claire, Herrero, Rolando, Holcatova, Ivana, Kanda, Jossy L., Kelsey, Karl, Hansen, Bo T., Koifman, Rosalina, Lagiou, Pagona, La Vecchia, Carlo, Levi, Fabio, Li, Guojun, Lissowska, Jolanta, Mendoza López, Rossana, Luce, Danièle, Macfarlane, Gary, Mates, Dana, Matsuo, Keitaro, McClean, Michael, Menezes, Ana, Menvielle, Gwenn, Morgenstern, Hal, Moysich, Kirsten, Negri, Eva, Olshan, Andrew F., Pandics, Tamas, Polesel, Jerry, Purdue, Mark, Radoi, Loredana, Ramroth, Heribert, Richiardi, Lorenzo, Schantz, Stimson, Schwartz, Stephen M., Serraino, Diego, Shangina, Oxana, Smith, Elaine, Sturgis, Erich M., Świątkowska, Beata, Thomson, Peter, Vaughan, Thomas L., Vilensky, Marta, Winn, Deborah M., Wunsch‐Filho, Victor, Yu, Guo‐Pei, Zevallos, Jose P., Zhang, Zuo‐Feng, Zheng, Tongzhang, Znaor, Ariana, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan‐Chin A., Muscat, Joshua E.

Source: Oral diseases. 29(4):1565-1578

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182102070.0x000001&indx=1&recIds=ETOCvdc_100182102070.0x000001

PM2.5 and cardiovascular diseases: State-of-the-Art review

Authors: Krittanawong, Chayakrit, Qadeer, Yusuf Kamran, Hayes, Richard B., Wang, Zhen, Thurston, George D., Virani, Salim, Lavie, Carl J.

Source: In International Journal of Cardiology Cardiovascular Risk and Prevention December 2023 19

Risk-Stratified Screening for Colorectal Cancer Using Genetic and Environmental Risk Factors: A Cost-Effectiveness Analysis Based on Real-World Data

Authors: van den Puttelaar, Rosita, Meester, Reinier G.S., Peterse, Elisabeth F.P., Zauber, Ann G., Zheng, Jiayin, Hayes, Richard B., Su, Yu-Ru, Lee, Jeffrey K., Thomas, Minta, Sakoda, Lori C., Li, Yi, Corley, Douglas A., Peters, Ulrike, Hsu, Li, Lansdorp-Vogelaar, Iris

Source: In Clinical Gastroenterology and Hepatology December 2023 21(13):3415-3423

Noise Exposure and Cardiovascular Health

Authors: Krittanawong, Chayakrit, Qadeer, Yusuf Kamran, Hayes, Richard B., Wang, Zhen, Virani, Salim, Zeller, Marianne, Dadvand, Payam, Lavie, Carl J.

Source: In Current Problems in Cardiology December 2023 48(12)

A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer

Authors: Hunter, David J, Kraft, Peter, Jacobs, Kevin B, Cox, David G, Yeager, Meredith, Hankinson, Susan E, Wacholder, Sholom, Wang, Zhaoming, Welch, Robert, Hutchinson, Amy, Wang, Junwen, Yu, Kai, Chatterjee, Nilanjan, Orr, Nick, Willett, Walter C, Colditz, Graham A, Ziegler, Regina G, Berg, Christine D, Buys, Saundra S, McCarty, Catherine A, Feigelson, Heather Spencer, Calle, Eugenia E, Thun, Michael J, Hayes, Richard B, Tucker, Margaret, Gerhard, Daniela S, Fraumeni, Joseph F, Jr, Hoover, Robert N, Thomas, Gilles, Chanock, Stephen J

Source: Hunter, David J and Kraft, Peter and Jacobs, Kevin B and Cox, David G and Yeager, Meredith and Hankinson, Susan E and Wacholder, Sholom and Wang, Zhaoming and Welch, Robert and Hutchinson, Amy and Wang, Junwen and Yu, Kai and Chatterjee, Nilanjan and Orr, Nick and Willett, Walter C and Colditz, Graham A and Ziegler, Regina G and Berg, Christine D and Buys, Saundra S and McCarty, Catherine A and Feigelson, Heather Spencer and Calle, Eugenia E and Thun, Michael J and Hayes, Richard B and Tucker, Margaret and Gerhard, Daniela S and Fraumeni, Joseph F, Jr and Hoover, Robert N and Thomas, Gilles and Chanock, Stephen J (2007) A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nature Genetics, 39. pp. 870-874.

Relation: http://www.nature.com/ng/journal/v39/n7/full/ng2075.html; http://health-equity.pitt.edu/706/

Nonlinear low dose hematotoxicity of benzene; a pooled analyses of two studies among Chinese exposed workers

Authors: Vermeulen, Roel, Lan, Qing, Qu, Qingshan, Linet, Martha S., Zhang, Luoping, Li, Guilan, Portengen, Lutzen, Vlaanderen, Jelle, Sungkyoon, Kim, Hayes, Richard B., Yin, Songnian, Smith, Martyn T., Rappaport, Stephen M., Rothman, Nathaniel

Source: In Environment International July 2023 177

PM2.5 and Cardiovascular Health Risks

Authors: Krittanawong, Chayakrit, Qadeer, Yusuf Kamran, Hayes, Richard B., Wang, Zhen, Virani, Salim, Thurston, George D., Lavie, Carl J.

Source: In Current Problems in Cardiology June 2023 48(6)

Alu Retroelement Copy Number and Lung Cancer Risk in the Prospective Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

Authors: Wong, Jason Y.Y., Cawthon, Richard, Hu, Wei, Ezennia, Somayina, Gadalla, Shahinaz M., Breeze, Charles, Blechter, Batel, Freedman, Neal D., Huang, Wen-Yi, Hosgood, H. Dean, Seow, Wei Jie, Bassig, Bryan A., Rahman, Mohammad L., Hayes, Richard B., Rothman, Nathaniel, Lan, Qing

Source: Chest. 162(4):942-945

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100175110023.0x000001&indx=1&recIds=ETOCvdc_100175110023.0x000001

Tooth count, untreated caries and mortality in US adults: a population-based cohort study

Authors: Liu, Jie, Zong, Xiaoyu, Vogtmann, Emily, Cao, Chao, James, Aimee S, Chan, Andrew T, Rimm, Eric B, Hayes, Richard B, Colditz, Graham A, Michaud, Dominique S, Joshipura, Kaumudi J, Abnet, Christian C, Cao, Yin

Source: International journal of epidemiology. 51(4):1291-1303

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100163723807.0x000001&indx=1&recIds=ETOCvdc_100163723807.0x000001

Risk Stratification for Early-Onset Colorectal Cancer Using a Combination of Genetic and Environmental Risk Scores: An International Multi-Center Study

Authors: Archambault, Alexi N, Jeon, Jihyoun, Lin, Yi, Thomas, Minta, Harrison, Tabitha A, Bishop, D Timothy, Brenner, Hermann, Casey, Graham, Chan, Andrew T, Chang-Claude, Jenny, Figueiredo, Jane C, Gallinger, Steven, Gruber, Stephen B, Gunter, Marc J, Guo, Feng, Hoffmeister, Michael, Jenkins, Mark A, Keku, Temitope O, Le Marchand, Loïc, Li, Li, Moreno, Victor, Newcomb, Polly A, Pai, Rish, Parfrey, Patrick S, Rennert, Gad, Sakoda, Lori C, Lee, Jeffrey K, Slattery, Martha L, Song, Mingyang, Win, Aung Ko, Woods, Michael O, Murphy, Neil, Campbell, Peter T, Su, Yu-Ru, Lansdorp-Vogelaar, Iris, Peterse, Elisabeth F P, Cao, Yin, Zeleniuch-Jacquotte, Anne, Liang, Peter S, Du, Mengmeng, Corley, Douglas A, Hsu, Li, Peters, Ulrike, Hayes, Richard B

Source: Journal of the National Cancer Institute. 114(4):528-539

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100148831718.0x000001&indx=1&recIds=ETOCvdc_100148831718.0x000001

Evaluation of a commercial database to estimate residence histories in the los angeles ultrafines study

Authors: Medgyesi, Danielle N., Fisher, Jared A., Flory, Abigail R., Hayes, Richard B., Thurston, George D., Liao, Linda M., Ward, Mary H., Silverman, Debra T., Jones, Rena R.

Source: In Environmental Research June 2021 197

Identifying Novel Susceptibility Genes for Colorectal Cancer Risk From a Transcriptome-Wide Association Study of 125,478 Subjects

Authors: Guo, Xingyi, Lin, Weiqiang, Wen, Wanqing, Huyghe, Jeroen, Bien, Stephanie, Cai, Qiuyin, Harrison, Tabitha, Chen, Zhishan, Qu, Conghui, Bao, Jiandong, Long, Jirong, Yuan, Yuan, Wang, Fangqin, Bai, Mengqiu, Abecasis, Goncalo R., Albanes, Demetrius, Berndt, Sonja I., Bézieau, Stéphane, Bishop, D. Timothy, Brenner, Hermann, Buch, Stephan, Burnett-Hartman, Andrea, Campbell, Peter T., Castellví-Bel, Sergi, Chan, Andrew T., Chang-Claude, Jenny, Chanock, Stephen J., Cho, Sang Hee, Conti, David V., Chapelle, Albert de la, Feskens, Edith J.M., Gallinger, Steven J., Giles, Graham G., Goodman, Phyllis J., Gsur, Andrea, Guinter, Mark, Gunter, Marc J., Hampe, Jochen, Hampel, Heather, Hayes, Richard B., Hoffmeister, Michael, Kampman, Ellen, Kang, Hyun Min, Keku, Temitope O., Kim, Hyeong Rok, Le Marchand, Loic, Lee, Soo Chin, Li, Christopher I., Li, Li, Lindblom, Annika, Lindor, Noralane, Milne, Roger L., Moreno, Victor, Murphy, Neil, Newcomb, Polly A., Nickerson, Deborah A., Offit, Kenneth, Pearlman, Rachel, Pharoah, Paul D.P., Platz, Elizabeth A., Potter, John D., Rennert, Gad, Sakoda, Lori C., Schafmayer, Clemens, Schmit, Stephanie L., Schoen, Robert E., Schumacher, Fredrick R., Slattery, Martha L., Su, Yu-Ru, Tangen, Catherine M., Ulrich, Cornelia M., van Duijnhoven, Franzel J.B., Van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Wang, Xiaoliang, White, Emily, Wolk, Alicja, Woods, Michael O., Casey, Graham, Hsu, Li, Jenkins, Mark A., Gruber, Stephen B., Peters, Ulrike, Zheng, Wei

Source: In Gastroenterology March 2021 160(4):1164-1178

Environmental Influences on the Human Microbiome and Implications for Noncommunicable Disease

Authors: Ahn, Jiyoung, Hayes, Richard B.

Source: Annual review of public health. 42:277-292

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN626773483&indx=1&recIds=ETOCRN626773483

Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer

Authors: Bravi, Francesca, Lee, Yuan‐Chin Amy, Hashibe, Mia, Boffetta, Paolo, Conway, David I., Ferraroni, Monica, La Vecchia, Carlo, Edefonti, Valeria, Agudo, Antonio, Ahrens, Wolfgang, Benhamou, Simone, Boccia, Stefania, Brennan, Paul, Brenner, Hermann, Cadoni, Gabriella, Canova, Cristina, Chen, Chu, Chuang, Shu‐Chun, Curado, Maria Paula, Dal Maso, Luigino, Daudt, Alexander W, D'Souza, Gypsyamber, Fabianova, Eleonora, Fernandez, Leticia, Franceschi, Silvia, Garavello, Werner, Gillison, Maura, Gross, Neil D, Hayes, Richard B, Healy, Claire, Herrero, Rolando, Holcatova, Ivana, Kelsey, Karl, Kjaerheim, Kristina, Koifman, Rosalina, Lagiou, Pagona, Lazarus, Philip, Levi, Fabio, Li, Guojun, Lissowska, Jolanta, Luce, Daniele, Macfarlane, Gary J, Mates, Dana, Matsuo, Keitaro, McClean, Michael, Menezes, Ana, Menvielle, Gwenn, Morgenstern, Hal, Moyses, Raquel A, Moysich, Kirsten, Muscat, Joshua, Negri, Eva, Olshan, Andrew F, Pandics, Tamas, Polesel, Jerry, Purdue, Mark P, Radoï, Loredana, Ramroth, Heribert, Richiardi, Lorenzo, Schantz, Stimson, Schwartz, Stephen M, Serraino, Diego, Shangina, Oxana, Smith, Elaine, Sturgis, Erich M, Świątkowska, Beata, Thomson, Peter, Toporcov, Tatiana N, Vaughan, Thomas L, Vilensky, Marta, Winn, Deborah M, Wunsch‐Filho, Victor, Yu, Guo‐Pei, Zevallos, Jose P, Zhang, Zuo‐Feng, Zheng, Tongzhang, Znaor, Ariana

Source: Oral diseases. 27(1):73-93

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100119338958.0x000001&indx=1&recIds=ETOCvdc_100119338958.0x000001

Oral Microbiome and Subsequent Risk of Head and Neck Squamous Cell Cancer.

Authors: Kwak, Soyoung, Wang, Chan, Usyk, Mykhaylo, Wu, Feng, Freedman, Neal D., Huang, Wen-Yi, McCullough, Marjorie L., Um, Caroline Y., Shrubsole, Martha J., Cai, Qiuyin, Li, Huilin, Ahn, Jiyoung, Hayes, Richard B.

Source: JAMA Oncology; Nov2024, Vol. 10 Issue 11, p1537-1547, 11p

Risk Factors Associated With Early-Onset Colorectal Cancer

Authors: Gausman, Valerie, Dornblaser, David, Anand, Sanya, Hayes, Richard B., O'Connell, Kelli, Du, Mengmeng, Liang, Peter S.

Source: In Clinical Gastroenterology and Hepatology November 2020 18(12):2752-2759

Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk

Authors: Thomas, Minta, Sakoda, Lori C., Hoffmeister, Michael, Rosenthal, Elisabeth A., Lee, Jeffrey K., van Duijnhoven, Franzel J.B., Platz, Elizabeth A., Wu, Anna H., Dampier, Christopher H., de la Chapelle, Albert, Wolk, Alicja, Joshi, Amit D., Burnett-Hartman, Andrea, Gsur, Andrea, Lindblom, Annika, Castells, Antoni, Win, Aung Ko, Namjou, Bahram, Van Guelpen, Bethany, Tangen, Catherine M., He, Qianchuan, Li, Christopher I., Schafmayer, Clemens, Joshu, Corinne E., Ulrich, Cornelia M., Bishop, D. Timothy, Buchanan, Daniel D., Schaid, Daniel, Drew, David A., Muller, David C., Duggan, David, Crosslin, David R., Albanes, Demetrius, Giovannucci, Edward L., Larson, Eric, Qu, Flora, Mentch, Frank, Giles, Graham G., Hakonarson, Hakon, Hampel, Heather, Stanaway, Ian B., Figueiredo, Jane C., Huyghe, Jeroen R., Minnier, Jessica, Chang-Claude, Jenny, Hampe, Jochen, Harley, John B., Visvanathan, Kala, Curtis, Keith R., Offit, Kenneth, Li, Li, Le Marchand, Loic, Vodickova, Ludmila, Gunter, Marc J., Jenkins, Mark A., Slattery, Martha L., Lemire, Mathieu, Woods, Michael O., Song, Mingyang, Murphy, Neil, Lindor, Noralane M., Dikilitas, Ozan, Pharoah, Paul D.P., Campbell, Peter T., Newcomb, Polly A., Milne, Roger L., MacInnis, Robert J., Castellví-Bel, Sergi, Ogino, Shuji, Berndt, Sonja I., Bézieau, Stéphane, Thibodeau, Stephen N., Gallinger, Steven J., Zaidi, Syed H., Harrison, Tabitha A., Keku, Temitope O., Hudson, Thomas J., Vymetalkova, Veronika, Moreno, Victor, Martín, Vicente, Arndt, Volker, Wei, Wei-Qi, Chung, Wendy, Su, Yu-Ru, Hayes, Richard B., White, Emily, Vodicka, Pavel, Casey, Graham, Gruber, Stephen B., Schoen, Robert E., Chan, Andrew T., Potter, John D., Brenner, Hermann, Jarvik, Gail P., Corley, Douglas A., Peters, Ulrike, Hsu, Li

Source: In The American Journal of Human Genetics 3 September 2020 107(3):432-444

Cumulative Burden of Colorectal Cancer–Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer

Authors: Archambault, Alexi N., Su, Yu-Ru, Jeon, Jihyoun, Thomas, Minta, Lin, Yi, Conti, David V., Win, Aung Ko, Sakoda, Lori C., Lansdorp-Vogelaar, Iris, Peterse, Elisabeth F.P., Zauber, Ann G., Duggan, David, Holowatyj, Andreana N., Huyghe, Jeroen R., Brenner, Hermann, Cotterchio, Michelle, Bézieau, Stéphane, Schmit, Stephanie L., Edlund, Christopher K., Southey, Melissa C., MacInnis, Robert J., Campbell, Peter T., Chang-Claude, Jenny, Slattery, Martha L., Chan, Andrew T., Joshi, Amit D., Song, Mingyang, Cao, Yin, Woods, Michael O., White, Emily, Weinstein, Stephanie J., Ulrich, Cornelia M., Hoffmeister, Michael, Bien, Stephanie A., Harrison, Tabitha A., Hampe, Jochen, Li, Christopher I., Schafmayer, Clemens, Offit, Kenneth, Pharoah, Paul D., Moreno, Victor, Lindblom, Annika, Wolk, Alicja, Wu, Anna H., Li, Li, Gunter, Marc J., Gsur, Andrea, Keku, Temitope O., Pearlman, Rachel, Bishop, D. Timothy, Castellví-Bel, Sergi, Moreira, Leticia, Vodicka, Pavel, Kampman, Ellen, Giles, Graham G., Albanes, Demetrius, Baron, John A., Berndt, Sonja I., Brezina, Stefanie, Buch, Stephan, Buchanan, Daniel D., Trichopoulou, Antonia, Severi, Gianluca, Chirlaque, María-Dolores, Sánchez, Maria-José, Palli, Domenico, Kühn, Tilman, Murphy, Neil, Cross, Amanda J., Burnett-Hartman, Andrea N., Chanock, Stephen J., de la Chapelle, Albert, Easton, Douglas F., Elliott, Faye, English, Dallas R., Feskens, Edith J.M., FitzGerald, Liesel M., Goodman, Phyllis J., Hopper, John L., Hudson, Thomas J., Hunter, David J., Jacobs, Eric J., Joshu, Corinne E., Küry, Sébastien, Markowitz, Sanford D., Milne, Roger L., Platz, Elizabeth A., Rennert, Gad, Rennert, Hedy S., Schumacher, Fredrick R., Sandler, Robert S., Seminara, Daniela, Tangen, Catherine M., Thibodeau, Stephen N., Toland, Amanda E., van Duijnhoven, Franzel J.B., Visvanathan, Kala, Vodickova, Ludmila, Potter, John D., Männistö, Satu, Weigl, Korbinian, Figueiredo, Jane, Martín, Vicente, Larsson, Susanna C., Parfrey, Patrick S., Huang, Wen-Yi, Lenz, Heinz-Josef, Castelao, Jose E., Gago-Dominguez, Manuela, Muñoz-Garzón, Victor, Mancao, Christoph, Haiman, Christopher A., Wilkens, Lynne R., Siegel, Erin, Barry, Elizabeth, Younghusband, Ban, Van Guelpen, Bethany, Harlid, Sophia, Zeleniuch-Jacquotte, Anne, Liang, Peter S., Du, Mengmeng, Casey, Graham, Lindor, Noralane M., Le Marchand, Loic, Gallinger, Steven J., Jenkins, Mark A., Newcomb, Polly A., Gruber, Stephen B., Schoen, Robert E., Hampel, Heather, Corley, Douglas A., Hsu, Li, Peters, Ulrike, Hayes, Richard B.

Source: In Gastroenterology April 2020 158(5):1274-1286

Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE)

Authors: Chang, Chun-Pin, Chang, Shen-Chih, Chuang, Shu-Chun, Berthiller, Julien, Ferro, Gilles, Matsuo, Keitaro, Wünsch-Filho, Victor, Toporcov, Tatiana N., de Carvalho, Marcos Brasilino, La Vecchia, Carlo, Olshan, Andrew F., Zevallos, Jose P., Serraino, Diego, Muscat, Joshua, Sturgis, Erich M., Li, Guojun, Morgenstern, Hal, Levi, Fabio, Dal Maso, Luigino, Smith, Elaine, Kelsey, Karl, McClean, Michael, Vaughan, Thomas L., Lazarus, Philip, Ramroth, Heribert, Chen, Chu, Schwartz, Stephen M., Winn, Deborah M., Bosetti, Cristina, Edefonti, Valeria, Garavello, Werner, Negri, Eva, Hayes, Richard B., Purdue, Mark P., Boccia, Stefania, Cadoni, Gabriella, Shangina, Oxana, Koifman, Rosalina, Curado, Maria Paula, Vilensky, Marta, Swiatkowska, Beata, Herrero, Rolando, Franceschi, Silvia, Benhamou, Simone, Fernandez, Leticia, Menezes, Ana M.B., Daudt, Alexander W., Mates, Dana, Schantz, Stimson, Yu, Guo-Pei, Lissowska, Jolanta, Brenner, Hermann, Fabianova, Eleonora, Rudnai, Peter, Brennan, Paul, Boffetta, Paolo, Zhang, Zuo-Feng, Hashibe, Mia, Lee, Yuan-Chin Amy

Source: In Cancer Epidemiology December 2019 63

Association Between Intake of Red and Processed Meat and Survival in Patients With Colorectal Cancer in a Pooled Analysis

Authors: Carr, Prudence R., Banbury, Barbara L., Berndt, Sonja I., Campbell, Peter T., Chang-Claude, Jenny, Hayes, Richard B., Howard, Barbara V., Jansen, Lina, Jacobs, Eric J., Lane, Dorothy S., Nishihara, Reiko, Ogino, Shuji, Phipps, Amanda I., Slattery, Martha L., Stefanick, Marcia L., Wallace, Robert, Walter, Viola, White, Emily, Wu, Kana, Peters, Ulrike, Chan, Andrew T., Newcomb, Polly A., Brenner, Hermann, Hoffmeister, Michael

Source: In Clinical Gastroenterology and Hepatology July 2019 17(8):1561-1570