A pathologist's guide for the diagnostic workup of paediatric central nervous system tumours

Authors: D'Arcy, Colleen E. ¹, Hawkins, Cynthia E. ^{2, ⁎}

Source: In Pathology March 2025 57(2):157-170

Molecular markers for pediatric low-grade glioma.

Authors: Levine, Adrian B.^1,2,3 (AUTHOR), Hawkins, Cynthia E.^1,2,3 (AUTHOR) Cynthia.hawkins@sickkids.ca

Source: Child's Nervous System. Oct2024, Vol. 40 Issue 10, p3223-3228. 6p.

Subject Terms: *TUMOR suppressor genes, *ASTROCYTOMAS, *NEUROFIBROMATOSIS, *GLIOMAS, *BRAF genes

Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma

Authors: Nobre, Liana, Zapotocky, Michal, Khan, Sara, Fukuoka, Kohei, Fonseca, Adriana, McKeown, Tara, Sumerauer, David, Vicha, Ales, Grajkowska, Wieslawa A., Trubicka, Joanna, Li, Kay Ka Wai, Ng, Ho-Keung, Massimi, Luca, Lee, Ji Yeoun, Kim, Seung-Ki, Zelcer, Shayna, Vasiljevic, Alexandre, Faure-Conter, Cécile, Hauser, Peter, Lach, Boleslaw, van Veelen-Vincent, Marie-Lise, French, Pim J., Van Meir, Erwin G., Weiss, William A., Gupta, Nalin, Pollack, Ian F., Hamilton, Ronald L., Nageswara Rao, Amulya A., Giannini, Caterina, Rubin, Joshua B., Moore, Andrew S., Chambless, Lola B., Vibhakar, Rajeev, Ra, Young Shin, Massimino, Maura, McLendon, Roger E., Wheeler, Helen, Zollo, Massimo, Ferruci, Veronica, Kumabe, Toshihiro, Faria, Claudia C., Sterba, Jaroslav, Jung, Shin, López-Aguilar, Enrique, Mora, Jaume, Carlotti, Carlos G., Olson, James M., Leary, Sarah, Cain, Jason, Krskova, Lenka, Zamecnik, Josef, Hawkins, Cynthia E., Tabori, Uri, Huang, Annie, Bartels, Ute, Northcott, Paul A., Taylor, Michael D., Yip, Stephen, Hansford, Jordan R., Bouffet, Eric, Ramaswamy, Vijay

Source: In Cell Reports Medicine 23 June 2020 1(3)

A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases

Authors: Garzia, Livia, Kijima, Noriyuki, Morrissy, A. Sorana, De Antonellis, Pasqualino, Guerreiro-Stucklin, Ana, Holgado, Borja L., Wu, Xiaochong, Wang, Xin, Parsons, Michael, Zayne, Kory, Manno, Alex, Kuzan-Fischer, Claudia, Nor, Carolina, Donovan, Laura K., Liu, Jessica, Qin, Lei, Garancher, Alexandra, Liu, Kun-Wei, Mansouri, Sheila, Luu, Betty, Thompson, Yuan Yao, Ramaswamy, Vijay, Peacock, John, Farooq, Hamza, Skowron, Patryk, Shih, David J.H., Li, Angela, Ensan, Sherine, Robbins, Clinton S., Cybulsky, Myron, Mitra, Siddhartha, Ma, Yussanne, Moore, Richard, Mungall, Andy, Cho, Yoon-Jae, Weiss, William A., Chan, Jennifer A., Hawkins, Cynthia E., Massimino, Maura, Jabado, Nada, Zapotocky, Michal, Sumerauer, David, Bouffet, Eric, Dirks, Peter, Tabori, Uri, Sorensen, Poul H.B., Brastianos, Priscilla K., Aldape, Kenneth, Jones, Steven J.M., Marra, Marco A., Woodgett, James R., Wechsler-Reya, Robert J., Fults, Daniel W., Taylor, Michael D.

Source: In Cell 22 February 2018 172(5):1050-1062

Intertumoral Heterogeneity within Medulloblastoma Subgroups

Authors: Cavalli, Florence M.G., Remke, Marc, Rampasek, Ladislav, Peacock, John, Shih, David J.H., Luu, Betty, Garzia, Livia, Torchia, Jonathon, Nor, Carolina, Morrissy, A. Sorana, Agnihotri, Sameer, Thompson, Yuan Yao, Kuzan-Fischer, Claudia M., Farooq, Hamza, Isaev, Keren, Daniels, Craig, Cho, Byung-Kyu, Kim, Seung-Ki, Wang, Kyu-Chang, Lee, Ji Yeoun, Grajkowska, Wieslawa A., Perek-Polnik, Marta, Vasiljevic, Alexandre, Faure-Conter, Cecile, Jouvet, Anne, Giannini, Caterina, Nageswara Rao, Amulya A., Li, Kay Ka Wai, Ng, Ho-Keung, Eberhart, Charles G., Pollack, Ian F., Hamilton, Ronald L., Gillespie, G. Yancey, Olson, James M., Leary, Sarah, Weiss, William A., Lach, Boleslaw, Chambless, Lola B., Thompson, Reid C., Cooper, Michael K., Vibhakar, Rajeev, Hauser, Peter, van Veelen, Marie-Lise C., Kros, Johan M., French, Pim J., Ra, Young Shin, Kumabe, Toshihiro, López-Aguilar, Enrique, Zitterbart, Karel, Sterba, Jaroslav, Finocchiaro, Gaetano, Massimino, Maura, Van Meir, Erwin G., Osuka, Satoru, Shofuda, Tomoko, Klekner, Almos, Zollo, Massimo, Leonard, Jeffrey R., Rubin, Joshua B., Jabado, Nada, Albrecht, Steffen, Mora, Jaume, Van Meter, Timothy E., Jung, Shin, Moore, Andrew S., Hallahan, Andrew R., Chan, Jennifer A., Tirapelli, Daniela P.C., Carlotti, Carlos G., Fouladi, Maryam, Pimentel, José, Faria, Claudia C., Saad, Ali G., Massimi, Luca, Liau, Linda M., Wheeler, Helen, Nakamura, Hideo, Elbabaa, Samer K., Perezpeña-Diazconti, Mario, Chico Ponce de León, Fernando, Robinson, Shenandoah, Zapotocky, Michal, Lassaletta, Alvaro, Huang, Annie, Hawkins, Cynthia E., Tabori, Uri, Bouffet, Eric, Bartels, Ute, Dirks, Peter B., Rutka, James T., Bader, Gary D., Reimand, Jüri, Goldenberg, Anna, Ramaswamy, Vijay, Taylor, Michael D.

Source: In Cancer Cell 12 June 2017 31(6):737-754

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors

Authors: Torchia, Jonathon, Golbourn, Brian, Feng, Shengrui, Ho, King Ching, Sin-Chan, Patrick, Vasiljevic, Alexandre, Norman, Joseph D., Guilhamon, Paul, Garzia, Livia, Agamez, Natalia R., Lu, Mei, Chan, Tiffany S., Picard, Daniel, de Antonellis, Pasqualino, Khuong-Quang, Dong-Anh, Planello, Aline C., Zeller, Constanze, Barsyte-Lovejoy, Dalia, Lafay-Cousin, Lucie, Letourneau, Louis, Bourgey, Mathieu, Yu, Man, Gendoo, Deena M.A., Dzamba, Misko, Barszczyk, Mark, Medina, Tiago, Riemenschneider, Alexandra N., Morrissy, A. Sorana, Ra, Young-Shin, Ramaswamy, Vijay, Remke, Marc, Dunham, Christopher P., Yip, Stephen, Ng, Ho-keung, Lu, Jian-Qiang, Mehta, Vivek, Albrecht, Steffen, Pimentel, Jose, Chan, Jennifer A., Somers, Gino R., Faria, Claudia C., Roque, Lucia, Fouladi, Maryam, Hoffman, Lindsey M., Moore, Andrew S., Wang, Yin, Choi, Seung Ah, Hansford, Jordan R., Catchpoole, Daniel, Birks, Diane K., Foreman, Nicholas K., Strother, Doug, Klekner, Almos, Bognár, Laszló, Garami, Miklós, Hauser, Péter, Hortobágyi, Tibor, Wilson, Beverly, Hukin, Juliette, Carret, Anne-Sophie, Van Meter, Timothy E., Hwang, Eugene I., Gajjar, Amar, Chiou, Shih-Hwa, Nakamura, Hideo, Toledano, Helen, Fried, Iris, Fults, Daniel, Wataya, Takafumi, Fryer, Chris, Eisenstat, David D., Scheinemann, Katrin, Fleming, Adam J., Johnston, Donna L., Michaud, Jean, Zelcer, Shayna, Hammond, Robert, Afzal, Samina, Ramsay, David A., Sirachainan, Nongnuch, Hongeng, Suradej, Larbcharoensub, Noppadol, Grundy, Richard G., Lulla, Rishi R., Fangusaro, Jason R., Druker, Harriet, Bartels, Ute, Grant, Ronald, Malkin, David, McGlade, C. Jane, Nicolaides, Theodore, Tihan, Tarik, Phillips, Joanna, Majewski, Jacek, Montpetit, Alexandre, Bourque, Guillaume, Bader, Gary D., Reddy, Alyssa T., Gillespie, G. Yancey, Warmuth-Metz, Monika, Rutkowski, Stefan, Tabori, Uri, Lupien, Mathieu, Brudno, Michael, Schüller, Ulrich, Pietsch, Torsten, Judkins, Alexander R., Hawkins, Cynthia E., Bouffet, Eric, Kim, Seung-Ki, Dirks, Peter B., Taylor, Michael D., Erdreich-Epstein, Anat, Arrowsmith, Cheryl H., De Carvalho, Daniel D., Rutka, James T., Jabado, Nada, Huang, Annie

Source: In Cancer Cell 12 December 2016 30(6):891-908

Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis

Authors: Thompson, Eric M ^*, Hielscher, Thomas ^*, Bouffet, Eric, Remke, Marc, Luu, Betty, Gururangan, Sridharan, McLendon, Roger E, Bigner, Darell D, Lipp, Eric S, Perreault, Sebastien, Cho, Yoon-Jae, Grant, Gerald, Kim, Seung-Ki, Lee, Ji Yeoun, Rao, Amulya A Nageswara, Giannini, Caterina, Li, Kay Ka Wai, Ng, Ho-Keung, Yao, Yu, Kumabe, Toshihiro, Tominaga, Teiji, Grajkowska, Wieslawa A, Perek-Polnik, Marta, Low, David C Y, Seow, Wan Tew, Chang, Kenneth T E, Mora, Jaume, Pollack, Ian F, Hamilton, Ronald L, Leary, Sarah, Moore, Andrew S, Ingram, Wendy J, Hallahan, Andrew R, Jouvet, Anne, Fèvre-Montange, Michelle, Vasiljevic, Alexandre, Faure-Conter, Cecile, Shofuda, Tomoko, Kagawa, Naoki, Hashimoto, Naoya, Jabado, Nada, Weil, Alexander G, Gayden, Tenzin, Wataya, Takafumi, Shalaby, Tarek, Grotzer, Michael, Zitterbart, Karel, Sterba, Jaroslav, Kren, Leos, Hortobágyi, Tibor, Klekner, Almos, László, Bognár, Pócza, Tímea, Hauser, Peter, Schüller, Ulrich, Jung, Shin, Jang, Woo-Youl, French, Pim J, Kros, Johan M, van Veelen, Marie-Lise C, Massimi, Luca, Leonard, Jeffrey R, Rubin, Joshua B, Vibhakar, Rajeev, Chambless, Lola B, Cooper, Michael K, Thompson, Reid C, Faria, Claudia C, Carvalho, Alice, Nunes, Sofia, Pimentel, José, Fan, Xing, Muraszko, Karin M, López-Aguilar, Enrique, Lyden, David, Garzia, Livia, Shih, David J H, Kijima, Noriyuki, Schneider, Christian, Adamski, Jennifer, Northcott, Paul A, Kool, Marcel, Jones, David T W, Chan, Jennifer A, Nikolic, Ana, Garre, Maria Luisa, Van Meir, Erwin G, Osuka, Satoru, Olson, Jeffrey J, Jahangiri, Arman, Castro, Brandyn A, Gupta, Nalin, Weiss, William A, Moxon-Emre, Iska, Mabbott, Donald J, Lassaletta, Alvaro, Hawkins, Cynthia E, Tabori, Uri, Drake, James, Kulkarni, Abhaya, Dirks, Peter, Rutka, James T, Korshunov, Andrey, Pfister, Stefan M, Packer, Roger J, Ramaswamy, Vijay, Taylor, Michael D ^*

Source: In The Lancet Oncology April 2016 17(4):484-495

Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis

Authors: Torchia, Jonathon, Picard, Daniel, Lafay-Cousin, Lucie, Hawkins, Cynthia E, Kim, Seung-Ki, Letourneau, Louis, Ra, Young-Shin, Ho, King Ching, Chan, Tiffany Sin Yu, Sin-Chan, Patrick, Dunham, Christopher P, Yip, Stephen, Ng, Ho-keung, Lu, Jian-Qiang, Albrecht, Steffen, Pimentel, José, Chan, Jennifer A, Somers, Gino R, Zielenska, Maria, Faria, Claudia C, Roque, Lucia, Baskin, Berivan, Birks, Diane, Foreman, Nick, Strother, Douglas, Klekner, Almos, Garami, Miklos, Hauser, Peter, Hortobágyi, Tibor, Bognár, Laszló, Wilson, Beverly, Hukin, Juliette, Carret, Anne-Sophie, Van Meter, Timothy E, Nakamura, Hideo, Toledano, Helen, Fried, Iris, Fults, Daniel, Wataya, Takafumi, Fryer, Chris, Eisenstat, David D, Scheineman, Katrin, Johnston, Donna, Michaud, Jean, Zelcer, Shayna, Hammond, Robert, Ramsay, David A, Fleming, Adam J, Lulla, Rishi R, Fangusaro, Jason R, Sirachainan, Nongnuch, Larbcharoensub, Noppadol, Hongeng, Suradej, Barakzai, Muhammad Abrar, Montpetit, Alexandre, Stephens, Derek, Grundy, Richard G, Schüller, Ulrich, Nicolaides, Theodore, Tihan, Tarik, Phillips, Joanna, Taylor, Michael D, Rutka, James T, Dirks, Peter, Bader, Gary D, Warmuth-Metz, Monika, Rutkowski, Stefan, Pietsch, Torsten, Judkins, Alexander R, Jabado, Nada, Bouffet, Eric, Huang, Annie

Source: In The Lancet Oncology May 2015 16(5):569-582

Abnormal megakaryocyte development and platelet function in Nbeal2−/− mice

Authors: Kahr, Walter H.A., Lo, Richard W., Li, Ling, Pluthero, Fred G., Christensen, Hilary, Ni, Ran, Vaezzadeh, Nima, Hawkins, Cynthia E., Weyrich, Andrew S., Di Paola, Jorge, Landolt-Marticorena, Carolina, Gross, Peter L.

Source: In Blood 7 November 2013 122(19):3349-3358

Markers of survival and metastatic potential in childhood CNS primitive neuro-ectodermal brain tumours: an integrative genomic analysis

Authors: Picard, Daniel, Miller, Suzanne, Hawkins, Cynthia E, Bouffet, Eric, Rogers, Hazel A, Chan, Tiffany SY, Kim, Seung-Ki, Ra, Young-Shin, Fangusaro, Jason, Korshunov, Andrey, Toledano, Helen, Nakamura, Hideo, Hayden, James T, Chan, Jennifer, Lafay-Cousin, Lucie, Hu, Pingzhao, Fan, Xing, Muraszko, Karin M, Pomeroy, Scott L, Lau, Ching C, Ng, Ho-Keung, Jones, Chris, Van Meter, Timothy, Clifford, Steven C, Eberhart, Charles, Gajjar, Amar, Pfister, Stefan M, Grundy, Richard G, Huang, Annie

Source: In Lancet Oncology August 2012 13(8):838-848

Multiple CDK/CYCLIND genes are amplified in medulloblastoma and supratentorial primitive neuroectodermal brain tumor

Authors: Li, Meihua, Lockwood, Will, Zielenska, Maria, Northcott, Paul, Ra, Young Shing, Bouffet, Eric, Yoshimoto, Maisa, Rutka, James T., Yan, Hai, Taylor, Michael D., Eberhart, Charles, Hawkins, Cynthia E., Lam, Wan, Squire, Jeremy A., Huang, Annie

Source: In Cancer Genetics May 2012 205(5):220-231

Delineation of Two Clinically and Molecularly Distinct Subgroups of Posterior Fossa Ependymoma

Authors: Witt, Hendrik, Mack, Stephen C., Ryzhova, Marina, Bender, Sebastian, Sill, Martin, Isserlin, Ruth, Benner, Axel, Hielscher, Thomas, Milde, Till, Remke, Marc, Jones, David T.W., Northcott, Paul A., Garzia, Livia, Bertrand, Kelsey C., Wittmann, Andrea, Yao, Yuan, Roberts, Stephen S., Massimi, Luca, Van Meter, Tim, Weiss, William A., Gupta, Nalin, Grajkowska, Wiesia, Lach, Boleslaw, Cho, Yoon-Jae, von Deimling, Andreas, Kulozik, Andreas E., Witt, Olaf, Bader, Gary D., Hawkins, Cynthia E., Tabori, Uri, Guha, Abhijit, Rutka, James T., Lichter, Peter, Korshunov, Andrey, Taylor, Michael D., Pfister, Stefan M.

Source: In Cancer Cell 2011 20(2):143-157

A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor

Authors: Sin-Chan, Patrick, Mumal, Iqra, Suwal, Tannu, Ho, Ben, Fan, Xiaolian, Singh, Irtisha, Du, Yuchen, Lu, Mei, Patel, Neilket, Torchia, Jonathon, Popovski, Dean, Fouladi, Maryam, Guilhamon, Paul, Hansford, Jordan R., Leary, Sarah, Hoffman, Lindsey M., Mulcahy Levy, Jean M., Lassaletta, Alvaro, Solano-Paez, Palma, Rivas, Eloy, Reddy, Alyssa, Gillespie, G. Yancey, Gupta, Nalin, Van Meter, Timothy E., Nakamura, Hideo, Wong, Tai-Tong, Ra, Young-Shin, Kim, Seung-Ki, Massimi, Luca, Grundy, Richard G., Fangusaro, Jason, Johnston, Donna, Chan, Jennifer, Lafay-Cousin, Lucie, Hwang, Eugene I., Wang, Yin, Catchpoole, Daniel, Michaud, Jean, Ellezam, Benjamin, Ramanujachar, Ramya, Lindsay, Holly, Taylor, Michael D., Hawkins, Cynthia E., Bouffet, Eric, Jabado, Nada, Singh, Sheila K., Kleinman, Claudia L., Barsyte-Lovejoy, Dalia, Li, Xiao-Nan, Dirks, Peter B., Lin, Charles Y., Mack, Stephen C., Rich, Jeremy N., Huang, Annie

Source: Cancer cell. 36(1):51-67.e7

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100084897659.0x000001&indx=1&recIds=ETOCvdc_100084897659.0x000001

Cap myopathy caused by a mutation of the skeletal alpha-actin gene ACTA1

Authors: Hung, Ryan M., Yoon, Grace, Hawkins, Cynthia E., Halliday, Willliam, Biggar, Doug, Vajsar, Jiri

Source: In Neuromuscular Disorders 2010 20(4):238-240

Frequent Amplification of a chr19q13.41 MicroRNA Polycistron in Aggressive Primitive Neuroectodermal Brain Tumors

Authors: Li, Meihua, Lee, Kyle F., Lu, Yuntao, Clarke, Ian, Shih, David, Eberhart, Charles, Collins, V. Peter, Van Meter, Tim, Picard, Daniel, Zhou, Limei, Boutros, Paul C., Modena, Piergiorgio, Liang, Muh-Lii, Scherer, Steve W., Bouffet, Eric, Rutka, James T., Pomeroy, Scott L., Lau, Ching C., Taylor, Michael D., Gajjar, Amar, Dirks, Peter B., Hawkins, Cynthia E., Huang, Annie

Source: In Cancer Cell 8 December 2009 16(6):533-546

Telomerase inhibition induces acute ATM-dependent growth arrest in human astrocytomas

Authors: Wong, Vincent C.H., Ma, Jing, Hawkins, Cynthia E.

Source: In Cancer Letters 2009 274(1):151-159

Immunohistochemical and nanoString-Based Subgrouping of Clinical Medulloblastoma Samples.

Authors: D'Arcy, Colleen E, Nobre, Liana Figueiredo, Arnaldo, Anthony, Ramaswamy, Vijay, Taylor, Michael D, Naz-Hazrati, Lili, Hawkins, Cynthia E

Source: Journal of Neuropathology & Experimental Neurology; Apr2020, Vol. 79 Issue 4, p437-447, 11p

This result is not displayed to guests.
Login for full access.

Reply to D.T.W. Jones et al

Authors: Tabori, Uri, Bouffet, Eric, Hawkins, Cynthia E.

Source: Journal of clinical oncology. 36(1):97-97

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN614043827&indx=1&recIds=ETOCRN614043827

This result is not displayed to guests.
Login for full access.