Unveiling the Molecular Features of SCLC With a Clinical RNA Expression Panel

Authors: Ozakinci, Hilal, Alontaga, Aileen Y., Cano, Pedro, Koomen, John M., Perez, Bradford A., Beg, Amer A., Chiappori, Alberto A., Haura, Eric B., Boyle, Theresa A.

Source: In JTO Clinical and Research Reports November 2024 5(11)

Implementation of a High-Accuracy Targeted Gene Expression Panel for Clinical Care

Authors: Alontaga, Aileen Y., Cano, Pedro, Ozakinci, Hilal, Puskas, John A., Stewart, Paul A., Welsh, Eric A., Yoder, Sean J., Hicks, J. Kevin, Saltos, Andreas N., Bossler, Aaron D., Haura, Eric B., Koomen, John M., Boyle, Theresa A.

Source: In The Journal of Molecular Diagnostics August 2024 26(8):685-699

Differential network analysis of ROS1 inhibitors reveals lorlatinib polypharmacology through co-targeting PYK2

Authors: Liao, Yi, Remsing Rix, Lily L., Li, Xueli, Fang, Bin, Izumi, Victoria, Welsh, Eric A., Monastyrskyi, Andrii, Haura, Eric B., Koomen, John M., Doebele, Robert C., Rix, Uwe

Source: In Cell Chemical Biology 15 February 2024 31(2):284-297

Dose-Limiting Pulmonary Toxicity in a Phase 1/2 Study of Radiation and Chemotherapy with Ipilimumab Followed by Nivolumab for Patients With Stage 3 Unresectable Non-Small Cell Lung Cancer

Authors: Liveringhouse, Casey L., Latifi, Kujtim, Asous, Amalin G., Lam, Nghi B., Rosenberg, Stephen A., Dilling, Thomas J., MacMillan, Gretchen V., Chiappori, Alberto A., Haura, Eric B., Creelan, Ben, Gray, Jhanelle E., Tanvetyanon, Tawee, Shafique, Michael R., Saltos, Andreas N., Weiner, Ashley A., Clarke, Jeffrey, Kelsey, Christopher R., Kim, Sungjune, Caudell, James J., Rose, Trevor A., Conejo-Garcia, Jose R., Li, Jiannong, Schell, Michael J., Antonia, Scott J., Perez, Bradford A.

Source: International journal of radiation oncology, biology, physics. 116(4):837-848

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193520500.0x000001&indx=1&recIds=ETOCvdc_100193520500.0x000001

Management of infusion-related reactions (IRRs) in patients receiving amivantamab in the CHRYSALIS study

Authors: Park, Keunchil, Sabari, Joshua K., Haura, Eric B., Shu, Catherine A., Spira, Alexander, Salgia, Ravi, Reckamp, Karen L., Sanborn, Rachel E., Govindan, Ramaswamy, Bauml, Joshua M., Curtin, Joshua C., Xie, John, Roshak, Amy, Lorenzini, Patricia, Millington, Dawn, Thayu, Meena, Knoblauch, Roland E., Cho, Byoung Chul

Source: Lung cancer. 178:166-171

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186488316.0x000001&indx=1&recIds=ETOCvdc_100186488316.0x000001

Chemical Proteomics with Novel Fully Functionalized Fragments and Stringent Target Prioritization Identifies the Glutathione-Dependent Isomerase GSTZ1 as a Lung Cancer Target

Authors: Liao, Yi, Chan, Sean Chin, Welsh, Eric A., Fang, Bin, Sun, Luxin, Schönbrunn, Ernst, Koomen, John M., Duckett, Derek R., Haura, Eric B., Monastyrskyi, Andrii

Source: ACS chemical biology. 18(2):251-264

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A phase I/IB trial of binimetinib in combination with erlotinib in NSCLC harboring activating KRAS or EGFR mutations

Authors: Saltos, Andreas N., Creelan, Ben C., Tanvetyanon, Tawee, Chiappori, Alberto A., Antonia, Scott J., Shafique, Michael R., Ugrenovic-Petrovic, Milijana, Sansil, Samer, Neuger, Anthony, Ozakinci, Hilal, Boyle, Theresa A., Kim, Jongphil, Haura, Eric B., Gray, Jhanelle E.

Source: In Lung Cancer September 2023 183

Poziotinib in Treatment-Naive NSCLC Harboring HER2 Exon 20 Mutations: ZENITH20-4, A Multicenter, Multicohort, Open-Label, Phase 2 Trial (Cohort 4)

Authors: Cornelissen, Robin, Prelaj, Arsela, Sun, Sophie, Baik, Christina, Wollner, Mirjana, Haura, Eric B., Mamdani, Hirva, Riess, Jonathan W., Cappuzzo, Federico, Garassino, Marina C., Heymach, John V., Socinski, Mark A., Leu, Szu-Yun, Bhat, Gajanan, Lebel, Francois, Le, Xiuning

Source: In Journal of Thoracic Oncology August 2023 18(8):1031-1041

Inhibition of Epidermal Growth Factor Receptor Signaling by Antisense Oligonucleotides as a Novel Approach to Epidermal Growth Factor Receptor Inhibition

Authors: Madanayake, Thushara W., Welsh, Eric A., Darville, Lancia N.F., Koomen, John M., Chalfant, Charles E., Haura, Eric B., Robinson, Timothy J.

Source: Nucleic acid therapeutics. 32(5):391-400

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The non-canonical target PARP16 contributes to polypharmacology of the PARP inhibitor talazoparib and its synergy with WEE1 inhibitors

Authors: Palve, Vinayak, Knezevic, Claire E., Bejan, Daniel S., Luo, Yunting, Li, Xueli, Novakova, Silvia, Welsh, Eric A., Fang, Bin, Kinose, Fumi, Haura, Eric B., Monteiro, Alvaro N., Koomen, John M., Cohen, Michael S., Lawrence, Harshani R., Rix, Uwe

Source: In Cell Chemical Biology 17 February 2022 29(2):202-214

The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling

Authors: Mohamed, Eslam, Sierra, Rosa A., Trillo-Tinoco, Jimena, Cao, Yu, Innamarato, Patrick, Payne, Kyle K., de Mingo Pulido, Alvaro, Mandula, Jessica, Zhang, Shuzhong, Thevenot, Paul, Biswas, Subir, Abdalla, Sarah K., Costich, Tara Lee, Hänggi, Kay, Anadon, Carmen M., Flores, Elsa R., Haura, Eric B., Mehrotra, Shikhar, Pilon-Thomas, Shari, Ruffell, Brian, Munn, David H., Cubillos-Ruiz, Juan R., Conejo-Garcia, Jose R., Rodriguez, Paulo C.

Source: In Immunity 14 April 2020 52(4):668-682

Surgical results of the Lung Cancer Mutation Consortium 3 trial: A phase II multicenter single-arm study to investigate the efficacy and safety of atezolizumab as neoadjuvant therapy in patients with stages IB-select IIIB resectable non–small cell lung cancer

Authors: Rusch, Valerie W., Nicholas, Alan, Patterson, G. Alexander, Waqar, Salama N., Toloza, Eric M., Haura, Eric B., Raz, Dan J., Reckamp, Karen L., Merritt, Robert E., Owen, Dwight H., Finley, David J., McNamee, Ciaran J., Blasberg, Justin D., Garon, Edward B., Mitchell, John D., Doebele, Robert C., Baciewicz, Frank, Nagasaka, Misako, Pass, Harvey I., Schulze, Katja, Johnson, Ann, Bunn, Paul A., Johnson, Bruce E., Kris, Mark G., Kwiatkowski, David J., Wistuba, Ignacio I., Chaft, Jamie E., Carbone, David P., Lee, Jay M.

Source: Journal of thoracic and cardiovascular surgery. 165(3):828-839.e5

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Differential Chemoproteomics Reveals MARK2/3 as Cell Migration‐Relevant Targets of the ALK Inhibitor Brigatinib

Authors: Hu, Qianqian, Liao, Yi, Cao, Jessica, Fang, Bin, Yun, Sang Y., Kinose, Fumi, Haura, Eric B., Lawrence, Harshani R., Doebele, Robert C., Koomen, John M., Rix, Uwe

Source: Chembiochem. 24(11)

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Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone

Authors: Torrente, Laura, Prieto-Farigua, Nicolas, Falzone, Aimee, Elkins, Cody M., Boothman, David A., Haura, Eric B., DeNicola, Gina M.

Source: In Redox Biology February 2020 30

Preventing smoking relapse in patients with cancer: A randomized controlled trial

Authors: Simmons, Vani N., Sutton, Steven K., Meltzer, Lauren R., Martinez, Ursula, Palmer, Amanda M., Meade, Cathy D., Jacobsen, Paul B., McCaffrey, Judith C., Haura, Eric B., Brandon, Thomas H.

Source: Cancer. 126(23):5165-5172

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A community‐based lung cancer rapid tissue donation protocol provides high‐quality drug‐resistant specimens for proteogenomic analyses

Authors: Boyle, Theresa A., Quinn, Gwendolyn P., Schabath, Matthew B., Muñoz‐Antonia, Teresita, Saller, James J., Duarte, Luisa F., Hair, Laura S., Teer, Jamie K., Chiang, Derek Y., Leary, Rebecca, Wong, Connie C., Savchenko, Alexander, Singh, Angad P., Charette, LaSalette, Mendell, Kate, Gorgun, Gullu, Antonia, Scott J., Chiappori, Alberto A., Creelan, Benjamin C., Gray, Jhanelle E., Haura, Eric B.

Source: Cancer medicine. 9(1):225-237

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Round Robin Evaluation of MET Protein Expression in Lung Adenocarcinomas Improves Interobserver Concordance

Authors: Boyle, Theresa A., Khalil, Farah K., Mino-Kenudson, Mari, Sica, Gabriel L., Moreira, Andre L., Sholl, Lynette M., Knight, Mirna Z., Zhang, Liping, Saller, James, Varella-Garcia, Marileila, Berry, Lynne D., Chen, Heidi, Ellison, Kim E., Rivard, Christopher J., Kugler, Kelly, Wistuba, Ignacio I., Fujimoto, Junya, Kwiatkowski, David J., Bunn, Paul A., Kris, Mark G., Haura, Eric B., Hirsch, Fred R.

Source: Applied immunohistochemistry & molecular morphology. 28(9):669-677

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Fully Automated Protein Proximity Assay in Formalin-Fixed, Paraffin-Embedded Tissue Using Caged Haptens

Authors: Polaske, Nathan W., Kelly, Brian D., Smith, Matthew A., Haura, Eric B., Belosludtsev, Yuri Y.

Source: Bioconjugate chemistry. 31(6):1635-1640

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GMSimpute: a generalized two-step Lasso approach to impute missing values in label-free mass spectrum analysis

Authors: Li, Qian, Fisher, Kate, Meng, Wenjun, Fang, Bin, Welsh, Eric, Haura, Eric B, Koomen, John M, Eschrich, Steven A, Fridley, Brooke L, Chen, Y Ann

Source: Bioinformatics. 36(1):257-263

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Functional Proteomics and Deep Network Interrogation Reveal a Complex Mechanism of Action of Midostaurin in Lung Cancer Cells

Authors: Ctortecka, Claudia ^‡, Palve, Vinayak ^‡, Kuenzi, Brent M. ^{‡, §}, Fang, Bin ^¶, Sumi, Natalia J. ^{‡, §}, Izumi, Victoria ^¶, Novakova, Silvia ^‡, Kinose, Fumi ^‖, Remsing Rix, Lily L. ^‡, Haura, Eric B. ^‖, Koomen, John Matthew ^**, Rix, Uwe ^{‡, ‡‡}

Source: In Molecular & Cellular Proteomics December 2018 17(12):2434-2447