NUP98 fusion proteins and KMT2A-MENIN antagonize PRC1.1 to drive gene expression in AML

Authors: Heikamp, Emily B. ¹, Martucci, Cynthia ¹, Henrich, Jill A. ², Neel, Dana S. ¹, Mahendra-Rajah, Sanisha ³, Rice, Hannah ¹, Wenge, Daniela V. ¹, Perner, Florian ⁴, Wen, Yanhe ¹, Hatton, Charlie ¹, Armstrong, Scott A. ^{1, 5, ∗}

Source: In Cell Reports 26 November 2024 43(11)

Mezigdomide is effective alone and in combination with menin inhibition in preclinical models of KMT2A-r and NPM1c AML

Authors: Bourgeois, Wallace, Cutler, Jevon A., Aubrey, Brandon J., Wenge, Daniela V., Perner, Florian, Martucci, Cynthia, Henrich, Jill A., Klega, Kelly, Nowak, Radosław P., Donovan, Katherine A., Boileau, Meaghan, Wen, Yanhe, Hatton, Charlie, Apazidis, Athina A., Olsen, Sarah Naomi, Kirmani, Nadia, Pikman, Yana, Pollard, Jessica A., Perry, Jennifer A., Sperling, Adam S., Ebert, Benjamin L., McGeehan, Gerard M., Crompton, Brian D., Fischer, Eric S., Armstrong, Scott A.

Source: In Blood 11 April 2024 143(15):1513-1527

UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability

Authors: Tsai, Jonathan M., Aguirre, Jacob D., Li, Yen-Der, Brown, Jared, Focht, Vivian, Kater, Lukas, Kempf, Georg, Sandoval, Brittany, Schmitt, Stefan, Rutter, Justine C., Galli, Pius, Sandate, Colby R., Cutler, Jevon A., Zou, Charles, Donovan, Katherine A., Lumpkin, Ryan J., Cavadini, Simone, Park, Paul M.C., Sievers, Quinlan, Hatton, Charlie, Ener, Elizabeth, Regalado, Brandon D., Sperling, Micah T., Słabicki, Mikołaj, Kim, Jeonghyeon, Zon, Rebecca, Zhang, Zinan, Miller, Peter G., Belizaire, Roger, Sperling, Adam S., Fischer, Eric S., Irizarry, Rafael, Armstrong, Scott A., Thomä, Nicolas H., Ebert, Benjamin L.

Source: In Molecular Cell 3 August 2023 83(15):2753-2767

Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition

Authors: Ghosh, Srimoyee, Taylor, Alexander, Chin, Melissa, Huang, Hon-Ren, Conery, Andrew R., Mertz, Jennifer A., Salmeron, Andres, Dakle, Pranal J., Mele, Deanna, Cote, Alexandre, Jayaram, Hari, Setser, Jeremy W., Poy, Florence, Hatzivassiliou, Georgia, DeAlmeida-Nagata, Denise, Sandy, Peter, Hatton, Charlie, Romero, F. Anthony, Chiang, Eugene, Reimer, Thornik, Crawford, Terry, Pardo, Eneida, Watson, Venita G., Tsui, Vickie, Cochran, Andrea G., Zawadzke, Laura, Harmange, Jean-Christophe, Audia, James E., Bryant, Barbara M., Cummings, Richard T., Magnuson, Steven R., Grogan, Jane L., Bellon, Steve F., Albrecht, Brian K., Sims, Robert J., III, Lora, Jose M.

Source: In Journal of Biological Chemistry 17 June 2016 291(25):13014-13027

EZH2 Inhibitor Efficacy in Non-Hodgkin’s Lymphoma Does Not Require Suppression of H3K27 Monomethylation

Authors: Bradley, William D., Arora, Shilpi, Busby, Jennifer, Balasubramanian, Srividya, Gehling, Victor S., Nasveschuk, Christopher G., Vaswani, Rishi G., Yuan, Chih-Chi, Hatton, Charlie, Zhao, Feng, Williamson, Kaylyn E., Iyer, Priyadarshini, Méndez, Jacqui, Campbell, Robert, Cantone, Nico, Garapaty-Rao, Shivani, Audia, James E., Cook, Andrew S., Dakin, Les A., Albrecht, Brian K., Harmange, Jean-Christophe, Daniels, Danette L., Cummings, Richard T., Bryant, Barbara M., Normant, Emmanuel, Trojer, Patrick

Source: In Chemistry & Biology 20 November 2014 21(11):1463-1475

Prospective Enterprise-Level Molecular Genotyping of a Cohort of Cancer Patients

Authors: MacConaill, Laura E., Garcia, Elizabeth, Shivdasani, Priyanka, Ducar, Matthew, Adusumilli, Ravali, Breneiser, Marc, Byrne, Mark, Chung, Lawrence, Conneely, Jodie, Crosby, Lauren, Garraway, Levi A., Gong, Xin, Hahn, William C., Hatton, Charlie, Kantoff, Philip W., Kluk, Michael, Kuo, Frank, Jia, Yonghui, Joshi, Ruchi, Longtine, Janina, Manning, Allison, Palescandolo, Emanuele, Sharaf, Nematullah, Sholl, Lynette, van Hummelen, Paul, Wade, Jacqueline, Wollinson, Bruce M., Zepf, Dimity, Rollins, Barrett J., Lindeman, Neal I.

Source: In The Journal of Molecular Diagnostics November 2014 16(6):660-672

Drug-Sensitive FGFR2 Mutations in Endometrial Carcinoma

Authors: Dutt, Amit, Salvesen, Helga B., Chen, Tzu-Hsiu, Ramos, Alex H., Onofrio, Robert C., Hatton, Charlie, Nicoletti, Richard, Winckler, Wendy, Grewal, Rupinder, Hanna, Megan, Wyhs, Nicolas, Ziaugra, Liuda, Richter, Daniel J., Trovik, Jone, Engelsen, Ingeborg B., Stefansson, Ingunn M., Fennell, Tim, Cibulskis, Kristian, Zody, Michael C., Akslen, Lars A., Gabriel, Stacey, Wong, Kwok-Kin, Sellers, William R., Meyerson, Matthew, Greulich, Heidi

Source: Proceedings of the National Academy of Sciences of the United States of America, 2008 Jun . 105(25), 8713-8717.

Access URL: https://www.jstor.org/stable/25462852

High-throughput mutation profiling of CTCL samples reveals KRAS and NRAS mutations sensitizing tumors toward inhibition of the RAS/RAF/MEK signaling cascade

Authors: Kießling, Michael K. ^*, Oberholzer, Patrick A. ^*, Mondal, Chandrani, Karpova, Maria B., Zipser, Marie C., Lin, William M., Girardi, Michael, MacConaill, Laura E., Kehoe, Sarah M., Hatton, Charlie, French, Lars E., Garraway, Levi A., Polier, Gernot, Süss, Dorothee, Klemke, Claus-Detlev, Krammer, Peter H., Gülow, Karsten, Dummer, Reinhard

Source: In Blood 24 February 2011 117(8):2433-2440

Assessing the Significance of Chromosomal Aberrations in Cancer: Methodology and Application to Glioma

Authors: Beroukhim, Rameen, Getz, Gad, Nghiemphu, Leia, Barretina, Jordi, Hsueh, Teli, Linhart, David, Vivanco, Igor, Lee, Jeffrey C., Huang, Julie H., Alexander, Sethu, Du, Jinyan, Kau, Tweeny, Thomas, Roman K., Shah, Kinjal, Soto, Horacio, Perner, Sven, Prensner, John, Debiasi, Ralph M., Demichelis, Francesca, Hatton, Charlie, Rubin, Mark A., Garraway, Levi A., Nelson, Stan F., Liau, Linda, Mischel, Paul S., Cloughesy, Tim F., Meyerson, Matthew, Golub, Todd A., Lander, Eric S., Mellinghoff, Ingo K., Sellers, William R.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2007 Dec 01. 104(50), 20007-20012.

Access URL: https://www.jstor.org/stable/25450832

A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia

Authors: Krivtsov, Andrei V., Evans, Kathryn, Gadrey, Jayant Y., Eschle, Benjamin K., Hatton, Charlie, Uckelmann, Hannah J., Ross, Kenneth N., Perner, Florian, Olsen, Sarah N., Pritchard, Tara, McDermott, Lisa, Jones, Connor D., Jing, Duohui, Braytee, Ali, Chacon, Diego, Earley, Eric, McKeever, Brian M., Claremon, David, Gifford, Andrew J., Lee, Heather J., Teicher, Beverly A., Pimanda, John E., Beck, Dominik, Perry, Jennifer A., Smith, Malcolm A., McGeehan, Gerard M., Lock, Richard B., Armstrong, Scott A.

Source: Cancer cell. 36(6):660-673.e11

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100093950868.0x000001&indx=1&recIds=ETOCvdc_100093950868.0x000001

KDM6A epigenetically regulates subtype plasticity in small cell lung cancer

Authors: Duplaquet, Leslie, Li, Yixiang, Booker, Matthew A., Xie, Yingtian, Olsen, Sarah Naomi, Patel, Radhika A., Hong, Deli, Hatton, Charlie, Denize, Thomas, Walton, Emily, Laimon, Yasmin N., Li, Rong, Jiang, Yijia, Bronson, Roderick T., Southard, Jackson, Li, Shuqiang, Signoretti, Sabina, Qiu, Xintao, Cejas, Paloma, Armstrong, Scott A., Long, Henry W., Tolstorukov, Michael Y., Haffner, Michael C., Oser, Matthew G.

Source: Nature Cell Biology; September 2023, Vol. 25 Issue: 9 p1346-1358, 13p

MEN1 mutations mediate clinical resistance to menin inhibition.

Authors: Perner, Florian, Stein, Eytan M., Wenge, Daniela V., Singh, Sukrit, Kim, Jeonghyeon, Apazidis, Athina, Rahnamoun, Homa, Anand, Disha, Marinaccio, Christian, Hatton, Charlie, Wen, Yanhe, Stone, Richard M., Schaller, David, Mowla, Shoron, Xiao, Wenbin, Gamlen, Holly A., Stonestrom, Aaron J., Persaud, Sonali, Ener, Elizabeth, Cutler, Jevon A.

Source: Nature; Mar2023, Vol. 615 Issue 7954, p913-919, 7p

MEN1mutations mediate clinical resistance to menin inhibition

Authors: Perner, Florian, Stein, Eytan M., Wenge, Daniela V., Singh, Sukrit, Kim, Jeonghyeon, Apazidis, Athina, Rahnamoun, Homa, Anand, Disha, Marinaccio, Christian, Hatton, Charlie, Wen, Yanhe, Stone, Richard M., Schaller, David, Mowla, Shoron, Xiao, Wenbin, Gamlen, Holly A., Stonestrom, Aaron J., Persaud, Sonali, Ener, Elizabeth, Cutler, Jevon A., Doench, John G., McGeehan, Gerard M., Volkamer, Andrea, Chodera, John D., Nowak, Radosław P., Fischer, Eric S., Levine, Ross L., Armstrong, Scott A., Cai, Sheng F.

Source: Nature; 20230101, Issue: Preprints p1-7, 7p

Using UMLS metathesaurus concepts to describe medical images: dermatology vocabulary

Authors: Woods, James W., Sneiderman, Charles A., Hameed, Kamran, Ackerman, Michael J., Hatton, Charlie

Source: In Computers in Biology and Medicine 2006 36(1):89-100

UBR5 Is a Hect E3 Ubiquitin Ligase That Regulates Chromatin Bound Nuclear Hormone Receptor Stability

Authors: Tsai, Jonathan M ^*, Aguirre, Jacob D ^*, Brown, Jared ^*, Focht, Vivian ^*, Li, Yen-Der ^*, Kempf, Georg ^*, Kater, Lukas ^*, Galli, Pius ^*, Cavadini, Simone ^*, Sandoval, Brittany E ^*, Zou, Charles ^*, Rutter, Justine ^*, Donovan, Katherine ^*, Sievers, Quinlan, Park, Paul ^*, Cutler, Jevon A. ^*, Hatton, Charlie ^*, Ener, Elizabeth ^*, Sperling, Micah T ^*, Slabicki, Mikolaj ^*, Miller, Peter G. ^*, Belizaire, Roger, Sperling, Adam S., Armstrong, Scott A., Fischer, Eric S. ^*, Thomä, Nicolas ^*, Ebert, Benjamin L.

Source: In Blood 15 November 2022 140 Supplement 1:2968-2969

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Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway.

Authors: Lovejoy, Courtney A.¹, Li, Wendi¹, Reisenweber, Steven¹, Thongthip, Supawat¹, Bruno, Joanne¹, De Lange, Titia¹, delange@mail.rockfeller.edu, De, Saurav², Petrini, John H. J.², Sung, Patricia A.³, Jasin, Maria³, Rosenbluh, Joseph⁴, Zwang, Yaara^4,5, Weir, Barbara A.⁴, Hatton, Charlie⁵, Ivanova, Elena⁵, Macconaill, Laura⁵, Hanna, Megan⁵, Hahn, William C.^4,5, Lue, Neal F.⁶, Reddel, Roger R.^7,8

Source: PLoS Genetics; Jul2012, Vol. 8 Issue 7, Special section p1-16, 16p, 2 Color Photographs, 1 Chart, 4 Graphs

DNA.

Authors: Hatton, Charlie

Source: Mountain Biking UK; Jan2024, Issue 429, p14-14, 1p, 1 Color Photograph