In vitro toxicological assessment of aerosols from indirectly heated tobacco products using a solvent-free extraction method

Authors: Hashizume, Tsuneo ^⁎, Yamamoto, Haruna, Ito, Hiroshi, Otsu, Yasunari

Source: In Food and Chemical Toxicology May 2025 199

A solvent-free squeezing method for extraction of collected mass from aerosols of electronic cigarettes and heated tobacco products

Authors: Ito, Hiroshi, Shigeto, Atsushi, Hashizume, Tsuneo

Source: In Journal of Chromatography A 19 July 2024 1727

Chemical and in vitro toxicological comparison of emissions from a heated tobacco product and the 1R6F reference cigarette

Authors: Hashizume, Tsuneo, Ishikawa, Shinkichi, Matsumura, Kazushi, Ito, Shigeaki, Fukushima, Toshiro

Source: Toxicology reports. 10:281-292

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193481386.0x000001&indx=1&recIds=ETOCvdc_100193481386.0x000001

Effects of antioxidant capacity on micronucleus induction by cigarette smoke in mammalian cells

Authors: Yamamoto, Haruna, Shibuya, Kaori, Fukushima, Toshiro, Hashizume, Tsuneo ^*

Source: In Mutation Research - Genetic Toxicology and Environmental Mutagenesis January 2022 873

Exploring the role of oxidative stress and mitochondrial dysfunction in β-damascone-induced aneuploidy.

Authors: Hashizume, Tsuneo¹ (AUTHOR) tsuneo.hashizume@jt.com, Munakata, Satoru¹ (AUTHOR), Takahashi, Tomohiro¹ (AUTHOR), Watanabe, Taku¹ (AUTHOR)

Source: Genes & Environment. 11/25/2024, Vol. 46 Issue 1, p1-14. 14p.

Subject Terms: *AMES test, *CHROMOSOME segregation, *REACTIVE oxygen species, *MOIETIES (Chemistry), *MEMBRANE potential, *OXIDATIVE stress, *GENETIC toxicology

Meeting report, ICH M7 relevant workshop: use of (Q)SAR systems and expert judgment

Authors: Mishima, Masayuki, Hashizume, Tsuneo, Haranosono, Yu, Nagato, Yusuke, Takeshita, Kentaro, Fukuchi, Junichi, Homma, Masamitsu

Source: Genes and environment. 40(1):1-7

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184274639.0x000001&indx=1&recIds=ETOCvdc_100184274639.0x000001

Pyrene did not induce gene mutation in red blood cell Pig-a assay and PIGRET assay in rats

Authors: Yoshida, Ikuma, Matsumoto, Akemi, Sakai, Yumi, Harada, Yumiko, Hashizume, Tsuneo

Source: In Mutation Research - Genetic Toxicology and Environmental Mutagenesis 15 November 2016 811:49-53

Red blood cell Pig-a assay and PIGRET assay in rats with azathioprine

Authors: Yoshida, Ikuma, Matsumoto, Akemi, Sakai, Yumi, Harada, Yumiko, Hashizume, Tsuneo

Source: In Mutation Research - Genetic Toxicology and Environmental Mutagenesis 15 November 2016 811:60-64

Evaluation of the sensitivity and specificity of in vivo erythrocyte micronucleus and transgenic rodent gene mutation tests to detect rodent carcinogens

Authors: Morita, Takeshi, Hamada, Shuichi, Masumura, Kenichi, Wakata, Akihiro, Maniwa, Jiro, Takasawa, Hironao, Yasunaga, Katsuaki, Hashizume, Tsuneo, Honma, Masamitsu

Source: In Mutation Research - Genetic Toxicology and Environmental Mutagenesis May 2016 802:1-29

Development of an In Vitro Sensitisation Test Using a Coculture System of Human Bronchial Epithelium and Immune Cells.

Authors: Tanabe, Ikuya, Yoshida, Kunitaka, Ishikawa, Shinkichi, Ishimori, Kanae, Hashizume, Tsuneo, Yoshimoto, Takayuki, Ashikaga, Takao

Source: Alternatives to Laboratory Animals; Nov2023, Vol. 51 Issue 6, p387-400, 14p

Development of an In VitroSensitisation Test Using a Coculture System of Human Bronchial Epithelium and Immune Cells

Authors: Tanabe, Ikuya, Yoshida, Kunitaka, Ishikawa, Shinkichi, Ishimori, Kanae, Hashizume, Tsuneo, Yoshimoto, Takayuki, Ashikaga, Takao

Source: Alternatives to Laboratory Animals; November 2023, Vol. 51 Issue: 6 p387-400, 14p

In vitro micronucleus test in HepG2 transformants expressing a series of human cytochrome P450 isoforms with chemicals requiring metabolic activation

Authors: Hashizume, Tsuneo, Yoshitomi, Sumie, Asahi, Satoru, Matsumura, Shigeo, Chatani, Fumio, Oda, Hiroaki

Source: In Mut.Res.-Genetic Toxicology and Environmental Mutagenesis 2009 677(1):1-7

Key Challenges and Recommendations for In Vitro Testing of Tobacco Products for Regulatory Applications: Consideration of Test Materials and Exposure Parameters.

Authors: Moore, Martha M., Abraham, Irene, Ballantyne, Mark, Behrsing, Holger, Cao, Xuefei, Clements, Julie, Gaca, Marianna, Gillman, Gene, Hashizume, Tsuneo, Heflich, Robert H., Hurtado, Sara, Jordan, Kristen G., Leverette, Robert, McHugh, Damian, Miller-Holt, Jacqueline, Phillips, Gary, Recio, Leslie, Roy, Shambhu, Scian, Mariano, Simms, Liam

Source: Alternatives to Laboratory Animals; Jan2023, Vol. 51 Issue 1, p55-79, 25p

Key Challenges and Recommendations for In VitroTesting of Tobacco Products for Regulatory Applications: Consideration of Test Materials and Exposure Parameters

Authors: Moore, Martha M., Abraham, Irene, Ballantyne, Mark, Behrsing, Holger, Cao, Xuefei, Clements, Julie, Gaca, Marianna, Gillman, Gene, Hashizume, Tsuneo, Heflich, Robert H., Hurtado, Sara, Jordan, Kristen G., Leverette, Robert, McHugh, Damian, Miller-Holt, Jacqueline, Phillips, Gary, Recio, Leslie, Roy, Shambhu, Scian, Mariano, Simms, Liam, Smart, Daniel J., Stankowski, Leon F., Tarran, Robert, Thorne, David, Weber, Elisabeth, Wieczorek, Roman, Yoshino, Kei, Curren, Rodger

Source: Alternatives to Laboratory Animals; January 2023, Vol. 51 Issue: 1 p55-79, 25p

Weight of evidence approach using a TK gene mutation assay with human TK6 cells for follow-up of positive results in Ames tests: a collaborative study by MMS/JEMS.

Authors: Yasui, Manabu, Fukuda, Takayuki, Ukai, Akiko, Maniwa, Jiro, Imamura, Tadashi, Hashizume, Tsuneo, Yamamoto, Haruna, Shibuya, Kaori, Narumi, Kazunori, Fujiishi, Yohei, Okada, Emiko, Fujishima, Saori, Yamamoto, Mika, Otani, Naoko, Nakamura, Maki, Nishimura, Ryoichi, Ueda, Maya, Mishima, Masayuki, Matsuzaki, Kaori, Takeiri, Akira

Source: Genes & Environment; 3/6/2021, Vol. 43 Issue 1, p1-19, 19p

Subject Terms: AMES test, GENETIC mutation, CARCINOGENICITY testing, MUTAGENICITY testing, DNA repair, FALSE positive error

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