A multifaceted approach towards organometallic anticancer agent development

Authors: Hartinger, Christian G.

Source: In Journal of Organometallic Chemistry 15 May 2024 1012

On-Resin Conjugation of the Ruthenium Anticancer Agent Plecstatin-1 to Peptide Vectors

Authors: Kumar, Saawan, Riisom, Mie, Jamieson, Stephen M. F., Kavianinia, Iman, Harris, Paul W. R., Metzler-Nolte, Nils, Brimble, Margaret A., Hartinger, Christian G.

Source: INORGANIC CHEMISTRY -AMERICAN CHEMICAL SOCIETY-. 62(35):14310-14317

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Exploiting reduced-symmetry ligands with pyridyl and imidazole donors to construct a second-generation stimuli-responsive heterobimetallic [PdPtL4]4+ cageElectronic supplementary information (ESI) available. CCDC 2175042–2175046. For ESI and crystallographic data in CIF or other electronic format see DOI: https://doi.org/10.1039/d3sc01354e

Authors: Pearcy, Aston C., Lisboa, Lynn S., Preston, Dan, Page, Nick B., Lawrence, Tristan, Wright, L. James, Hartinger, Christian G., Crowley, James D.

Source: Chemical science. 14(32):8615-8623

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Ferrocene-Derived Palladium(II)-Based Metallosupramolecular Structures: Synthesis, Guest Interaction, and Stimulus-Responsiveness Studies

Authors: Tremlett, William D. J., Söhnel, Tilo, Crowley, James D., Wright, L. James, Hartinger, Christian G.

Source: Inorganic chemistry. 62(8):3616-3628

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Platinum(terpyridine) complexes with N-heterocyclic carbene co-ligands: high antiproliferative activity and low toxicity in vivoElectronic supplementary information (ESI) available: The Experimental section, NMR spectra and additional data on the zebrafish and gel electrophoresis studies. See DOI: https://doi.org/10.1039/d2dt02539f

Authors: Sullivan, Matthew P., Adams, Muneebah, Riisom, Mie, Herbert, Caitlin D., Tong, Kelvin K. H., Astin, Jonathan W., Jamieson, Stephen M. F., Hanif, Muhammad, Goldstone, David C., Hartinger, Christian G.

Source: Dalton transactions. 52(5):1388-1392

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Anticancer Ru and Os complexes of N-(4-chlorophenyl)pyridine-2-carbothioamide: Substitution of the labile chlorido ligand with phosphines

Authors: Riaz, Zahid, Lee, Betty Y.T., Stjärnhage, Julia, Movassaghi, Sanam, Söhnel, Tilo, Jamieson, Stephen M.F., Shaheen, Muhammad Ashraf, Hanif, Muhammad, Hartinger, Christian G.

Source: In Journal of Inorganic Biochemistry April 2023 241

Impact of the ferrocenyl group on cytotoxicity and KSP inhibitory activity of ferrocenyl monastrol conjugatesElectronic supplementary information (ESI) available: Copies of the NMR spectra and HPLC-ESI-MS analysis. CCDC 2010957 and 2010958. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/d1dt03553c

Authors: Wieczorek-Błauż, Anna, Kowalczyk, Karolina, Błauż, Andrzej, Makal, Anna, Pawlędzio, Sylwia, Eurtivong, Chatchakorn, Arabshahi, Homayon J., Reynisson, Jóhannes, Hartinger, Christian G., Rychlik, Błażej, Plażuk, Damian

Source: Dalton transactions. 51(2):491-508

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Hydrazone- and imine-containing [PdPtL4]4+ cages: a comparative study of the stability and host–guest chemistryElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2dt02720h

Authors: Lisboa, Lynn S., Riisom, Mie, Dunne, Henry J., Preston, Dan, Jamieson, Stephen M. F., Wright, L. James, Hartinger, Christian G., Crowley, James D.

Source: Dalton transactions. 51(48):18438-18445

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167723085.0x000001&indx=1&recIds=ETOCvdc_100167723085.0x000001

Biotin functionalization of 8-hydroxyquinoline anticancer organometallics: low in vivo toxicity but potent in vitro activity.

Authors: Steel, Tasha R., Stjärnhage, Julia, Lin, Zexiong, Bloomfield, Hugh O., Herbert, Caitlin D., Astin, Jonathan W., Krawczyk, Krzysztof, Rychlik, Błażej, Plażuk, Damian, Jamieson, Stephen M. F., Hartinger, Christian G.

Source: Dalton Transactions: An International Journal of Inorganic Chemistry; 1/28/2025, Vol. 54 Issue 4, p1583-1596, 14p

Subject Terms: CISPLATIN, ELEMENTAL analysis, MASS spectrometry, NUCLEAR magnetic resonance spectroscopy, ANTINEOPLASTIC agents

Substitution of the chlorido ligand for PPh3 in anticancer organoruthenium complexes of sulfonamide-functionalized pyridine-2-carbothioamides leads to high cytotoxic activity

Authors: Iqbal, Shahid, Siddiqui, Waseeq Ahmad, Ashraf, Adnan, Tong, Kelvin K.H., Aman, Farhana, Söhnel, Tilo, Jamieson, Stephen M.F., Hanif, Muhammad, Hartinger, Christian G.

Source: In Inorganica Chimica Acta 1 June 2022 536

Design concepts of half-sandwich organoruthenium anticancer agents based on bidentate bioactive ligands

Authors: Tremlett, William D.J., Goodman, David M., Steel, Tasha R., Kumar, Saawan, Wieczorek-Błauż, Anna, Walsh, Fearghal P., Sullivan, Matthew P., Hanif, Muhammad, Hartinger, Christian G.

Source: In Coordination Chemistry Reviews 15 October 2021 445

Monodentately-coordinated bioactive moieties in multimodal half-sandwich organoruthenium anticancer agents

Authors: Steel, Tasha R., Walsh, Fearghal, Wieczorek-Błauż, Anna, Hanif, Muhammad, Hartinger, Christian G.

Source: In Coordination Chemistry Reviews 15 July 2021 439

Biological properties of ruthenium(II)/(III) complexes with flavonoids as ligands

Authors: Małecka, Magdalena, Skoczyńska, Anna, Goodman, David M., Hartinger, Christian G., Budzisz, Elzbieta

Source: In Coordination Chemistry Reviews 1 June 2021 436

Homodinuclear organometallics of ditopic N,N-chelates: Synthesis, reactivity and in vitro anticancer activity

Authors: Steel, Tasha R., Tong, Kelvin K.H., Söhnel, Tilo, Jamieson, Stephen M.F., Wright, L. James, Crowley, James D., Hanif, Muhammad, Hartinger, Christian G.

Source: In Inorganica Chimica Acta 1 April 2021 518

Incorporation of β‐Alanine in Cu(II) ATCUN Peptide Complexes Increases ROS Levels, DNA Cleavage and Antiproliferative Activity**

Authors: Heinrich, Julian, Bossak‐Ahmad, Karolina, Riisom, Mie, Haeri, Haleh H., Steel, Tasha R., Hergl, Vinja, Langhans, Alexander, Schattschneider, Corinna, Barrera, Jannis, Jamieson, Stephen M. F., Stein, Matthias, Hinderberger, Dariush, Hartinger, Christian G., Bal, Wojciech, Kulak, Nora

Source: Chemistry. 27(72):18093-18102

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Determination of Relative Stabilities of Metal‐Peptide Bonds in the Gas Phase

Authors: Cziferszky, Monika, Truong, Dianna, Hartinger, Christian G., Gust, Ronald

Source: Chemistry. 27(66):16401-16406

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135312952.0x000001&indx=1&recIds=ETOCvdc_100135312952.0x000001

Probing the Paradigm of Promiscuity for N‐Heterocyclic Carbene Complexes and their Protein Adduct Formation

Authors: Sullivan, Matthew P., Cziferszky, Monika, Tolbatov, Iogann, Truong, Dianna, Mercadante, Davide, Re, Nazzareno, Gust, Ronald, Goldstone, David C., Hartinger, Christian G.

Source: Angewandte Chemie. 133(36):20081-20085

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100128996234.0x000001&indx=1&recIds=ETOCvdc_100128996234.0x000001

Tracing the anticancer compound [RuII(η6-p-cymene)(8-oxyquinolinato)Cl] in a biological environment by mass spectrometric methodsElectronic supplementary information (ESI) available. See DOI: 10.1039/d0ay02311f

Authors: Yano, Ena, Riisom, Mie, Tong, Kelvin K. H., Hanif, Muhammad, Leung, Euphemia, Hartinger, Christian G.

Source: Analytical methods. 13(12):1463-1469

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Carbon Monoxide is an Inhibitor of HIF Prolyl Hydroxylase Domain 2

Authors: Mbenza, Naasson M., Nasarudin, Nawal, Vadakkedath, Praveen G., Patel, Kamal, Ismail, A. Z., Hanif, Muhammad, Wright, L. James, Sarojini, Vijayalekshmi, Hartinger, Christian G., Leung, Ivanhoe K. H.

Source: Chembiochem. 22(15):2521-2525

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125697135.0x000001&indx=1&recIds=ETOCvdc_100125697135.0x000001

Anthracenyl Functionalization of Half-Sandwich Carbene Complexes: In Vitro Anticancer Activity and Reactions with Biomolecules

Authors: Lee, Betty Y. T., Sullivan, Matthew P., Yano, Ena, Tong, Kelvin K. H., Hanif, Muhammad, Kawakubo-Yasukochi, Tomoyo, Jamieson, Stephen M. F., Soehnel, Tilo, Goldstone, David C., Hartinger, Christian G.

Source: Inorganic chemistry. 60(19):14636-14644

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN633282340&indx=1&recIds=ETOCRN633282340