Structures of the Varicella Zoster Virus Glycoprotein E and Epitope Mapping of Vaccine-Elicited Antibodies.

Authors: Harshbarger, Wayne D., Holzapfel, Genevieve, Seraj, Nishat, Tian, Sai, Chesterman, Chelsy, Fu, Zongming, Pan, Yan, Harelson, Claire, Peng, Dongjun, Huang, Ying, Chandramouli, Sumana, Malito, Enrico, Bottomley, Matthew James, Williams, James

Source: Vaccines; Oct2024, Vol. 12 Issue 10, p1111, 18p

Subject Terms: HERPES zoster, VARICELLA-zoster virus, RECOMBINANT antibodies, ANTIBODY formation, CHICKENPOX

Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing

Authors: Liu, Yan, Ferguson, Fleur M., Li, Lianbo, Kuljanin, Miljan, Mills, Caitlin E., Subramanian, Kartik, Harshbarger, Wayne, Gondi, Sudershan, Wang, Jinhua, Sorger, Peter K., Mancias, Joseph D., Gray, Nathanael S., Westover, Kenneth D.

Source: In Cell Chemical Biology 15 October 2020 27(10):1229-1240

A strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-orlistat hybrids

Authors: Zhu, Mingzhao, Harshbarger, Wayne D., Robles, Omar, Krysiak, Joanna, Hull, Kenneth G., Cho, Sung Wook, Richardson, Robyn D., Yang, Yanyan, Garcia, Andres, Spiegelman, Lindsey, Ramirez, Bianca, Wilson, Christopher T., Yau, Ju Anne, Moore, James T., Walker, Caitlen B., Sacchettini, James C., Liu, Wenshe R., Sieber, Stephan A., Smith, Jeffrey W., Romo, Daniel

Source: In Bioorganic & Medicinal Chemistry 1 June 2017 25(11):2901-2916

Structural and Biochemical Analyses Reveal the Mechanism of Glutathione S-Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine

Alternate Title: Hydrolyzed Piperlongumine Inhibits GSTP1 (English)

Authors: Harshbarger, Wayne, Gondi, Sudershan, Ficarro, Scott B., Hunter, John, Udayakumar, Durga, Gurbani, Deepak, Singer, William D., Liu, Yan, Li, Lianbo, Marto, Jarrod A., Westover, Kenneth D.

Source: In Journal of Biological Chemistry 6 January 2017 292(1):112-120

Improved epitope resolution of the prefusion trimer-specific antibody AM14 bound to the RSV F glycoprotein

Authors: Harshbarger, Wayne, Abeyrathne, Priyanka D., Tian, Sai, Huang, Ying, Chandramouli, Sumana, Bottomley, Matthew James, Malito, Enrico

Source: MAbs. 13(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140347903.0x000001&indx=1&recIds=ETOCvdc_100140347903.0x000001

Unique structural solution from a VH3-30 antibody targeting the hemagglutinin stem of influenza A viruses

Authors: Harshbarger, Wayne D., Deming, Derrick, Lockbaum, Gordon J., Attatippaholkun, Nattapol, Kamkaew, Maliwan, Hou, Shurong, Somasundaran, Mohan, Wang, Jennifer P., Finberg, Robert W., Zhu, Quan Karen, Schiffer, Celia A., Marasco, Wayne A.

Source: Nature communications. 12(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193131430.0x000001&indx=1&recIds=ETOCvdc_100193131430.0x000001

Convergent structural features of respiratory syncytial virus neutralizing antibodies and plasticity of the site V epitope on prefusion F.

Authors: Harshbarger, Wayne¹ (AUTHOR), Tian, Sai¹ (AUTHOR), Wahome, Newton¹ (AUTHOR), Balsaraf, Ankita¹ (AUTHOR), Bhattacharya, Deep¹ (AUTHOR), Jiang, Desheng¹ (AUTHOR), Pandey, Ratnesh¹ (AUTHOR), Tungare, Kunal¹ (AUTHOR), Friedrich, Kristian¹ (AUTHOR), Mehzabeen, Nurjahan¹ (AUTHOR), Biancucci, Marco¹ (AUTHOR), Chinchilla-Olszar, Diana¹ (AUTHOR), Mallett, Corey P.¹ (AUTHOR), Huang, Ying¹ (AUTHOR), Wang, Zihao¹ (AUTHOR), Bottomley, Matthew James¹ (AUTHOR), Malito, Enrico¹ (AUTHOR) enrico.x.malito@gsk.com, Chandramouli, Sumana¹ (AUTHOR) enrico.x.malito@gsk.com

Source: PLoS Pathogens. 11/2/2020, Vol. 16 Issue 11, p1-23. 23p.

Subject Terms: *VIRAL antibodies, *RESPIRATORY syncytial virus, *VACCINE development, *CHIMERIC proteins, *MOLECULAR recognition

Synthesis and Structure–Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5,11-Dihydro‑6H‑benzo[e]pyrimido[5,4‑b][1,4]diazepin-6-one Scaffold.

Authors: Ferguson, Fleur M., Yan Liu, Harshbarger, Wayne, Ling Huang, Jinhua Wang, Xianming Deng, Capuzzi, Stephen J., Muratov, Eugene N., Tropsha, Alexander, Muthuswamy, Senthil, Westover, Kenneth D., Gray, Nathanael S.

Source: Journal of Medicinal Chemistry; 7/23/2020, Vol. 63 Issue 14, p7817-7826, 10p

Crystal Structure of the Human 20S Proteasome in Complex with Carfilzomib

Authors: Harshbarger, Wayne, Miller, Chase, Diedrich, Chandler, Sacchettini, James

Source: In Structure 3 February 2015 23(2):418-424

Discovery of a selective inhibitor of doublecortin like kinase 1

Authors: Ferguson, Fleur M., Nabet, Behnam, Raghavan, Srivatsan, Liu, Yan, Leggett, Alan L., Kuljanin, Miljan, Kalekar, Radha L., Yang, Annan, He, Shuning, Wang, Jinhua, Ng, Raymond W. S., Sulahian, Rita, Li, Lianbo, Poulin, Emily J., Huang, Ling, Koren, Jost, Dieguez-Martinez, Nora, Espinosa, Sergio, Zeng, Zhiyang, Corona, Cesear R., Vasta, James D., Ohi, Ryoma, Sim, Taebo, Kim, Nam Doo, Harshbarger, Wayne, Lizcano, Jose M., Robers, Matthew B., Muthaswamy, Senthil, Lin, Charles Y., Look, A. Thomas, Haigis, Kevin M., Mancias, Joseph D., Wolpin, Brian M., Aguirre, Andrew J., Hahn, William C., Westover, Kenneth D., Gray, Nathanael S.

Source: Nature Chemical Biology; June 2020, Vol. 16 Issue: 6 p635-643, 9p

Correction to "Synthesis and Structure–Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5,11-Dihydro‑6H‑benzo[e]pyrimido[5,4‑b][1,4]diazepin-6-one Scaffold".

Authors: Ferguson, Fleur M., Liu, Yan, Harshbarger, Wayne, Huang, Ling, Wang, Jinhua, Deng, Xianming, Capuzzi, Stephen J., Muratov, Eugene N., Tropsha, Alexander, Muthuswamy, Senthil, Westover, Kenneth D., Gray, Nathanael S.

Source: Journal of Medicinal Chemistry; 9/10/2020, Vol. 63 Issue 17, p10088-10088, 1p

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Structural and computational design of a SARS-CoV-2 spike antigen with improved expression and immunogenicity.

Authors: Williams, James A.¹, Biancucci, Marco¹, Lessen, Laura¹, Sai Tian¹, Balsaraf, Ankita¹, Chen, Lynn¹, Chesterman, Chelsy¹, Maruggi, Giulietta¹, Vandepaer, Sarah¹, Ying Huang¹, Mallett, Corey P.¹, Steff, Ann-Muriel¹, Bottomley, Matthew James¹, Malito, Enrico¹, Wahome, Newton¹ newton@wahome.org, Harshbarger, Wayne D.¹ wayne.d.harshbarger@gsk.com

Source: Science Advances. 6/9/2023, Vol. 9 Issue 23, p1-17. 17p.

Subject Terms: *SARS-CoV-2, *IMMUNE response, *STRUCTURAL design