DrugMap: A quantitative pan-cancer analysis of cysteine ligandability

Authors: Takahashi, Mariko, Chong, Harrison B., Zhang, Siwen, Yang, Tzu-Yi, Lazarov, Matthew J., Harry, Stefan, Maynard, Michelle, Hilbert, Brendan, White, Ryan D., Murrey, Heather E., Tsou, Chih-Chiang, Vordermark, Kira, Assaad, Jonathan, Gohar, Magdy, Dürr, Benedikt R., Richter, Marianne, Patel, Himani, Kryukov, Gregory, Brooijmans, Natasja, Alghali, Aliyu Sidi Omar, Rubio, Karla, Villanueva, Antonio, Zhang, Junbing, Ge, Maolin, Makram, Farah, Griesshaber, Hanna, Harrison, Drew, Koglin, Ann-Sophie, Ojeda, Samuel, Karakyriakou, Barbara, Healy, Alexander, Popoola, George, Rachmin, Inbal, Khandelwal, Neha, Neil, Jason R., Tien, Pei-Chieh, Chen, Nicholas, Hosp, Tobias, van den Ouweland, Sanne, Hara, Toshiro, Bussema, Lillian, Dong, Rui, Shi, Lei, Rasmussen, Martin Q., Domingues, Ana Carolina, Lawless, Aleigha, Fang, Jacy, Yoda, Satoshi, Nguyen, Linh Phuong, Reeves, Sarah Marie, Wakefield, Farrah Nicole, Acker, Adam, Clark, Sarah Elizabeth, Dubash, Taronish, Kastanos, John, Oh, Eugene, Fisher, David E., Maheswaran, Shyamala, Haber, Daniel A., Boland, Genevieve M., Sade-Feldman, Moshe, Jenkins, Russell W., Hata, Aaron N., Bardeesy, Nabeel M., Suvà, Mario L., Martin, Brent R., Liau, Brian B., Ott, Christopher J., Rivera, Miguel N., Lawrence, Michael S., Bar-Peled, Liron

Source: In Cell 9 May 2024 187(10):2536-2556

An Electrochemical Approach to Directed Fluorination

Authors: Holt, Eric, Wang, Muyuan, Harry, Stefan Andrew, He, Chengkun, Wang, Yuang, Henriquez, Nicolas, Xiang, Michael Richard, Zhu, Andrea, Ghorbani, Fereshte, Lectka, Thomas

Source: Journal of organic chemistry. 88(4):2557-2560

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631928169&indx=1&recIds=ETOCRN631928169

The C[sbnd]F⋅⋅⋅H[sbnd]CF2 interaction: A combination of hydrogen bonding and n → σ* stabilization

Authors: Garrison, Nathaniel G., Harry, Stefan Andrew, Siegler, Maxime A., Cariello, Guilherme, Cormanich, Rodrigo A., Lectka, Thomas

Source: In Journal of Fluorine Chemistry November 2023 272

Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway

Authors: Zhang, Junbing, Simpson, Claire M., Berner, Jacqueline, Chong, Harrison B., Fang, Jiafeng, Ordulu, Zehra, Weiss-Sadan, Tommy, Possemato, Anthony P., Harry, Stefan, Takahashi, Mariko, Yang, Tzu-yi, Richter, Marianne, Patel, Himani, Smith, Abby E., Carlin, Alexander D., Hubertus de Groot, Adriaan F., Wolf, Konstantin, Shi, Lei, Wei, Ting-Yu, Dürr, Benedikt R., Chen, Nicholas J., Vornbäumen, Tristan, Wichmann, Nina O., Mahamdeh, Mohammed S., Pooladanda, Venkatesh, Matoba, Yusuke, Kumar, Shaan, Kim, Eugene, Bouberhan, Sara, Oliva, Esther, Rueda, Bo R., Soberman, Roy J., Bardeesy, Nabeel, Liau, Brian B., Lawrence, Michael, Stokes, Matt P., Beausoleil, Sean A., Bar-Peled, Liron

Source: In Cell 25 May 2023 186(11):2361-2379

NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer

Authors: Weiss-Sadan, Tommy, Ge, Maolin, Hayashi, Makiko, Gohar, Magdy, Yao, Cong-Hui, de Groot, Adriaan, Harry, Stefan, Carlin, Alexander, Fischer, Hannah, Shi, Lei, Wei, Ting-Yu, Adelmann, Charles H., Wolf, Konstantin, Vornbäumen, Tristan, Dürr, Benedikt R., Takahashi, Mariko, Richter, Marianne, Zhang, Junbing, Yang, Tzu-Yi, Vijay, Vindhya, Fisher, David E., Hata, Aaron N., Haigis, Marcia C., Mostoslavsky, Raul, Bardeesy, Nabeel, Papagiannakopoulos, Thales, Bar-Peled, Liron

Source: In Cell Metabolism 7 March 2023 35(3):487-503

Hydroxy-directed fluorination of remote unactivated C(sp3)–H bonds: a new age of diastereoselective radical fluorinationElectronic supplementary information (ESI) available. See https://doi.org/10.1039/d2sc01907h

Authors: Harry, Stefan Andrew, Xiang, Michael Richard, Holt, Eric, Zhu, Andrea, Ghorbani, Fereshte, Patel, Dhaval, Lectka, Thomas

Source: Chemical science. 13(23):7007-7013

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100157703602.0x000001&indx=1&recIds=ETOCvdc_100157703602.0x000001

Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations

Authors: Xie, Xiaowen, Zhang, Olivia, Yeo, Megan J. R., Lee, Ceejay, Tao, Ran, Harry, Stefan A., Payne, N. Connor, Nam, Eunju, Paul, Leena, Li, Yiran, Kwok, Hui Si, Jiang, Hanjie, Mao, Haibin, Hadley, Jennifer L., Lin, Hong, Batts, Melissa, Gosavi, Pallavi M., D’Angiolella, Vincenzo, Cole, Philip A., Mazitschek, Ralph, Northcott, Paul A., Zheng, Ning, Liau, Brian B.

Source: Nature; March 2025, Vol. 639 Issue: 8053 p241-249, 9p

UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors

Authors: Yeo, Megan J. R., Zhang, Olivia, Xie, Xiaowen, Nam, Eunju, Payne, N. Connor, Gosavi, Pallavi M., Kwok, Hui Si, Iram, Irtiza, Lee, Ceejay, Li, Jiaming, Chen, Nicholas J., Nguyen, Khanh, Jiang, Hanjie, Wang, Zhipeng A., Lee, Kwangwoon, Mao, Haibin, Harry, Stefan A., Barakat, Idris A., Takahashi, Mariko, Waterbury, Amanda L., Barone, Marco, Mattevi, Andrea, Carr, Steven A., Udeshi, Namrata D., Bar-Peled, Liron, Cole, Philip A., Mazitschek, Ralph, Liau, Brian B., Zheng, Ning

Source: Nature; March 2025, Vol. 639 Issue: 8053 p232-240, 9p

Bifurcated hydrogen bonding to fluorine in an all cis-difluoro-hydroxy array

Authors: Wang, Muyuan, Sachs, Roseann K., Harry, Stefan Andrew, Holt, Eric, Siegler, Maxime A., Lectka, Thomas

Source: Journal of fluorine chemistry. 267

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186482089.0x000001&indx=1&recIds=ETOCvdc_100186482089.0x000001

Carbonyl-Directed Aliphatic Fluorination: A Special Type of Hydrogen Atom Transfer Beats Out Norrish II

Authors: Ghorbani, Fereshte, Harry, Stefan Andrew, Capilato, Joseph N., Pitts, Cody Ross, Joram, Jacob, Peters, Garvin N., Tovar, John D., Smajlagic, Ivor, Siegler, Maxime A., Dudding, Travis

Source: Journal of the American Chemical Society. 142(34):14710-14724

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN624570313&indx=1&recIds=ETOCRN624570313

Spectroscopic and Crystallographic Characterization of the R3N+−C−H⋅⋅⋅X Interaction

Authors: Capilato, Joseph N., Harry, Stefan A., Siegler, Maxime A., Lectka, Thomas

Source: Chemistry. 28(8)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140389440.0x000001&indx=1&recIds=ETOCvdc_100140389440.0x000001

The Close Interaction of a C−F Bond with an Amide Carbonyl: Crystallographic and Spectroscopic Characterization

Authors: Harry, Stefan Andrew, Kazim, Muhammad, Nguyen, Phuong Minh, Zhu, Andrea, Xiang, Michael Richard, Catazaro, Jonathan, Siegler, Maxime, Lectka, Thomas

Source: Angewandte Chemie. 134(34)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100175748938.0x000001&indx=1&recIds=ETOCvdc_100175748938.0x000001

Multiple Enone-Directed Reactivity Modes Lead to the Selective Photochemical Fluorination of Polycyclic Terpenoid Derivatives

Authors: Pitts, Cody Ross, Bume, Desta Doro, Harry, Stefan Andrew, Siegler, Maxime A., Lectka, Thomas

Source: Journal of the American Chemical Society. 139(6):2208-2211

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN610758007&indx=1&recIds=ETOCRN610758007

C–F Bonds as "Frozen" Nucleophiles: Unconsummated SN2 Reactions.

Authors: Harry, Stefan Andrew, Garrison, Nathaniel G., Zhu, Andrea, Xiang, Michael Richard, Siegler, Maxime A., Lectka, Thomas

Source: Journal of Organic Chemistry; 10/7/2022, Vol. 87 Issue 19, p13406-13410, 5p

Rational Computational Design of Systems Exhibiting Strong Halogen Bonding Involving Fluorine in Bicyclic Diamine Derivatives.

Authors: Harry, Stefan Andrew, Vemulapalli, Srini, Dudding, Travis, Lectka, Thomas

Source: Journal of Organic Chemistry; 7/1/2022, Vol. 87 Issue 13, p8413-8419, 7p

Universal load address/value prediction using stride-based pattern history and last-value prediction in a two-level table scheme

Checkpointing a superscalar, out-of-order processor for error recovery

Hydroxy-directed fluorination of remote unactivated C(sp³)–H bonds: a new age of diastereoselective radical fluorination.

Authors: Harry, Stefan Andrew, Xiang, Michael Richard, Holt, Eric, Zhu, Andrea, Ghorbani, Fereshte, Patel, Dhaval, Lectka, Thomas

Source: Chemical Science; 6/21/2022, Vol. 13 Issue 23, p7007-7013, 7p

Spectroscopic and Crystallographic Characterization of the R3N⁺−C−H⋅⋅⋅X Interaction.

Authors: Capilato, Joseph N.¹ (AUTHOR), Harry, Stefan A.¹ (AUTHOR), Siegler, Maxime A.¹ (AUTHOR), Lectka, Thomas¹ (AUTHOR) lectka@jhu.edu

Source: Chemistry - A European Journal. 2/7/2022, Vol. 28 Issue 8, p1-8. 8p.

Subject Terms: *LEWIS bases, *HYDROGEN bonding, *ATOMS

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