Pembrolizumab with or without chemotherapy in recurrent or metastatic head and neck squamous cell carcinoma: 5-year follow-up from the randomized phase III KEYNOTE-048 study

Authors: Tahara, Makoto ^{a, ⁎}, Greil, Richard ^b, Rischin, Danny ^c, Harrington, Kevin J. ^d, Burtness, Barbara ^e, de Castro, Gilberto ^f, Psyrri, Amanda ^g, Braña, Irene ^h, Neupane, Prakash ⁱ, Bratland, Åse ^j, Fuereder, Thorsten ^k, Hughes, Brett G.M. ^l, Mesía, Ricard ^m, Ngamphaiboon, Nuttapong ⁿ, Rordorf, Tamara ^o, Ishak, Wan Zamaniah Wan ^p, Lin, Jianxin ^q, Gumuscu, Burak ^q, Lerman, Nati ^q, Soulières, Denis ^r

Source: In European Journal of Cancer 15 May 2025 221

Clinical trials for patients with salivary gland cancers: A systematic review of worldwide registers and an evaluation of current challenges

Authors: Jiménez-Labaig, Pablo ^{a, b, c, ⁎, 1}, Lorini, Luigi ^d, Gurizzan, Cristina ^d, Kinloch, Emma ^e, Burton, Sarah ^{a, f}, Forster, Martin D. ^{g, h}, Metcalf, Robert ^{i, j}, Ferrarotto, Renata ^k, Bossi, Paolo ^{d, l}, O´leary, Ben ^{a, b}, Hanna, Glenn ^m, Felip, Enriqueta ^{n, o}, Garcia, Irene Braña ^{n, o}, Harrington, Kevin J. ^{a, b}

Source: In Critical Reviews in Oncology / Hematology July 2025 211

Prevalence of depressive and anxiety symptoms in patients with head and neck cancer undergoing radiotherapy: A systematic review and meta-analysis of longitudinal studies

Authors: Jiménez-Labaig, Pablo, Aymerich, Claudia, Rullan, Antonio, Cacicedo, Jon, Braña, Irene, Nutting, Christopher, Newbold, Kate, Harrington, Kevin J., Catalan, Ana

Source: In Radiotherapy and Oncology January 2025 202

A systematic review of antibody-drug conjugates and bispecific antibodies in head and neck squamous cell carcinoma and nasopharyngeal carcinoma: Charting the course of future therapies

Authors: Jiménez-Labaig, Pablo, Rullan, Antonio, Hernando-Calvo, Alberto, Llop, Sandra, Bhide, Shreerang, O’Leary, Ben, Braña, Irene, Harrington, Kevin J.

Source: In Cancer Treatment Reviews July 2024 128

Intratumoral therapies in head and neck squamous cell carcinoma: A systematic review and future perspectives

Authors: Jiménez-Labaig, Pablo, Rullan, Antonio, Braña, Irene, Hernando-Calvo, Alberto, Moreno, Victor, Doger, Bernard, Bitar, George, Ap Dafydd, Derfel, Melcher, Alan, Harrington, Kevin J.

Source: In Cancer Treatment Reviews June 2024 127

Pembrolizumab plus concurrent chemoradiotherapy versus placebo plus concurrent chemoradiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck (KEYNOTE-412): a randomised, double-blind, phase 3 trial

Authors: Rischin, Danny, Hughes, Brett GM, Gao, Bo, McGrath, Margaret, Greil, Richard, Thurnher, Dietmar, Fuereder, Thorsten, Burian, Martin, Rottey, Sylvie, Machiels, Jean-Pascal, Clement, Paul M, Henry, Stéphanie, Deheneffe, Stéphanie, Vasconcelos Alves, Gustavo, Lima, Iane Pinto Figueiredo, Mourão Dias, Josiane, De Marchi, Pedro Rafael Martins, Mak, Milena Perez, Pereira de Santana Gomes, Andrea Juliana, Oliveira de Castro Junior, Dalvaro, Motta, Tatiane Cardoso, Agostinho Padoan, Monica Luciana, Victorina, Ana Paula, de Azevedo, Sergio Jobim, Siu, Lillian L, Brule, Stephanie, Hilton, John, Wang, Chang Shu, Bouganim, Nathaniel, Webster, Marc, Walker, John, Chua, Neil, Zambrano, Angela Regina, Quiroga Echeverri, Alicia, Niño Gomez, Oscar Mauricio, Ortiz, Carlos Alberto, Rojas, Luis, Cardona Zorilla, Andrés, Urrego Meléndez, Olga Marcela, Holečková, Petra Beran, Melichar, Bohuslav, Cvek, Jakub, Prausová, Jana, Vošmik, Milan, Delord, Jean-Pierre, Zasadny, Xavier, Geoffrois, Lionnel, Tao, Yungan, Pointreau, Yoann, Fietkau, Rainer, Haderlein, Marlen, Mueller, Andreas H, Schroeder, Ursula, Wollenberg, Barbara, Laban, Simon, Ivanyi, Philipp, Gruenwald, Viktor, Schafhausen, Philippe, Gutfeld, Orit, Gluck, Iris, Popovtzer, Aron, Meirovitz, Amichay, Billan, Salem, Brenner, Baruch, Limon, Dror, Licitra, Lisa, Perri, Francesco, Caponigro, Francesco, Violati, Martina, Ferrari, Daris, Nole, Franco, Bertolini, Federica, Livi, Lorenzo, Ghi, Maria Grazia, Imarisio, Ilaria, Tahara, Makoto, Homma, Akihiro, Ueda, Tsutomu, Asada, Yukinori, Yamazaki, Tomoko, Matsumoto, Koji, Fujii, Takashi, Ikeda, Sadakatsu, Takahashi, Shunji, Kinoshita, Takashi, Sasaki, Keita, Tsuji, Akihito, Ahn, Myung-Ju, Cho, Byoung Chul, Lee, Keun-Wook, Lee, Ki Hyeong, Choi, Moon Ki, Yun, Hwan Jung, Hendriks, Mathijs P, Oosting, Sjoukje F, Buter, Jan, Van Meerten, Esther, Graham, Jonathan, Kawecki, Andrzej, Debicka, Izabella, Maciejczyk, Adam, Pysz, Maciej, Filarska, Dorota, Hetnał, Marcin, Koralewski, Piotr, Wygoda, Andrzej, Składowski, Krzysztof, Talerczyk, Małgorzata, Berrocal Jaime, Alfonso, Pérez Segura, Pedro, Braña García, Irene, Basté Rotllan, Neus, Mesía Nin, Ricard, Taberna Sanz, Miren, Iglesias Docampo, Lara, Soria Rivas, Ainara, Rueda Domínguez, Antonio, Trigo Pérez, José Manuel, Hong, Ruey-Long, Li, Shau-Hsuan, Wang, Hung-Ming, Yen, Chia-Jui, Yang, Muh-Hwa, Chang, Yi-Fang, Liu, Yi-Chun, Lin, Jin-Ching, Ekenel, Meltem, Harputluoğlu, Hakan, Aksoy, Sercan, Özyilkan, Özgür, Bılıcı, Ahmet, Şendur, Mehmet Alı Nahıt, Arslan, Cagatay, Harrington, Kevin, Ramkumar, Shanmugasundaram, Gujral, Dorothy, Stewart, Simon, Powell, Melanie, Sibtain, Amen, Roques, Tom, Yip, Kent, Mirza, Arafat, Sivaramalingam, Muthiah, Belman, Neil D, Agarwala, Sanjiv, Anderson, Ian, Patel, Arpan, Maggiore, Ronald, Baumgart, Megan, Burtness, Barbara, Fidler, Mary Jo, Kaur, Varinder, Gaughan, Elizabeth, Worden, Francis, Rodriguez, Cristina P, Sukari, Ammar, Wong, Deborah, Yom, Sue, Walsh, William V, Fiorillo, Joseph A, Yorio, Jeffrey T, Obara, Grzegorz S, Alves, Gustavo ^g, Hughes, Brett G M ⁱ, Mesía, Ricard ^q, Taberna, Miren ^r, Waldron, John N ^s, Simon, Christian ^t, Grégoire, Vincent ^u, Harrington, Kevin J ^v, Swaby, Ramona F ^w, Zhang, Yayan ^w, Gumuscu, Burak ^w, Bidadi, Behzad ^w

Source: In The Lancet Oncology May 2024 25(5):572-587

DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cells

Authors: Hristova, Dayana B. ¹, Oliveira, Marisa ¹, Wagner, Emma ¹, Melcher, Alan ², Harrington, Kevin J. ², Belot, Alexandre ³, Ferguson, Brian J. ^{1, 4, ∗}

Source: In iScience 19 January 2024 27(1)

Breaking the barriers in cancer care: The next generation of herpes simplex virus-based oncolytic immunotherapies for cancer treatment

Authors: Khushalani, Nikhil I., Harrington, Kevin J., Melcher, Alan, Bommareddy, Praveen K., Zamarin, Dmitriy

Source: In Molecular Therapy - Oncolytics 19 December 2023 31

Pembrolizumab alone or with chemotherapy for recurrent or metastatic head and neck squamous cell carcinoma: Health-related quality-of-life results from KEYNOTE-048

Authors: Rischin, Danny, Harrington, Kevin J., Greil, Richard, Soulières, Denis, Tahara, Makoto, de Castro Jr, Gilberto, Psyrri, Amanda, Braña, Irene, Neupane, Prakash, Bratland, Åse, Fuereder, Thorsten, Hughes, Brett G.M., Mesía, Ricard, Ngamphaiboon, Nuttapong, Rordorf, Tamara, Ishak, Wan Zamaniah Wan, Hong, Ruey-Long, Mendoza, René Gonzalez, Jia, Liyi, Chirovsky, Diana, Norquist, Josephine, Jin, Fan, Burtness, Barbara

Source: In Oral Oncology May 2022 128

Management of Head and Neck Mucosal Melanoma

Authors: Nenclares, Pablo, Harrington, Kevin J.

Source: In Oral and Maxillofacial Surgery Clinics of North America May 2022 34(2):299-314

Using a Bayesian Feature-selection Algorithm to Identify Dose-response Models Based on the Shape of the 3D Dose-distribution: An Example from a Head-and-neck Cancer Trial

Authors: Buettner, Florian, Gulliford, Sarah L., Webb, Steve, Partridge, Mike, Miah, Aisha B., Harrington, Kevin J., Nutting, Christopher M.

Source: 2010 Ninth International Conference on Machine Learning and Applications Machine Learning and Applications (ICMLA), 2010 Ninth International Conference on. :740-745 Dec, 2010

Relation: 2010 International Conference on Machine Learning and Applications (ICMLA)

Dose-escalated intensity-modulated radiotherapy in patients with locally advanced laryngeal and hypopharyngeal cancers: ART DECO, a phase III randomised controlled trial

Authors: Nutting, Christopher M., Griffin, Clare L., Sanghera, Paul, Foran, Bernadette, Beasley, Matthew, Bernstein, David, Cosgrove, Vivian, Fisher, Shelia, West, Catherine M., Sibtain, Amen, Palaniappan, Nachi, Urbano, Teresa Guerrero, Sen, Mehmet, Soe, Win, Rizwanullah, Mohammed, Wood, Katie, Ramkumar, Shanmugasundaram, Junor, Elizabeth, Cook, Audrey, Roques, Tom, Scrase, Christopher, Bhide, Shreerang A., Gujral, Dorothy, Harrington, Kevin J., Mehanna, Hisham, Miah, Aisha, Emson, Marie, Gardiner, Deborah, Morden, James P., Hall, Emma

Source: In European Journal of Cancer August 2021 153:242-256

Head and neck mucosal melanoma: The United Kingdom national guidelines

Authors: Nenclares, Pablo, Ap Dafydd, Derfel, Bagwan, Izhar, Begg, Donna, Kerawala, Cyrus, King, Emma, Lingley, Ken, Paleri, Vinidh, Paterson, Gillian, Payne, Miranda, Silva, Priyamal, Steven, Neil, Turnbull, Nancy, Yip, Kent, Harrington, Kevin J.

Source: In European Journal of Cancer October 2020 138:11-18

Predictive Modelling of Toxicity Resulting from Radiotherapy Treatments of Head and Neck Cancer

Authors: Dean, Jamie A., Welsh, Liam C., Harrington, Kevin J., Nutting, Christopher M., Gulliford, Sarah L.

Subject Terms: Physics - Medical Physics, Computer Science - Computational Engineering, Finance, and Science, Quantitative Biology - Quantitative Methods

Access URL: http://arxiv.org/abs/1412.6399

Impact of antibiotic use during curative treatment of locally advanced head and neck cancers with chemotherapy and radiotherapy

Authors: Nenclares, Pablo, Bhide, Sheerang A., Sandoval-Insausti, Helena, Pialat, Pierre, Gunn, Lucinda, Melcher, Alan, Newbold, Kate, Nutting, Christopher M., Harrington, Kevin J.

Source: In European Journal of Cancer May 2020 131:9-15

The PERK Inhibitor GSK2606414 Enhances Reovirus Infection in Head and Neck Squamous Cell Carcinoma via an ATF4-Dependent Mechanism

Authors: McLaughlin, Martin, Pedersen, Malin, Roulstone, Victoria, Bergerhoff, Katharina F., Smith, Henry G., Whittock, Harriet, Kyula, Joan N., Dillon, Magnus T., Pandha, Hardev S., Vile, Richard, Melcher, Alan A., Harrington, Kevin J.

Source: In Molecular Therapy - Oncolytics 27 March 2020 16:238-249

Patritumab or placebo, with cetuximab plus platinum therapy in recurrent or metastatic squamous cell carcinoma of the head and neck: A randomised phase II study

Authors: Forster, Martin D., Dillon, Magnus T., Kocsis, Judit, Remenár, Éva, Pajkos, Gabor, Rolland, Frederic, Greenberg, Jonathan, Harrington, Kevin J.

Source: In European Journal of Cancer December 2019 123:36-47

Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study

Authors: Lerzo, Guillermo, Tatangelo, Marcelo, Varela, Mirta, Zarba, Juan Jose, Boyer, Michael, Gan, Hui, Gao, Bo, Hughes, Brett, Mallesara, Girish, Rischin, Danny, Taylor, Anne, Burian, Martin, Fuereder, Thorsten, Greil, Richard, Barrios, Carlos Henrique, de Castro Junior, Dalvaro Oliveira, Castro, Gilberto, Franke, Fabio Andre, Girotto, Gustavo, Lima, Iane Pinto Figueiredo, Nicolau, Ulisses Ribaldo, Pinto, Gustavo Dix Junqueira, Santos, Lucas, Victorino, Ana-Paula, Chua, Neil, Couture, Felix, Gregg, Richard, Hansen, Aaron, Hilton, John, McCarthy, Joy, Soulieres, Denis, Ascui, Rodrigo, Gonzalez, Pablo, Villanueva, Luis, Torregroza, Marco, Zambrano, Angela, Holeckova, Petra, Kral, Zdenek, Melichar, Bohuslav, Prausova, Jana, Vosmik, Milan, Andersen, Maria, Gyldenkerne, Niels, Jurgens, Hannes, Putnik, Kadri, Reinikainen, Petri, Gruenwald, Viktor, Laban, Simon, Aravantinos, Gerasimos, Boukovinas, Ioannis, Georgoulias, Vassilis, Psyrri, Amanda, Kwong, Dora, Al-Farhat, Yousuf, Csoszi, Tibor, Erfan, Jozsef, Horvai, Geza, Landherr, Laszlo, Remenar, Eva, Ruzsa, Agnes, Szota, Judit, Billan, Salem, Gluck, Iris, Gutfeld, Orit, Popovtzer, Aron, Benasso, Marco, Bui, Simona, Ferrari, Vittorio, Licitra, Lisa, Nole, Franco, Fujii, Takashi, Fujimoto, Yasushi, Hanai, Nobuhiro, Hara, Hiroki, Matsumoto, Koji, Mitsugi, Kenji, Monden, Nobuya, Nakayama, Masahiro, Okami, Kenji, Oridate, Nobuhiko, Shiga, Kiyoto, Shimizu, Yasushi, Sugasawa, Masashi, Tahara, Makoto, Takahashi, Masanobu, Takahashi, Shunji, Tanaka, Kaoru, Ueda, Tsutomu, Yamaguchi, Hironori, Yamazaki, Tomoko, Yasumatsu, Ryuji, Yokota, Tomoya, Yoshizaki, Tomokazu, Kudaba, Iveta, Stara, Zinaida, Wan Ishak, Wan Zamaniah, Cheah, Soon Keat, Aguilar Ponce, Jose, Gonzalez Mendoza, Rene, Hernandez Hernandez, Carlos, Medina Soto, Francisco, Buter, Jan, Hoeben, Ann, Oosting, S., Suijkerbuijk, Karijn, Bratland, Aase, Brydoey, Marianne, Alvarez, Renzo, Mas, Luis, Caguioa, Priscilla, Querol, John, Regala, Eugenio Emmanuel, Tamayo, Maria Belen, Villegas, Ellie May, Kawecki, Andrzej, Karpenko, Andrey, Klochikhin, Arkadiy, Smolin, Alexey, Zarubenkov, Oleg, Goh, Boon Cher, Cohen, Graham, du Toit, Johanna, Jordaan, Christa, Landers, Gregory, Ruff, Paul, Szpak, Waldemar, Tabane, Neonyana, Brana, Irene, Iglesias Docampo, Lara, Lavernia, Javier, Mesia, Ricard, Abel, Edvard, Muratidu, Valentina, Nielsen, Niels, Cristina, Valerie, Rordorf, Tamara, Rothschild, Sacha, Hong, Ruey-Long, Wang, Hung-Ming, Yang, Muh-Hwa, Yeh, Su-Peng, Yen, Chia-Jui, Ngamphaiboon, Nuttapong, Soparattanapaisarn, Nopadol, Sriuranpong, Virote, Aksoy, Sercan, Cicin, Irfan, Ekenel, Meltem, Harputluoglu, Hakan, Ozyilkan, Ozgur, Harrington, Kevin, Agarwala, Sanjiv, Ali, Haythem, Alter, Robert, Anderson, Daniel, Bruce, Justine, Burtness, Barbara, Campbell, Nicholas, Conde, Miguel, Deeken, John, Edenfield, William, Feldman, Lawrence, Gaughan, Elizabeth, Goueli, Basem, Halmos, Balazs, Hegde, Upendra, Hunis, Brian, Jotte, Robert, Karnad, Anand, Khan, Saad, Laudi, Noel, Laux, Douglas, Martincic, Danko, McCune, Steven, McGaughey, Dean, Misiukiewicz, Krzysztof, Mulford, Deborah, Nadler, Eric, Neupane, Prakash, Nunnink, Johannes, Ohr, James, O'Malley, Meaghan, Patson, Brian, Paul, Doru, Popa, Elizabeta, Powell, Steven, Redman, Rebecca, Rella, Vincent, Rocha Lima, Chaio, Sivapiragasam, Abirami, Su, Yungpo, Sukari, Ammar, Wong, Stuart, Yilmaz, Emrullah, Yorio, Jeffrey, Harrington, Kevin J, Soulières, Denis, de Castro, Gilberto, Jr, Basté, Neus, Bratland, Åse, Hughes, Brett G M, Mesía, Ricard, González Mendoza, René, Roy, Ananya, Zhang, Yayan, Gumuscu, Burak, Cheng, Jonathan D, Jin, Fan

Source: In The Lancet 23-29 November 2019 394(10212):1915-1928

The transformation of radiation oncology using real-time magnetic resonance guidance: A review

Authors: Hall, William A. ^*, Paulson, Eric S., van der Heide, Uulke A., Fuller, Clifton D., Raaymakers, B.W., Lagendijk, Jan J.W., Li, X. Allen, Jaffray, David A., Dawson, Laura A., Erickson, Beth, Verheij, Marcel, Harrington, Kevin J., Sahgal, Arjun, Lee, Percy, Parikh, Parag J., Bassetti, Michael F., Robinson, Clifford G., Minsky, Bruce D., Choudhury, Ananya, Tersteeg, Robert J.H.A., Schultz, Christopher J.

Source: In European Journal of Cancer November 2019 122:42-52

Nivolumab versus investigator’s choice in patients with recurrent or metastatic squamous cell carcinoma of the head and neck: Efficacy and safety in CheckMate 141 by age

Authors: Saba, Nabil F., Blumenschein, George, Jr., Guigay, Joel, Licitra, Lisa, Fayette, Jerome, Harrington, Kevin J., Kiyota, Naomi, Gillison, Maura L., Ferris, Robert L., Jayaprakash, Vijayvel, Li, Li, Brossart, Peter

Source: In Oral Oncology September 2019 96:7-14