Identification and characterization of tumor and stromal derived liquid biopsy analytes in pancreatic ductal adenocarcinoma

Authors: Julian Götze, Kira Meißner, Thais Pereira-Veiga, Yassine Belloum, Svenja Schneegans, Jolanthe Kropidlowski, Joao Gorgulho, Alina Busch, Kim Christin Honselmann, Martin Schönrock, Arne Putscher, Sven Peine, Christine Nitschke, Ronald Simon, Volker Spindler, Jakob Robert Izbicki, Thilo Hackert, Carsten Bokemeyer, Klaus Pantel, Faik Güntaç Uzunoglu, Marianne Sinn, Harriet Wikman

Source: Journal of Experimental & Clinical Cancer Research, Vol 44, Iss 1, Pp 1-13 (2025)

Subject Terms: PDAC, CCAFs, Liquid biopsy, Stroma, Hyaluronan, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/521eb48f51dd4918b6164191f24d0e39

Soluble and EV-bound CD27 act as antagonistic biomarkers in patients with solid tumors undergoing immunotherapy

Authors: Joao Gorgulho, Sven H. Loosen, Ramsha Masood, Franziska Giehren, Francesca Pagani, Gustav Buescher, Lorenz Kocheise, Vincent Joerg, Constantin Schmidt, Kornelius Schulze, Christoph Roderburg, Eva Kinkel, Britta Fritzsche, Simon Wehmeyer, Benjamin Schmidt, Paul Kachel, Christina Rolling, Julian Götze, Alina Busch, Marianne Sinn, Thais Pereira-Veiga, Harriet Wikman, Maria Geffken, Sven Peine, Urte Matschl, Markus Altfeld, Samuel Huber, Ansgar W. Lohse, Fabian Beier, Tim H. Brümmendorf, Carsten Bokemeyer, Tom Luedde, Johann von Felden

Source: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-15 (2024)

Subject Terms: PD-1, Liquid biopsy, Immunotherapy, Soluble immune checkpoints, Prognosis, Biomarker, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/c2fb5d5ae25641debf5ff764186a0fca

Master corepressor inactivation through multivalent SLiM-induced polymerization mediated by the oncogene suppressor RAI2

Authors: Nishit Goradia, Stefan Werner, Edukondalu Mullapudi, Sarah Greimeier, Lina Bergmann, Andras Lang, Haydyn Mertens, Aleksandra Węglarz, Simon Sander, Grzegorz Chojnowski, Harriet Wikman, Oliver Ohlenschläger, Gunhild von Amsberg, Klaus Pantel, Matthias Wilmanns

Source: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/5074a5174b144e20817298b0df93967f

HERC5 downregulation in non-small cell lung cancer is associated with altered energy metabolism and metastasis

Authors: Svenja Schneegans, Jana Löptien, Angelika Mojzisch, Desirée Loreth, Oliver Kretz, Christoph Raschdorf, Annkathrin Hanssen, Antonia Gocke, Bente Siebels, Karthikeyan Gunasekaran, Yi Ding, Leticia Oliveira-Ferrer, Laura Brylka, Thorsten Schinke, Hartmut Schlüter, Ilkka Paatero, Hannah Voß, Stefan Werner, Klaus Pantel, Harriet Wikman

Source: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-18 (2024)

Subject Terms: HERC5, NSCLC, Metastasis, DTC, Cancer metabolism, OXPHOS, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/8ee82af4958b47ecbef81f24542bd06c

RNF40 epigenetically modulates glycolysis to support the aggressiveness of basal-like breast cancer

Authors: Evangelos Prokakis, Shaishavi Jansari, Angela Boshnakovska, Maria Wiese, Kathrin Kusch, Christof Kramm, Christian Dullin, Peter Rehling, Markus Glatzel, Klaus Pantel, Harriet Wikman, Steven A. Johnsen, Julia Gallwas, Florian Wegwitz

Source: Cell Death and Disease, Vol 14, Iss 9, Pp 1-17 (2023)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/45a4565c3aba4ddb93e42ef339891e35

Comparative evaluation of PD‐L1 expression in cytology imprints, circulating tumour cells and tumour tissue in non‐small cell lung cancer patients

Authors: Mustafa Abdo, Yassine Belloum, David Heigener, Lutz Welker, Sönke vonWeihe, Milena Schmidt, Nadine Heuer‐Olewinski, Iris Watermann, Marlen Szewczyk, Jolanthe Kropidlowski, Thais Pereira‐Veiga, Hatice Elmas, Sven Perner, Stefan Steurer, Harriet Wikman, Klaus Pantel, Martin Reck

Source: Molecular Oncology, Vol 17, Iss 5, Pp 737-746 (2023)

Subject Terms: CTCs, cytology imprints, NSCLC, PD‐L1, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1574-7891; https://doaj.org/toc/1878-0261

Access URL: https://doaj.org/article/5f86dcedcf5f4cf3aad21b856a6d9805

The role of the desmosomal protein desmocollin 2 in tumour progression in triple negative breast cancer patients

Authors: Francesca Reimer, Sarah Bryan, Karen Legler, Thomas Karn, Serenella Eppenberger-Castori, Jakob Matschke, Thais Pereira-Veiga, Harriet Wikman, Isabell Witzel, Volkmar Müller, Barbara Schmalfeldt, Karin Milde-Langosch, Udo Schumacher, Christine Stürken, Leticia Oliveira-Ferrer

Source: Cancer Cell International, Vol 23, Iss 1, Pp 1-17 (2023)

Subject Terms: DSC2, Desmosome, CTC cluster, Breast cancer, Brain metastasis, Pulmonary metastasis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2867

Access URL: https://doaj.org/article/7dd783cb52b64e1398cec4d6e4826b38

Decreased PRC2 activity supports the survival of basal-like breast cancer cells to cytotoxic treatments

Authors: Iga K. Mieczkowska, Garyfallia Pantelaiou-Prokaki, Evangelos Prokakis, Geske E. Schmidt, Lukas C. Müller-Kirschbaum, Marcel Werner, Madhobi Sen, Taras Velychko, Katharina Jannasch, Christian Dullin, Joanna Napp, Klaus Pantel, Harriet Wikman, Maria Wiese, Christof M. Kramm, Frauke Alves, Florian Wegwitz

Source: Cell Death and Disease, Vol 12, Iss 12, Pp 1-13 (2021)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/20c0c3f49a9e491b86d9b16315f3a86d

Clinical determinants impacting overall survival of patients with operable brain metastases from non-small cell lung cancer

Authors: Andras Piffko, Benedikt Asey, Lasse Dührsen, Inka Ristow, Johannes Salamon, Harriet Wikman, Cecile L. Maire, Katrin Lamszus, Manfred Westphal, Thomas Sauvigny, Malte Mohme

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: NSCLC, metastasis, brain metastasis, survival, resectable, surgery, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.951805/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/6d3671d62d0a4be786863941023d525f

Pre‐analytical factors affecting the establishment of a single tube assay for multiparameter liquid biopsy detection in melanoma patients

Authors: Svenja Schneegans, Lelia Lück, Katharina Besler, Leonie Bluhm, Julia‐Christina Stadler, Janina Staub, Rüdiger Greinert, Beate Volkmer, Mikael Kubista, Christoffer Gebhardt, Alexander Sartori, Darryl Irwin, Elina Serkkola, Taija afHällström, Evi Lianidou, Markus Sprenger‐Haussels, Melanie Hussong, Peter Mohr, Stefan W. Schneider, Jonathan Shaffer, Klaus Pantel, Harriet Wikman

Source: Molecular Oncology, Vol 14, Iss 5, Pp 1001-1015 (2020)

Subject Terms: CTC, ctDNA, EV, liquid biopsy, melanoma, miRNA, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1574-7891; https://doaj.org/toc/1878-0261

Access URL: https://doaj.org/article/9e3df0b98bd64b93a6f200e8ad0438b0

Tumor-Stroma Interaction in PDAC as a New Approach for Liquid Biopsy and its Potential Clinical Implications

Authors: Julian Götze, Christine Nitschke, Faik G. Uzunoglu, Klaus Pantel, Marianne Sinn, Harriet Wikman

Source: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Subject Terms: pancreatic cancer, liquid biopsy, cancer-associated fibroblasts (CAFs), tumor microenvironment, circulating tumor cells (CTCs), Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2022.918795/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/467dabdb5eba492bbdb914f65655bd4b

Clonality of circulating tumor cells in breast cancer brain metastasis patients

Authors: Carlotta Riebensahm, Simon A. Joosse, Malte Mohme, Annkathrin Hanssen, Jakob Matschke, Yvonne Goy, Isabell Witzel, Katrin Lamszus, Jolanthe Kropidlowski, Cordula Petersen, Anja Kolb-Kokocinski, Sascha Sauer, Kerstin Borgmann, Markus Glatzel, Volkmar Müller, Manfred Westphal, Sabine Riethdorf, Klaus Pantel, Harriet Wikman

Source: Breast Cancer Research, Vol 21, Iss 1, Pp 1-11 (2019)

Subject Terms: CTC, Breast cancer, Brain metastases, Clonality, CNA, NGS, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13058-019-1184-2; https://doaj.org/toc/1465-542X

Access URL: https://doaj.org/article/9ce323027a994649b8033de0443befc4

Circulating Cancer Associated Macrophage-like Cells as a Potential New Prognostic Marker in Pancreatic Ductal Adenocarcinoma

Authors: Christine Nitschke, Benedikt Markmann, Leonie Konczalla, Jolanthe Kropidlowski, Thais Pereira-Veiga, Pasquale Scognamiglio, Martin Schönrock, Marianne Sinn, Marie Tölle, Jakob Izbicki, Klaus Pantel, Faik G. Uzunoglu, Harriet Wikman

Source: Biomedicines, Vol 10, Iss 11, p 2955 (2022)

Subject Terms: liquid biopsy, Circulating Cancer Associated Macrophage-like cells, pancreatic ductal adenocarcinoma, biomarker, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/10/11/2955; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/cd0cee1a519f47e4ae0d74c5b114a9fb

Decellularized In Vitro Capillaries for Studies of Metastatic Tendency and Selection of Treatment

Authors: Outi Huttala, Desiree Loreth, Synnöve Staff, Minna Tanner, Harriet Wikman, Timo Ylikomi

Source: Biomedicines, Vol 10, Iss 2, p 271 (2022)

Subject Terms: tumor microenvironment, cancer, metastatic niches, vasculature, patient-derived cancer cells drug screening, human adipose stromal cells, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/10/2/271; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/85f7689fbc0345c488bebfc5de3e9a26

Circulating Tumour Cell Release after Cement Augmentation of Vertebral Metastases

Authors: Malte Mohme, Sabine Riethdorf, Marc Dreimann, Stefan Werner, Cecile L. Maire, Simon A. Joosse, Frederic Bludau, Volkmar Mueller, Rui P. L. Neves, Nikolas H. Stoecklein, Katrin Lamszus, Manfred Westphal, Klaus Pantel, Harriet Wikman, Sven O. Eicker

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/91d6cac1f9e843848dfa4e20a239fc07

Discovery of Targetable Genetic Alterations in NSCLC Patients with Different Metastatic Patterns Using a MassARRAY-Based Circulating Tumor DNA Assay

Authors: Yassine Belloum, Melanie Janning, Malte Mohme, Ronald Simon, Jolanthe Kropidlowski, Alexander Sartori, Darryl Irwin, Manfred Westphal, Katrin Lamszus, Sonja Loges, Sabine Riethdorf, Klaus Pantel, Harriet Wikman

Source: Cells, Vol 9, Iss 11, p 2337 (2020)

Subject Terms: lung cancer, ctDNA, mutations, liquid biopsy, brain metastases, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/9/11/2337; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/5e71ad33583a4db885e88ab03c845aa4

Stromal Caveolin-1 and Caveolin-2 Expression in Primary Tumors and Lymph Node Metastases

Authors: Wladimir Gerstenberger, Michaela Wrage, Eeva Kettunen, Klaus Pantel, Sisko Anttila, Stefan Steurer, Harriet Wikman

Source: Analytical Cellular Pathology, Vol 2018 (2018)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2210-7177; https://doaj.org/toc/2210-7185

Access URL: https://doaj.org/article/9e96a3ad66434ea09d76c5204db26c8c

Prevention of DNA Replication Stress by CHK1 Leads to Chemoresistance Despite a DNA Repair Defect in Homologous Recombination in Breast Cancer

Authors: Felix Meyer, Saskia Becker, Sandra Classen, Ann Christin Parplys, Wael Yassin Mansour, Britta Riepen, Sara Timm, Claudia Ruebe, Maria Jasin, Harriet Wikman, Cordula Petersen, Kai Rothkamm, Kerstin Borgmann

Source: Cells, Vol 9, Iss 1, p 238 (2020)

Subject Terms: triple-negative breast cancer (tnbc), chromosomal instability (cin), cin70 score, homologous recombination (hr), dna-damage response (ddr), chk1, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/9/1/238; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/b53ca6d143a1471da7002a4f957552d2

Loss of 4q21.23-22.1 is a prognostic marker for disease free and overall survival in non-small cell lung cancer.

Authors: Faik G Uzunoglu, Ebba Dethlefsen, Annkathrin Hanssen, Michaela Wrage, Lena Deutsch, Katharina Harms-Effenberger, Yogesh K Vashist, Matthias Reeh, Guido Sauter, Ronald Simon, Maximillian Bockhorn, Klaus Pantel, Jakob R Izbicki, Harriet Wikman

Source: PLoS ONE, Vol 9, Iss 12, p e113315 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4263470?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/6312138208bc422a8969085d34b4a2f8

Clinical relevance of loss of 11p15 in primary and metastatic breast cancer: association with loss of PRKCDBP expression in brain metastases.

Authors: Harriet Wikman, Bettina Sielaff-Frimpong, Jolanthe Kropidlowski, Isabell Witzel, Karin Milde-Langosch, Guido Sauter, Manfred Westphal, Katrin Lamszus, Klaus Pantel

Source: PLoS ONE, Vol 7, Iss 10, p e47537 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3485301?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/61147d9336f44255ace46982f4c7eae8