Integrated tumor identification and automated scoring minimizes pathologist involvement and provides new insights to key biomarkers in breast cancer

Authors: Bankhead, Peter, Fernández, José A, McArt, Darragh G, Boyle, David P, Li, Gerald, Loughrey, Maurice B, Irwin, Gareth W, Harkin, D Paul, James, Jacqueline A, McQuaid, Stephen, Salto-Tellez, Manuel, Hamilton, Peter W

Source: In Laboratory Investigation January 2018 98(1):15-26

Molecular Subgroup of Primary Prostate Cancer Presenting with Metastatic Biology

Authors: Walker, Steven M., Knight, Laura A., McCavigan, Andrena M., Logan, Gemma E., Berge, Viktor, Sherif, Amir, Pandha, Hardev, Warren, Anne Y., Davidson, Catherine, Uprichard, Adam, Blayney, Jaine K., Price, Bethanie, Jellema, Gera L., Steele, Christopher J., Svindland, Aud, McDade, Simon S., Eden, Christopher G., Foster, Chris, Mills, Ian G., Neal, David E., Mason, Malcolm D., Kay, Elaine W., Waugh, David J., Harkin, D. Paul, Watson, R. William, Clarke, Noel W., Kennedy, Richard D.

Source: In European Urology October 2017 72(4):509-518

Inactivating Mutations in an SH2 Domain-Encoding Gene in X-Linked Lymphoproliferative Syndrome

Authors: Nichols, Kim E., Harkin, D. Paul, Levitz, Seth, Krainer, Michael, Kolquist, Kathryn Ann, Genovese, Cameo, Bernard, Amy, Ferguson, Martin, Zuo, Lin, Snyder, Eric, Buckler, Alan J., Wise, Carol, Ashley, Jennifer, Lovett, Michael, Valentine, Marcus B., Look, A. Thomas, Gerald, William, Housman, David E., Haber, Daniel A.

Source: Proceedings of the National Academy of Sciences of the United States of America, 1998 Nov 01. 95(23), 13765-13770.

Access URL: https://www.jstor.org/stable/46761

Prevalence of Germ-Line Mutations in p16, p19ARF, and CDK4 in Familial Melanoma: Analysis of a Clinic-Based Population

Authors: FitzGerald, Michael G., Harkin, D. Paul, Silva-Arrieta, Sandra, MacDonald, Deborah J., Lucchina, Leslie C., Unsal, Hilal, O'Neill, Erin, Koh, Jim, Finkelstein, Dianne M., Isselbacher, Kurt J., Sober, Arthur J., Haber, Daniel A.

Source: Proceedings of the National Academy of Sciences of the United States of America, 1996 Aug 01. 93(16), 8541-8545.

Access URL: https://www.jstor.org/stable/39899

Analysis of wntless (WLS) expression in gastric, ovarian, and breast cancers reveals a strong association with HER2 overexpression

Authors: Stewart, Jonathan, James, Jacqueline, McCluggage, Glenn W, McQuaid, Stephen, Arthur, Kenneth, Boyle, David, Mullan, Paul, McArt, Darragh, Yan, Benedict, Irwin, Gareth, Harkin, D Paul, Zhengdeng, Lei, Ong, Chee-Wee, Yu, Jia, Virshup, David M, Salto-Tellez, Manuel

Source: In Modern Pathology March 2015 28(3):428-436

Identification of a BRCA1-mRNA Splicing Complex Required for Efficient DNA Repair and Maintenance of Genomic Stability

Authors: Savage, Kienan I., Gorski, Julia J., Barros, Eliana M., Irwin, Gareth W., Manti, Lorenzo, Powell, Alexander J., Pellagatti, Andrea, Lukashchuk, Natalia, McCance, Dennis J., McCluggage, W. Glenn, Schettino, Giuseppe, Salto-Tellez, Manuel, Boultwood, Jacqueline, Richard, Derek J., McDade, Simon S., Harkin, D. Paul

Source: In Molecular Cell 8 May 2014 54(3):445-459

Implications for Powering Biomarker Discovery Studies

Authors: Dibben, Sian M., Holt, Robert J., Davison, Timothy S., Wilson, Claire L., Taylor, Janet, Paul, Ian, McManus, Kieran, Kelly, Paul J., Proutski, Vitali, Harkin, D. Paul, Kerr, Peter, Fennell, Dean A., James, Jacqueline A., Kennedy, Richard D.

Source: In The Journal of Molecular Diagnostics March-April 2012 14(2):130-139

BRCA1 is both a prognostic and predictive biomarker of response to chemotherapy in sporadic epithelial ovarian cancer

Authors: Carser, Judith E., Quinn, Jennifer E., Michie, Caroline O., O'Brien, Eamonn J., McCluggage, W. Glenn, Maxwell, Perry, Lamers, Elisabeth, Lioe, Tong F., Williams, Alistair R.W., Kennedy, Richard D., Gourley, Charlie, Harkin, D. Paul

Source: In Gynecologic Oncology 2011 123(3):492-498

BRCA1 and implications for response to chemotherapy in ovarian cancer

Authors: Quinn, Jennifer E. ^⁎, Carser, Judith E., James, Colin R., Kennedy, Richard D., Harkin, D. Paul

Source: In Gynecologic Oncology 2009 113(1):134-142

BRCA1—A good predictive marker of drug sensitivity in breast cancer treatment?

Authors: Mullan, Paul B., Gorski, Julia J., Harkin, D. Paul

Source: In BBA - Reviews on Cancer 2006 1766(2):205-216

Infrequent mutations of Archipelago ( hAGO, hCDC4, Fbw7) in primary ovarian cancer

Authors: Kwak, Eunice L., Moberg, Kenneth H., Wahrer, Doke C.R., Quinn, Jennifer E., Gilmore, Paula M., Graham, Colin A., Hariharan, Iswar K., Harkin, D. Paul, Haber, Daniel A., Bell, Daphne W.

Source: In Gynecologic Oncology 2005 98(1):124-128

Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1.

Authors: Harkin, D. Paul, Bean, James M., Miklos, David

Source: Cell; May 28 1999, Vol. 97 Issue 5, p575-586, 12p

BRCA1: mechanisms of inactivation and implications for management of patients

Authors: Kennedy, Richard D, Quinn, Jennifer E, Johnston, Patrick G, Harkin, D Paul

Source: In The Lancet 28 September 2002 360(9338):1007-1014

BRCA1 Regulates the Interferon γ-mediated Apoptotic Response

Authors: Andrews, Heather N. ^{‡, §}, Mullan, Paul B. ^{‡, §}, McWilliams, Stewart ^‡, Sebelova, Sarka ^‡, Quinn, Jennifer E. ^‡, Gilmore, Paula M. ^‡, McCabe, Nuala ^‡, Pace, Amy ^¶, Koller, Beverly ^¶, Johnston, Patrick G. ^‡, Haber, Daniel A. ^‖, Harkin, D. Paul ^{‡, **}

Source: In Journal of Biological Chemistry 19 July 2002 277(29):26225-26232

Generation of a non-small cell lung cancer transcriptome microarray

Authors: Johnston Patrick G, Field John K, Farragher Susan M, Fulton Ciaran E, Mulligan Jude M, Kennedy Richard D, Farztdinov Vadim, Oliver Gavin R, Tanney Austin, Harkin D Paul, Proutski Vitali, Mulligan Karl A

Source: BMC Medical Genomics, Vol 1, Iss 1, p 20 (2008)

Subject Terms: Internal medicine, RC31-1245, Genetics, QH426-470

File Description: electronic resource

Relation: http://www.biomedcentral.com/1755-8794/1/20; https://doaj.org/toc/1755-8794

Access URL: https://doaj.org/article/f25d399c8abf40498790eaad2de9130c

BRCA1, a 'complex' protein involved in the maintenance of genomic stability.

Authors: Savage, Kienan I.¹, Harkin, D. Paul¹

Source: FEBS Journal. Feb2015, Vol. 282 Issue 4, p630-646. 17p.

Subject Terms: *PROTEIN genetics, *CANCER invasiveness, *CANCER genetics, *GENETIC mutation, *DNA repair, *DNA damage

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5-Fluorouracil: mechanisms of action and clinical strategies.

Authors: Longley, Daniel B., Harkin, D. Paul, Johnston, Patrick G.

Source: Nature Reviews Cancer. May2003, Vol. 3 Issue 5, p330. 9p.

Subject Terms: *FLUOROURACIL, *CANCER treatment, *DRUG therapy, *BIOMARKERS, *DNA microarrays

PICan: An integromics framework for dynamic cancer biomarker discovery

Authors: McArt, Darragh G., Blayney, Jaine K., Boyle, David P., Irwin, Gareth W., Moran, Michael, Hutchinson, Ryan A., Bankhead, Peter, Kieran, Declan, Wang, Yinhai, Dunne, Philip D., Kennedy, Richard D., Mullan, Paul B., Harkin, D. Paul, Catherwood, Mark A., James, Jacqueline A., Salto-Tellez, Manuel, Hamilton, Peter W.

Source: In Molecular Oncology June 2015 9(6):1234-1240