Nasal brushing molecular endotyping distinguishes patients with chronic rhinosinusitis with nasal polyps with better response to dupilumab

Authors: Gayvert, Kaitlyn, Desrosiers, Martin, Laidlaw, Tanya M., Mannent, Leda P., Patel, Kiran, Horowitz, Julie, Amin, Nikhil, Jagerschmidt, Alexandre, Hamilton, Jennifer D., Lim, Wei Keat, Harel, Sivan

Source: In The Journal of Allergy and Clinical Immunology September 2024 154(3):619-630

Baseline FeNO Independently Predicts the Dupilumab Response in Patients With Moderate-to-Severe Asthma

Authors: Pavord, Ian D., Deniz, Yamo, Corren, Jonathan, Casale, Thomas B., FitzGerald, J. Mark, Izuhara, Kenji, Daizadeh, Nadia, Ortiz, Benjamin, Johnson, Robert R., Harel, Sivan, Djandji, Michel, Goga, Ledia, Crikelair, Nora, Rowe, Paul J., Busse, William W.

Source: In The Journal of Allergy and Clinical Immunology: In Practice April 2023 11(4):1213-1220

Pharmacokinetics and pharmacodynamics of itepekimab in healthy adults and patients with asthma: Phase I first‐in‐human and first‐in‐patient trials

Authors: Kosloski, Matthew P., Kalliolias, George D., Xu, Christine R., Harel, Sivan, Lai, Ching‐Ha, Zheng, Wenjun, Davis, John D., Kamal, Mohamed A.

Source: Clinical and translational science. 15(2):384-395

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100141601622.0x000001&indx=1&recIds=ETOCvdc_100141601622.0x000001

Dupilumab efficacy and biomarkers in chronic rhinosinusitis with nasal polyps: Association between dupilumab treatment effect on nasal polyp score and biomarkers of type 2 inflammation in patients with chronic rhinosinusitis with nasal polyps in the phase 3 SINUS‐24 and SINUS‐52 trials

Authors: Bachert, Claus, Corren, Jonathan, Lee, Stella E., Zhang, Haixin, Harel, Sivan, Cunoosamy, Danen, Khan, Asif H., Jacob‐Nara, Juby A., Siddiqui, Shahid, Nash, Scott, Rowe, Paul J., Deniz, Yamo

Source: International forum of allergy & rhinology. 12(9):1191-1195

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100158942350.0x000001&indx=1&recIds=ETOCvdc_100158942350.0x000001

Baseline FeNO as a prognostic biomarker for subsequent severe asthma exacerbations in patients with uncontrolled, moderate-to-severe asthma receiving placebo in the LIBERTY ASTHMA QUEST study: a post-hoc analysis

Authors: Busse, William W ^*, Wenzel, Sally E, Casale, Thomas B, FitzGerald, J Mark, Rice, Megan S, Daizadeh, Nadia, Deniz, Yamo, Patel, Naimish, Harel, Sivan, Rowe, Paul J, Graham, Neil M H, O'Riordan, Thomas, Pavord, Ian D

Source: In The Lancet Respiratory Medicine October 2021 9(10):1165-1173

Dupilumab suppresses type 2 inflammatory biomarkers across multiple atopic, allergic diseases

Authors: Hamilton, Jennifer D., Harel, Sivan, Swanson, Brian N., Brian, William, Chen, Zhen, Rice, Megan S., Amin, Nikhil, Ardeleanu, Marius, Radin, Allen, Shumel, Brad, Ruddy, Marcella, Patel, Naimish, Pirozzi, Gianluca, Mannent, Leda, Graham, Neil M. H.

Source: Clinical & experimental allergy. 51(7):915-931

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123828621.0x000001&indx=1&recIds=ETOCvdc_100123828621.0x000001

Efficacy of dupilumab on clinical outcomes in patients with asthma and perennial allergic rhinitis

Authors: Busse, William W., Maspero, Jorge F., Lu, Yufang, Corren, Jonathan, Hanania, Nicola A., Chipps, Bradley E., Katelaris, Constance H., FitzGerald, J. Mark, Quirce, Santiago, Ford, Linda B., Rice, Megan S., Kamat, Siddhesh, Khan, Asif H., Jagerschmidt, Alexandre, Harel, Sivan, Rowe, Paul, Pirozzi, Gianluca, Amin, Nikhil, Ruddy, Marcella, Graham, Neil M.H., Teper, Ariel

Source: In Annals of Allergy, Asthma & Immunology November 2020 125(5):565-576

Dupilumab Efficacy in Patients with Uncontrolled, Moderate-to-Severe Allergic Asthma

Authors: Corren, Jonathan, Castro, Mario, O'Riordan, Thomas, Hanania, Nicola A., Pavord, Ian D., Quirce, Santiago, Chipps, Bradley E., Wenzel, Sally E., Thangavelu, Karthinathan, Rice, Megan S., Harel, Sivan, Jagerschmidt, Alexandre, Khan, Asif H., Kamat, Siddhesh, Maroni, Jaman, Rowe, Paul, Lu, Yufang, Amin, Nikhil, Pirozzi, Gianluca, Ruddy, Marcella, Graham, Neil M.H., Teper, Ariel

Source: In The Journal of Allergy and Clinical Immunology: In Practice February 2020 8(2):516-526

Dupilumab Efficacy in Uncontrolled, Moderate-to-Severe Asthma with Self-Reported Chronic Rhinosinusitis

Authors: Maspero, Jorge F., Katelaris, Constance H., Busse, William W., Castro, Mario, Corren, Jonathan, Chipps, Bradley E., Peters, Anju T., Pavord, Ian D., Ford, Linda B., Sher, Lawrence, Rabe, Klaus F., Rice, Megan S., Rowe, Paul, Lu, Yufang, Harel, Sivan, Jagerschmidt, Alexandre, Khan, Asif H., Kamat, Siddhesh, Pirozzi, Gianluca, Amin, Nikhil, Ruddy, Marcella, Graham, Neil M.H., Mannent, Leda P., Teper, Ariel

Source: In The Journal of Allergy and Clinical Immunology: In Practice February 2020 8(2):527-539

Dupilumab efficacy across serum IgE and blood eosinophil levels in chronic rhinosinusitis with nasal polyposis.

Authors: Bachert, Claus, Gevaert, Philippe, Lipworth, Brian, Mustafa, Syed Shahzad, Lane, Andrew P., Mullol, Joaquim, Rowe, Paul, Deniz, Yamo, Kamat, Siddhesh, Khan, Asif H., Jacob‐Nara, Juby, Siddiqui, Shahid, Ruddy, Marcella, Laws, Elizabeth, Msihid, Jérôme, Harel, Sivan, Jagerschmidt, Alexandre, Amin, Nikhil, Mannent, Leda, Rout, Raj

Source: Allergy; Oct2024, Vol. 79 Issue 10, p2858-2861, 4p

Subject Terms: IMMUNOGLOBULIN E, STOCK options, OLFACTOMETRY, MEDICAL writing, ENDOSCOPIC surgery, NASAL polyps

Pharmacokinetics and pharmacodynamics of itepekimab in adults with moderate‐to‐severe atopic dermatitis: Results from two terminated phase II trials.

Authors: Kosloski, Matthew P., Guttman‐Yassky, Emma, Cork, Michael J., Worm, Margitta, Nahm, Dong‐Ho, Zhu, Xiaoping, Ruddy, Marcella K., Harel, Sivan, Kamal, Mohamed A., Goulaouic, Hélène, Xu, Christine R., Avetisova, Elena, Davis, John D., Nivens, Michael C., Shabbir, Arsalan, Radin, Allen

Source: CTS: Clinical & Translational Science; Aug2024, Vol. 17 Issue 8, p1-14, 14p

Subject Terms: CHRONIC obstructive pulmonary disease, EPITHELIUM, ATOPIC dermatitis, EPITHELIAL cells, DUPILUMAB

Differential modulation of allergic rhinitis nasal transcriptome by dupilumab and allergy immunotherapy.

Authors: Wipperman, Matthew F., Gayvert, Kaitlyn M., Atanasio, Amanda, Wang, Claire Q., Corren, Jonathan, Covarrubias, Angelica, Setliff, Ian, Chio, Erica, Laws, Elizabeth, Wolfe, Kelley, Harel, Sivan, Maloney, Jennifer, Herman, Gary, Orengo, Jamie M., Lim, Wei Keat, Hamon, Sara C., Hamilton, Jennifer D., O'Brien, Meagan P.

Source: Allergy; Apr2024, Vol. 79 Issue 4, p894-907, 14p

Subject Terms: ALLERGIC rhinitis, DUPILUMAB, TRANSCRIPTOMES, IMMUNOTHERAPY, INFLAMMATORY mediators

FGF5 is a crucial regulator of hair length in humans

Authors: Higgins, Claire A., Petukhova, Lynn, Harel, Sivan, Ho, Yuan Y., Drill, Esther, Shapiro, Lawrence, Wajid, Muhammad, Christiano, Angela M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2014 Jul . 111(29), 10648-10653.

Access URL: https://www.jstor.org/stable/23803691

Effect of Dupilumab on Type 2 Biomarkers in Chronic Rhinosinusitis With Nasal Polyps: SINUS-52 Study Results.

Authors: Bachert, Claus, Laidlaw, Tanya M., Cho, Seong H., Mullol, Joaquim, Swanson, Brian N., Naimi, Souad, Classe, Marion, Harel, Sivan, Jagerschmidt, Alexandre, Laws, Elizabeth, Ruddy, Marcella, Praestgaard, Amy, Amin, Nikhil, Mannent, Leda P.

Source: Annals of Otology, Rhinology & Laryngology; Dec2023, Vol. 132 Issue 12, p1649-1661, 13p

Subject Terms: THERAPEUTIC use of monoclonal antibodies, NASAL polyps, BIOMARKERS, DRUG efficacy, EOSINOPHILS, INTERLEUKINS, IMMUNOGLOBULINS, MONOCLONAL antibodies, TREATMENT duration, HEALTH outcome assessment, RANDOMIZED controlled trials, PLACEBOS, COMPARATIVE studies, SINUSITIS, MAST cells, BLIND experiment, DESCRIPTIVE statistics, RESEARCH funding, STATISTICAL sampling, CHEMOKINES, LEUKOTRIENES

Mo1228 DUPILUMAB NORMALIZES THE EOSINOPHILIC ESOPHAGITIS DISEASE TRANSCRIPTOME IN ADULT PATIENTS WITH EOSINOPHILIC ESOPHAGITIS

Authors: Hamilton, Jennifer D., Lim, Wei Keat, Hamon, Sara C., Rothenberg, Marc E., Collins, Margaret H., Chehade, Mirna, Harel, Sivan, Wipperman, Matthew F., Hirano, Ikuo, Dellon, Evan S., Brian, William, Mannent, Leda, Graham, Neil M., Patel, Naimish, Ruddy, Marcella, Radin, Allen

Source: Gastroenterology. 158(6):S-835-S-835

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131715554.0x000001&indx=1&recIds=ETOCvdc_100131715554.0x000001

Genetics of Structural Hair Disorders

Authors: Harel, Sivan, Christiano, Angela M.

Source: In Journal of Investigative Dermatology November 2012 132 Supplement 3:E22-E26

Dupilumab Reduces Biomarkers of Type 2 Inflammation in Adult and Adolescent Patients With Eosinophilic Esophagitis: Results From Parts A and C of a Three-Part, Phase 3 LIBERTY EoE TREET Study

Authors: Rothenberg, Marc, Hirano, Ikuo, Dellon, Evan, Collins, Margaret, Leung, John, Schlag, Christoph, Schoepfer, Alain, Zhao, Qiong, Maloney, Jennifer, Harel, Sivan, Patel, Kiran, Shumel, Brad, Khodzhayev, Angela, Goga, Ledia, Jacob-Nara, Juby, Deniz, Yamo, Rowe, Paul, Laws, Elizabeth, Akinlade, Bola, Mannent, Leda, Amin, Nikhil, Cunoosamy, Danen, Hamilton, Jennifer

Source: Journal of allergy and clinical immunology. 149(2):AB210-AB210

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100157120817.0x000001&indx=1&recIds=ETOCvdc_100157120817.0x000001

Dupilumab treatment significantly improves skin barrier function in adult and adolescent patients with moderate to severe atopic dermatitis

Authors: Berdyshev, Evgeny, Goleva, Elena, Bissonnette, Robert, Bronova, Irina, Bronoff, Anna Sofia, Richers, Brittany, Garcia, Shannon, Gama, Marco Ramirez, Taylor, Patricia, Bologna, Gabriel, Agueusop, Inoncent, Boguniewicz, Mark, Harel, Sivan, Levit, Noah, Rossi, Ana, Zhang, Annie, Leung, Donald

Source: Journal of allergy and clinical immunology. 149(2):AB10-AB10

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100157225120.0x000001&indx=1&recIds=ETOCvdc_100157225120.0x000001

Zfx Controls the Self-Renewal of Embryonic and Hematopoietic Stem Cells

Authors: Galan-Caridad, Jose M., Harel, Sivan, Arenzana, Teresita L., Hou, Z. Esther, Doetsch, Fiona K., Mirny, Leonid A., Reizis, Boris

Source: In Cell 20 April 2007 129(2):345-357

Keratin 71 Mutations: From Water Dogs to Woolly Hair

Authors: Harel, Sivan, Christiano, Angela M.

Source: Journal of investigative dermatology. 132(10):2315-2317

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100053668465.0x000001&indx=1&recIds=ETOCvdc_100053668465.0x000001