Pre-clinical phaeochromocytoma and paraganglioma models: Cell lines, animal models, and a human primary culture model

Authors: Wang, Katharina ^a, Fischer, Alessa ^b, Maccio, Umberto ^c, Hantel, Constanze ^{b, d}, Beuschlein, Felix ^{a, b, e}, Grossman, Ashley B. ^{f, g}, Pacak, Karel ^h, Nölting, Svenja ^{a, b, ⁎, 1}

Source: In Best Practice & Research Clinical Endocrinology & Metabolism December 2024 38(6)

A targetable antioxidant defense mechanism to EZH2 inhibitors enhances tumor cell vulnerability to ferroptosis.

Authors: Nocito, Marta C., Hantel, Constanze, Lerario, Antonio M., Mastrorocco, Fabrizio, De Martino, Luca, Musicco, Clara, Perrotta, Ida D., Scalise, Mariafrancesca, Indiveri, Cesare, Giannattasio, Sergio, Val, Pierre, Lanzino, Marilena, Pezzi, Vincenzo, Casaburi, Ivan, Sirianni, Rosa

Source: Cell Death & Disease; 4/14/2025, Vol. 16 Issue 1, p1-15, 15p

Therapeutic potential of targeting the FLNA‐regulated Wee1 kinase in adrenocortical carcinomas.

Authors: Esposito, Emanuela, Marra, Giusy, Catalano, Rosa, Maioli, Sara, Nozza, Emma, Barbieri, Anna Maria, Hantel, Constanze, Di Dalmazi, Guido, Sigala, Sandra, Geginat, Jens, Cassinotti, Elisa, Baldari, Ludovica, Palmieri, Serena, Mangone, Alessandra, Berruti, Alfredo, Ferrante, Emanuele, Mantovani, Giovanna, Peverelli, Erika

Source: International Journal of Cancer; Mar2025, Vol. 156 Issue 6, p1256-1271, 16p

Subject Terms: CANCER treatment, KINASES, GENETIC regulation, CELL communication, CANCER invasiveness, ADRENAL tumors, PROTEINS

Emerging role of IGF1R and IR expression and localisation in adrenocortical carcinomas.

Authors: Catalano, Rosa, Nozza, Emma, Altieri, Barbara, Esposito, Emanuela, Croci, Giorgio A., Barbieri, Anna Maria, Treppiedi, Donatella, Di Bari, Sonia, Kimpel, Otilia, Detomas, Mario, Tamburello, Mariangela, Schauer, Marc P., Herterich, Sabine, Angelousi, Anna, Luconi, Michaela, Canu, Letizia, Nesi, Gabriella, Hantel, Constanze, Sigala, Sandra, Landwehr, Laura-Sophie

Source: Cell Communication & Signaling; 3/4/2025, Vol. 23 Issue 1, p1-16, 16p

Subject Terms: SOMATOMEDIN A, MEDICAL sciences, TUMOR markers, CELL membranes, CELL growth

Sexual dimorphism in COVID-19: potential clinical and public health implications

Authors: Bechmann, Nicole ^*, Barthel, Andreas ^*, Schedl, Andreas, Herzig, Stephan, Varga, Zsuzsanna, Gebhard, Catherine, Mayr, Manuel, Hantel, Constanze, Beuschlein, Felix, Wolfrum, Christian, Perakakis, Nikolaos, Poston, Lucilla, Andoniadou, Cynthia L, Siow, Richard, Gainetdinov, Raul R, Dotan, Arad, Shoenfeld, Yehuda, Mingrone, Geltrude, Bornstein, Stefan R ^*

Source: In The Lancet Diabetes & Endocrinology March 2022 10(3):221-230

Development and Characterization of 3-Dimensional Cell Culture Models of Adrenocortical Carcinoma.

Authors: Feely, Sarah, Mullen, Nathan, Donlon, Padraig T, Reidy, Eileen, Challapalli, Ritihaas Surya, Hassany, Mariam, Sorushanova, Anna, Martinez, Eduardo Ribes, Owens, Peter, Quinn, Anne Marie, Pandit, Abhay, Harhen, Brendan, Finn, David P, Hantel, Constanze, O'Halloran, Martin, Prakash, Punit, Dennedy, Michael C

Source: Endocrinology; Jan2025, Vol. 166 Issue 1, p1-10, 10p

Subject Terms: ADRENAL cortex, PATHOLOGY, CELL culture, CELL lines, TUMOR microenvironment

Exquisite sensitivity of adrenocortical carcinomas to induction of ferroptosis

Authors: Belavgeni, Alexia, Bornstein, Stefan R., von Mässenhausen, Anne, Tonnus, Wulf, Stumpf, Julian, Meyer, Claudia, Othmar, Evelyn, Latk, Markus, Kanczkowski, Waldemar, Kroiss, Matthias, Hantel, Constanze, Hugo, Christian, Fassnacht, Martin, Ziegler, Christian G., Schally, Andrew V., Krone, Nils P., Linkermann, Andreas

Source: Proceedings of the National Academy of Sciences of the United States of America, 2019 Oct . 116(44), 22269-22274.

Access URL: https://www.jstor.org/stable/26859871

In vitro cytotoxicity of cabazitaxel in adrenocortical carcinoma cell lines and human adrenocortical carcinoma primary cell cultures☆

Authors: Fragni, Martina, Palma Lopez, Lilian Patricia, Rossini, Elisa, Abate, Andrea, Cosentini, Deborah, Salvi, Valentina, Vezzoli, Sara, Poliani, Pietro Luigi, Bosisio, Daniela, Hantel, Constanze, Tiberio, Guido A.M., Grisanti, Salvatore, Memo, Maurizio, Terzolo, Massimo, Berruti, Alfredo, Sigala, Sandra

Source: In Molecular and Cellular Endocrinology 1 December 2019 498

Contemporary preclinical human models of adrenocortical carcinoma

Authors: Pinto, Emilia Modolo, Kiseljak-Vassiliades, Katja, Hantel, Constanze

Source: In Current Opinion in Endocrine and Metabolic Research October 2019 8:139-144

Opposing Effects of Cannabidiol in Patient-derived Neuroendocrine Tumor, Pheochromocytoma/Paraganglioma Primary Cultures.

Authors: Wang, Katharina, Schober, Laura, Fischer, Alessa, Bechmann, Nicole, Maurer, Julian, Peischer, Lea, Reul, Astrid, Hantel, Constanze, Reincke, Martin, Beuschlein, Felix, Robledo, Mercedes, Mohr, Hermine, Pellegata, Natalia S, Schilbach, Katharina, Knösel, Thomas, Ilmer, Matthias, Angele, Martin, Kroiss, Matthias, Maccio, Umberto, Broglie-Däppen, Martina

Source: Journal of Clinical Endocrinology & Metabolism; Nov2024, Vol. 109 Issue 11, p2892-2904, 13p

Subject Terms: NEUROENDOCRINE tumors, CANNABINOIDS, CANNABIDIOL, TUMOR surgery, PARAGANGLIOMA

Human and Murine Cell Lines for Adrenocortical Carcinoma and Pheochromocytoma.

Authors: Luca, Edlira, Abate, Andrea, Wang, Katharina, Bornstein, Stefan, Sigala, Sandra, Beuschlein, Felix, Nölting, Svenja, Hantel, Constanze

Source: Endocrines; Sep2024, Vol. 5 Issue 3, p261-276, 16p

Subject Terms: ADRENAL cortex, ADRENAL glands, CELL lines, PHEOCHROMOCYTOMA, ANIMAL models in research

Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma

Authors: Akbani, Rehan, Ally, Adrian, Amar, Laurence, Amelio, Antonio L., Arachchi, Harindra, Asa, Sylvia L., Auchus, Richard J., Auman, J. Todd, Baertsch, Robert, Balasundaram, Miruna, Balu, Saianand, Bartsch, Detlef K., Baudin, Eric, Bauer, Thomas, Beaver, Allison, Benz, Christopher, Beroukhim, Rameen, Beuschlein, Felix, Bodenheimer, Tom, Boice, Lori, Bowen, Jay, Bowlby, Reanne, Brooks, Denise, Carlsen, Rebecca, Carter, Suzie, Cassol, Clarissa A., Cherniack, Andrew D., Chin, Lynda, Cho, Juok, Chuah, Eric, Chudamani, Sudha, Cope, Leslie, Crain, Daniel, Curley, Erin, Danilova, Ludmila, de Cubas, Aguirre A., de Krijger, Ronald R., Demchok, John A., Deutschbein, Timo, Dhalla, Noreen, Dimmock, David, Dinjens, Winand N.M., Else, Tobias, Eng, Charis, Eschbacher, Jennifer, Fassnacht, Martin, Felau, Ina, Feldman, Michael, Ferguson, Martin L., Fiddes, Ian, Fishbein, Lauren, Frazer, Scott, Gabriel, Stacey B., Gardner, Johanna, Gastier-Foster, Julie M., Gehlenborg, Nils, Gerken, Mark, Getz, Gad, Geurts, Jennifer, Ghayee, Hans K., Gimenez-Roqueplo, Anne-Paule, Giordano, Thomas J., Goldman, Mary, Graim, Kiley, Gupta, Manaswi, Haan, David, Hahner, Stefanie, Hantel, Constanze, Haussler, David, Hayes, D. Neil, Heiman, David I., Hoadley, Katherine A., Holt, Robert A., Hoyle, Alan P., Huang, Mei, Hunt, Bryan, Hutter, Carolyn M., Jefferys, Stuart R., Johnson, Amy R., Jones, Steven J.M., Jones, Corbin D., Kasaian, Katayoon, Kebebew, Electron, Kim, Jaegil, Kimes, Patrick, Knijnenburg, Theo, Korpershoek, Esther, Lander, Eric, Lawrence, Michael S., Lechan, Ronald, Lee, Darlene, Leraas, Kristen M., Lerario, Antonio, Leshchiner, Ignaty, Lichtenberg, Tara M., Lin, Pei, Ling, Shiyun, Liu, Jia, LiVolsi, Virginia A., Lolla, Laxmi, Lotan, Yair, Lu, Yiling, Ma, Yussanne, Maison, Nicole, Makowski, Liza, Mallery, David, Mannelli, Massimo, Marquard, Jessica, Marra, Marco A., Matthew, Thomas, Mayo, Michael, Méatchi, Tchao, Meng, Shaowu, Merino, Maria J., Mete, Ozgur, Meyerson, Matthew, Mieczkowski, Piotr A., Mills, Gordon B., Moore, Richard A., Morozova, Olena, Morris, Scott, Mose, Lisle E., Mungall, Andrew J., Murray, Bradley A., Naresh, Rashi, Nathanson, Katherine L., Newton, Yulia, Ng, Sam, Ni, Ying, Noble, Michael S., Nwariaku, Fiemu, Pacak, Karel, Parker, Joel S., Paul, Evan, Penny, Robert, Perou, Charles M., Perou, Amy H., Pihl, Todd, Powers, James, Rabaglia, Jennifer, Radenbaugh, Amie, Ramirez, Nilsa C., Rao, Arjun, Rathmell, W. Kimryn, Riester, Anna, Roach, Jeffrey, Robertson, A. Gordon, Sadeghi, Sara, Saksena, Gordon, Salama, Sofie, Saller, Charles, Sandusky, George, Sbiera, Silviu, Schein, Jacqueline E., Schumacher, Steven E., Shelton, Candace, Shelton, Troy, Sheth, Margi, Shi, Yan, Shih, Juliann, Shmulevich, Ilya, Simons, Janae V., Sipahimalani, Payal, Skelly, Tara, Sofia, Heidi J., Sokolov, Artem, Soloway, Matthew G., Sougnez, Carrie, Stuart, Josh, Sun, Charlie, Swatloski, Teresa, Tam, Angela, Tan, Donghui, Tarnuzzer, Roy, Tarvin, Katherine, Thiessen, Nina, Thorne, Leigh B., Timmers, Henri J., Tischler, Arthur S., Tse, Kane, Uzunangelov, Vlado, van Berkel, Anouk, Veluvolu, Umadevi, Vicha, Ales, Voet, Doug, Waldmann, Jens, Walter, Vonn, Wan, Yunhu, Wang, Zhining, Wang, Tracy S., Weaver, Joellen, Weinstein, John N., Weismann, Dirk, Wenz, Brandon, Wilkerson, Matthew D., Wise, Lisa, Wong, Tina, Wong, Christopher, Wu, Ye, Yang, Liming, Zelinka, Tomas, Zenklusen, Jean C., Zhang, Jiashan (Julia), Zhang, Wei, Zhu, Jingchun, Zinzindohoué, Franck, Zmuda, Erik

Source: In Cancer Cell 13 February 2017 31(2):181-193

IGF1-R inhibition and liposomal doxorubicin: Progress in preclinical evaluation for the treatment of adrenocortical carcinoma

Authors: Beuschlein, Felix, Jakoby, Judith, Mentz, Susanne, Zambetti, Gerard, Jung, Sara, Reincke, Martin, Süss, Regine, Hantel, Constanze

Source: In Molecular and Cellular Endocrinology 15 June 2016 428:82-88

TNF alpha signaling is associated with therapeutic responsiveness to vascular disrupting agents in endocrine tumors

Authors: Hantel, Constanze, Ozimek, Alexandra, Lira, Regia, Ragazzon, Bruno, Jäckel, Carsten, Frantsev, Roman, Reincke, Martin, Bertherat, Jérôme, Mussack, Thomas, Beuschlein, Felix

Source: In Molecular and Cellular Endocrinology 5 March 2016 423:87-95

Xenograft models for adrenocortical carcinoma

Authors: Hantel, Constanze ^*, Beuschlein, Felix

Source: In Molecular and Cellular Endocrinology 5 February 2016 421:28-33

Zona Glomerulosa–Derived Klotho Modulates Aldosterone Synthase Expression in Young Female Mice.

Authors: Daryadel, Arezoo, Tang, Cong, Xie, Ye, Peitzsch, Mirko, Fisi, Viktoria, Hantel, Constanze, Loffing-Cueni, Dominique, Breault, David T, Penton, David, Loffing, Johannes, Beuschlein, Felix

Source: Endocrinology; May2024, Vol. 165 Issue 5, p1-9, 9p

Subject Terms: CLOTHO (Greek deity), ALDOSTERONE, IMMUNOFLUORESCENCE

Impact of the PI3K-alpha inhibitor alpelisib on everolimus resistance and somatostatin receptor expression in an orthotopic pancreatic NEC xenograft mouse model.

Authors: Mohan, Ajay-Mohan, Prasad, Sonal, Schmitz-Peiffer, Fabian, Lange, Catharina, Lukas, Mathias, Koziolek, Eva J., Albrecht, Jakob, Messroghli, Daniel, Stein, Ulrike, Ilmer, Matthias, Wang, Katharina, Schober, Laura, Reul, Astrid, Maurer, Julian, Friemel, Juliane, Weber, Achim, Zuellig, Richard A., Hantel, Constanze, Fritsch, Ralph, Reincke, Martin

Source: Endocrine-Related Cancer; Jan2024, Vol. 31 Issue 1, p1-15, 15p

Subject Terms: EVEROLIMUS, SOMATOSTATIN receptors, LABORATORY mice, ANIMAL disease models, NEUROENDOCRINE tumors, ORAL drug administration

Responses to systemic therapy in metastatic pheochromocytoma/paraganglioma: a retrospective multicenter cohort study.

Authors: Fischer, Alessa, Kloos, Simon, Remde, Hanna, Dischinger, Ulrich, Pamporaki, Christina, Timmers, Henri J. L. M., Robledo, Mercedes, Fliedner, Stephanie M. J., Wang, Katharina, Maurer, Julian, Reul, Astrid, Bechmann, Nicole, Hantel, Constanze, Mohr, Hermine, Pellegata, Natalia S., Bornstein, Stefan R., Kroiss, Matthias, Auernhammer, Christoph J., Reincke, Martin, Pacak, Karel

Source: European Journal of Endocrinology; Nov2023, Vol. 189 Issue 5, p546-565, 20p

Subject Terms: SYSTEMIC family therapy, PHEOCHROMOCYTOMA

PD-L1 and HIF-2α Upregulation in Head and Neck Paragangliomas after Embolization.

Authors: Fischer, Alessa, Maccio, Umberto, Wang, Katharina, Friemel, Juliane, Broglie Daeppen, Martina A., Vetter, Diana, Lehmann, Kuno, Reul, Astrid, Robledo, Mercedes, Hantel, Constanze, Bechmann, Nicole, Pacak, Karel, Zitzmann, Kathrin, Auernhammer, Christoph J., Grossman, Ashley B., Beuschlein, Felix, Nölting, Svenja

Source: Cancers; Nov2023, Vol. 15 Issue 21, p5199, 15p

Subject Terms: PROTEINS, KRUSKAL-Wallis Test, PROGRAMMED death-ligand 1, IMMUNE checkpoint inhibitors, IMMUNOHISTOCHEMISTRY, HEAD & neck cancer, THERAPEUTIC embolization, PEARSON correlation (Statistics), COMPARATIVE studies, CHI-squared test, DESCRIPTIVE statistics, PHEOCHROMOCYTOMA, RESEARCH funding, PARAGANGLIOMA, DATA analysis software, TUMOR markers, HYPOXEMIA, CELL death

Metastatic Pheochromocytoma and Paraganglioma: Somatostatin Receptor 2 Expression, Genetics, and Therapeutic Responses.

Authors: Fischer, Alessa, Kloos, Simon, Maccio, Umberto, Friemel, Juliane, Remde, Hanna, Fassnacht, Martin, Pamporaki, Christina, Eisenhofer, Graeme, Timmers, Henri J. L. M., Robledo, Mercedes, Fliedner, Stephanie M. J., Wang, Katharina, Maurer, Julian, Reul, Astrid, Zitzmann, Kathrin, Bechmann, Nicole, Žygienė, Gintarė, Richter, Susan, Hantel, Constanze, Vetter, Diana

Source: Journal of Clinical Endocrinology & Metabolism; Oct2023, Vol. 108 Issue 10, p2676-2685, 10p

Subject Terms: PHEOCHROMOCYTOMA, PARAGANGLIOMA, SOMATOSTATIN receptors