BCMA-directed CAR T-cell therapy in patients with multiple myeloma and CNS involvement

Authors: Gaballa, Mahmoud R. ¹, Puglianini, Omar Castaneda ², Cohen, Adam ³, Vogl, Dan ³, Chung, Alfred ⁴, Ferreri, Christopher J. ⁵, Voorhees, Peter ⁵, Hansen, Doris K. ², Patel, Krina K. ^{1, ∗}

Source: In Blood Advances 11 March 2025 9(5):1171-1180

Safety and efficacy of standard-of-care ciltacabtagene autoleucel for relapsed/refractory multiple myeloma

Authors: Sidana, Surbhi ^{1, ∗}, Patel, Krina K. ², Peres, Lauren C. ³, Bansal, Radhika ⁴, Kocoglu, Mehmet H. ⁵, Shune, Leyla ⁶, Atrash, Shebli ⁷, Smith, Kinaya ⁸, Midha, Shonali ⁹, Ferreri, Christopher ⁷, Dhakal, Binod ⁸, Dima, Danai ¹⁰, Costello, Patrick ⁹, Wagner, Charlotte ¹¹, Reshef, Ran ¹², Hosoya, Hitomi ¹, Mikkilineni, Lekha ¹, Atanackovic, Djordje ⁵, Chhabra, Saurabh ¹³, Parrondo, Ricardo ¹⁴, Nadeem, Omar ⁹, Mann, Hashim ¹⁵, Kalariya, Nilesh ², Hovanky, Vanna ¹, De Avila, Gabriel ³, Freeman, Ciara L. ³, Locke, Frederick L. ³, Alsina, Melissa ³, Wong, Sandy ¹⁶, Herr, Megan ¹⁷, Htut, Myo ¹⁸, McGuirk, Joseph ⁶, Sborov, Douglas W. ¹¹, Khouri, Jack ¹⁰, Martin, Thomas ¹⁶, Janakiram, Murali ¹⁸, Lin, Yi ⁴, Hansen, Doris K. ^{3, ∗∗}

Source: In Blood 2 January 2025 145(1):85-97

Tumor burden quantified by soluble B-cell maturation antigen and metabolic tumor volume determines myeloma CAR-T outcomes

Authors: Freeman, Ciara L. ^{1, ∗}, Noble, Jerald ², Menges, Meghan ², Villanueva, Ricardo ³, Nakashima, Justyn Y. ⁴, Figura, Nicholas B. ⁴, Tonseth, Rolf Petter ⁵, Werner Idiaquez, Dietrich ⁶, Skelson, Lawrence ¹, Smith, Eric ¹, Abraham-Miranda, Julieta ², Corallo, Salvatore ², De Avila, Gabriel ², Castaneda Puglianini, Omar A. ¹, Liu, Hien ¹, Alsina, Melissa ¹, Nishihori, Taiga ¹, Shain, Kenneth H. ⁷, Baz, Rachid ⁷, Blue, Brandon ⁷, Grajales-Cruz, Ariel ⁷, Koomen, John M. ⁸, Atkins, Reginald M. ², Hansen, Doris K. ¹, S. Silva, Ariosto ⁹, Kim, Jongphil ¹⁰, Balagurunathan, Yoganand ¹¹, Locke, Frederick L. ¹

Source: In Blood October 2024

Clinical outcomes after idecabtagene vicleucel in older patients with multiple myeloma: a multicenter real-world experience

Authors: Kalariya, Nilesh M., Hildebrandt, Michelle A. T., Hansen, Doris K., Sidana, Surbhi, Khouri, Jack, Ferreri, Christopher J., Doyle, William N., Castaneda-Puglianini, Omar, Freeman, Ciara L., Hovanky, Vanna, Hosoya, Hitomi, Shune, Leyla O., Patel, Krina K.

Source: In Blood Advances 10 September 2024 8(17):4679-4688

Applying the EHA/EBMT grading for ICAHT after CAR-T: comparative incidence and association with infections and mortality

Authors: Rejeski, Kai, Wang, Yucai, Hansen, Doris K., Iacoboni, Gloria, Bachy, Emmanuel, Bansal, Radhika, Penack, Olaf, Müller, Fabian, Bethge, Wolfgang, Munoz, Javier, Mohty, Razan, Bücklein, Veit L., Barba, Pere, Locke, Frederick L., Lin, Yi, Jain, Michael D., Subklewe, Marion

Source: In Blood Advances 23 April 2024 8(8):1857-1868

Racial and ethnic differences in clinical outcomes among patients with multiple myeloma treated with CAR T-cell therapy

Authors: Peres, Lauren C., Oswald, Laura B., Dillard, Christen M., De Avila, Gabriel, Nishihori, Taiga, Blue, Brandon J., Freeman, Ciara L., Locke, Frederick L., Alsina, Melissa, Castaneda Puglianini, Omar, Shune, Leyla, Sborov, Douglas W., Wagner, Charlotte, Dima, Danai, Hashmi, Hamza, Davis, James A., Kocoglu, Mehmet H., Badros, Ashraf Z., Atrash, Shebli, Simmons, Gary, Kalariya, Nilesh, Ferreri, Christopher, Anderson, Larry D., Jr, Afrough, Aimaz, Kaur, Gurbakhash, Lin, Yi, Liu, Lawrence, Nadeem, Omar, Voorhees, Peter, Khouri, Jack, McGuirk, Joseph, Sidana, Surbhi, Hansen, Doris K., Patel, Krina

Source: In Blood Advances 9 January 2024 8(1):251-259

Idecabtagene Vicleucel for Relapsed/Refractory Multiple Myeloma: Real-World Experience From the Myeloma CAR T Consortium

Authors: Hansen, Doris K., Sidana, Surbhi, Peres, Lauren C., Colin Leitzinger, Christelle, Shune, Leyla, Shrewsbury, Alexandria, Gonzalez, Rebecca, Sborov, Douglas W., Wagner, Charlotte, Dima, Danai, Hashmi, Hamza, Kocoglu, Mehmet H., Atrash, Shebli, Simmons, Gary, Kalariya, Nilesh, Ferreri, Christopher, Afrough, Aimaz, Kansagra, Ankit, Voorhees, Peter, Baz, Rachid, Khouri, Jack, Alsina, Melissa, McGuirk, Joseph, Locke, Frederick L., Patel, Krina K.

Source: Journal of clinical oncology. 41(11):2087-2097

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100188948893.0x000001&indx=1&recIds=ETOCvdc_100188948893.0x000001

Cardiac events after standard of care idecabtagene vicleucel for relapsed and refractory multiple myeloma

Authors: Lee, Dae Hyun, Kumar, Abhishek, Mohammed, Turab, Peres, Lauren C., Alsina, Melissa, Bachmeier, Christina, Blue, Brandon J., Brayer, Jason, Chandrasekhar, Sanjay, Grajales Cruz, Ariel, De Avila, Gabe, Elmariah, Hany, Faramand, Rawan, Freeman, Ciara, Jain, Michael, Khadka, Sushmita, Khimani, Farhad, Liu, Hien, Nishihori, Taiga, Oswald, Laura B., Castaneda Puglianini, Omar A., Shain, Kenneth H., Smith, Eric, Baz, Rachid C., Locke, Frederick L., Oliveira, Guilherme H., Alomar, Mohammed, Hansen, Doris K.

Source: In Blood Advances 22 August 2023 7(16):4247-4257

Early cytopenias and infections after standard of care idecabtagene vicleucel in relapsed or refractory multiple myeloma

Authors: Logue, Jennifer M., Peres, Lauren C., Hashmi, Hamza, Colin-Leitzinger, Christelle M., Shrewsbury, Alexandria M., Hosoya, Hitomi, Gonzalez, Rebecca M., Copponex, Christina, Kottra, Krista H., Hovanky, Vanna, Sahaf, Bita, Patil, Sunita, Lazaryan, Aleksandr, Jain, Michael D., Baluch, Aliyah, Klinkova, Olga V., Bejanyan, Nelli, Faramand, Rawan G., Elmariah, Hany, Khimani, Farhad, Davila, Marco L., Mishra, Asmita, Blue, Brandon J., Grajales-Cruz, Ariel F., Castaneda Puglianini, Omar A., Liu, Hien D., Nishihori, Taiga, Freeman, Ciara L., Brayer, Jason B., Shain, Kenneth H., Baz, Rachid C., Locke, Frederick L., Alsina, Melissa, Sidana, Surbhi ^∗∗, Hansen, Doris K. ^∗

Source: In Blood Advances 27 December 2022 6(24):6109-6119

Patient and caregiver perspectives on treatment decision-making for stem cell transplantation in multiple myeloma.

Authors: Hansen, Doris K.¹ (AUTHOR) Doris.Hansen@Moffitt.org, Bixby, Todd² (AUTHOR), Fixler, Karen² (AUTHOR), Shea, Lisa² (AUTHOR), Martin, Jodie³ (AUTHOR), Brittle, Christine⁴ (AUTHOR), Liu, Yi-Hsuan² (AUTHOR), Brunisholz, Kimberly² (AUTHOR), Huo, Jinhai Stephen² (AUTHOR)

Source: Supportive Care in Cancer. Feb2025, Vol. 33 Issue 2, p1-9. 9p.

The knowns and unknowns of disparities, biology, and clinical outcomes in Hispanic and Latinx multiple myeloma patients in the U.S.

Authors: Peres, Lauren C., Hansen, Doris K., Maura, Francesco, Kazandjian, Dickran

Source: In Seminars in Oncology February 2022 49(1):3-10

The Impact of Outpatient versus Inpatient Administration of CAR-T Therapies on Clinical, Economic, and Humanistic Outcomes in Patients with Hematological Cancer: A Systematic Literature Review.

Authors: Hansen, Doris K.¹ (AUTHOR) doris.hansen@moffitt.org, Liu, Yi-Hsuan² (AUTHOR), Ranjan, Sandip³ (AUTHOR), Bhandari, Hitesh³ (AUTHOR), Potluri, Ravi⁴ (AUTHOR), McFarland, Lindsay⁵ (AUTHOR), De Braganca, Kevin C.⁶ (AUTHOR), Huo, Stephen² (AUTHOR) doris.hansen@moffitt.org

Source: Cancers. Dec2023, Vol. 15 Issue 24, p5746. 32p.

Subject Terms: *DRUG efficacy, *SAFETY, *SYSTEMATIC reviews, *CELL receptors, *MEDICAL care costs, *TREATMENT effectiveness, *MEDICAL care use, *HEMATOLOGIC malignancies, *HOSPITAL care, *QUALITY of life, *DESCRIPTIVE statistics, *ECONOMIC aspects of diseases, *DRUG side effects, *LYMPHOMAS, *MULTIPLE myeloma, *OUTPATIENT services in hospitals, *PATIENT safety, *EVALUATION

Toxicities associated with adoptive cellular therapies

Authors: Hansen, Doris K., Dam, Marian, Faramand, Rawan G.

Source: In Best Practice & Research Clinical Haematology September 2021 34(3)

Simple Score of Albumin and CRP Predicts High-Grade Toxicity in Patients with Multiple Myeloma Receiving CAR-T Therapy

Authors: Akhtar, Othman S., Modi, Karnav, Kim, Jongphil, Skelson, Lawrence, Smith, Eric, Al-Jumayli, Mohammed A., Extermann, Martine, De Avila, Gabriel, Parker, Nathan, Castaneda Puglianini, Omar, Grajales Cruz, Ariel, Baz, Rachid, Blue, Brandon, Shain, Kenneth, Alsina, Melissa, Liu, Hien, Nishihori, Taiga, Jain, Michael D., Locke, Frederick L., Hansen, Doris K., Freeman, Ciara L.

Source: In Transplantation and Cellular Therapy March 2024 30(3):283-283

Comparison of Time to Next Treatment or Death Between Front‐Line Daratumumab, Lenalidomide, and Dexamethasone (DRd) Versus Bortezomib, Lenalidomide, and Dexamethasone (VRd) Among Transplant‐Ineligible Patients With Multiple Myeloma.

Authors: Hansen, Doris K.¹ (AUTHOR) doris.hansen@moffitt.org, Gautam, Santosh² (AUTHOR), Lafeuille, Marie‐Hélène³ (AUTHOR), Rossi, Carmine³ (AUTHOR), Moore, Bronwyn³ (AUTHOR), Tardif‐Samson, Anabelle³ (AUTHOR), Thompson‐Leduc, Philippe³ (AUTHOR), Fu, Alex Z.² (AUTHOR), Cortoos, Annelore² (AUTHOR), Kaila, Shuchita² (AUTHOR), Fonseca, Rafael⁴ (AUTHOR)

Source: Cancer Medicine. Nov2024, Vol. 13 Issue 21, p1-10. 10p.

Subject Terms: *PROPORTIONAL hazards models, *STEM cell transplantation, *DRUG therapy, *MULTIPLE myeloma, *BLOOD diseases

The CAR-HEMATOTOX score as a prognostic model of toxicity and response in patients receiving BCMA-directed CAR-T for relapsed/refractory multiple myeloma.

Authors: Rejeski, Kai^1,2,3,4 (AUTHOR) kai.rejeski@med.uni-muenchen.de, Hansen, Doris K.⁵ (AUTHOR), Bansal, Radhika⁶ (AUTHOR), Sesques, Pierre⁷ (AUTHOR), Ailawadhi, Sikander⁸ (AUTHOR), Logue, Jennifer M.⁵ (AUTHOR), Bräunlein, Eva⁹ (AUTHOR), Cordas dos Santos, David M.^1,3 (AUTHOR), Freeman, Ciara L.⁵ (AUTHOR), Alsina, Melissa⁵ (AUTHOR), Theurich, Sebastian^1,3 (AUTHOR), Wang, Yucai⁶ (AUTHOR), Krackhardt, Angela M.^3,4,9,10 (AUTHOR), Locke, Frederick L.⁵ (AUTHOR), Bachy, Emmanuel⁷ (AUTHOR), Jain, Michael D.⁵ (AUTHOR), Lin, Yi⁶ (AUTHOR), Subklewe, Marion^1,2,3,4 (AUTHOR)

Source: Journal of Hematology & Oncology. 7/31/2023, Vol. 16 Issue 1, p1-13. 13p.

Subject Terms: *MULTIPLE myeloma, *PROGNOSTIC models, *INFECTIVE endocarditis, *SURVIVAL rate, *INFLAMMATION

Impact of weight and creatinine adjustments on the accuracy of Cockcroft‐gault equation in hematopoietic cell transplant patients

Authors: Emanuel, Natasha A., Price, Samantha, Hansen, Doris K., Whiting, Junmin, Kim, Jongphil, Gaskill, Eric

Source: Clinical transplantation. 37(10)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195602395.0x000001&indx=1&recIds=ETOCvdc_100195602395.0x000001

Universal driving restrictions beyond 4 weeks appear unnecessary following CAR-T therapy in multiple myeloma

Authors: Banerjee, Rahul ^{1, ∗}, Richards, Alicia ², Midha, Shonali ³, Afrough, Aimaz ⁴, Anwer, Faiz ⁵, Atanackovic, Djordje ⁶, Atrash, Shebli ⁷, Bachanova, Veronika ⁸, Beitinjaneh, Amer M. ⁹, Bhurtel, Evguenia ¹⁰, Castaneda Puglianini, Omar ², Chhabra, Saurabh ¹¹, Cicero, Kara I. ¹, Davis, James A. ¹², Dhakal, Binod ¹³, Dima, Danai ^{1, 5}, Ferreri, Christopher J. ⁷, Forsberg, Peter A. ¹⁴, Freeman, Ciara L. ², Herr, Megan M. ¹⁵, Jain, Tania ¹⁶, Janakiram, Murali ¹⁷, Khouri, Jack ⁵, Kocoglu, Mehmet H. ⁶, Kumar, Anupama ¹⁸, Liu, Yuxin ³, Locke, Frederick ², McGuirk, Joseph P. ¹⁰, Mikkilineni, Lekha ¹⁹, Nadeem, Omar ³, Parrondo, Ricardo D. ²⁰, Pasvolsky, Oren ²¹, Peres, Lauren C. ², Purvey, Sneha ²², Raza, Shahzad ⁵, Reshef, Ran ²³, Richard, Shambavi ²⁴, Rossi, Adriana C. ²⁴, Sborov, Douglas W. ²⁵, Shune, Leyla ¹⁰, Wagner, Charlotte B. ²⁵, Zanwar, Saurabh S. ²⁶, Sidana, Surbhi ¹⁹, Patel, Krina K. ²¹, Hansen, Doris K. ², Kumar, Shaji K. ²⁶, Lin, Yi ²⁶, Martin, Thomas G. ¹⁸, Voorhees, Peter M. ⁷, Anderson, Larry D., Jr ⁴, Cowan, Andrew J. ¹, Kaur, Gurbakhash ²⁴

Source: In Blood Advances February 2025

Outcomes of Haploidentical Stem Cell Transplant Recipients With HHV-6B Reactivation.

Authors: Handley, Guy, Yepes, Amanda, Eliassen, Eva, Dominguez, Gabriel, Pasikhova, Yanina, Klinkova, Olga, Baluch, Aliyah, Febres-Aldana, Anthony J, Alsina, Melissa, Elmariah, Hany, Khimani, Farhad, Hansen, Doris K, Freeman, Ciara L, Jain, Michael D, Locke, Frederick, Lazaryan, Aleksandr, Liu, Hein D, Mishra, Asmita, Mirza, Abu-Sayeef, Nishihori, Taiga

Source: Open Forum Infectious Diseases; Oct2024, Vol. 11 Issue 10, p1-8, 8p

Subject Terms: STEM cell transplantation, HEMATOPOIETIC stem cells, CENTRAL nervous system, VIRUS reactivation, ACUTE diseases

Cost-per-responder analysis of patients with lenalidomide-refractory multiple myeloma receiving ciltacabtagene autoleucel in CARTITUDE-4.

Authors: Hansen, Doris K., Xiaoxiao Lu, Puglianini, Omar Castaneda, Sorensen, Sonja, Usmani, Saad Z., Zhang, Eileen, Huo, Stephen, Yan Zhang, Qureshi, Zaina P., Jagannath, Sundar

Source: Frontiers in Immunology; 2024, p01-09, 9p

Subject Terms: CYTOKINE release syndrome, CLINICAL trials, CHIMERIC antigen receptors, TERMINAL care, MULTIPLE myeloma