Efficacy of subsequent therapies in patients with advanced ovarian cancer who relapse after first-line olaparib maintenance: results of the PAOLA-1/ENGOT-ov25 trial

Authors: Bogner, Gerhard, Marth, Christian, Petru, Edgar, Reinthaller, Alexander, Schauer, Christian, Sevelda, Paul, D’Hondt, Lionel, Vergote, Ignace, Vuylsteke, Peter, Hietanen, Sakari, Lindahl, Gabriel, Mäenpää, Johanna, Nøttrup, Trine Jakobi, Puistola, Ulla, Abadie-Lacourtoisie, Sophie, Alexandre, Jérôme, Berton-Rigaud, Dominique, Boissier, Emilie, Bourgeois, Hugues, Chevalier-Place, Annick, Combe, Pierre, Costan, Cristina, Dauba, Jérôme, De Cock, Laure, Desauw, Christophe, Despax, Raymond, Dohollou, Nadine, Dubot, Coraline, Fabbro, Michel, Favier, Laure, Floquet, Anne, Follana, Philippe, Tixidre, Claire Garnier, Garnier, Georges, Gladieff, Laurence, Grenier, Julien, Guillemet, Cécile, Hardy-Bessard, Anne-Claire, Joly, Florence, Kalbacher, Elsa, Kaminsky, Marie-Christine, Kurtz, Jean-Emmanuel, Largillier, Rémy, Lefeuvre-Plesse, Claudia, Lesoin, Anne, Levache, Charles Briac, L’Haridon, Tifenn, Lortholary, Alain, Lotz, Jean-Pierre, Medioni, Jacques, Meunier, Jérôme, Mousseau, Mirerille, Mouret-Reynier, Marie-Ange, Pautier, Patricia, Petit, Thierry, Provansal, Magali, Pujade-Lauraine, Eric, Raban, Nadia, Ray-Coquard, Isabelle, Rodrigues, Manuel, Selle, Frédéric, Sverdlin, Robert, Tazi, Youssef, You, Benoît, Aktas, Bahriye, Olaf Bauerschlag, Dirk, Beck, Thomas, Belau, Antje, Bronger, Holger, Buchholz, Stefan, Buderath, Paul, Burges, Alexander, Canzler, Ulrich, de Gregorio, Nikolaus, Denschlag, Dominik, Dieterich, Max, Eichbaum, Michael, El-Balat, Ahmed, Emons, Günter, Fasching, Peter, Feisel-Schwickardi, Gabriele, Frank, Matthias, Friedrich, Michael, Grischke, Eva-Maria, Gropp-Meier, Martina, Hanker, Lars, Hannig, Carla, Harter, Philipp, Hasenburg, Annette, Hellriegel, Martin, Herwig, Uwe, Heubner, Martin, Hulde, Joachim, Jackisch, Christian, Kögel, Matthias, Krieger, Peter, Kühn, Thorsten, Liebrich, Clemens, Lück, HansJoachim, Mallmann, Peter, Marmé, Frederik, Meier, Werner, Möbus, Voker, Mohamed, Omar Farag, Nestle-Krämling, Carolin, Neunhöffer, Tanja, Oskay-Özcelik, Gülten, Park-Simon, Tjoung-Won, Rautenberg, Beate, Rein, Daniel, Ruhwedel, Wencke, Runnebaum, Ingo, Sagasser, Jacqueline, Schmalfeldt, Barbara, Schneeweiss, Andreas, Schnelzer, Andreas, Scholz, Heinz, Sehouli, Jalid, Sperfeld, Antje, Steckkönig, Annette, Strauß, Hans-Georg, Tomé, Oliver, Treustedt, Jörn, Voß, Hermann, Wischnik, Arthur, Witteler, Ralf, Wöckel, Achim, Woeltjen, Hans-Heinrich, Zorr, Andreas, Bologna, Alessandra, Colombo, Nicoletta, Tognon, Germana, Cinieri, Saverio, Lorusso, Domenica, Mosconi, Anna Maria, Pignata, Sandro, Savarese, Antonella, Scambia, Giovanni, Sorio, Roberto, Zamagni, Claudio, Fujiwara, Keiichi, Fujiwara, Hiroyuki, Kobayashi, Hiroaki, Matsumoto, Takashi, Nagao, Shoji, Satoh, Toyomi, Yonemori, Kan, Yoshida, Hiroyuki, Bratos, Raquel, Caballero, Cristina, Garica, Yolanda, González-Martín, Antonio, Guerra-Alía, Eva Maria, Hernando, Susana, Herrero, Ana, Lainez, Nuria, Manso, Luis, Martin, Cristina, Murata, Eleonor, Ortega, Eugenia, Palacio, Isabel, Poveda, Andres, Romero, Ignacio, Rubio-Pérez, María Jesús, Harter, P. ^{1, 2, 3, †}, Marth, C. ^{4, 5, †}, Mouret-Reynier, M.-A. ^{6, 7}, Cropet, C. ⁸, Lorusso, D. ^{9, 10, 11}, Guerra-Alía, E.M. ^{12, 13}, Matsumoto, T. ^{14, 15}, Vergote, I. ^{16, 17}, Colombo, N. ^{18, 19}, Mäenpää, J. ^{20, 21}, Lebreton, C. ^{7, 22}, de Gregorio, N. ^{3, 23}, Mosconi, A.M. ^{11, 24}, Rubio-Pérez, M.J. ^{13, 25}, Bourgeois, H. ^{7, 26}, Fasching, P.A. ^{3, 27}, Cecere, S.C. ^{11, 28}, Hardy-Bessard, A.-C. ^{7, 29}, Denschlag, D. ^{3, 30}, de Percin, S. ^{7, 31}, Hanker, L. ^{3, 32, 33}, Favier, L. ^{7, 34}, Bauerschlag, D. ^{3, 35, ‡}, Desauw, C. ^{7, 36}, Hillemanns, P. ^{3, 37}, Largillier, R. ^{7, 38}, Sehouli, J. ^{3, 39}, Grenier, J. ^{7, 40}, Pujade-Lauraine, E. ^{7, 41}, Ray-Coquard, I. ^{7, 42, ∗}

Source: In Annals of Oncology February 2025 36(2):185-196

Prognostic and clinical heterogeneity of PD1 and PD-L1- immunohistochemical scores in endometrial cancers.

Authors: Proppe, L., Jagomast, T., Beume, S., Köster, F., Bräutigam, K., Rody, A., Perner, S., Hemptenmacher, F., Ribbat-Idel, J., Hanker, L. C.

Source: Archives of Gynecology & Obstetrics; May2025, Vol. 311 Issue 5, p1395-1405, 11p

Subject Terms: PROGRAMMED cell death 1 receptors, STATISTICAL significance, IMMUNOHISTOCHEMISTRY, ENDOMETRIAL cancer, PROGNOSIS

Age-dependent differences in borderline ovarian tumours (BOT) regarding clinical characteristics and outcome: results from a sub-analysis of the Arbeitsgemeinschaft Gynaekologische Onkologie (AGO) ROBOT study

Authors: Trillsch, F., Mahner, S. ^*, Woelber, L., Vettorazzi, E., Reuss, A., Ewald-Riegler, N., de Gregorio, N., Fotopoulou, C., Schmalfeldt, B., Burges, A., Hilpert, F., Fehm, T., Meier, W., Hillemanns, P., Hanker, L., Hasenburg, A., Strauss, H.G., Hellriegel, M., Wimberger, P., Baumann, K., Keyver-Paik, M.D., Canzler, U., Wollschlaeger, K., Forner, D., Pfisterer, J., Schroeder, W., Muenstedt, K., Richter, B., Kommoss, F., Hauptmann, S., du Bois, A.

Source: In Annals of Oncology July 2014 25(7):1320-1327

Overexpression of the orphan nuclear receptor NR2F6 is associated with improved survival across molecular subgroups in endometrial cancer patients.

Authors: Proppe, L., Jagomast, T., Beume, S., Klapper, L., Gitas, G., Köster, F., Perner, S., Rody, A., Ribbat-Idel, J., Hanker, L. C.

Source: Journal of Cancer Research & Clinical Oncology; Aug2023, Vol. 149 Issue 10, p7155-7164, 10p

Subject Terms: ENDOMETRIAL cancer, CANCER patients, ORPHANS, GENETIC overexpression, IMMUNE checkpoint proteins

Dostarlimab for Primary Advanced or Recurrent Endometrial Cancer.

Authors: Mirza, M. R.¹, mansoor@rh.regionh.dk, Chase, D. M.², Slomovitz, B. M.³, Christensen, R. dePont⁴, Novák, Z.⁵, Black, D.⁶, Gilbert, L.⁷, Sharma, S.⁸, Valabrega, G.⁹, Landrum, L. M.¹⁰, Hanker, L. C.¹¹, Stuckey, A.¹², Boere, I.¹³, Gold, M. A.¹⁴, Auranen, A.¹⁵, Pothuri, B.¹⁶, Cibula, D.¹⁷, McCourt, C.¹⁸, Raspagliesi, F.¹⁹, Shahin, M. S.²⁰

Source: New England Journal of Medicine; 6/8/2023, Vol. 388 Issue 23, p2145-2158, 14p

Prognostic impact of thymidine phosphorylase expression in breast cancer – Comparison of microarray and immunohistochemical data

Authors: Ruckhäberle, E., Karn, T., Engels, K., Turley, H., Hanker, L., Müller, V., Schmidt, M., Ahr, A., Gaetje, R., Holtrich, U., Kaufmann, M., Rody, A.

Source: In European Journal of Cancer 2010 46(3):549-557

Long-term satisfaction of patients after laparoscopic and robotic-assisted hysterectomy.

Authors: Gitas, Georgios, Alkatout, I., Proppe, L., Hanker, L., Allahqoli, L., Grimbizis, G., Rody, A., Werner, N., Sommer, S., Baum, S.

Source: Archives of Gynecology & Obstetrics; Jun2022, Vol. 305 Issue 6, p1481-1490, 10p

Hyperlipidemia and atherosclerosis.

Authors: Ross, R., Hanker, L.

Source: Science; September 17 1976, Vol. 193, p1094-1100, 7p

1524P Epidemiology and demography of gynecological sarcoma: Results of the prospective intergroup registry for gynecological sarcoma REGSA (NOGGO RU1)

Authors: Roser, E., Noack, A-S., Zocholl, D., Kommoss, S., Harter, P., Kalder, M., Egger, E.K., Buderath, P., Marth, C., Ulrich, U., Klar, M., Weigel, M., Traub, L., Strauß, H-G., Hanker, L., Pölcher, M., Wimberger, P., Beck, F., Pietzner, K., Sehouli, J.

Source: In Annals of Oncology September 2022 33 Supplement 7:S1242-S1242

1496P Trabectedin for patients with advanced soft tissue sarcoma: A non-interventional, prospective, multicenter study

Authors: Grünwald, V., Pink, D., Egerer, G., Schalk, E., Augustin, M., Deinzer, C.K., Kob, V., Reichert, D., Kebenko, M., Brandl, S.F., Hahn, D.A., Lindner, L.H., Hoiczyk, M., Ringsdorf, U., Hanker, L., Hempel, D., Pontes, M.J., Wismann, T., Ivanyi, P.

Source: In Annals of Oncology September 2022 33 Supplement 7:S1231-S1231

561P When to treat the pelvis in node-positive vulvar cancer: Results from the AGO-VOP.2 QS vulva study

Authors: Hampl, M., Jaeger, A., Eulenburg, C., Prieske, K., Hambrecht, J., Fuerst, S., Klapdor, R., Heublein, S., Gass, P., Rohner, A., Canzler, U., Becker, S., Bommert, M., Bauerschlag, D., Denecke, A., Hanker, L., Sehouli, J., Dannecker, C., Mahner, S., Woelber, L.

Source: In Annals of Oncology September 2022 33 Supplement 7:S805-S805

533P Real-world data of treatment and outcome of patients with relapsed ovarian cancer (OC) in Germany (QS ovar of the AGO study group)

Authors: Harter, P., du Bois, A., Hilpert, F., Kerkmann, M., Sehouli, J., Mahner, S., de Gregorio, N., Hanker, L., Heitz, F., Marmé, F., Woelber, L., Holtmann, L., Elser, G., Pfisterer, J.

Source: In Annals of Oncology September 2022 33 Supplement 7:S791-S792

820TiP ENGOT-EN6/GOG-3031/NSGO-CTU-RUBY part 2: A phase III, randomized, double-blind, study of dostarlimab + carboplatin-paclitaxel followed by dostarlimab + niraparib versus placebo (PBO) + carboplatin-paclitaxel followed by PBO in recurrent or advanced endometrial cancer (EC)

Authors: Mirza, M.R., Coleman, R.L., Hanker, L., Slomovitz, B., Valabrega, G., DeMars, L., Walker, M., Duan, T., Powell, M.

Source: In Annals of Oncology September 2021 32 Supplement 5:S770-S771

Sphingosine-kinase-1 expression is associated with improved overall survival in high-grade serous ovarian cancer.

Authors: Hanker, L. C.¹ (AUTHOR) lars.hanker@uni-luebeck.de, El-Balat, A.² (AUTHOR), Drosos, Z.¹ (AUTHOR), Kommoss, S.³ (AUTHOR), Karn, T.² (AUTHOR), Holtrich, U.² (AUTHOR), Gitas, G.¹ (AUTHOR), Graeser-Mayer, M.⁴ (AUTHOR), Anglesio, M.⁵ (AUTHOR), Huntsman, D.⁵ (AUTHOR), Rody, A.¹ (AUTHOR), Gevensleben, H.⁶ (AUTHOR), Hoellen, F.¹ (AUTHOR)

Source: Journal of Cancer Research & Clinical Oncology. May2021, Vol. 147 Issue 5, p1421-1430. 10p.

Subject Terms: *OVARIAN cancer, *OVARIAN epithelial cancer, *PROGNOSIS, *ENZYME metabolism, *CARCINOGENESIS, TUMOR surgery

BrEast cancer in the VEry eldeRLY (BEVERLY-1): Patient characteristics, co-morbidities, drug intake and guideline adherence. (German)

Authors: Jost, N., Fick, F., Matlac, D. M., Milewski, K., Tauber, N., Banys-Kotomska, J., Krawczyk, N., Rody, A., Hemptenmacher, F., Hanker, L., Banys-Paluchowski, M.

Source: Senologie; Jun2024, Vol. 21 Issue 2, pe15-e15, 1p

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Differentially expressed genes of reprogrammed human pluripotent stem cells in breast cancer

Authors: Rody, A., Karn, T., Ruckhaeberle, E., Hanker, L., Gaetje, R., Holtrich, U., Kaufmann, M.

Source: In European Journal of Cancer 2008 44(13):1789-1792

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