Dose‐dependent expression of GFI1 alters metabolism in the haematopoietic progenitors and MLL::AF9‐induced leukaemic cells

Authors: Patnana, Pradeep Kumar, Liu, Longlong, Frank, Daria, Nimmagadda, Subbaiah Chary, Behrens, Matthias, Ahmed, Helal, Xie, Xiaoqing, Liebmann, Marie, Wei, Lanying, Gerdemann, Andrea, Thivakaran, Aniththa, Humpf, Hans‐Ulrich, Klotz, Luisa, Dugas, Martin, Varghese, Julian, Trajkovic‐Arsic, Marija, Siveke, Jens T., Hanenberg, Helmut, Opalka, Bertram, Dührsen, Ulrich, Reinhardt, Hans Christian, Guenther, Ulrich, Bubnoff, Nikolas, Khandanpour, Cyrus

Source: British journal of haematology. 202(5):1033-1048

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195880819.0x000001&indx=1&recIds=ETOCvdc_100195880819.0x000001

Cell-based BSEP trans-inhibition: A novel, non-invasive test for diagnosis of antibody-induced BSEP deficiency

Authors: Stindt, Jan, Dröge, Carola, Lainka, Elke, Kathemann, Simone, Pfister, Eva-Doreen, Baumann, Ulrich, Stalke, Amelie, Grabhorn, Enke, Shagrani, Mohammad Ali, Mozer-Glassberg, Yael, Hartley, Jane, Wammers, Marianne, Klindt, Caroline, Philippski, Paulina, Liebe, Roman, Herebian, Diran, Mayatepek, Ertan, Berg, Thomas, Schmidt-Choudhury, Anjona, Wiek, Constanze, Hanenberg, Helmut, Luedde, Tom, Keitel, Verena

Source: In JHEP Reports July 2023 5(7)

Profiling the 3D interaction between germ cell tumors and microenvironmental cells at the transcriptome and secretome level

Authors: Skowron, Margaretha A., Eul, Katharina, Stephan, Alexa, Ludwig, Gillian F., Wakileh, Gamal A., Bister, Arthur, Söhngen, Christian, Raba, Katharina, Petzsch, Patrick, Poschmann, Gereon, Kuffour, Edmund Osei, Degrandi, Daniel, Ali, Shafaqat, Wiek, Constanze, Hanenberg, Helmut, Münk, Carsten, Stühler, Kai, Köhrer, Karl, Mass, Elvira, Nettersheim, Daniel

Source: Molecular oncology. 16(17):3107-3127

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100159582359.0x000001&indx=1&recIds=ETOCvdc_100159582359.0x000001

Engineering a single-chain variable fragment of cetuximab for CAR T-cell therapy against head and neck squamous cell carcinomas

Authors: Haist, Corinna, Poschinski, Zoe, Bister, Arthur, Hoffmann, Michèle J., Grunewald, Camilla M., Hamacher, Alexandra, Kassack, Matthias, Wiek, Constanze, Scheckenbach, Kathrin, Hanenberg, Helmut

Source: In Oral Oncology June 2022 129

A novel CD34-derived hinge for rapid and efficient detection and enrichment of CAR T cells

Authors: Bister, Arthur, Ibach, Tabea, Haist, Corinna, Smorra, Denise, Roellecke, Katharina, Wagenmann, Martin, Scheckenbach, Kathrin, Gattermann, Norbert, Wiek, Constanze, Hanenberg, Helmut

Source: In Molecular Therapy - Oncolytics 17 December 2021 23:534-546

A homozygous nonsense mutation early in exon 5 of BRCA2 is associated with very severe Fanconi anemia

Authors: Radulovic, Ivana, Kuechler, Alma, Schündeln, Michael M., Paulussen, Michael, von Neuhoff, Nils, Reinhardt, Dirk, Hanenberg, Helmut

Source: In European Journal of Medical Genetics August 2021 64(8)

CD44v6-targeted CAR T-cells specifically eliminate CD44 isoform 6 expressing head/neck squamous cell carcinoma cells

Authors: Haist, Corinna, Schulte, Elena, Bartels, Nina, Bister, Arthur, Poschinski, Zoe, Ibach, Tabea C., Geipel, Katja, Wiek, Constanze, Wagenmann, Martin, Monzel, Cornelia, Scheckenbach, Kathrin, Hanenberg, Helmut

Source: In Oral Oncology May 2021 116

Replication stress at microsatellites causes DNA double-strand breaks and break-induced replication

Authors: Gadgil, Rujuta Yashodhan, Romer, Eric J., Goodman, Caitlin C., Rider, S.Dean, Jr., Damewood, French J., Barthelemy, Joanna R., Shin-ya, Kazuo, Hanenberg, Helmut, Leffak, Michael ^*

Source: In Journal of Biological Chemistry 6 November 2020 295(45):15378-15397

Acute myeloid leukemia–induced remodeling of the human bone marrow niche predicts clinical outcome

Authors: Chen, Yiyang, Hoffmeister, Lina Marie, Zaun, Yasmin, Arnold, Lucas, Schmid, Kurt Werner, Giebel, Bernd, Klein-Hitpass, Ludger, Hanenberg, Helmut, Squire, Anthony, Reinhardt, H. Christian, Dührsen, Ulrich, Bertram, Stefanie, Hanoun, Maher

Source: In Blood Advances 27 October 2020 4(20):5257-5268

Heterologous Expression and Functional Characterization of Novel CYP2C9 Variants Identified in the Alaska Native People

Authors: McDonald, Matthew G., Henderson, Lindsay M., Ray, Sutapa, Yeung, Catherine K., Johnson, Amanda L., Kowalski, John P., Hanenberg, Helmut, Wiek, Constanze, Thummel, Kenneth E., Rettie, Allan E. ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics August 2020 374(2):233-240

NHEJ-Mediated Repair of CRISPR-Cas9-Induced DNA Breaks Efficiently Corrects Mutations in HSPCs from Patients with Fanconi Anemia

Authors: Román-Rodríguez, Francisco José, Ugalde, Laura, Álvarez, Lara, Díez, Begoña, Ramírez, María José, Risueño, Cristina, Cortón, Marta, Bogliolo, Massimo, Bernal, Sara, March, Francesca, Ayuso, Carmen, Hanenberg, Helmut, Sevilla, Julián, Rodríguez-Perales, Sandra, Torres-Ruiz, Raúl, Surrallés, Jordi, Bueren, Juan Antonio, Río, Paula

Source: In Cell Stem Cell 7 November 2019 25(5):607-621

Unpaired cysteine insertions favor transmembrane dimerization and induce ligand-independent constitutive cytokine receptor signaling.

Authors: Baumgärtner, Lynn Affrica Felicitas, Ettich, Julia, Balles, Helene, Lapp, Dorothee Johanna, Mossner, Sofie, Bassenge, Christin, Ouzin, Meryem, Hanenberg, Helmut, Scheller, Jürgen, Floss, Doreen Manuela

Source: Biological Chemistry; Jul2024, Vol. 405 Issue 7/8, p531-544, 14p

Subject Terms: TRANSMEMBRANE domains, SYNTHETIC receptors, CYTOKINE receptors, DIMERIZATION, LYMPHOCYTIC leukemia, CYSTEINE, SYNTHETIC biology

Influence of Stereochemistry on the Bioactivation and Glucuronidation of 4-Ipomeanol

Authors: Teitelbaum, Aaron M. ^*, McDonald, Matthew G., Kowalski, John P., Parkinson, Oliver T., Scian, Michele, Whittington, Dale, Roellecke, Katharina, Hanenberg, Helmut, Wiek, Constanze, Rettie, Allan E.

Source: In The Journal of Pharmacology and Experimental Therapeutics February 2019 368(2):308-316

Deficiency of Bruton's Tyrosine Kinase in B Cell Precursor Leukemia Cells

Authors: Feldhahn, Niklas, Río, Paula, Liedtke, Stefanie, Sprangers, Mieke, Klein, Florian, Wernet, Peter, Jumaa, Hassan, Hofmann, Wolf-Karsten, Hanenberg, Helmut, Rowley, Janet D., Müschen, Markus

Source: Proceedings of the National Academy of Sciences of the United States of America, 2005 Sep . 102(37), 13266-13271.

Access URL: https://www.jstor.org/stable/3376551

Structure—Activity Relationships for CYP4B1 Bioactivation of 4-Ipomeanol Congeners: Direct Correlation between Cytotoxicity and Trapped Reactive Intermediates

Authors: Kowalski, John P., McDonald, Matthew G., Whittington, Dale, Guttman, Miklos, Scian, Michele, Girhard, Marco, Hanenberg, Helmut, Wiek, Constanze, Rettie, Allan E.

Source: Chemical research in toxicology. 32(12):2488-2498

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631486422&indx=1&recIds=ETOCRN631486422

P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim

Authors: Hu, Ping, Nebreda, Angel, Hanenberg, Helmut, Kinnebrew, Garrett, Ivan, Mircea, Yoder, Mervin, Filippi, Marie-Dominique, Broxmeyer, Hal, Kapur, Reuben

Source: Nature communications. 9(1):1-15

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178401580.0x000001&indx=1&recIds=ETOCvdc_100178401580.0x000001

Effects of novel HDAC inhibitors on urothelial carcinoma cells

Authors: Kaletsch, Aline, Pinkerneil, Maria, Hoffmann, Michèle, Jaguva Vasudevan, Ananda, Wang, Chenyin, Hansen, Finn, Wiek, Constanze, Hanenberg, Helmut, Gertzen, Christoph, Gohlke, Holger, Kassack, Matthias, Kurz, Thomas, Schulz, Wolfgang, Niegisch, Günter

Source: Clinical epigenetics. 10(1):1-18

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174785659.0x000001&indx=1&recIds=ETOCvdc_100174785659.0x000001

Fanconi Anemia Proteins Function in Mitophagy and Immunity

Authors: Sumpter, Rhea, Jr., Sirasanagandla, Shyam, Fernández, Álvaro F., Wei, Yongjie, Dong, Xiaonan, Franco, Luis, Zou, Zhongju, Marchal, Christophe, Lee, Ming Yeh, Clapp, D. Wade, Hanenberg, Helmut, Levine, Beth

Source: In Cell 5 May 2016 165(4):867-881

The role of apoptosis repressor with a CARD domain (ARC) in the therapeutic resistance of renal cell carcinoma (RCC): the crucial role of ARC in the inhibition of extrinsic and intrinsic apoptotic signalling

Authors: Toth, Csaba, Funke, Sarah, Nitsche, Vanessa, Liverts, Anna, Zlachevska, Viktoriya, Gasis, Marcia, Wiek, Constanze, Hanenberg, Helmut, Mahotka, Csaba, Schirmacher, Peter, Heikaus, Sebastian

Source: Cell communication and signaling. 15(1):1-14

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129108236.0x000001&indx=1&recIds=ETOCvdc_100129108236.0x000001

Specifically differentiated T cell subset promotes tumor immunity over fatal immunity

Authors: Ramadan, Abdulraouf, Griesenauer, Brad, Adom, Djamilatou, Kapur, Reuben, Hanenberg, Helmut, Liu, Chen, Kaplan, Mark H., Paczesny, Sophie

Source: Journal of experimental medicine. 214(12):3577-3596

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN613893099&indx=1&recIds=ETOCRN613893099