Unraveling the role of cAMP signaling in Giardia: insights into PKA-mediated regulation of encystation and subcellular interactions

Authors: Han-Wei Shih, Germain C. M. Alas, Alexander R. Paredez

Source: mSphere, Vol 9, Iss 11 (2024)

Subject Terms: encystationc, PKA, cyclic AMP, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2379-5042

Access URL: https://doaj.org/article/07af8913d5cb4e4daa755e22f8a0db64

Encystation stimuli sensing is mediated by adenylate cyclase AC2-dependent cAMP signaling in Giardia

Authors: Han-Wei Shih, Germain C. M. Alas, Alexander R. Paredez

Source: Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4f402cefa2d2428b9ab1748ba429f99c

Staging Encystation Progression in Giardia lamblia Using Encystation-Specific Vesicle Morphology and Associating Molecular Markers

Authors: Elizabeth B. Thomas, Renaldo Sutanto, Richard S. Johnson, Han-Wei Shih, Germain C. M. Alas, Jana Krtková, Michael J. MacCoss, Alexander R. Paredez

Source: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Subject Terms: Giardia, encystation, Rho GTPase, Rac, ESV, membrane trafficking, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.662945/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/dac6cecc6a5e4545a83c954bc5c3eb47

Screening of the Pathogen Box for inhibitors with dual efficacy against Giardia lamblia and Cryptosporidium parvum.

Authors: Kelly M Hennessey, Ilse C Rogiers, Han-Wei Shih, Matthew A Hulverson, Ryan Choi, Molly C McCloskey, Grant R Whitman, Lynn K Barrett, Ethan A Merritt, Alexander R Paredez, Kayode K Ojo

Source: PLoS Neglected Tropical Diseases, Vol 12, Iss 8, p e0006673 (2018)

Subject Terms: Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC6095626?pdf=render; https://doaj.org/toc/1935-2727; https://doaj.org/toc/1935-2735

Access URL: https://doaj.org/article/7a29ec6e8e4b46608002ddb8fa8b679e

A cell-cycle-dependent GARP-like transcriptional repressor regulates the initiation of differentiation in Giardia lamblia.

Authors: Han-Wei Shih¹, Alas, Germain C. M.¹, Paredez, Alexander R.¹ aparedez@uw.edu

Source: Proceedings of the National Academy of Sciences of the United States of America. 5/31/2022, Vol. 119 Issue 22, p1-9. 21p.

Subject Terms: *GIARDIA lamblia, *GENETIC transcription regulation, *PROTEIN domains, *TRANSCRIPTION factors, *CELL cycle