A distal super enhancer mediates estrogen-dependent mouse uterine–specific gene transcription of Igf1 (insulin-like growth factor 1)

Authors: Hewitt, Sylvia C., Lierz, Sydney L., Garcia, Marleny, Hamilton, Katherine J., Gruzdev, Artiom, Grimm, Sara A., Lydon, John P., Demayo, Francesco J. ^**, Korach, Kenneth S.

Source: In Journal of Biological Chemistry 21 June 2019 294(25):9746-9759

The genomic regulatory elements for estrogen receptor alpha transactivation‐function‐1 regulated genes

Authors: Arao, Yukitomo, Hamilton, Katherine J., Grimm, Sara A., Korach, Kenneth S.

Source: FASEB journal. 34(12):16003-16021

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112223900.0x000001&indx=1&recIds=ETOCvdc_100112223900.0x000001

DNA methylation and transcriptome aberrations mediated by ERα in mouse seminal vesicles following developmental DES exposure

Authors: Li, Yin, Hamilton, Katherine J., Wang, Tianyuan, Coons, Laurel A., Jefferson, Wendy N., Li, Ruifang, Wang, Yu, Grimm, Sara A., Ramsey, J. Tyler, Liu, Liwen, Gerrish, Kevin E., Williams, Carmen J., Wade, Paul A., Korach, Kenneth S.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2018 May 01. 115(18), E4189-E4198.

Access URL: https://www.jstor.org/stable/26508767

N-terminal transactivation function, AF-1, of estrogen receptor alpha controls obesity through enhancement of energy expenditure

Authors: Arao, Yukitomo, Hamilton, Katherine J., Lierz, Sydney L., Korach, Kenneth S.

Source: In Molecular Metabolism December 2018 18:68-78

Experimental models for evaluating non-genomic estrogen signaling

Authors: Stefkovich, Megan L., Arao, Yukitomo, Hamilton, Katherine J., Korach, Kenneth S.

Source: In Steroids May 2018 133:34-37

Dysregulation of hypothalamic‐pituitary estrogen receptor α–mediated signaling causes episodic LH secretion and cystic ovary

Authors: Arao, Yukitomo, Hamilton, Katherine J., Wu, San-Pin, Tsai, Ming-Jer, Demayo, Francesco J., Korach, Kenneth S.

Source: FASEB journal. 33(6):7375-7386

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103322720.0x000001&indx=1&recIds=ETOCvdc_100103322720.0x000001

Negative elongation factor is essential for endometrial function

Authors: Hewitt, Sylvia C., Li, Rong, Adams, Nyssa, Winuthayanon, Wipawee, Hamilton, Katherine J., Donoghue, Lauren J., Lierz, Sydney L., Garcia, Marleny, Lydon, John P., DeMayo, Francesco J., Adelman, Karen, Korach, Kenneth S.

Source: FASEB journal. 33(2):3010-3023

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103608681.0x000001&indx=1&recIds=ETOCvdc_100103608681.0x000001

SCA-1 Labels a Subset of Estrogen-Responsive Bipotential Repopulating Cells within the CD24+ CD49fhi Mammary Stem Cell-Enriched Compartment

Authors: Dall, Genevieve V., Vieusseux, Jessica L., Korach, Kenneth S., Arao, Yukitomo, Hewitt, Sylvia C., Hamilton, Katherine J., Dzierzak, Elaine, Boon, Wah Chin, Simpson, Evan R., Ramsay, Robert G., Stein, Torsten, Morris, Joanne S., Anderson, Robin L., Risbridger, Gail P., Britt, Kara L.

Source: In Stem Cell Reports 14 February 2017 8(2):417-431

Estrogen Hormone Biology

Authors: Hamilton, Katherine J., Hewitt, Sylvia C., Arao, Yukitomo, Korach, Kenneth S.

Source: Current topics in developmental biology. 125:109-146

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN611308061&indx=1&recIds=ETOCRN611308061

Estrogen hormone physiology: Reproductive findings from estrogen receptor mutant mice

Authors: Hamilton, Katherine J., Arao, Yukitomo, Korach, Kenneth S.

Source: In Reproductive Biology March 2014 14(1):3-8

Estrogen Receptor α L543A,L544A Mutation Changes Antagonists to Agonists, Correlating with the Ligand Binding Domain Dimerization Associated with DNA Binding Activity

Authors: Arao, Yukitomo, Hamilton, Katherine J., Coons, Laurel A., Korach, Kenneth S.

Source: In Journal of Biological Chemistry 19 July 2013 288(29):21105-21116

Expression of a dominant negative estrogen receptor alpha variant in transgenic mice accelerates uterine cancer induced by the potent estrogen diethylstilbestrol

Authors: Davis, Vicki L., Newbold, Retha R., Couse, John F., Rea, Sheri L., Gallagher, Katie M., Hamilton, Katherine J., Goulding, Eugenia H., Jefferson, Wendy, Eddy, E.M., Bullock, Bill C., Korach, Kenneth S.

Source: In Reproductive Toxicology December 2012 34(4):512-521

Transactivating function (AF) 2-mediated AF-1 activity of estrogen receptor α is crucial to maintain male reproductive tract function

Authors: Arao, Yukitomo, Hamilton, Katherine J., Goulding, Eugenia H., Janardhan, Kyathanahalli S., Eddy, Edward M., Korach, Kenneth S.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2012 Dec . 109(51), 21140-21145.

Access URL: https://www.jstor.org/stable/41830678

Estrogen receptor α AF-2 mutation results in antagonist reversal and reveals tissue selective function of estrogen receptor modulators

Authors: Arao, Yukitomo, Hamilton, Katherine J., Ray, Manas K., Scott, Gregory, Mishina, Yuji, Korach, Kenneth S.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2011 Sep 01. 108(36), 14986-14991.

Access URL: https://www.jstor.org/stable/27979413

Multiple tissue-specific epigenetic alterations regulate persistent gene expression changes following developmental DES exposure in mouse reproductive tissues.

Authors: Jefferson, Tanner B., Wang, Tianyuan, Jefferson, Wendy N., Yin Li, Hamilton, Katherine J., Wade, Paul A., Williams, Carmen J., Korach, Kenneth S.

Source: Epigenetics; 2023, Vol. 18 Issue 1, p1-21, 21p

Subject Terms: GENE expression, MALE reproductive organs, EPIGENETICS, ENDOCRINE disruptors, GENITALIA, PUBERTY, DECITABINE

Novel Mouse Model to Analyze Non-Genomic ERα Physiological Actions.

Authors: Arao, Yukitomo, Gruzdev, Artiom, Scott, Gregory J, Ray, Manas K, Donoghue, Lauren J, Neufeld, Thomas I, Lierz, Sydney L, Stefkovich, Megan L, Mathura, Emilie, Jefferson, Tanner, Foley, Julie F, Mahler, Beth W, Asghari, Arvand, Le, Courtney, McConnell, Bradley K, Stephen, Robert, Berridge, Brian R, Hamilton, Katherine J, Hewitt, Sylvia C, Umetani, Michihisa

Source: Journal of the Endocrine Society; Sep2022, Vol. 6 Issue 9, p1-11, 11p

Subject Terms: LABORATORY mice, ANIMAL disease models, ESTROGEN receptors, PHYSIOLOGY, ANIMAL models in research

Chapter Four - Estrogen Hormone Biology

Authors: Hamilton, Katherine J., Hewitt, Sylvia C., Arao, Yukitomo, Korach, Kenneth S.

Source: In Current Topics in Developmental Biology 2017 125:109-146

Diethylstilbestrol (DES)-Stimulated Hormonal Toxicity Is Mediated by ERα Alteration of Target Gene Methylation Patterns and Epigenetic Modifiers (DNMT3A, MBD2, and HDAC2) in the Mouse Seminal Vesicle.

Authors: Li, Yin¹, Hamilton, Katherine J.¹, Lai, Anne Y.², Burns, Katherine A.¹, Li, Leping³, Wade, Paul A.², Korach, Kenneth S.¹ korach@niehs.nih.gov

Source: Environmental Health Perspectives. Mar2014, Vol. 122 Issue 3, p262-268. 7p. 3 Diagrams, 2 Graphs.

Subject Terms: *ANALYSIS of variance, *ANIMAL experimentation, *CELL receptors, *DIETHYLSTILBESTROL, *ESTROGEN, *GENE expression, *MALE reproductive organs, *HORMONES, *IMMUNOHISTOCHEMISTRY, *METHYLATION, *MICE, *POLYMERASE chain reaction, *RESEARCH funding, *RNA, *STATISTICS, *DATA analysis, *DATA analysis software, *DESCRIPTIVE statistics

ESR1 Mutations Associated With Estrogen Insensitivity Syndrome Change Conformation of Ligand-Receptor Complex and Altered Transcriptome Profile.

Authors: Li, Yin, Hamilton, Katherine J, Perera, Lalith, Wang, Tianyuan, Gruzdev, Artiom, Jefferson, Tanner B, Zhang, Austin X, Mathura, Emilie, Gerrish, Kevin E, Wharey, Laura, Martin, Negin P, Li, Jian-Liang, Korach, Kenneth S

Source: Endocrinology; Jun2020, Vol. 161 Issue 6, p1-17, 17p

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