PRMT5 Regulates DNA Repair by Controlling the Alternative Splicing of Histone-Modifying Enzymes

Authors: Hamard, Pierre-Jacques, Santiago, Gabriel E., Liu, Fan, Karl, Daniel L., Martinez, Concepcion, Man, Na, Mookhtiar, Adnan K., Duffort, Stephanie, Greenblatt, Sarah, Verdun, Ramiro E., Nimer, Stephen D.

Source: In Cell Reports 4 September 2018 24(10):2643-2657

A novel regulatory circuit between p53 and GFI1 controls induction of apoptosis in T cells

Authors: Vadnais, Charles, Chen, Riyan, Fraszczak, Jennifer, Hamard, Pierre-Jacques, Manfredi, James, Möröy, Tarik

Source: Scientific reports. 9(1):1-9

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100133337060.0x000001&indx=1&recIds=ETOCvdc_100133337060.0x000001

Tyrosine phosphorylation of CARM1 promotes its enzymatic activity and alters its target specificity.

Authors: Itonaga, Hidehiro, Mookhtiar, Adnan K., Greenblatt, Sarah M., Liu, Fan, Martinez, Concepcion, Bilbao, Daniel, Rains, Masai, Hamard, Pierre-Jacques, Sun, Jun, Umeano, Afoma C., Duffort, Stephanie, Chen, Chuan, Man, Na, Mas, Gloria, Tottone, Luca, Totiger, Tulasigeri, Bradley, Terrence, Taylor, Justin, Schürer, Stephan, Nimer, Stephen D.

Source: Nature Communications; 4/22/2024, Vol. 15 Issue 1, p1-19, 19p

Subject Terms: PROTEIN arginine methyltransferases, PHOSPHORYLATION, ACUTE myeloid leukemia, TYROSINE, TRANSCRIPTION factors

p53 Basic C Terminus Regulates p53 Functions through DNA Binding Modulation of Subset of Target Genes

Authors: Hamard, Pierre-Jacques, Lukin, Dana J., Manfredi, James J.

Source: In Journal of Biological Chemistry 22 June 2012 287(26):22397-22407

Mdm2's Dilemma: To Degrade or To Translate p53?

Authors: Hamard, Pierre-Jacques, Manfredi, James J.

Source: In Cancer Cell 17 January 2012 21(1):3-5

p38β2-Mediated Phosphorylation and Sumoylation of ATF7 Are Mutually Exclusive

Authors: Camuzeaux, Barbara, Diring, Jessica, Hamard, Pierre-Jacques, Oulad-Abdelghani, Mustapha, Donzeau, Mariel, Vigneron, Marc, Kedinger, Claude, Chatton, Bruno ^⁎

Source: In Journal of Molecular Biology 26 December 2008 384(4):980-991

CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis

Authors: Greenblatt, Sarah M., Man, Na, Hamard, Pierre-Jacques, Asai, Takashi, Karl, Daniel, Martinez, Concepcion, Bilbao, Daniel, Stathias, Vasileios, Jermakowicz, Anna M., Duffort, Stephanie, Tadi, Madhavi, Blumenthal, Ezra, Newman, Samantha, Vu, Ly, Xu, Ye, Liu, Fan, Schurer, Stephan C., McCabe, Michael T., Kruger, Ryan G., Xu, Mingjiang, Yang, Feng-Chun, Tenen, Daniel G., Watts, Justin, Vega, Francisco, Nimer, Stephen D.

Source: Cancer cell. 33(6):1111-1127.e5

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100142432502.0x000001&indx=1&recIds=ETOCvdc_100142432502.0x000001

Tyrosine Phosphorylation of CARM1 Promotes Its Enzymatic Activity and Alters Its Target Specificity in Myeloid Neoplasms with Hyperactivated JAK2

Authors: Itonaga, Hidehiro, Mookhtiar, Adnan K ^*, Greenblatt, Sarah ^*, Liu, Fan ^*, Martinez, Concepcion ^*, Grozovsky, Renata, Bilbao, Daniel, Rains, Masai ^*, Hamard, Pierre-Jacques, Sun, Jun ^*, Umeano, Afoma ^*, Duffort, Stephanie ^*, Chen, Chuan ^*, Man, Na ^*, Mas Martin, Gloria ^*, Schürer, Stephen ^*, Nimer, Stephen D

Source: In Blood 15 November 2022 140 Supplement 1:3021-3022

CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis

Authors: Greenblatt, Sarah M., Man, Na, Hamard, Pierre-Jacques, Asai, Takashi, Karl, Daniel, Martinez, Concepcion, Bilbao, Daniel, Stathias, Vasileios, Jermakowicz, Anna M., Duffort, Stephanie, Tadi, Madhavi, Blumenthal, Ezra, Newman, Samantha, Vu, Ly, Xu, Ye, Liu, Fan, Schurer, Stephan C., McCabe, Michael T., Kruger, Ryan G., Xu, Mingjiang, Yang, Feng-Chun, Tenen, Daniel G., Watts, Justin, Vega, Francisco, Nimer, Stephen D.

Source: Cancer cell. 35(1):156-156

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100074701383.0x000001&indx=1&recIds=ETOCvdc_100074701383.0x000001

PRMT5-mediated histone arginine methylation antagonizes transcriptional repression by polycomb complex PRC2.

Authors: Liu, Fan, Xu, Ye, Lu, Xiaoqing, Hamard, Pierre-Jacques, Karl, Daniel L, Man, Na, Mookhtiar, Adnan K, Martinez, Concepcion, Lossos, Izidore S, Sun, Jun, Nimer, Stephen D

Source: Nucleic Acids Research; 4/6/2020, Vol. 48 Issue 6, p2956-2968, 13p

A functional interaction between ATF7 and TAF12 that is modulated by TAF4.

Authors: Hamard, Pierre-Jacques¹, Dalbies-Tran, Rozenn¹, Hauss, Charlotte¹, Davidson, Irwin², Kedinger, Claude¹, Chatton, Bruno¹

Source: Oncogene. 5/12/2005, Vol. 24 Issue 21, p3472-3483. 12p.

Subject Terms: *PROTEINS, *TRANSCRIPTION factors, *BIOMOLECULES, *ORGANIC compounds, *PHOSPHOTRANSFERASES, *TRANSFERASES

EP300 Suppresses Leukemia Development in Myelodysplastic Syndrome through Myb Repression

Authors: Man, Na ^*, Mas Martin, Gloria ^*, Karl, Daniel ^*, Sun, Jun ^*, Liu, Fan ^*, Torres-Martin, Miguel ^*, Itonaga, Hidehiro ^*, Martinez, Concepcion ^*, Chen, Shi ^*, Duffort, Stephanie ^*, Hamard, Pierre-Jacques, Xu, Ye ^*, Cimmino, Luisa ^*, Yang, Feng-Chun, Cole, Philip A. ^*, Xu, Mingjiang, Figueroa, Maria E., Nimer, Stephen

Source: In Blood 13 November 2019 134 Supplement 1:561-561

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PRMT5 Regulates DNA Repair By Controlling the Alternative Splicing of Epigenetic Factors

Authors: Hamard, Pierre-Jacques, Santiago, Gabriel Emmanuel ^*, Liu, Fan ^*, Greenblatt, Sarah ^*, Karl, Daniel ^*, Martinez, Concepcion ^*, Verdun, Ramiro E ^*, Nimer, Stephen D.

Source: In Blood 8 December 2017 130 Supplement 1:1148-1148

CARM1/PRMT4 As a Novel Therapeutic Target for AML

Authors: Greenblatt, Sarah ^*, Man, Na ^*, Hamard, Pierre-Jacques, Martinez, Concepcion ^*, Xu, Ye ^*, Liu, Fan ^*, Watts, Justin M, Tenen, Daniel G., Nimer, Stephen D.

Source: In Blood 8 December 2017 130 Supplement 1:241-241

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Declined presentation PRMT5 methyltransferase activity is required to sustain adult hematopoiesis

Authors: Nimer, Stephen D., Liu, Fan, Cheng, Guoyan, Perna, Fabiana, Haiming, Xu, Hamard, Pierre-Jacques, Luciani, Luisa, Nimer, Stephen

Source: Experimental hematology. 43:S85-S85

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100031072378.0x000001&indx=1&recIds=ETOCvdc_100031072378.0x000001

Prmt5 Negatively Regulates Erythropoiesis By Multiple Mechanisms, Including Controlling DNA Methyltransferase 3A Protein Levels

Authors: Hamard, Pierre-Jacques, Luciani, Luisa ^*, Liu, Fan ^*, Cheng, Guoyan ^*, Hatlen, Megan A. ^*, Guryanova, Olga A ^*, Zhao, Xinyang, Levine, Ross L., Nimer, Stephen D.

Source: In Blood 3 December 2015 126(23):1181-1181

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