Synthesis, Antitumor Activities, and Apoptosis-Inducing Activities of Schiff’s Bases Incorporating Imidazolidine-2,4-dione Scaffold: Molecular Docking Studies and Enzymatic Inhibition Activities

Authors: Fhdah S. Alanazi, Hamad M. Alkahtani, Alaa A.-M. Abdel-Aziz, Adel S. El-Azab, Hanadi H. Asiri, Ahmed H. Bakheit, Fatmah A. Al-Omary

Source: Pharmaceuticals, Vol 18, Iss 4, p 496 (2025)

Subject Terms: 5,5-diphenylacetophenone, EGFR2, HER2, molecular docking, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/18/4/496; https://doaj.org/toc/1424-8247

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New Benzofuran–Pyrazole-Based Compounds as Promising Antimicrobial Agents: Design, Synthesis, DNA Gyrase B Inhibition, and In Silico Studies

Authors: Somaia S. Abd El-Karim, Manal M. Anwar, Yasmin M. Syam, Hassan M. Awad, Asmaa Negm El-Dein, Mohamed K. El-Ashrey, Hamad M. Alkahtani, Sameh H. Abdelwahed

Source: Pharmaceuticals, Vol 17, Iss 12, p 1664 (2024)

Subject Terms: benzofuran–pyrazole scaffold, antimicrobial activity, antioxidant, in vitro anti-inflammatory DNA gyrase enzyme, computational studies, Medicine, Pharmacy and materia medica, RS1-441

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Relation: https://www.mdpi.com/1424-8247/17/12/1664; https://doaj.org/toc/1424-8247

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Cheminformatics-based identification of phosphorylated RET tyrosine kinase inhibitors for human cancer

Authors: Md. Enamul Kabir Talukder, Md. Aktaruzzaman, Noimul Hasan Siddiquee, Sabrina Islam, Tanveer A. Wani, Hamad M. Alkahtani, Seema Zargar, Md. Obayed Raihan, Md. Mashiar Rahman, Sushil Pokhrel, Foysal Ahammad

Source: Frontiers in Chemistry, Vol 12 (2024)

Subject Terms: phosphorylated rearranged during transfection tyrosine kinase, cancer, high-throughput virtual screening, extra precision docking, docking validation, phase database, Chemistry, QD1-999

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Relation: https://www.frontiersin.org/articles/10.3389/fchem.2024.1407331/full; https://doaj.org/toc/2296-2646

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Theoretical study of the antioxidant mechanism and structure-activity relationships of 1,3,4-oxadiazol-2-ylthieno[2,3-d]pyrimidin-4-amine derivatives: a computational approach

Authors: Ahmed H. Bakheit, Tanveer A. Wani, Abdulrahman A. Al-Majed, Hamad M. Alkahtani, Manal M. Alanazi, Fahad Rubayyi Alqahtani, Seema Zargar

Source: Frontiers in Chemistry, Vol 12 (2024)

Subject Terms: antioxidants, thieno[2, 3-d]pyrimidine derivatives, density functional theory (DFT), hydrogen atom transfer (HAT), free radicals, single electron transfer-proton transfer (SET-PT), Chemistry, QD1-999

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Relation: https://www.frontiersin.org/articles/10.3389/fchem.2024.1443718/full; https://doaj.org/toc/2296-2646

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Network Pharmacology and Molecular Docking Reveal Anti-Asthmatic Potential of Zephyranthes rosea Lindl. in an Ovalbumin-Induced Asthma Model

Authors: Amir Ali, Hafiz Majid Rasheed, Siddique Akber Ansari, Shoeb Anwar Ansari, Hamad M. Alkahtani

Source: Pharmaceuticals, Vol 17, Iss 11, p 1558 (2024)

Subject Terms: asthma, ovalbumin, bronchoalveolar lavage fluid, interleukin 6, AKT serine/threonine kinase 1, proto-oncogene tyrosine-protein kinase Src, Medicine, Pharmacy and materia medica, RS1-441

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Relation: https://www.mdpi.com/1424-8247/17/11/1558; https://doaj.org/toc/1424-8247

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Integration of FTIR Spectroscopy, Volatile Compound Profiling, and Chemometric Techniques for Advanced Geographical and Varietal Analysis of Moroccan Eucalyptus Essential Oils

Authors: Aimen El Orche, Abdennacer El Mrabet, Amal Ait Haj Said, Soumaya Mousannif, Omar Elhamdaoui, Siddique Akber Ansari, Hamad M. Alkahtani, Shoeb Anwar Ansari, Ibrahim Sbai El Otmani, Mustapha Bouatia

Source: Sensors, Vol 24, Iss 22, p 7337 (2024)

Subject Terms: eucalyptus essential oil, FTIR Spectroscopy, volatile compound profiles, chemical composition variations, chemometric analyses, Chemical technology, TP1-1185

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Relation: https://www.mdpi.com/1424-8220/24/22/7337; https://doaj.org/toc/1424-8220

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Advancing Bioanalytical Method Validation: A Comprehensive ICH M10 Approach for Validating LC–MS/MS to Quantify Fluoxetine in Human Plasma and Its Application in Pharmacokinetic Studies

Authors: Aimen El Orche, Amine Cheikh, Choukri El Khabbaz, Houda Bouchafra, My El Abbes Faouzi, Yahya Cherrah, Siddique Akber Ansari, Hamad M. Alkahtani, Shoeb Anwar Ansari, Mustapha Bouatia

Source: Molecules, Vol 29, Iss 19, p 4588 (2024)

Subject Terms: bioanalysis, validation, LC-MS-MS, fluoxetine, pharmacokinetics application, Organic chemistry, QD241-441

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Relation: https://www.mdpi.com/1420-3049/29/19/4588; https://doaj.org/toc/1420-3049

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Synthesis, in silico ADMET prediction analysis, and pharmacological evaluation of sulfonamide derivatives tethered with pyrazole or pyridine as anti-diabetic and anti-Alzheimer's agents

Authors: Nagwa M. Abdelazeem, Wael M. Aboulthana, Ashraf S. Hassan, Abdulrahman A. Almehizia, Ahmed M. Naglah, Hamad M. Alkahtani

Source: Saudi Pharmaceutical Journal, Vol 32, Iss 5, Pp 102025- (2024)

Subject Terms: Sulfonamide derivatives, Pyrazole and pyridine moieties, Anti-diabetic and anti-Alzheimer's agent, α-Amylase and α-glucosidase enzymes, Structure–activity relationship study, Computational studies, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1319016424000756; https://doaj.org/toc/1319-0164

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Design, synthesis, and carbonic anhydrase inhibition activities of Schiff bases incorporating benzenesulfonamide scaffold: Molecular docking application

Authors: Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Silvia Bua, Alessio Nocentini, Ahmed H. Bakheit, Hamad M. Alkahtani, Mohamed M. Hefnawy, Claudiu T. Supuran

Source: Saudi Pharmaceutical Journal, Vol 31, Iss 12, Pp 101866- (2023)

Subject Terms: Metalloenzyme, Quinazolines synthesis, Hydrazones incorporating ethylsulfonamide, CA inhibitors, CA selectivity, Therapeutics. Pharmacology, RM1-950

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Relation: http://www.sciencedirect.com/science/article/pii/S1319016423003614; https://doaj.org/toc/1319-0164

Access URL: https://doaj.org/article/1b543ab78ca8435c914ea8a96d403b3f

Quercetin and Kaempferol as Multi-Targeting Antidiabetic Agents against Mouse Model of Chemically Induced Type 2 Diabetes

Authors: Muhammad Ali, Mudassir Hassan, Siddique Akber Ansari, Hamad M. Alkahtani, Lamees S. Al-Rasheed, Shoeb Anwar Ansari

Source: Pharmaceuticals, Vol 17, Iss 6, p 757 (2024)

Subject Terms: type 2 diabetes, molecular docking, anticancer activity, kaempferol, quercetin, multi-target compounds, Medicine, Pharmacy and materia medica, RS1-441

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Relation: https://www.mdpi.com/1424-8247/17/6/757; https://doaj.org/toc/1424-8247

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Screening and identification of potential MERS-CoV papain-like protease (PLpro) inhibitors; Steady-state kinetic and Molecular dynamic studies

Authors: Mohammed Ali Dahhas, Hamad M. Alkahtani, Ajamaluddin Malik, Abdulrahman A Almehizia, Ahmed H. Bakheit, Siddique Akber Ansar, Abdullah S. AlAbdulkarim, Lamees S.Alrasheed, Mohammad A. Alsenaidy

Source: Saudi Pharmaceutical Journal, Vol 31, Iss 2, Pp 228-244 (2023)

Subject Terms: MERS-CoV PLpro Inhibitors, Papain-like protease, Drug Design, Drug Discovery, Inhibitors, Nonstructural proteins, Therapeutics. Pharmacology, RM1-950

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Relation: http://www.sciencedirect.com/science/article/pii/S1319016422003061; https://doaj.org/toc/1319-0164

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Chitosan loaded RNA polymerase inhibitor nanoparticles increased attenuation in toxin release from Streptococcus pneumonia

Authors: Fulwah Yahya Alqahtani, Fadilah Sfouq Aleanizy, Hamad M. Alkahtani, Eram El Tahir, Siddique Akber Ansari, Atheer Alharbi, Asmaa Al-Bdrawy, Faiyaz Shakeel, Nazrul Haq, Lamees S. Al-Rasheed, Rihaf Alfaraj, Abdullah K. Alshememry, Ibrahim A. Alsarra

Source: Saudi Pharmaceutical Journal, Vol 31, Iss 1, Pp 170-179 (2023)

Subject Terms: Streptococcus pneumonia, Chitosan, C3-005, Hemolysis, Nanoparticles, Toxin, Therapeutics. Pharmacology, RM1-950

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Relation: http://www.sciencedirect.com/science/article/pii/S1319016422002912; https://doaj.org/toc/1319-0164

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Multi-stage structure-based virtual screening approach towards identification of potential SARS-CoV-2 NSP13 helicase inhibitors

Authors: Mahmoud A. El Hassab, Wagdy M. Eldehna, Sara T. Al-Rashood, Amal Alharbi, Razan O. Eskandrani, Hamad M. Alkahtani, Eslam B. Elkaeed, Sahar M. Abou-Seri

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 563-572 (2022)

Subject Terms: sars cov-2 nsp13 helicase, protein-ligand interaction fingerprint, structure-based pharmacophore, docking, molecular dynamics simulations, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

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Preparation and characterization of Meta-bromo-thiolactone calcium alginate nanoparticles

Authors: Esra Kamal Eltayb, Fadilah Sfouq Aleanizy, Fulwah Y. Alqahtani, Hamad M. Alkahtani, Siddique Akber Ansari, Ibrahim Alsarra

Source: Saudi Pharmaceutical Journal, Vol 30, Iss 7, Pp 946-953 (2022)

Subject Terms: Calcium alginate, Meta-bromo-thiolactone (mBTL), Pseudomonas aeruginosa, Alginate nanoparticles, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1319016422001359; https://doaj.org/toc/1319-0164

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Green synthesis and characterization of silver nanoparticles through the Piper cubeba ethanolic extract and their enzyme inhibitory activities

Authors: Khalil Ahmad, Hafiz Muhammad Asif, Taimoor Afzal, Mohsin Abbas Khan, Muhammad Younus, Umair Khurshid, Maryem Safdar, Sohaib Saifulah, Bashir Ahmad, Abubakar Sufyan, Siddique Akber Ansari, Hamad M. Alkahtani, Irfan Aamer Ansari

Source: Frontiers in Chemistry, Vol 11 (2023)

Subject Terms: silver nanoparticles (AgNPs), Piper cubeba, enzyme inhibitory activity, anti-urease activity, spectroscopy, FTIR analysis, Chemistry, QD1-999

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fchem.2023.1065986/full; https://doaj.org/toc/2296-2646

Access URL: https://doaj.org/article/002bfffb428b4d809d41e13b3148e1f4

Gauging Quince Phytonutrients and Its 4% Emulgel Effect on Amplifying Facial Skin Moisturizing Potential

Authors: Tanzila Khiljee, Naveed Akhtar, Sonia Khiljee, Bushra Khiljee, Hafiz Majid Rasheed, Siddique Akber Ansari, Hamad M. Alkahtani, Irfan Aamer Ansari

Source: Gels, Vol 9, Iss 12, p 934 (2023)

Subject Terms: quince, in vivo assessment, moisturizer, chlorogenic acid, facial skin resilience, Science, Chemistry, QD1-999, Inorganic chemistry, QD146-197, General. Including alchemy, QD1-65

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Relation: https://www.mdpi.com/2310-2861/9/12/934; https://doaj.org/toc/2310-2861

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Spilanthes acmella Extract-Based Natural Oils Loaded Emulgel for Anti-Microbial Action against Dermatitis

Authors: Aqsa Afzal, Syed Nisar Hussain Shah, Hina Javed, Asma Mumtaz, Javeria Saeed, Hafiz Majid Rasheed, Rabia Arshad, Siddique Akber Ansari, Hamad M. Alkahtani, Irfan Aamer Ansari

Source: Gels, Vol 9, Iss 10, p 832 (2023)

Subject Terms: Spilanthes acmella, spilanthol, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, emulgel, Science, Chemistry, QD1-999, Inorganic chemistry, QD146-197, General. Including alchemy, QD1-65

File Description: electronic resource

Relation: https://www.mdpi.com/2310-2861/9/10/832; https://doaj.org/toc/2310-2861

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In Vitro Evaluation and Bioinformatics Analysis of Schiff Bases Bearing Pyrazole Scaffold as Bioactive Agents: Antioxidant, Anti-Diabetic, Anti-Alzheimer, and Anti-Arthritic

Authors: Hamad M. Alkahtani, Abdulrahman A. Almehizia, Mohamed A. Al-Omar, Ahmad J. Obaidullah, Amer A. Zen, Ashraf S. Hassan, Wael M. Aboulthana

Source: Molecules, Vol 28, Iss 20, p 7125 (2023)

Subject Terms: Schiff bases, pyrazole scaffold, bioinformatics analysis, anti-arthritic therapeutic, molecular lipophilicity potential, molecular polar surface area, Organic chemistry, QD241-441

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Relation: https://www.mdpi.com/1420-3049/28/20/7125; https://doaj.org/toc/1420-3049

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Development of a New Benzofuran–Pyrazole–Pyridine-Based Molecule for the Management of Osteoarthritis

Authors: Somaia S. Abd El-Karim, Ahlam H. Mahmoud, Asmaa K. Al-Mokaddem, Noha E. Ibrahim, Hamad M. Alkahtani, Amer Alhaj Zen, Manal M. Anwar

Source: Molecules, Vol 28, Iss 19, p 6814 (2023)

Subject Terms: synthesis, osteoarthritis, antioxidant, pro-inflammatory mediators, histopathology, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/28/19/6814; https://doaj.org/toc/1420-3049

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Integrated Structural, Functional, and ADMET Analysis of 2-Methoxy-4,6-diphenylnicotinonitrile: The Convergence of X-ray Diffraction, Molecular Docking, Dynamic Simulations, and Advanced Computational Insights

Authors: Ahmed H. Bakheit, Hamad M. Alkahtani

Source: Molecules, Vol 28, Iss 19, p 6859 (2023)

Subject Terms: 2-methoxy-4,6-diphenylnicotinonitrile, X-ray diffraction, orthorhombic crystal system, CH–π interaction, Hirshfeld surface, π–π stacking, Organic chemistry, QD241-441

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Relation: https://www.mdpi.com/1420-3049/28/19/6859; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/3dfa47d09edc46659a30d12db4392402